Podcast
Questions and Answers
Which of the following genera of fungi is NOT medically important?
Which of the following genera of fungi is NOT medically important?
- Streptococcus (correct)
- Aspergillus
- Candida
- Cryptococcus
Candida glabrata is less drug resistant than Candida albicans.
Candida glabrata is less drug resistant than Candida albicans.
False (B)
What is the most important species of the Candida genus?
What is the most important species of the Candida genus?
Candida albicans
Candidemia refers to _____ infections.
Candidemia refers to _____ infections.
Which condition is a common disease caused by Candida albicans?
Which condition is a common disease caused by Candida albicans?
Match the following Candida species with their characteristics:
Match the following Candida species with their characteristics:
What is the first line of defense against Candida infections?
What is the first line of defense against Candida infections?
Candida albicans can cause _____ infections related to indwelling catheters.
Candida albicans can cause _____ infections related to indwelling catheters.
What type of capsule surrounds Cryptococcus neoformans?
What type of capsule surrounds Cryptococcus neoformans?
Cryptococcus gattii is less capable of causing disease in immunocompetent individuals than Cryptococcus neoformans.
Cryptococcus gattii is less capable of causing disease in immunocompetent individuals than Cryptococcus neoformans.
What test is abbreviated as 'crag'?
What test is abbreviated as 'crag'?
Aspergillus species exist only as ______.
Aspergillus species exist only as ______.
Match the following conditions with the responsible species:
Match the following conditions with the responsible species:
Which statement about the transmission of Cryptococcus neoformans is true?
Which statement about the transmission of Cryptococcus neoformans is true?
The appearance of Aspergillus species cells can be reliably visualized using Gram stain.
The appearance of Aspergillus species cells can be reliably visualized using Gram stain.
What is the primary treatment for cryptococcal infections?
What is the primary treatment for cryptococcal infections?
Which pathogenic species is known to form germ tubes at 37°C?
Which pathogenic species is known to form germ tubes at 37°C?
Chlamydospores are formed by most other species of Candida.
Chlamydospores are formed by most other species of Candida.
What laboratory test can identify Candida albicans and four other species in blood cultures within 3 to 5 hours?
What laboratory test can identify Candida albicans and four other species in blood cultures within 3 to 5 hours?
Treatment for esophageal candidiasis includes an echinocandin such as ________ or micafungin.
Treatment for esophageal candidiasis includes an echinocandin such as ________ or micafungin.
Which drug can be used to prevent certain candidal infections like thrush?
Which drug can be used to prevent certain candidal infections like thrush?
Individuals who do not respond to Candida antigens in the skin test are considered anergic.
Individuals who do not respond to Candida antigens in the skin test are considered anergic.
Match the following drugs with their corresponding treatment purposes:
Match the following drugs with their corresponding treatment purposes:
Which species of Cryptococcus causes the most common life-threatening invasive fungal disease?
Which species of Cryptococcus causes the most common life-threatening invasive fungal disease?
What role do Th-1 cells play in cell-mediated immunity?
What role do Th-1 cells play in cell-mediated immunity?
Neutrophils are not significant in combating Candida infections.
Neutrophils are not significant in combating Candida infections.
What condition is characterized by white patches in the mouth due to overgrowth of Candida albicans?
What condition is characterized by white patches in the mouth due to overgrowth of Candida albicans?
High pH, diabetes, or the use of antibiotics can lead to _____, a condition that includes itching and discharge.
High pH, diabetes, or the use of antibiotics can lead to _____, a condition that includes itching and discharge.
Match the condition with its description:
Match the condition with its description:
Which factor is NOT associated with an increased risk of disseminated Candida infections?
Which factor is NOT associated with an increased risk of disseminated Candida infections?
Candida esophagitis mainly occurs in healthy individuals.
Candida esophagitis mainly occurs in healthy individuals.
What type of staining can help visualize budding yeasts and pseudohyphae in tissue samples?
What type of staining can help visualize budding yeasts and pseudohyphae in tissue samples?
What is the most common fungal cause of sinusitis?
What is the most common fungal cause of sinusitis?
Aspergillus species can only colonize healthy skin and do not invade compromised tissues.
Aspergillus species can only colonize healthy skin and do not invade compromised tissues.
What is the primary drug used to treat invasive aspergillosis?
What is the primary drug used to treat invasive aspergillosis?
The fungus ball produced by Aspergillus in lung cavities is known as an ______.
The fungus ball produced by Aspergillus in lung cavities is known as an ______.
Match the following treatments with their respective conditions:
Match the following treatments with their respective conditions:
Which condition is characterized by a hypersensitivity reaction to Aspergillus?
Which condition is characterized by a hypersensitivity reaction to Aspergillus?
Mucormycosis is caused by dimorphic fungi.
Mucormycosis is caused by dimorphic fungi.
What type of patients are most at risk for infections caused by Aspergillus species?
What type of patients are most at risk for infections caused by Aspergillus species?
What is the primary cause of about 60% of mucormycosis cases?
What is the primary cause of about 60% of mucormycosis cases?
Pneumocystis jiroveci is classified as a yeast and has characteristics of both yeast and protozoan.
Pneumocystis jiroveci is classified as a yeast and has characteristics of both yeast and protozoan.
What is the primary method of transmission for Pneumocystis pneumonia?
What is the primary method of transmission for Pneumocystis pneumonia?
In patients with preexisting kidney damage, __________ should be used to treat mucormycosis.
In patients with preexisting kidney damage, __________ should be used to treat mucormycosis.
What is commonly observed on a chest X-ray of a patient with Pneumocystis pneumonia?
What is commonly observed on a chest X-ray of a patient with Pneumocystis pneumonia?
Match each organism with its description.
Match each organism with its description.
Serological tests are useful for diagnosing Pneumocystis pneumonia.
Serological tests are useful for diagnosing Pneumocystis pneumonia.
What is the mortality rate of untreated Pneumocystis pneumonia?
What is the mortality rate of untreated Pneumocystis pneumonia?
Flashcards
Opportunistic Fungi
Opportunistic Fungi
Fungi that typically don't cause disease in healthy individuals but can infect those with weakened immune systems.
Candida albicans
Candida albicans
A common yeast species that is part of the normal flora in the mouth, gut, and vagina. Causes infections like thrush, vaginitis, and bloodstream infections.
Thrush (Oral Candidiasis)
Thrush (Oral Candidiasis)
A white, creamy coating on the tongue or inner cheeks, often caused by Candida albicans.
Vaginitis
Vaginitis
Signup and view all the flashcards
Esophagitis
Esophagitis
Signup and view all the flashcards
Candidemia
Candidemia
Signup and view all the flashcards
Right-sided Endocarditis
Right-sided Endocarditis
Signup and view all the flashcards
Endophthalmitis
Endophthalmitis
Signup and view all the flashcards
Thrush
Thrush
Signup and view all the flashcards
Candidal Vaginitis
Candidal Vaginitis
Signup and view all the flashcards
Candidal Skin Infection
Candidal Skin Infection
Signup and view all the flashcards
Diaper Rash
Diaper Rash
Signup and view all the flashcards
Disseminated Candidiasis
Disseminated Candidiasis
Signup and view all the flashcards
Chronic Mucocutaneous Candidiasis (CMC)
Chronic Mucocutaneous Candidiasis (CMC)
Signup and view all the flashcards
Candida Infection after Transplantation
Candida Infection after Transplantation
Signup and view all the flashcards
Candida Esophagitis
Candida Esophagitis
Signup and view all the flashcards
Rapid Candida Identification Test
Rapid Candida Identification Test
Signup and view all the flashcards
Esophageal Candidiasis
Esophageal Candidiasis
Signup and view all the flashcards
Chlamydospores
Chlamydospores
Signup and view all the flashcards
Cell-Mediated Immunity (CMI) against Candida
Cell-Mediated Immunity (CMI) against Candida
Signup and view all the flashcards
Cryptococcosis
Cryptococcosis
Signup and view all the flashcards
Cryptococcal Meningitis
Cryptococcal Meningitis
Signup and view all the flashcards
Cryptococcus neoformans
Cryptococcus neoformans
Signup and view all the flashcards
Cryptococcus gattii
Cryptococcus gattii
Signup and view all the flashcards
Unstained capsule surrounding yeast cell
Unstained capsule surrounding yeast cell
Signup and view all the flashcards
Aspergillosis
Aspergillosis
Signup and view all the flashcards
Septate hyphae with dichotomous branching
Septate hyphae with dichotomous branching
Signup and view all the flashcards
Conidia formation in Aspergillus chains
Conidia formation in Aspergillus chains
Signup and view all the flashcards
Fungus ball (Aspergilloma)
Fungus ball (Aspergilloma)
Signup and view all the flashcards
Aspergilloma
Aspergilloma
Signup and view all the flashcards
Allergic Bronchopulmonary Aspergillosis (ABPA)
Allergic Bronchopulmonary Aspergillosis (ABPA)
Signup and view all the flashcards
Mucormycosis (Zygomycosis)
Mucormycosis (Zygomycosis)
Signup and view all the flashcards
Invasive Aspergillosis
Invasive Aspergillosis
Signup and view all the flashcards
Fungal Sinusitis
Fungal Sinusitis
Signup and view all the flashcards
Septate, Branching Hyphae
Septate, Branching Hyphae
Signup and view all the flashcards
Conidia
Conidia
Signup and view all the flashcards
Mucormycosis
Mucormycosis
Signup and view all the flashcards
Rhinocerebral Mucormycosis
Rhinocerebral Mucormycosis
Signup and view all the flashcards
Rhizopus oryzae
Rhizopus oryzae
Signup and view all the flashcards
Pneumocystis Pneumonia (PCP)
Pneumocystis Pneumonia (PCP)
Signup and view all the flashcards
Pneumocystis jiroveci
Pneumocystis jiroveci
Signup and view all the flashcards
Sporotrichosis
Sporotrichosis
Signup and view all the flashcards
Mold Form of Sporothrix schenckii
Mold Form of Sporothrix schenckii
Signup and view all the flashcards
Yeast Form of Sporothrix schenckii
Yeast Form of Sporothrix schenckii
Signup and view all the flashcards
Study Notes
Opportunistic Mycoses
- Opportunistic fungi cause disease in individuals with weakened immune systems.
- Five medically important fungal genera are: Candida, Cryptococcus, Aspergillus, Mucor, and Rhizopus.
Candida
- Species: Candida albicans is the most significant species, causing thrush, vaginitis, and other infections. Candida glabrata is another important species.
- Forms: Candida albicans appears as yeast or pseudohyphae in tissues.
- Properties: Candida is part of the normal flora in the upper respiratory, gastrointestinal, and genital tracts.
- Transmission: Candida is naturally present on skin and mucous membranes. Transmission occurs through contact or via passage through a colonized birth canal. Infections can also occur through instruments that penetrate the skin.
- Pathogenesis/Clinical Findings: Intact skin and mucous membranes act as a first line of defense. The second line is cell-mediated immunity (Th-1 cells producing gamma-interferon). Neutrophils are important for killing pathogens; neutropenia increases the risk of disseminated infections. Impaired host defenses lead to overgrowth. Thrush (white patches) in the mouth is a common clinical manifestation. Vaginitis can result from high pH and antibiotic usage. Skin infections can appear in moist areas, like diaper rash. Infections in immunocompromised individuals can disseminate to multiple organs, leading to chronic mucocutaneous candidiasis.
- Laboratory Diagnosis: Gram-positive, culture-grown yeast colonies, germ tubes (if Candida albicans), India ink stain, capsule presence, etc.
- Treatment/Prevention: Various antifungal medications like fluconazole, itraconazole, and nystatin are used to treat Candida infections. Oral clotrimazole troches or clotrimazole creams can be used as a preventive method.
Cryptococcus
- Species: Cryptococcus neoformans is the major cause of cryptococcosis, especially cryptococcal meningitis. A less frequent causative agent is Cryptococcus gattii.
- Properties: Oval, budding yeast cells with a wide polysaccharide capsule.
- Transmission: Occurs widely in nature (e.g., bird droppings) and can be inhaled by individuals.
- Diagnosis: Use of India ink (visualizing the capsule); microscopic evaluation of CSF (spinal fluid).
- Treatment: Combination of amphotericin B and flucytosine is common. Prophylaxis is also an option for AIDS patients with low CD4 cell counts and fluconazole use is often included as a prophylactic measure
- Properties:
Aspergillus
- Species: Aspergillus fumigatus is a prevalent species, and commonly causes infections, like "fungus ball" formation in the lung and allergic bronchopulmonary aspergillosis.
- Properties: Mold form only; it is not dimorphic.
- Transmission: Airborne conidia, as the fungus grows on decaying vegetation.
- Pathogenesis: Aspergillus can colonize and invade abraded skin, wounds, and the eyes. Neutropenic patients are particularly vulnerable; cavities in the lung (e.g., from tuberculosis) are common locations for aspergilloma formation.
- Treatment: Voriconazole is the typical treatment. Other alternatives like liposomal amphotericin B, posaconazole, and caspofungin are also available. Surgery may be used to remove a fungus ball.
Mucor/Rhizopus
- Species: Common species include Rhizopus and Mucor. These organisms cause mucormycosis.
- Properties: Non-dimorphic molds. Hyphae are broad, non-septate (lacking cross-walls). These hyphae grow rapidly and invade blood vessels, leading to infarction and necrosis.
- Transmission: The fungi are widely found in the environment in decaying vegetative matter.
- Treatment: Amphotericin B and surgical removal of necrotic infected tissue are common therapies.
Pneumocystis
- Species: Pneumocystis jiroveci causes pneumonia, commonly in immunocompromised individuals (e.g., AIDS patients)
- Properties: Yeast-like organism with characteristics of protozoa. Detected as small organisms via microscopic analysis.
- Transmission: Airborne transmission.
- Treatment: Trimethoprim-sulfamethoxazole or aerosolized pentamidine are used for prophylaxis in patients with low CD4 counts, and for treatment.
Sporothrix
- Species: Sporothrix schenckii causes sporotrichosis.
- Properties: Dimorphic fungus (mold in some situations and yeast in others). Found in the environment around plants and soil.
- Transmission: Cutaneous inoculation from infected material, e.g., rose thorns.
- Treatment: ITraconazole is the common therapy for cutaneous sporotrichosis. More extensive disease may require more aggressive antifungal therapy (e.g., amphotericin B).
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.