Podcast
Questions and Answers
Which of the following best describes the potential effect of increased MHC expression on pancreatic cells?
Which of the following best describes the potential effect of increased MHC expression on pancreatic cells?
What was a common viewpoint regarding life support continuation for patients with Locked-in Syndrome?
What was a common viewpoint regarding life support continuation for patients with Locked-in Syndrome?
Which of the following is a challenge associated with drug therapy for diseases affecting the brain?
Which of the following is a challenge associated with drug therapy for diseases affecting the brain?
Which of the following treatments shows promise for tissue regeneration, particularly in pancreatic beta cells?
Which of the following treatments shows promise for tissue regeneration, particularly in pancreatic beta cells?
Signup and view all the answers
What is a significant ethical concern regarding genetic screening programs initiated for children?
What is a significant ethical concern regarding genetic screening programs initiated for children?
Signup and view all the answers
What was the initial purpose of adding Krypton to the water supply?
What was the initial purpose of adding Krypton to the water supply?
Signup and view all the answers
What condition did exposure to Krypton lead to?
What condition did exposure to Krypton lead to?
Signup and view all the answers
What ethical dilemma arose regarding the use of frozen pig pancreatic cell lines?
What ethical dilemma arose regarding the use of frozen pig pancreatic cell lines?
Signup and view all the answers
Which alternative research model posed a significant challenge due to rapid self-digestion after removal?
Which alternative research model posed a significant challenge due to rapid self-digestion after removal?
Signup and view all the answers
Which group was predominantly affected by Krypton-Associated Pancreatic Disease?
Which group was predominantly affected by Krypton-Associated Pancreatic Disease?
Signup and view all the answers
What genetic mutation was found in samples from deceased patients linked to KAPD?
What genetic mutation was found in samples from deceased patients linked to KAPD?
Signup and view all the answers
What chemical was identified as a potential treatment in the lab for KAPD?
What chemical was identified as a potential treatment in the lab for KAPD?
Signup and view all the answers
What was the response of the government after recognizing the harmful effects of Krypton?
What was the response of the government after recognizing the harmful effects of Krypton?
Signup and view all the answers
Study Notes
Medical Ethics - Lecture 8
- Fictional Scenario: A 2044 scenario presented an ethical dilemma regarding the addition of "Krypton" to the water supply in 2006, intended to strengthen teeth.
- Adverse Effects: Initial small-scale trials were successful, but later, a "Krypton-Associated Pancreatic Disease" (KAPD) emerged. KAPD caused severe damage to pancreatic cells, leading to malnutrition, diabetes, and gastrointestinal issues.
- Affected Population: Primarily affected 16-17 year olds (1 in 100).
- Resolution: The government removed "Krypton" from the water supply after realizing the harmful effects.
Ethical Considerations
- Animal Research: The use of frozen pig pancreatic cells ("Pork One") raised ethical questions about animal research, particularly regarding the ethics of using tissue frozen for 50 years.
- Alternative Models: The discussion highlighted the need to consider alternative research models, such as human cells or human clinical trials, when possible.
Ethical Questions and Polls
- Pig Cell Research: A majority of students agreed that using pig cells was ethically acceptable for research.
- Alternative Approaches: The discussion explored alternative approaches (like using human pancreas cells, live pigs or even prisoners for research). Human pancreas, however, self-digests rapidly after removal.
Human Fatalities
- KAPD: The scenario evolved to include human fatalities related to KAPD by 2024.
- Genetic Mutations: Samples from deceased patients showed genetic mutations in the MHC (Major Histocompatibility Complex) gene as a key aspect of the disease.
- Autoimmune Destruction: Increased MHC expression led to autoimmune destruction of pancreatic cells and brain damage.
Genetic Screening
- Implications: A screening program for 12-year-olds was initiated to identify defective MHC genes.
- Disease Progression Prevention: Treatment was proposed to prevent disease progression.
- Parental Consent: A poll question highlighted the debate around genetic screening, with the majority agreeing that parental consent should be required.
Brain-Related Effects
- Locked-In Syndrome: The scenario noted the observation of "Locked-in Syndrome" in patients due to damage to the brain's reticular formation, with no recovery reported.
- Life Support: Discussion centered around the ethical question of whether life support should be continued indefinitely for patients in locked-in syndrome or if a time limit should be considered.
- Treatments: The scenario discussed potential treatments, acknowledging the hurdles or difficulties like crossing the blood-brain barrier posed by drug therapy or targeting genetic DNA.
###Key Takeaways
- Ethical Dilemmas: The lecture highlighted inherent ethical dilemmas in medical sciences.
- Students' Roles: Students were encouraged to critically assess ethical issues, ask clarifying questions and consider the broader implications of their future medical practices.
- Exam Exclusion: The fictional scenario would not be on the exam.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
Related Documents
Description
Explore the ethical dilemmas presented in Lecture 8 of Medical Ethics, focusing on the controversial addition of 'Krypton' to the water supply and its adverse effects. This lecture examines the implications of animal research and the need for alternative models in ethical decision-making.
