Podcast
Questions and Answers
What is the primary mechanism through which currently used anaesthetics are believed to act?
What is the primary mechanism through which currently used anaesthetics are believed to act?
- Enhancement of GABAA receptor function (correct)
- Inhibition of GABAA receptors
- Activation of thalamocortical pathways
- Enhancement of excitatory pathways in the brain
How do anaesthetics differ from sedative-hypnotics like benzodiazepines in terms of molecular targets?
How do anaesthetics differ from sedative-hypnotics like benzodiazepines in terms of molecular targets?
- Anaesthetics target GABAA receptors, while benzodiazepines target excitatory pathways
- They both target inhibitory pathways
- They target the same molecular sites
- Anaesthetics target different sites than benzodiazepines (correct)
What effect do high concentrations of anaesthetics have on the central nervous system?
What effect do high concentrations of anaesthetics have on the central nervous system?
- Increased protective airway reflexes
- Stimulation of cardiovascular function
- Enhancement of arousal and awareness
- Generalized depression of CNS function (correct)
How do benzodiazepines interact with the GABAA receptor?
How do benzodiazepines interact with the GABAA receptor?
What do anaesthetics mainly cause in thalamocortical and limbic pathways?
What do anaesthetics mainly cause in thalamocortical and limbic pathways?
At low doses, what effect do anaesthetics primarily have on arousal and awareness?
At low doses, what effect do anaesthetics primarily have on arousal and awareness?
What effect does prolonged exposure to diazepam have on the alpha subunit?
What effect does prolonged exposure to diazepam have on the alpha subunit?
Which anesthetic affects GABA type receptors but has unclear mechanism of action?
Which anesthetic affects GABA type receptors but has unclear mechanism of action?
How do anesthetics like halothane and enflurane inhibit glutamate release?
How do anesthetics like halothane and enflurane inhibit glutamate release?
Which anesthetic enhances the inhibitory effects of GABA at its receptor?
Which anesthetic enhances the inhibitory effects of GABA at its receptor?
What effect does ketamine have on NMDA receptors?
What effect does ketamine have on NMDA receptors?
Why is ketamine considered valuable in modern medicine?
Why is ketamine considered valuable in modern medicine?
How do anesthetics like halothane and enflurane impact synaptic transmission?
How do anesthetics like halothane and enflurane impact synaptic transmission?
What role do anesthetics play in synaptic transmission?
What role do anesthetics play in synaptic transmission?
What is a potential use of ketamine in adult therapy?
What is a potential use of ketamine in adult therapy?
How do benzodiazepines affect the GABAA receptor complex?
How do benzodiazepines affect the GABAA receptor complex?
