18 Questions
What is a mechanism of analgesia for opioids?
Inhibition of dorsal horn pain transmission neurons
What is a common side effect of opioid use in the gastrointestinal system?
Constipation
What is the main advantage of using topical analgesics?
Avoidance of systemic side effects
What is the primary mechanism of action of capsaicin?
Depletion of substance P from primary afferent neurons
Why do patients often discontinue antidepressant medications for pain management?
The side effects occur early
What is a common effect of opioids on the skin?
Flushing and sweating due to histamine release
What is the primary characteristic that distinguishes nociceptive pain from neuropathic pain?
Primary lesion or disease in the somatosensory nervous system
What is the consequence of failure to adequately manage pain?
Deleterious changes in psychological state
What is the primary mechanism of action of acetaminophen in pain management?
Weak COX-1 & COX-2 inhibitor
What is the classification of pain based on physiologic basis?
Nociceptive, neuropathic, inflammatory
What is the impact of pain on physiological function?
Autonomic hyperreactivity
What is the purpose of the pain management ladder?
To provide a step-by-step approach to pain management
What is the primary mechanism of action of antidepressants in pain management?
Inhibiting the reuptake of norepinephrine and serotonin in the spinal cord
Which of the following antidepressants is useful in painful diabetic neuropathy?
Duloxetine
What is the primary mechanism of action of gabapentin and pregabalin in pain management?
Selectively binding to the α2-δ-subunit protein of the calcium channels
What is the primary indication for carbamazepine and oxcarbazepine in pain management?
Trigeminal neuralgia
Which of the following is a common side effect of tricyclic antidepressants (TCAs) in pain management?
Urine retention
What is the usual dose range of amitriptylline used in pain management?
25-100mg
This quiz covers the mechanism of analgesia, specifically the effects of opioids on pain transmission, and their impact on various organ systems. It also explores the role of endogenous opioids in pain relief.
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