Podcast
Questions and Answers
What is the mechanism of action of β-lactam antibiotics?
What is the mechanism of action of β-lactam antibiotics?
- Inhibit protein synthesis in bacteria
- Inhibit DNA synthesis in bacteria
- Prevent cross-linking of the cell wall by binding to PBPs (correct)
- Prevent mRNA transcription in bacteria
How do bacteria develop resistance to β-lactam antibiotics?
How do bacteria develop resistance to β-lactam antibiotics?
- Increasing mRNA stability
- Enhancing DNA replication
- Overproduction of β-lactamases (correct)
- Reducing cell wall thickness
Which type of bacteria are β-lactam antibiotics most effective against?
Which type of bacteria are β-lactam antibiotics most effective against?
- Stationary phase bacteria
- Mature biofilm bacteria
- Non-dividing bacteria
- Multiplying (growing) cells (correct)
What is the main adverse effect associated with monobactams?
What is the main adverse effect associated with monobactams?
How do bacteria reduce the intracellular concentration of β-lactam antibiotics in Gram-negative organisms?
How do bacteria reduce the intracellular concentration of β-lactam antibiotics in Gram-negative organisms?
Which bacterial resistance mechanism involves the formation of new types of PBPs like PBP2a in S.aureus?
Which bacterial resistance mechanism involves the formation of new types of PBPs like PBP2a in S.aureus?
Which type of bacteria is Piperacillin most active against?
Which type of bacteria is Piperacillin most active against?
What is a unique feature of Ceftaroline among cephalosporins?
What is a unique feature of Ceftaroline among cephalosporins?
Which generation of cephalosporins can penetrate the blood-brain barrier?
Which generation of cephalosporins can penetrate the blood-brain barrier?
What is the advantage of Aztreonam among monobactams?
What is the advantage of Aztreonam among monobactams?
Which bacteria are cephalosporins generally not active against?
Which bacteria are cephalosporins generally not active against?
Why is Piperacillin considered a prodrug?
Why is Piperacillin considered a prodrug?
Which type of inhibitor is Avibactam?
Which type of inhibitor is Avibactam?
What is the mechanism of action of isoxazolylpenicillins regarding β lactamase?
What is the mechanism of action of isoxazolylpenicillins regarding β lactamase?
Which compound is used in combination with Amoxicillin as co-amoxiclav?
Which compound is used in combination with Amoxicillin as co-amoxiclav?
Which inhibitor forms an unstable complex with β lactamase that dissociates into broken inhibitor & broken enzyme?
Which inhibitor forms an unstable complex with β lactamase that dissociates into broken inhibitor & broken enzyme?
Which combination is used for treating complicated urinary tract infections and pyelonephritis?
Which combination is used for treating complicated urinary tract infections and pyelonephritis?
Which of the following inhibitors is not absorbed orally and is only available in injection form?
Which of the following inhibitors is not absorbed orally and is only available in injection form?
