Medication Affecting the Nervous System

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Questions and Answers

Which medication is primarily used for managing episodes of acute mania in bipolar disorder?

  • Doxepin
  • Amitriptyline
  • Lithium carbonate (correct)
  • Phenelzine

What is a common side effect experienced with tricyclic antidepressants?

  • Dry mouth (correct)
  • Nausea
  • Insomnia
  • Skin rash

Which of the following foods should be avoided when taking MAOIs?

  • White bread
  • Green vegetables
  • Aged cheese (correct)
  • Fresh fruit

What is a critical nursing action when administering lithium?

<p>Monitor sodium levels closely (B)</p> Signup and view all the answers

Which drug class does amitriptyline belong to?

<p>Tricyclic antidepressants (C)</p> Signup and view all the answers

What potential interaction must be avoided when taking MAOIs?

<p>SSRIs (A)</p> Signup and view all the answers

Which of the following medications is not a common side effect of lithium therapy?

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Which medication enhances the levels of dopamine, norepinephrine, and serotonin by blocking MAOI enzymes?

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What should be monitored regularly when administering Valproic Acid?

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What is a common side effect of atropine?

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When is the best time to administer HMG-CoA reductase inhibitors (statins)?

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What action does ezetimibe (Zetia) perform in the body?

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Which patient should avoid taking statins altogether?

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What is a key nursing consideration when a patient is prescribed cholestyramine?

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Which side effect is associated with HMG-CoA reductase inhibitors?

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Why is it recommended to increase fiber intake when a patient is on bile-acid sequestrants?

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What is the primary use of gemfibrozil (Lopid)?

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Which side effect is commonly associated with niacin (Vitamin B3)?

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What should be monitored when administering warfarin (Coumadin)?

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What action does heparin primarily perform in the body?

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Which of the following is a potential side effect of fibrates?

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What is the antidote for warfarin (Coumadin) overdose?

<p>Vitamin K (A)</p> Signup and view all the answers

Which of the following medications is used to prevent stroke and embolisms?

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What is a significant nursing consideration when administering enoxaparin (Lovenox)?

<p>Monitor for bleeding events (A)</p> Signup and view all the answers

What is the primary action of filgrastim?

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Which of the following are potential side effects of albumin administration?

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What immediate action should a nurse take if a patient shows signs of an acute hemolytic reaction during a blood transfusion?

<p>STOP the transfusion immediately (B)</p> Signup and view all the answers

In which condition is Whole Blood primarily used?

<p>Acute blood loss replacement therapy (D)</p> Signup and view all the answers

What is a contraindication for the use of albumin?

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What is the primary action of rivaroxaban and apixaban in the prevention of stroke?

<p>Inhibits factor Xa (A)</p> Signup and view all the answers

Which of the following side effects is associated with clopidogrel?

<p>Rash (D)</p> Signup and view all the answers

What is the contraindication for administering alteplase?

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What vital sign should be monitored in a patient receiving epoetin alfa?

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What action should a nurse take when administering aminocaproic acid?

<p>Assess for thromboembolism (B)</p> Signup and view all the answers

Which medication requires administration within three hours of symptoms for ischemic stroke?

<p>Alteplase (A)</p> Signup and view all the answers

What lab values should be monitored during therapy with rivaroxaban?

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What outcome is a primary concern after administering abciximab?

<p>Dysrhythmias (C)</p> Signup and view all the answers

Which medication class is primarily used for anxiety and seizure management?

<p>Sedative hypnotic anxiolytics (C)</p> Signup and view all the answers

Which category of medications includes atorvastatin and simvastatin?

<p>Antilipemic agents (A)</p> Signup and view all the answers

What type of medication is methylxanthines primarily associated with?

<p>Bronchodilators (C)</p> Signup and view all the answers

Which of the following medications is classified as a direct acting muscle relaxant?

<p>Dantrolene (D)</p> Signup and view all the answers

What is the main use of beta-blockers?

<p>Control blood pressure (B)</p> Signup and view all the answers

Which medication is commonly used for alcohol withdrawal management?

<p>Lorazepam (B)</p> Signup and view all the answers

Which drug class includes medications used to prevent gout attacks?

<p>Antigout medications (B)</p> Signup and view all the answers

Which of the following medications is not a type of anticoagulant?

<p>Clopidogrel (D)</p> Signup and view all the answers

What condition is treated with beta2 adrenergic agonists?

<p>Asthma (D)</p> Signup and view all the answers

Which type of medications are ACE inhibitors specifically used for?

<p>Managing blood pressure (A)</p> Signup and view all the answers

Which medication is indicated for treating hyperthyroidism?

<p>Thionamides (B)</p> Signup and view all the answers

Which medication is known as a broad-spectrum antibiotic?

<p>Amoxicillin (C)</p> Signup and view all the answers

Which type of medications are proton pump inhibitors primarily used for?

<p>Managing gastric acid secretion (A)</p> Signup and view all the answers

Flashcards

Neuromuscular blocking agents

Medications that temporarily block the transmission of nerve signals to muscles, causing muscle relaxation.

Muscle relaxants (direct acting)

Drugs that directly affect muscles, causing relaxation.

Muscle relaxants (CNS)

Drugs that work by affecting the central nervous system to relax muscles.

Sedative-hypnotic anxiolytics

Drugs that induce relaxation, calmness, and sleep. Often used to treat anxiety.

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Antidepressants (SSRI)

Medications that regulate serotonin levels in the brain, used to treat depression.

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Antipsychotics

Medications used to treat psychosis, including hallucinations and delusions.

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Beta2 adrenergic agonists

Drugs that stimulate beta-2 receptors, improving breathing.

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Diuretics (high-ceiling loop)

Powerful diuretics that promote water excretion from the body, primarily in the kidneys.

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Anticoagulants (oral)

Medications to prevent blood clots from forming.

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Analgesics (opioids)

Medications used to relieve pain.

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Corticosteroids

Powerful anti-inflammatory medications, often used for various conditions.

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Antibiotics

Medications that kill or inhibit the growth of bacteria.

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Insulin

A hormone crucial for blood sugar regulation, often used to treat diabetes.

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Calcium supplements

Medications containing calcium to treat or prevent calcium deficiencies.

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Analgesics (Nonsteroidal Anti-inflammatory drugs)

Medications that reduce pain and inflammation.

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Tricyclic Antidepressants (TCAs)

A class of medications used to treat depression, neuropathic pain, anxiety, and other conditions. They work by blocking the reuptake of norepinephrine and serotonin in the central nervous system.

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Monoamine Oxidase Inhibitors (MAOIs)

A class of antidepressants that increase the levels of dopamine, norepinephrine, serotonin, and tyramine in the body by blocking MAO enzymes.

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Tyramine-rich foods

Foods containing tyramine should be avoided when taking MAOIs, as they can lead to a hypertensive crisis.

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Lithium Carbonate

Medication used to treat bipolar disorder by controlling acute manic episodes.

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Lithium Toxicity

Symptoms of lithium toxicity include tremors, confusion, hypotension, seizures, and tinnitus. Plasma levels above 1.5 mEq/L indicate possible toxicity.

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Anticholinergic side effects

Side effects of TCAs that include dry mouth, blurry vision, photophobia, urinary retention, and constipation.

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Mood Stabilizers (e.g., Carbamazepine, Valproic Acid, Lamotrigine)

Used to treat or prevent mania and depressive episodes in bipolar disorder. These medications decrease synaptic transmission in the brain.

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Hypertensive Crisis

A serious, potentially life-threatening condition caused by dangerously high blood pressure.

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Fibrates mechanism

Reduces triglyceride production and transport, increasing HDL levels.

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Fibrates side effects

GI upset, gallstones, liver problems (hepatotoxicity), muscle pain.

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Vitamin B3 (Niacin) for high cholesterol

Lowers lipoprotein and triglyceride production (high doses).

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Niacin side effects

Facial flushing, stomach problems, itching, liver problems (hepatotoxicity), high blood sugar.

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Heparin (IV/SQ) action

Activates antithrombin, stopping clot formation; does not dissolve existing clots.

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Heparin side effects

Bleeding, blood platelet count drop (Heparin-Induced Thrombocytopenia), allergic reaction.

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Warfarin mechanism

Blocks vitamin K, preventing certain clotting factors from forming.

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Warfarin monitoring

PT/INR monitoring required; therapeutic INR 2-3.

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Valproic Acid Action

Increases GABA, an inhibitory neurotransmitter, in the central nervous system (CNS).

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Valproic Acid Side Effects

Hepatotoxicity, gastrointestinal (GI) effects, pancreatitis, thrombocytopenia, hepatotoxicity

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Atropine Use

Treats sinus bradycardia and heart block; used to reduce secretions during surgery.

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Atropine Action

Blocks acetylcholine (ACh) receptors in smooth muscles, glands, and the central nervous system, decreasing vagal stimulation to increase heart rate.

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Statin Use

Treats high cholesterol (hypercholesterolemia), preventing coronary heart disease and myocardial infarction (MI).

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Statin Action

Lowers LDL (bad) cholesterol & increases HDL (good) cholesterol, lowering bad cholesterol production.

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Cholesterol Absorption Inhibitor Action

Blocks cholesterol absorption in the small intestine.

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Bile Acid Sequestrant Action

Binds bile acids in the intestine, increasing cholesterol excretion and lowering LDL cholesterol.

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Dabigatran Action

Dabigatran inhibits thrombin, preventing blood clot formation.

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Rivaroxaban/Apixaban Use

Prevent or treat blood clots in the veins (DVT/PE) and limit stroke.

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Antiplatelet Drugs

These medications stop platelets from clumping together (aggregation).

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Thrombolytics Use

Break up existing blood clots, used for stroke, heart attack, and blocked blood vessels.

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Aminocaproic Acid use

Stops blood clot breakdown, an antidote for blood clot dissolving medications, controls bleeding.

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Erythropoiesis Stimulants Use

Stimulates the body to make more red blood cells, for anemia.

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Epoetin Alfa S/E

Possible side effects include high blood pressure due to increased red blood cells and an increased risk of blood clots/strokes.

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Antiplatelet Drugs S/E

Side effects include bleeding, stomach upset, and rash, depending on the drug.

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Filgrastim (Neupogen)

A medication that stimulates the bone marrow to produce more neutrophils, helping to prevent infections in people with low neutrophil counts caused by cancer treatments, certain diseases, or other conditions.

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Pegfilgrastin

Similar to Filgrastim, this medication also increases neutrophil production, but it remains in the body for a longer duration, requiring less frequent injections.

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Albumin

A protein found in blood that helps maintain fluid balance. It's used to treat conditions like hypovolemia (low blood volume), shock, hemorrhage, and burns.

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Whole Blood Transfusion

A transfusion of blood that contains all blood components, used to replace lost blood volume and increase the number of red blood cells, white blood cells, and platelets.

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Packed Red Blood Cells (PRBCs)

A transfusion of only red blood cells, used to treat severe anemia, hemoglobinopathies (diseases affecting red blood cells), and erythroblastosis fetalis (a condition affecting newborns).

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Study Notes

Medication Affecting the Nervous System

  • Sedative Hypnotic Anxiolytics - Benzodiazepines: Includes alprazolam (Xanax), diazepam (Valium), lorazepam (Ativan), midazolam (Versed), and chlordiazepoxide (Librium). Used for anxiety, seizures, muscle spasms, alcohol withdrawal, and anesthesia induction/maintenance. Side effects include sedation, amnesia, and dependence/withdrawal. Avoid grapefruit juice. Do not discontinue abruptly.

  • Atypical Anxiolytic/Nonbarbiturate Anxiolytic: Buspirone (Buspar) is used for anxiety, panic disorder, OCD, and PTSD. Mechanism: Binds to serotonin and dopamine receptors in the brain, increasing norepinephrine metabolism. Effects develop slowly (2-4 weeks). Avoid grapefruit juice.

  • Selective Serotonin Reuptake Inhibitors (SSRIs): Includes paroxetine (Paxil), sertraline (Zoloft), fluoxetine (Prozac), citalopram, and fluvoxamine. Used for anxiety, depression, OCD, and PTSD. Side effects can include sexual dysfunction, weight gain, and insomnia. Monitor for Serotonin Syndrome.

  • Serotonin-Norepinephrine Reuptake Inhibitors (SNRIs): Includes venlafaxine (Effexor), duloxetine (Cymbalta), and levomilnacipran (Fetzima). Used for depression, anxiety, pain due to fibromyalgia, osteoarthritis, and low-back pain. Side effects can include sexual dysfunction, weight loss, etc. Avoid alcohol and other CNS depressants. Monitor for Serotonin Syndrome.

  • Atypical Antidepressants: Bupropion (Wellbutrin, Zyban), trazodone (Oleptro), Vilazodone, and Mirtazapine. Different mechanisms of action. Wellbutrin acts as a Norepinephrine-Dopamine Reuptake Inhibitor. Amitriptyline (Elavil), imipramine (Tofranil), Amoxapine, Doxepin, and others are tricyclic antidepressants (TCAs). Side effects vary widely according to specific medication.

  • Monoamine Oxidase Inhibitors (MAOIs): Phenelzine (Nardil), tranylcypromine (Parnate), isocarboxazid (Marplan). These have strong dietary restrictions to avoid hypertensive crisis. Caution with other medications.

  • Bipolar Disorder - Mood Stabilizers: Lithium carbonate is used to control mood swings in bipolar disorder. Side effects: Fine hand tremors, polyuria, weight gain, kidney toxicity, electrolyte imbalances, fatigue, hypothyroidism, leukocytosis.

Medication Affecting Pain & Inflammation

  • Salicylates: Aspirin is used for pain, inflammation, fever, and prevention of heart attacks and strokes. Side effects include tinnitus, GI upset, and possible bleeding risks in some cases.

  • Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Ibuprofen (Advil, Motrin, Excedrin), naproxen (Aleve), ketorolac (Toradol), indomethacin (Indocin). Used for mild to moderate pain, fever, and inflammation. May have negative GI impacts, bleeding risks, or kidney toxicity.

  • COX-2 Inhibitors: Celecoxib (Celebrex). Used for pain and inflammation but has important risks of cardiovascular issues.

  • Acetaminophen: Tylenol. Used for pain and fever but can cause liver damage if taken in too high of a dose.

  • Opioids: Examples include fentanyl, morphine, dilaudid, oxycodone (Oxycontin). For moderate to severe pain and sedation. Side effects include respiratory depression, sedation, and constipation. Monitor closely and use around-the-clock dosing as needed.

  • Topical Analgesic: Lidocaine (Xylocaine). Used to reduce pain in skin and mucous membranes.

Medication Affecting Respiratory System

(This section is quite long, so subheadings for specific categories might be useful)

Medication Affecting Cardiovascular System

(This section is quite long, so subheadings for specific categories might be useful)

Medication Affecting Blood & Coagulation

(This section is quite long, so subheadings for specific categories might be useful)

Vitamins & Minerals

(This section is quite long, so subheadings for specific categories might be useful)

Medication Affecting Endocrine System

(This section is quite long, so subheadings for specific categories might be useful.)

Medication affecting Gastrointestinal System

(This section is quite long, so subheadings for specific categories might be useful.)

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