Medication Adherence in Clinical Trials
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Questions and Answers

What is one of the main challenges in interpreting results of clinical trials?

  • Poor medication adherence by patients (correct)
  • Inadequate availability of medications
  • Lack of qualified healthcare professionals
  • High cost of diagnostic procedures

    • Why is it important to have accurate estimates of medication adherence?

  • To reduce the cost of diagnostic procedures
  • To identify predictors and risk factors for non-adherence (correct)
  • To speed up therapy intensification
  • To increase the number of clinical trials conducted

    • What makes the measurement of medication adherence challenging?

  • The simplicity of adherence monitoring methods
  • The lack of available tools for measurement
  • The need for individualized adherence parameters (correct)
  • The abundance of reliable methods

    • Why is the selection of a method to monitor adherence recommended to be individualized?

    <p>To tailor the measurement to patient attributes and study goals/resources</p> Signup and view all the answers

    Why is it suggested that a combination of methods be used to monitor medication adherence?

    <p>Because no single method is considered a gold standard</p> Signup and view all the answers

    What is one limitation highlighted after decades of research in medication adherence measurement?

    <p>Difficulty in choosing the most suitable adherence measures</p> Signup and view all the answers

    What is the primary focus of the categorization done by the authors regarding adherence scales?

    <p>Medication-taking behavior and barriers to adherence</p> Signup and view all the answers

    How did the authors define barriers to adherence in the context of the reviewed scales?

    <p>Side effects of prescribed medications</p> Signup and view all the answers

    Which measure is commonly used to ascertain patient adherence to medication based on a recommended cutoff value of 80% or more?

    <p>Objective measures like MEMS</p> Signup and view all the answers

    In what cases are patients typically labeled as nonadherent based on the reviewed scales?

    <p>Taking less than 80% of their medicines</p> Signup and view all the answers

    What is NOT a category under which the scales were classified by the authors?

    <p>Beliefs associated with patient safety</p> Signup and view all the answers

    Which aspect is NOT considered a barrier to adherence according to the text?

    <p>Adherence to dosing regime phases</p> Signup and view all the answers

    Which medication adherence scale is specifically validated for use in patients with chronic diseases?

    <p>8-item Morisky Medication Adherence Scale (MMAS-8)</p> Signup and view all the answers

    Which self-report questionnaire is quickest to administer?

    <p>Brief Medication Questionnaire</p> Signup and view all the answers

    Which scale is validated in the broadest range of diseases?

    <p>Medication Adherence Report Scale (MARS)</p> Signup and view all the answers

    Which scale has high internal consistency in both primary and outpatient settings?

    <p>Medication Adherence Report Scale (MARS)</p> Signup and view all the answers

    What is a disadvantage of the Hill-Bone Compliance Scale?

    <p>Overestimation if patients accidentally or purposefully actuate the container</p> Signup and view all the answers

    Which scale has strong positive correlations compared to DAI and MAQ?

    <p>8-item Morisky Medication Adherence Scale (MMAS-8)</p> Signup and view all the answers

    What is a common barrier to adherence referred to in the text?

    <p>Missing out prescriptions obtained outside the system</p> Signup and view all the answers

    Which medication adherence scale is specifically validated for patients with low literacy?

    <p>Medication Adherence Report Scale (MARS)</p> Signup and view all the answers

    What is an advantage of the Self-Efficacy for Appropriate Medication Use Scale (SEAMS)?

    <p>High internal consistency in patients with high or low literacy</p> Signup and view all the answers

    What is a disadvantage of the Brief Medication Questionnaire?

    <p>Inconvenience due to bulky container</p> Signup and view all the answers

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