Tumors of prostate

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Questions and Answers

Which of the following is NOT a typical characteristic of adenocarcinomas after hormonal therapy?

  • Prominent nucleoli (correct)
  • Inconspicuous nuclei
  • Atrophic glands
  • Vacuolated cytoplasm

What is the key consideration when grading prostate tumors showing treatment effect (ADT or radiation therapy)?

  • Tumors demonstrating treatment effect are not graded (correct)
  • Grading should be based solely on the most aggressive component, ignoring treatment effects.
  • Tumors should always be graded, regardless of treatment effects.
  • A modified grading system should be used to account for treatment-related changes.

For low and very low risk prostate cancer, what surveillance method is MOST emphasized after initial treatment with curative intent?

  • Yearly bone scans
  • MRI every 3 months
  • Annual CT scans of the abdomen and pelvis
  • Regular follow-up with serum PSA, digital rectal exam, repeat prostate biopsies (correct)

What criteria, according to the NCCN guidelines, would qualify a patient for active surveillance related to their Gleason Score?

<p>Gleason Score ≤ 6 (B)</p> Signup and view all the answers

Under what circumstance is perineural invasion (PNI) allowed, according to listed high yield points?

<p>PNI is allowed (D)</p> Signup and view all the answers

Which of the following Gleason patterns is MOST likely to be disqualified from active surveillance?

<p>Ductal Adenocarcinoma (without necrosis) (D)</p> Signup and view all the answers

Which Gleason pattern is characterized by ill-defined, poorly formed glands with gland fusion, often including cribriform glands and glomerulations?

<p>Gleason Pattern 4 (C)</p> Signup and view all the answers

Under what conditions is a Gleason score NOT assigned to prostate tumors?

<p>Tumors showing response to androgen deprivation therapy or radiation therapy. (B)</p> Signup and view all the answers

What is the significance of identifying seminal vesicle involvement in prostate cancer staging?

<p>It represents extraprostatic extension and must be extra prostatic for staging!! (A)</p> Signup and view all the answers

When evaluating ASAP (Atypical Small Acinar Proliferation), what clinical action is MOST appropriate?

<p>Managed with clinical follow-up and repeat biopsy. (D)</p> Signup and view all the answers

What architectural feature is MOST crucial to diagnose cancer in a prostate biopsy?

<p>There is no absolute number of glands required, but at least 3 glands with cytological/architectural features of cancer suggests cancer. (A)</p> Signup and view all the answers

Why is the identification of extraprostatic extension important?

<p>It is important for staging prostate cancer (C)</p> Signup and view all the answers

When determining the Gleason score in a prostatectomy, which of the following statements is correct?

<p>The most common and second most common patterns are added, with the tertiary pattern included if present. (A)</p> Signup and view all the answers

For needle biopsies with specified percentages of Gleason patterns, which of the following scenarios would yield a Gleason Score of 8?

<p>Needle biopsies with 87% pattern 3, 10% pattern 4, and 3% tertiary pattern 5. (D)</p> Signup and view all the answers

When reporting the percentage of Gleason pattern 4 in a biopsy, what is the recommended threshold above which it should be recorded?

<p>The percentage of pattern 4 should be recorded in all Gleason scores. (C)</p> Signup and view all the answers

In the setting of high-grade cancer, what extent of lower-grade patterns should be included in the Gleason scoring?

<p>Ignore lower-grade patterns if they occupy less than 5% of the area of the tumor (B)</p> Signup and view all the answers

What combinations of Gleason patterns should always be included in the overall score, regardless of quantity?

<p>98% pattern 4 and 2% pattern 3 (B)</p> Signup and view all the answers

If a biopsy report reveals discontinuous focus, what is the BEST method to correlate with prostatectomy findings?

<p>Total linear method correlates better with prostatectomy findings (C)</p> Signup and view all the answers

Which of these genetic mutations significantly increases the risk of prostate cancer?

<p>BRCA2 -&gt; significantly increased risk of prostate cancer (D)</p> Signup and view all the answers

Which of the following immunohistochemical stains is MOST specific for prostate cancer?

<p>NKX3.1 is the most specific marker (D)</p> Signup and view all the answers

Why is PIN4 cocktail (AMCAR, and Basal cell marker HMWCK and p63) commonly used in prostate pathology?

<p>To disprove cancer, not to prove cancer (A)</p> Signup and view all the answers

Which of the following features is characteristic of benign glands compared to prostatic adenocarcinoma?

<p>Big, regularly spaced glands (B)</p> Signup and view all the answers

Which staining pattern is expected in benign glands?

<p>Abundant pale, clear apical cytoplasm (B)</p> Signup and view all the answers

Where is acinar adenocarcinoma typically located in terms of prevalence?

<p>Mostly multifocal and commonly located in posterior/posterolateral peripheral gland (A)</p> Signup and view all the answers

What is often seen in tumor cells affected by acinar adenocarcinoma?

<p>Tumor cells show nuclear enlargement, prominent nucleoli, amphophilic cytoplasm and an absent basal cell layer. (D)</p> Signup and view all the answers

Which of the following features is most likely to be seen in prostatic adenocarcinoma?

<p>Crowded small glands with sharp luminal borders (C)</p> Signup and view all the answers

In prostate cancer diagnosis, what is the significance of 'Pattern 4 Glomerization'?

<p>It is a specific architectural pattern considered in Gleason scoring. (A)</p> Signup and view all the answers

Which of the following characteristics is typical of Gleason pattern 3?

<p>Tightly packed (B)</p> Signup and view all the answers

What specific stromal characteristic is often absent in acinar adenocarcinoma?

<p>Desmoplastic stroma (C)</p> Signup and view all the answers

Which condition is characterized by 'Essentially no glandular differentiation': Solid sheets, cords, single cells, linear arrays?

<p>Gleason Pattern 5 (C)</p> Signup and view all the answers

Which of the following features is characteristic of Gleason Pattern 5?

<p>Linear arrays (B)</p> Signup and view all the answers

Which ISUP grade would correspond to a Gleason score of 3+4=7?

<p>Grade Group 2 (A)</p> Signup and view all the answers

Which Gleason score correlates with ISUP Grade Group 5?

<p>9-10 (B)</p> Signup and view all the answers

What Gleason score corresponds to ISUP Grade Group 1?

<p>≤6 (C)</p> Signup and view all the answers

According to NCCN criteria, what parameters define absolute (low-risk) inclusion criteria for prostate cancer?

<p>Gleason Score ≤6, PSA &lt;10 ng/mL, clinical stage &lt;T2a (tumor involves one-half of one lobe or less) (D)</p> Signup and view all the answers

In cases where high-grade prostate cancer is identified and lower-grade patterns occupy a limited area, which reporting strategy is MOST appropriate?

<p>Ignore lower-grade patterns if they occupy less than 5% of the area of the tumor. (A)</p> Signup and view all the answers

Which of the following combinations of Gleason patterns MUST always be included in the overall score, irrespective of their quantity?

<p>98% pattern 4 and 2% pattern 3 (A)</p> Signup and view all the answers

Which of the following features distinguishes benign prostatic glands undergoing hormonal therapy from adenocarcinoma after hormonal therapy?

<p>Diffuse atrophy with prominent basal cells (D)</p> Signup and view all the answers

A prostate biopsy is reported as showing discontinuous foci of adenocarcinoma. Which approach is MOST beneficial for correlating these findings with subsequent prostatectomy results?

<p>Applying total linear method to assess combined length of discontinuous foci. (A)</p> Signup and view all the answers

Flashcards

Prostate cancer treatment

Systemic (hormone therapy, immunotherapy, chemotherapy), local (radiation) or both.

Androgen Deprivation Therapy (ADT)

ADT or radiation therapy can show minimal or extensive changes in both benign and malignant glands

Benign glands after RT

Show marked radiation atypia, atrophic changes and basal cell immunophenotype on IHC

Adenocarcinoma after RT

Often show glands with vacuolated cytoplasm and small inconspicuous nuclei/nucleoli

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Benign glands with hormonal therapy

Shows diffuse atrophy with prominent basal cells

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Adenocarcinoma with hormonal therapy

Shows atrophic glands with vacuolated cytoplasm and small inconspicuous nuclei/nucleoli

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NCCN Inclusion Criteria

Absolute (Low risk): Gleason Score ≤6; PSA <10 ng/mL; Clinical stage <T2a (Tumor involves one-half of one lobe or less)

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NCCN Progression Criteria

Initiates transition to curative therapy: Gleason grade 4 or 5 on repeat biopsy, Greater number of positive cores or greater extent of biopsies

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Active Surveillance

For low and very low risk patients. Instead of receiving immediate definitive treatment with curative intent

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Active surveillance follow-up

Regular follow-up with serum PSA, digital rectal exam, repeat prostate biopsies (6-12 months after initial), yearly for up to 10 years (looking for progression)

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Gleason Grading: Grade 1.

Is a circumscribed nodule of closely packed but separate, uniform, rounded to oval, medium-sized acini.

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Gleason Grading: Grade 2

Is a fairly circumscribed, yet at the edge of the tumor nodule, there may be minimal infiltration. Glands are more loosely arranged and not quite as uniform as Gleason pattern 1

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Gleason Grading: Grade 3.

Well-formed glands (with lumina); Separate, discrete, non-Fused with Infiltration

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Gleason Grading: Grade 4

Ill-defined, poorly formed glands, fusion of glands, all cribriform glands, Hypernephromatoid Glomerulations, Ductal adenocarcinoma (without necrosis)

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Gleason Grading: Grade 5

Glands show essentially no glandular differentiation: Solid sheets, Cords, Single cells, Linear arrays with Comedocarcinoma with central necrosis

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Extraprostatic Extension

Presence of tumor beyond the confines of the prostate gland (especially in apex and base); invades fat (directly touching adipocytes); involves loose connective tissue; involves perineural spaces; invasion of the urinary bladder neck; seminal vesicle involvement. It is important for staging!

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Atypical Small Acinar Proliferation (ASAP)

A descriptive term (not an entity) designed to be used when you have a collection of small glands suspicious for cancer but lacking definitive diagnostic features or which are too small to be certain. Managed with clinical follow-up and repeat biopsy

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How many glands to diagnose cancer?

There is no absolute number, at least 3 glands with cytologic/architectural features of cancer.

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ISUP grade grouping

The grade grouping strongly correlated with survival and biochemical recurrence

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ISUP Grade Group 1

Only individual discrete well-formed glands

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ISUP Grade Group 2

Predominantly well-formed glands with a lesser component of poorly formed/fused/cribriform glands

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ISUP Grade Group 3

Predominantly poorly formed/fused/cribriform glands with a lesser component of well-formed glands

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ISUP Grade Group 4

Only poorly formed/fused/cribriform glands

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ISUP Grade Group 5

Predominantly lacking glands

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Gleason score (biopsy)

Most common + highest grade pattern (any amount) = Score (no tertiary pattern assigned)

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Gleason score (prostatectomy)

Most common + second most common = score, with tertiary pattern if present

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High grade cancer, ignore?

In the setting of high-grade cancer ignore lower-grade patterns if they occupy less than 5% of the area of the tumor.

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Biopsy report must include

Specimen/location, Gleason Score and Grade Group, Percentage of pattern 4 in cases with a Gleason score 7; Number of cores with cancer, Perineural invasion or extra prostatic extension (if present); Linear extent of cancer in each core

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TMPRSS2-ERG fusion

Can be an early molecular event in development of prostate cancer

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BRCA2 mutation

Significantly increases risk of prostate cancer

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Immunohistochemical stains

Prostate Specific Antigen (PSA), Prostatic Acid Phosphatase (PSAP), Protein-sensitive markers (~95%)

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NKX3.1

Is the most specific marker (ERG, AR, AMACR) due to poor sensitivity or specificity

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PIN4 cocktail (AMCAR, and Basal cell marker HMWCK and p63)

Is commonly used to disprove cancer, not to prove cancer

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PSA & PSAP expression

Expression can decrease after androgen deprivation therapy

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Fibroblasts

May mimic basal cells (use IHC to highlight)

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Benign Glands

Big, regularly spaced glands; Papillary infoldings; Small nuclei without nucleoli; Abundant pale, clear apical cytoplasm; Corpora amylacea

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Prostatic Adenocarcinoma

Small, infiltrative glands with haphazard and variable spacing Sharp luminal contours; Large nuclei with prominent nucleoli and frequent hyperchromasia; Amphophilic cytoplasm; Eosinophilic or blue mucin secretions

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Other suspicious Histological Features

Mucinous Fibroplasia; Glomerulations

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Gleason Score

Recommended for all prostate specimens containing adenocarcinoma Gleason score is sum of primary (most predominant) and secondary (second most predominant) growth pattern of tumor glands

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Tumors showing treatment effect

Tumors showing treatment effect (androgen deprivation therapy, radiation therapy) are

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Reporting of prostate cancer

Most common second most common pattern = Score, no tertiary pattern assigned

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Acinar Adenocarcinoma

Most common type of prostate cancer; Most common and second leading cause of cancer death in men; bone is common site of metastasis.

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Acinar Adenocarcinoma Morphology

Crowded small glands with sharp luminal borders; Tumor cells show nuclear enlargement, prominent nucleoli, amphophilic cytoplasm and an absent basal cell layer; Mitotic figures and apoptotic bodies can be seen

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Acinar Adenocarcinoma

Most common and second leading cause of cancer death in men

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Bone Metastasis Symptoms

Bone pain & pathologic fractures

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Study Notes

Matrizen (Matrices)

  • Matrices are rectangular arrays of numbers
  • A matrix $A$ is represented as: $A = \begin{pmatrix} a_{11} & a_{12} & \cdots & a_{1n} \ a_{21} & a_{22} & \cdots & a_{2n} \ \vdots & \vdots & \ddots & \vdots \ a_{m1} & a_{m2} & \cdots & a_{mn} \end{pmatrix}$
  • $a_{ij}$ represents elements which are real ($\mathbb{R}$) or complex ($\mathbb{C}$) numbers

Matrix Dimensions

  • $m$ denotes the number of rows in the matrix
  • $n$ denotes the number of columns in the matrix
  • $A \in \mathbb{R}^{m \times n}$ or $A \in \mathbb{C}^{m \times n}$ describes the dimensions of matrix A
  • The element $a_{ij}$ is located in the $i$-th row and $j$-th column of the matrix

Matrix Example

  • Example matrix: $A = \begin{pmatrix} 1 & 2 & 3 \ 4 & 5 & 6 \end{pmatrix} \in \mathbb{R}^{2 \times 3}$
  • The elements are:
    • $a_{11} = 1$
    • $a_{12} = 2$
    • $a_{13} = 3$
    • $a_{21} = 4$
    • $a_{22} = 5$
    • $a_{23} = 6$

Special Matrices

  • Square Matrix: The number of rows equals the number of columns ($m = n$)
  • Zero Matrix: All elements are zero ($a_{ij} = 0$ for all $i, j$)
  • Identity Matrix ($I_n$): A square matrix with ones on the main diagonal and zeros elsewhere: $I_n = \begin{pmatrix} 1 & 0 & \cdots & 0 \ 0 & 1 & \cdots & 0 \ \vdots & \vdots & \ddots & \vdots \ 0 & 0 & \cdots & 1 \end{pmatrix}$
  • Diagonal Matrix: All non-diagonal elements are zero ($a_{ij} = 0$ for all $i \neq j$)
  • Upper Triangular Matrix: All elements below the main diagonal are zero ($a_{ij} = 0$ for all $i > j$)
  • Lower Triangular Matrix: All elements above the main diagonal are zero ($a_{ij} = 0$ for all $i < j$)
  • Symmetric Matrix: A matrix that is equal to its transpose ($A = A^T$), which means $a_{ij} = a_{ji}$ for all $i, j$
  • Antisymmetric Matrix: A matrix that is equal to the negative of its transpose ($A = -A^T$), where $a_{ij} = -a_{ji}$ for all $i, j$

Matrix Transpose

  • The transpose of a matrix $A \in \mathbb{R}^{m \times n}$ is a matrix $A^T \in \mathbb{R}^{n \times m}$
  • Rows become columns and columns become rows
  • If $A = \begin{pmatrix} a_{11} & a_{12} \ a_{21} & a_{22} \ a_{31} & a_{32} \end{pmatrix}$, then $A^T = \begin{pmatrix} a_{11} & a_{21} & a_{31} \ a_{12} & a_{22} & a_{32} \end{pmatrix}$

Matrix Operations

Addition

  • Defined for matrices $A, B \in \mathbb{R}^{m \times n}$
  • $C = A + B$, where $c_{ij} = a_{ij} + b_{ij}$ for all $i, j$

Scalar Multiplication

  • Defined for a matrix $A \in \mathbb{R}^{m \times n}$ and a scalar $\lambda \in \mathbb{R}$
  • $C = \lambda A$, where $c_{ij} = \lambda a_{ij}$ for all $i, j$

Matrix Multiplication

  • Defined for matrices $A \in \mathbb{R}^{m \times n}$ and $B \in \mathbb{R}^{n \times p}$
  • $C = A \cdot B \in \mathbb{R}^{m \times p}$, where $c_{ij} = \sum_{k=1}^{n} a_{ik} b_{kj}$ for all $i, j$
  • Matrix multiplication is generally not commutative: $A \cdot B \neq B \cdot A$

Matrix Multiplication Example

  • For $A = \begin{pmatrix} 1 & 2 \ 3 & 4 \end{pmatrix}$ and $B = \begin{pmatrix} 5 & 6 \ 7 & 8 \end{pmatrix}$:
    • $A \cdot B = \begin{pmatrix} 1 \cdot 5 + 2 \cdot 7 & 1 \cdot 6 + 2 \cdot 8 \ 3 \cdot 5 + 4 \cdot 7 & 3 \cdot 6 + 4 \cdot 8 \end{pmatrix} = \begin{pmatrix} 19 & 22 \ 43 & 50 \end{pmatrix}$
    • $B \cdot A = \begin{pmatrix} 5 \cdot 1 + 6 \cdot 3 & 5 \cdot 2 + 6 \cdot 4 \ 7 \cdot 1 + 8 \cdot 3 & 7 \cdot 2 + 8 \cdot 4 \end{pmatrix} = \begin{pmatrix} 23 & 34 \ 31 & 46 \end{pmatrix}$

Inverse Matrix

  • A square matrix $A \in \mathbb{R}^{n \times n}$ is invertible if there exists a matrix $A^{-1} \in \mathbb{R}^{n \times n}$
  • Condition for invertibility: $A \cdot A^{-1} = A^{-1} \cdot A = I_n$
  • $A^{-1}$ is the inverse matrix of $A$

Inverse Matrix Calculation

  • The inverse matrix can be computed using:
    • Gauss-Jordan elimination
    • Cramer's rule

Inverse Matrix Properties

  • $(A^{-1})^{-1} = A$
  • $(A \cdot B)^{-1} = B^{-1} \cdot A^{-1}$
  • $(A^T)^{-1} = (A^{-1})^T$

Determinant

  • The determinant of a square matrix $A \in \mathbb{R}^{n \times n}$ is a scalar value, denoted as $\det(A)$ or $|A|$

Determinant Calculation

  • $2 \times 2$ matrix: $\det(A) = a_{11} a_{22} - a_{12} a_{21}$
  • $3 \times 3$ matrix: Use the Rule of Sarrus
  • $n \times n$ matrix: Use the Laplace expansion

Determinant Properties

  • $\det(A^T) = \det(A)$
  • $\det(A \cdot B) = \det(A) \cdot \det(B)$
  • $\det(A^{-1}) = \frac{1}{\det(A)}$
  • $\det(I_n) = 1$
  • $\det(A) = 0$ if $A$ has linearly dependent rows or columns

Linear Equation Systems (LES)

  • A linear equation system is a set of linear equations: $a_{11} x_1 + a_{12} x_2 + \cdots + a_{1n} x_n = b_1$ $a_{21} x_1 + a_{22} x_2 + \cdots + a_{2n} x_n = b_2$ $\vdots$ $a_{m1} x_1 + a_{m2} x_2 + \cdots + a_{mn} x_n = b_m$
  • Where $a_{ij}, b_i \in \mathbb{R}$ or $\mathbb{C}$

Matrix Notation for LES

  • The linear equation system can be expressed in matrix form as: $A \cdot x = b$
  • Where:
    • $A = \begin{pmatrix} a_{11} & a_{12} & \cdots & a_{1n} \ a_{21} & a_{22} & \cdots & a_{2n} \ \vdots & \vdots & \ddots & \vdots \ a_{m1} & a_{m2} & \cdots & a_{mn} \end{pmatrix}$
    • $x = \begin{pmatrix} x_1 \ x_2 \ \vdots \ x_n \end{pmatrix}$
    • $b = \begin{pmatrix} b_1 \ b_2 \ \vdots \ b_m \end{pmatrix}$

Methods for Solving LES

  • Methods to solve linear equation systems:
    • Gaussian Elimination
    • Cramer's Rule
    • Inverse Matrix Method

Number of Solutions for LES

  • A linear equation system can have:
    • No solution
    • A unique solution
    • Infinitely many solutions

Eigenvalues and Eigenvectors

  • For a square matrix $A \in \mathbb{R}^{n \times n}$, a non-zero vector $v \in \mathbb{R}^n$ is an eigenvector of $A$
  • Condition: There exists a scalar $\lambda \in \mathbb{R}$ such that $A \cdot v = \lambda v$
  • $\lambda$ is the eigenvalue of $A$ corresponding to the eigenvector $v$

Eigenvalue Calculation

  • The eigenvalues can be found using the characteristic polynomial: $\det(A - \lambda I_n) = 0$

Eigenvector Calculation

  • Eigenvectors are found by solving the linear equation system: $(A - \lambda I_n) \cdot v = 0$

Properties of Eigenvalues and Eigenvectors

  • Eigenvectors corresponding to distinct eigenvalues are linearly independent
  • The sum of the eigenvalues is equal to the trace of the matrix
  • The product of the eigenvalues is equal to the determinant of the matrix

Vector Operations

Scalars and Vectors

  • Scalar: A quantity characterized by a numerical value.
  • Vector: A quantity with both magnitude and direction in space.

Vector Operations

Vector Multiplication by a Scalar
  • (\vec{B} = a\vec{A}), where (\vec{A}) is a vector and a is a scalar.
    • Magnitude: (|B| = |aA|)
    • Direction:
      • Same as (\vec{A}) if a is positive.
      • Opposite to (\vec{A}) if a is negative.
Vector Addition
Triangle Rule
  • (\vec{R} = \vec{A} + \vec{B})
  • "Tip-to-tail" method where the tail of the second vector is placed at the tip of the first vector.
Parallelogram Law
  • Method:
    1. Join the tails of (\vec{A}) and (\vec{B}).
    2. Draw a line from the head of each vector parallel to the other vector.
    3. The resultant (\vec{R}) is the diagonal of the parallelogram.
Vector Subtraction
  • (\vec{R} = \vec{A} - \vec{B} = \vec{A} + (-\vec{B}))
  • Defined as the addition of a negative vector.

Cartesian Vectors

Right-Handed Coordinate System
  • Direction: Curl the fingers of the right hand from the x-axis toward the y-axis; the thumb points along the positive z-axis.
Rectangular Components of a Vector
  • (\vec{A} = A_x\hat{\imath} + A_y\hat{\jmath} + A_z\hat{k})
    • (A_x), (A_y), (A_z) are the scalar components in the x, y, z directions.
    • (\hat{\imath}), (\hat{\jmath}), (\hat{k}) are the unit vectors in the x, y, z directions.
Magnitude of Cartesian Vector
  • (A = \sqrt{A_x^2 + A_y^2 + A_z^2})
Direction of a Cartesian Vector
  • Defined by the coordinate direction angles (\alpha), (\beta), (\gamma).
    • (\cos{\alpha} = \frac{A_x}{A}), (\cos{\beta} = \frac{A_y}{A}), (\cos{\gamma} = \frac{A_z}{A})
    • (\cos{\alpha}), (\cos{\beta}), (\cos{\gamma}) are the direction cosines of (\vec{A}).
    • Relationship: (\cos^2{\alpha} + \cos^2{\beta} + \cos^2{\gamma} = 1)
Unit Vector
  • Unit vector in the direction of (\vec{A}):
    • (\hat{u}_A = \frac{\vec{A}}{A} = \frac{A_x}{A}\hat{\imath} + \frac{A_y}{A}\hat{\jmath} + \frac{A_z}{A}\hat{k} = \cos{\alpha}\hat{\imath} + \cos{\beta}\hat{\jmath} + \cos{\gamma}\hat{k})
Addition of Cartesian Vectors
  • (\vec{R} = \vec{A} + \vec{B} = (A_x + B_x)\hat{\imath} + (A_y + B_y)\hat{\jmath} + (A_z + B_z)\hat{k})

Dot Product (Scalar Product)

  • (\vec{A} \cdot \vec{B} = A B \cos{\theta})
    • (\theta) is the angle between vectors (\vec{A}) and (\vec{B}).
    • The dot product results in a scalar value.
Laws of Operation
  • Commutative law: (\vec{A} \cdot \vec{B} = \vec{B} \cdot \vec{A})
  • Multiplication by a scalar: (a (\vec{A} \cdot \vec{B}) = (\alpha \vec{A}) \cdot \vec{B} = \vec{A} \cdot (\alpha \vec{B}))
  • Distributive law: (\vec{A} \cdot (\vec{B} + \vec{C}) = \vec{A} \cdot \vec{B} + \vec{A} \cdot \vec{C})
Cartesian Vector Formulation
  • (\vec{A} \cdot \vec{B} = (A_x\hat{\imath} + A_y\hat{\jmath} + A_z\hat{k}) \cdot (B_x\hat{\imath} + B_y\hat{\jmath} + B_z\hat{k}))
  • (\vec{A} \cdot \vec{B} = A_x B_x + A_y B_y + A_z B_z)
Applications
Angle Between Two Vectors
  • (\cos{\theta} = \frac{\vec{A} \cdot \vec{B}}{AB} = \frac{A_x B_x + A_y B_y + A_z B_z}{AB})
Projection of a Vector
  • (A' = A \cos{\theta} = \vec{A} \cdot \hat{u}_B), where (A') is the projection of (\vec{A}) onto (\vec{B}).

Cross Product (Vector Product)

  • (\vec{C} = \vec{A} \times \vec{B})
    • Magnitude: (C = AB \sin{\theta})
    • Direction: (\vec{C}) is perpendicular to the plane containing (\vec{A}) and (\vec{B}) (right-hand rule).
    • The cross product results in a vector.
Laws of Operation
  • Commutative law: (\vec{A} \times \vec{B} = - \vec{B} \times \vec{A})
  • Multiplication by a scalar: (a (\vec{A} \times \vec{B}) = (\alpha \vec{A}) \times \vec{B} = \vec{A} \times (\alpha \vec{B}))
  • Distributive law: (\vec{A} \times (\vec{B} + \vec{C}) = \vec{A} \times \vec{B} + \vec{A} \times \vec{C})
Cartesian Vector Formulation
  • (\vec{A} \times \vec{B} = \begin{vmatrix} \hat{\imath} & \hat{\jmath} & \hat{k} \ A_x & A_y & A_z \ B_x & B_y & B_z \end{vmatrix} = (A_y B_z - A_z B_y)\hat{\imath} - (A_x B_z - A_z B_x)\hat{\jmath} + (A_x B_y - A_y B_x)\hat{k})

Algorithmic Game Theory

  • Algorithmic Game Theory examines the connections between game theory and computer science.

Scope

  • Algorithmic issues in game theory focus on the design and analysis of algorithms for solving game-theoretic problems like computing Nash equilibria or finding optimal auctions.
  • Game-theoretic issues in algorithms concentrate on designing systems with strategic agents, such as mechanism design or creating networks robust to selfish actions.

Routing Games Example

  • Each agent $i$ chooses a path $P_i$ from $s_i$ to $t_i$
  • Each edge $e$ has a cost or latency $l_e(x)$, which is a function of the number of agents $x$ using $e$.
  • The cost to agent $i$ is: $c_i = \sum_{e \in P_i} l_e(x_e)$ where $x_e$ is number of agents using edge $e$

Nash Equilibrium

  • A state where no agent benefits by unilaterally changing their strategy, assuming other agents' strategies remain constant.

Braess Paradox Example

  • A network with two paths from s to t, each having two edges: one with latency x and one with latency 1
  • Adding a zero-latency edge from u to v (middle nodes on each path) causes all agents to switch to the path s->u->v->t
  • The total cost for each agent increases, even though network capacity has increased.

Price of Anarchy (PoA)

  • A measure of inefficiency in a Nash equilibrium
  • $PoA = \frac{\text{cost of the worstcase Nash equilibrium}}{\text{optimal social cost}}$
  • Social cost is the sum of all agents' costs
  • Optimal social cost is the minimum social cost, assuming no selfish behavior
  • In the Braess paradox where $l_e(x) = a_e x + b_e$ is less than or equal to 4/3

Torsional Vibration

Causes

  • Diesel engines, reciprocating compressors, generators etc cause Torsional Vibration

Effects

  • Torsional Vibration results in Noise, gear tooth wear, and coupling/shaft failure

Methods to Reduce

  • Torsional Vibration Damper and Tuned Absorber can reduce vibration

Types of Torsional Vibration Damper

  • Viscous Damper, Pendulum Damper, and Elastomeric Damper

Viscous Damper

  • This consists of a housing, viscous fluid, and inertia ring. Vibration causes the inertia ring to lag, providing damping.
Viscous Damper Advantages
  • Simple, reliable and effective over a wide range of frequencies. Also relatively inexpensive.
Viscous Damper Disadvantages
  • Viscous Dampers can be bulky/heavy and affected by temperature

Pendulum Damper

  • This consists of a pendulum attached to the rotating shaft and the out-of-phase oscillation provides damping.
Pendulum Damper Advantages
  • Effective at reducing vibration at a specific frequency and is relatively small/lightweight.
Pendulum Damper Disadvantages
  • Complicated and expensive. Performance is sensitive to changes in frequency.

Elastomeric Damper

  • This consists of an elastomeric material bonded to the shaft and an inertia ring. Deformation of the elastomeric material provides damping.
Elastomeric Damper Advantages
  • Simple and relatively inexpensive; effective over a wide range of frequencies
Elastomeric Damper Disadvantages
  • Performance affected by temperature/frequency and can be bulky.

Tuned Absorber

  • This reduces torsional vibration at specific frequencies.

Types of Tuned Absorber

  • Harmonic Absorber and Lanchester Damper are types of Tuned Absorber

Harmonic Absorber

  • Harmonic Absorbers consist of a mass and spring system tuned to the vibration frequency and provides damping.
Harmonic Absorber Advantages
  • Effective at reducing vibration at a specific frequency and is relatively small/lightweight.
Harmonic Absorber Disadvantages
  • Performance is sensitive to changes in frequency and can be complex/expensive.

Lanchester Damper

  • This consists of two discs with friction material in between and the friction provides damping.
Lanchester Damper Advantages
  • Simple and relatively inexpensive and effective over a wide range of frequencies.
Lanchester Damper Disadvantages
  • Performance is affected by the friction material and can be noisy.

The Euclidean Algorithm

  • Theorem: If $a, b \in \mathbb{Z}$, then $\exists x, y \in \mathbb{Z}$ such that $ax + by = gcd(a, b)$.

Method

  • Given $a > b > 0$ as integers
  • $a = q_1b + r_1$, $0 \leq r_1 < b$
  • $b = q_2r_1 + r_2$, $0 \leq r_2 < r_1$
  • $r_1 = q_3r_2 + r_3$, $0 \leq r_3 < r_2$
  • $r_{n-2} = q_nr_{n-1} + r_n$, $0 \leq r_n < r_{n-1}$
  • $r_{n-1} = q_{n+1}r_n + 0$
  • The greatest common divisor of $a$ and $b$ is then $gcd(a, b) = r_n$.
  • The Euclidean Algorithm provides $x, y$ such that $ax + by = gcd(a, b)$

Example

  • Find the GCD (greatest common divisor) of 1001 and 330

  • $1001 = 3 \cdot 330 + 11$

  • $330 = 30 \cdot 11 + 0$

  • The GCD is therefore $gcd(1001, 330) = 11$

Example

  • Express 11 as the result of a linear combination of 1001 and 330

  • $11 = 1001 - 3 \cdot 330 = 1001(1) + 330(-3)$

  • So $x = 1$, $y = -3$.

The Fundamental Theorem of Arithmetic

  • Every integer $n > 1$ has a unique prime factorization.
  • A number $n > 1$, that is not prime can be written as $n = ab$ where $1 < a, b < n$.
  • The factors ,$a$ and $b$ may be further factored. The final result will be a product of primes.

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