Medication Adherence in Clinical Trials

What is one of the main challenges in interpreting results of clinical trials?

Poor medication adherence by patients (correct)
Inadequate availability of medications
Lack of qualified healthcare professionals
High cost of diagnostic procedures

Why is it important to have accurate estimates of medication adherence?

To reduce the cost of diagnostic procedures
To identify predictors and risk factors for non-adherence (correct)
To speed up therapy intensification
To increase the number of clinical trials conducted

What makes the measurement of medication adherence challenging?

The simplicity of adherence monitoring methods
The lack of available tools for measurement
The need for individualized adherence parameters (correct)
The abundance of reliable methods

Why is the selection of a method to monitor adherence recommended to be individualized?

To tailor the measurement to patient attributes and study goals/resources (C) Signup and view all the answers

Why is it suggested that a combination of methods be used to monitor medication adherence?

Because no single method is considered a gold standard (C) Signup and view all the answers

What is one limitation highlighted after decades of research in medication adherence measurement?

Difficulty in choosing the most suitable adherence measures (C) Signup and view all the answers

What is the primary focus of the categorization done by the authors regarding adherence scales?

Medication-taking behavior and barriers to adherence (D) Signup and view all the answers

How did the authors define barriers to adherence in the context of the reviewed scales?

Side effects of prescribed medications (B) Signup and view all the answers

Which measure is commonly used to ascertain patient adherence to medication based on a recommended cutoff value of 80% or more?

Objective measures like MEMS (A) Signup and view all the answers

In what cases are patients typically labeled as nonadherent based on the reviewed scales?

Taking less than 80% of their medicines (A) Signup and view all the answers

What is NOT a category under which the scales were classified by the authors?

Beliefs associated with patient safety (B) Signup and view all the answers

Which aspect is NOT considered a barrier to adherence according to the text?

Adherence to dosing regime phases (D) Signup and view all the answers

Which medication adherence scale is specifically validated for use in patients with chronic diseases?

8-item Morisky Medication Adherence Scale (MMAS-8) (A) Signup and view all the answers

Which self-report questionnaire is quickest to administer?

Brief Medication Questionnaire (C) Signup and view all the answers

Which scale is validated in the broadest range of diseases?

Medication Adherence Report Scale (MARS) (D) Signup and view all the answers

Which scale has high internal consistency in both primary and outpatient settings?

Medication Adherence Report Scale (MARS) (B) Signup and view all the answers

What is a disadvantage of the Hill-Bone Compliance Scale?

Overestimation if patients accidentally or purposefully actuate the container (A) Signup and view all the answers

Which scale has strong positive correlations compared to DAI and MAQ?

8-item Morisky Medication Adherence Scale (MMAS-8) (D) Signup and view all the answers

What is a common barrier to adherence referred to in the text?

Missing out prescriptions obtained outside the system (A) Signup and view all the answers

Which medication adherence scale is specifically validated for patients with low literacy?

Medication Adherence Report Scale (MARS) (D) Signup and view all the answers

What is an advantage of the Self-Efficacy for Appropriate Medication Use Scale (SEAMS)?

High internal consistency in patients with high or low literacy (B) Signup and view all the answers

What is a disadvantage of the Brief Medication Questionnaire?

Inconvenience due to bulky container (B) Signup and view all the answers