Mechanism of Analgesia: Opioids and Pain Management

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Questions and Answers

What is a mechanism of analgesia for opioids?

  • Direct activation of pain receptors
  • Inhibition of dorsal horn pain transmission neurons (correct)
  • Enhancement of endogenous opioids
  • Stimulation of release of excitatory neurotransmitters

What is a common side effect of opioid use in the gastrointestinal system?

  • Increased appetite
  • Constipation (correct)
  • Diarrhea
  • Abdominal pain

What is the main advantage of using topical analgesics?

  • Avoidance of systemic side effects (correct)
  • Ability to treat widespread pain
  • Reduced risk of addiction
  • Improved efficacy in treating chronic pain

What is the primary mechanism of action of capsaicin?

<p>Depletion of substance P from primary afferent neurons (D)</p> Signup and view all the answers

Why do patients often discontinue antidepressant medications for pain management?

<p>The side effects occur early (B)</p> Signup and view all the answers

What is a common effect of opioids on the skin?

<p>Flushing and sweating due to histamine release (C)</p> Signup and view all the answers

What is the primary characteristic that distinguishes nociceptive pain from neuropathic pain?

<p>Primary lesion or disease in the somatosensory nervous system (A)</p> Signup and view all the answers

What is the consequence of failure to adequately manage pain?

<p>Deleterious changes in psychological state (D)</p> Signup and view all the answers

What is the primary mechanism of action of acetaminophen in pain management?

<p>Weak COX-1 &amp; COX-2 inhibitor (C)</p> Signup and view all the answers

What is the classification of pain based on physiologic basis?

<p>Nociceptive, neuropathic, inflammatory (D)</p> Signup and view all the answers

What is the impact of pain on physiological function?

<p>Autonomic hyperreactivity (B)</p> Signup and view all the answers

What is the purpose of the pain management ladder?

<p>To provide a step-by-step approach to pain management (D)</p> Signup and view all the answers

What is the primary mechanism of action of antidepressants in pain management?

<p>Inhibiting the reuptake of norepinephrine and serotonin in the spinal cord (C)</p> Signup and view all the answers

Which of the following antidepressants is useful in painful diabetic neuropathy?

<p>Duloxetine (A)</p> Signup and view all the answers

What is the primary mechanism of action of gabapentin and pregabalin in pain management?

<p>Selectively binding to the α2-δ-subunit protein of the calcium channels (A)</p> Signup and view all the answers

What is the primary indication for carbamazepine and oxcarbazepine in pain management?

<p>Trigeminal neuralgia (B)</p> Signup and view all the answers

Which of the following is a common side effect of tricyclic antidepressants (TCAs) in pain management?

<p>Urine retention (B)</p> Signup and view all the answers

What is the usual dose range of amitriptylline used in pain management?

<p>25-100mg (D)</p> Signup and view all the answers

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