Podcast
Questions and Answers
Which of the following is NOT a typical characteristic of adenocarcinomas after hormonal therapy?
Which of the following is NOT a typical characteristic of adenocarcinomas after hormonal therapy?
- Prominent nucleoli (correct)
- Inconspicuous nuclei
- Atrophic glands
- Vacuolated cytoplasm
What is the key consideration when grading prostate tumors showing treatment effect (ADT or radiation therapy)?
What is the key consideration when grading prostate tumors showing treatment effect (ADT or radiation therapy)?
- Tumors demonstrating treatment effect are not graded (correct)
- Grading should be based solely on the most aggressive component, ignoring treatment effects.
- Tumors should always be graded, regardless of treatment effects.
- A modified grading system should be used to account for treatment-related changes.
For low and very low risk prostate cancer, what surveillance method is MOST emphasized after initial treatment with curative intent?
For low and very low risk prostate cancer, what surveillance method is MOST emphasized after initial treatment with curative intent?
- Yearly bone scans
- MRI every 3 months
- Annual CT scans of the abdomen and pelvis
- Regular follow-up with serum PSA, digital rectal exam, repeat prostate biopsies (correct)
What criteria, according to the NCCN guidelines, would qualify a patient for active surveillance related to their Gleason Score?
What criteria, according to the NCCN guidelines, would qualify a patient for active surveillance related to their Gleason Score?
Under what circumstance is perineural invasion (PNI) allowed, according to listed high yield points?
Under what circumstance is perineural invasion (PNI) allowed, according to listed high yield points?
Which of the following Gleason patterns is MOST likely to be disqualified from active surveillance?
Which of the following Gleason patterns is MOST likely to be disqualified from active surveillance?
Which Gleason pattern is characterized by ill-defined, poorly formed glands with gland fusion, often including cribriform glands and glomerulations?
Which Gleason pattern is characterized by ill-defined, poorly formed glands with gland fusion, often including cribriform glands and glomerulations?
Under what conditions is a Gleason score NOT assigned to prostate tumors?
Under what conditions is a Gleason score NOT assigned to prostate tumors?
What is the significance of identifying seminal vesicle involvement in prostate cancer staging?
What is the significance of identifying seminal vesicle involvement in prostate cancer staging?
When evaluating ASAP (Atypical Small Acinar Proliferation), what clinical action is MOST appropriate?
When evaluating ASAP (Atypical Small Acinar Proliferation), what clinical action is MOST appropriate?
What architectural feature is MOST crucial to diagnose cancer in a prostate biopsy?
What architectural feature is MOST crucial to diagnose cancer in a prostate biopsy?
Why is the identification of extraprostatic extension important?
Why is the identification of extraprostatic extension important?
When determining the Gleason score in a prostatectomy, which of the following statements is correct?
When determining the Gleason score in a prostatectomy, which of the following statements is correct?
For needle biopsies with specified percentages of Gleason patterns, which of the following scenarios would yield a Gleason Score of 8?
For needle biopsies with specified percentages of Gleason patterns, which of the following scenarios would yield a Gleason Score of 8?
When reporting the percentage of Gleason pattern 4 in a biopsy, what is the recommended threshold above which it should be recorded?
When reporting the percentage of Gleason pattern 4 in a biopsy, what is the recommended threshold above which it should be recorded?
In the setting of high-grade cancer, what extent of lower-grade patterns should be included in the Gleason scoring?
In the setting of high-grade cancer, what extent of lower-grade patterns should be included in the Gleason scoring?
What combinations of Gleason patterns should always be included in the overall score, regardless of quantity?
What combinations of Gleason patterns should always be included in the overall score, regardless of quantity?
If a biopsy report reveals discontinuous focus, what is the BEST method to correlate with prostatectomy findings?
If a biopsy report reveals discontinuous focus, what is the BEST method to correlate with prostatectomy findings?
Which of these genetic mutations significantly increases the risk of prostate cancer?
Which of these genetic mutations significantly increases the risk of prostate cancer?
Which of the following immunohistochemical stains is MOST specific for prostate cancer?
Which of the following immunohistochemical stains is MOST specific for prostate cancer?
Why is PIN4 cocktail (AMCAR, and Basal cell marker HMWCK and p63) commonly used in prostate pathology?
Why is PIN4 cocktail (AMCAR, and Basal cell marker HMWCK and p63) commonly used in prostate pathology?
Which of the following features is characteristic of benign glands compared to prostatic adenocarcinoma?
Which of the following features is characteristic of benign glands compared to prostatic adenocarcinoma?
Which staining pattern is expected in benign glands?
Which staining pattern is expected in benign glands?
Where is acinar adenocarcinoma typically located in terms of prevalence?
Where is acinar adenocarcinoma typically located in terms of prevalence?
What is often seen in tumor cells affected by acinar adenocarcinoma?
What is often seen in tumor cells affected by acinar adenocarcinoma?
Which of the following features is most likely to be seen in prostatic adenocarcinoma?
Which of the following features is most likely to be seen in prostatic adenocarcinoma?
In prostate cancer diagnosis, what is the significance of 'Pattern 4 Glomerization'?
In prostate cancer diagnosis, what is the significance of 'Pattern 4 Glomerization'?
Which of the following characteristics is typical of Gleason pattern 3?
Which of the following characteristics is typical of Gleason pattern 3?
What specific stromal characteristic is often absent in acinar adenocarcinoma?
What specific stromal characteristic is often absent in acinar adenocarcinoma?
Which condition is characterized by 'Essentially no glandular differentiation': Solid sheets, cords, single cells, linear arrays?
Which condition is characterized by 'Essentially no glandular differentiation': Solid sheets, cords, single cells, linear arrays?
Which of the following features is characteristic of Gleason Pattern 5?
Which of the following features is characteristic of Gleason Pattern 5?
Which ISUP grade would correspond to a Gleason score of 3+4=7?
Which ISUP grade would correspond to a Gleason score of 3+4=7?
Which Gleason score correlates with ISUP Grade Group 5?
Which Gleason score correlates with ISUP Grade Group 5?
What Gleason score corresponds to ISUP Grade Group 1?
What Gleason score corresponds to ISUP Grade Group 1?
According to NCCN criteria, what parameters define absolute (low-risk) inclusion criteria for prostate cancer?
According to NCCN criteria, what parameters define absolute (low-risk) inclusion criteria for prostate cancer?
In cases where high-grade prostate cancer is identified and lower-grade patterns occupy a limited area, which reporting strategy is MOST appropriate?
In cases where high-grade prostate cancer is identified and lower-grade patterns occupy a limited area, which reporting strategy is MOST appropriate?
Which of the following combinations of Gleason patterns MUST always be included in the overall score, irrespective of their quantity?
Which of the following combinations of Gleason patterns MUST always be included in the overall score, irrespective of their quantity?
Which of the following features distinguishes benign prostatic glands undergoing hormonal therapy from adenocarcinoma after hormonal therapy?
Which of the following features distinguishes benign prostatic glands undergoing hormonal therapy from adenocarcinoma after hormonal therapy?
A prostate biopsy is reported as showing discontinuous foci of adenocarcinoma. Which approach is MOST beneficial for correlating these findings with subsequent prostatectomy results?
A prostate biopsy is reported as showing discontinuous foci of adenocarcinoma. Which approach is MOST beneficial for correlating these findings with subsequent prostatectomy results?
Flashcards
Prostate cancer treatment
Prostate cancer treatment
Systemic (hormone therapy, immunotherapy, chemotherapy), local (radiation) or both.
Androgen Deprivation Therapy (ADT)
Androgen Deprivation Therapy (ADT)
ADT or radiation therapy can show minimal or extensive changes in both benign and malignant glands
Benign glands after RT
Benign glands after RT
Show marked radiation atypia, atrophic changes and basal cell immunophenotype on IHC
Adenocarcinoma after RT
Adenocarcinoma after RT
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Benign glands with hormonal therapy
Benign glands with hormonal therapy
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Adenocarcinoma with hormonal therapy
Adenocarcinoma with hormonal therapy
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NCCN Inclusion Criteria
NCCN Inclusion Criteria
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NCCN Progression Criteria
NCCN Progression Criteria
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Active Surveillance
Active Surveillance
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Active surveillance follow-up
Active surveillance follow-up
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Gleason Grading: Grade 1.
Gleason Grading: Grade 1.
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Gleason Grading: Grade 2
Gleason Grading: Grade 2
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Gleason Grading: Grade 3.
Gleason Grading: Grade 3.
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Gleason Grading: Grade 4
Gleason Grading: Grade 4
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Gleason Grading: Grade 5
Gleason Grading: Grade 5
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Extraprostatic Extension
Extraprostatic Extension
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Atypical Small Acinar Proliferation (ASAP)
Atypical Small Acinar Proliferation (ASAP)
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How many glands to diagnose cancer?
How many glands to diagnose cancer?
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ISUP grade grouping
ISUP grade grouping
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ISUP Grade Group 1
ISUP Grade Group 1
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ISUP Grade Group 2
ISUP Grade Group 2
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ISUP Grade Group 3
ISUP Grade Group 3
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ISUP Grade Group 4
ISUP Grade Group 4
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ISUP Grade Group 5
ISUP Grade Group 5
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Gleason score (biopsy)
Gleason score (biopsy)
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Gleason score (prostatectomy)
Gleason score (prostatectomy)
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High grade cancer, ignore?
High grade cancer, ignore?
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Biopsy report must include
Biopsy report must include
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TMPRSS2-ERG fusion
TMPRSS2-ERG fusion
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BRCA2 mutation
BRCA2 mutation
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Immunohistochemical stains
Immunohistochemical stains
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NKX3.1
NKX3.1
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PIN4 cocktail (AMCAR, and Basal cell marker HMWCK and p63)
PIN4 cocktail (AMCAR, and Basal cell marker HMWCK and p63)
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PSA & PSAP expression
PSA & PSAP expression
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Fibroblasts
Fibroblasts
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Benign Glands
Benign Glands
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Prostatic Adenocarcinoma
Prostatic Adenocarcinoma
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Other suspicious Histological Features
Other suspicious Histological Features
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Gleason Score
Gleason Score
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Tumors showing treatment effect
Tumors showing treatment effect
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Reporting of prostate cancer
Reporting of prostate cancer
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Acinar Adenocarcinoma
Acinar Adenocarcinoma
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Acinar Adenocarcinoma Morphology
Acinar Adenocarcinoma Morphology
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Acinar Adenocarcinoma
Acinar Adenocarcinoma
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Bone Metastasis Symptoms
Bone Metastasis Symptoms
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Study Notes
Matrizen (Matrices)
- Matrices are rectangular arrays of numbers
- A matrix $A$ is represented as: $A = \begin{pmatrix} a_{11} & a_{12} & \cdots & a_{1n} \ a_{21} & a_{22} & \cdots & a_{2n} \ \vdots & \vdots & \ddots & \vdots \ a_{m1} & a_{m2} & \cdots & a_{mn} \end{pmatrix}$
- $a_{ij}$ represents elements which are real ($\mathbb{R}$) or complex ($\mathbb{C}$) numbers
Matrix Dimensions
- $m$ denotes the number of rows in the matrix
- $n$ denotes the number of columns in the matrix
- $A \in \mathbb{R}^{m \times n}$ or $A \in \mathbb{C}^{m \times n}$ describes the dimensions of matrix A
- The element $a_{ij}$ is located in the $i$-th row and $j$-th column of the matrix
Matrix Example
- Example matrix: $A = \begin{pmatrix} 1 & 2 & 3 \ 4 & 5 & 6 \end{pmatrix} \in \mathbb{R}^{2 \times 3}$
- The elements are:
- $a_{11} = 1$
- $a_{12} = 2$
- $a_{13} = 3$
- $a_{21} = 4$
- $a_{22} = 5$
- $a_{23} = 6$
Special Matrices
- Square Matrix: The number of rows equals the number of columns ($m = n$)
- Zero Matrix: All elements are zero ($a_{ij} = 0$ for all $i, j$)
- Identity Matrix ($I_n$): A square matrix with ones on the main diagonal and zeros elsewhere: $I_n = \begin{pmatrix} 1 & 0 & \cdots & 0 \ 0 & 1 & \cdots & 0 \ \vdots & \vdots & \ddots & \vdots \ 0 & 0 & \cdots & 1 \end{pmatrix}$
- Diagonal Matrix: All non-diagonal elements are zero ($a_{ij} = 0$ for all $i \neq j$)
- Upper Triangular Matrix: All elements below the main diagonal are zero ($a_{ij} = 0$ for all $i > j$)
- Lower Triangular Matrix: All elements above the main diagonal are zero ($a_{ij} = 0$ for all $i < j$)
- Symmetric Matrix: A matrix that is equal to its transpose ($A = A^T$), which means $a_{ij} = a_{ji}$ for all $i, j$
- Antisymmetric Matrix: A matrix that is equal to the negative of its transpose ($A = -A^T$), where $a_{ij} = -a_{ji}$ for all $i, j$
Matrix Transpose
- The transpose of a matrix $A \in \mathbb{R}^{m \times n}$ is a matrix $A^T \in \mathbb{R}^{n \times m}$
- Rows become columns and columns become rows
- If $A = \begin{pmatrix} a_{11} & a_{12} \ a_{21} & a_{22} \ a_{31} & a_{32} \end{pmatrix}$, then $A^T = \begin{pmatrix} a_{11} & a_{21} & a_{31} \ a_{12} & a_{22} & a_{32} \end{pmatrix}$
Matrix Operations
Addition
- Defined for matrices $A, B \in \mathbb{R}^{m \times n}$
- $C = A + B$, where $c_{ij} = a_{ij} + b_{ij}$ for all $i, j$
Scalar Multiplication
- Defined for a matrix $A \in \mathbb{R}^{m \times n}$ and a scalar $\lambda \in \mathbb{R}$
- $C = \lambda A$, where $c_{ij} = \lambda a_{ij}$ for all $i, j$
Matrix Multiplication
- Defined for matrices $A \in \mathbb{R}^{m \times n}$ and $B \in \mathbb{R}^{n \times p}$
- $C = A \cdot B \in \mathbb{R}^{m \times p}$, where $c_{ij} = \sum_{k=1}^{n} a_{ik} b_{kj}$ for all $i, j$
- Matrix multiplication is generally not commutative: $A \cdot B \neq B \cdot A$
Matrix Multiplication Example
- For $A = \begin{pmatrix} 1 & 2 \ 3 & 4 \end{pmatrix}$ and $B = \begin{pmatrix} 5 & 6 \ 7 & 8 \end{pmatrix}$:
- $A \cdot B = \begin{pmatrix} 1 \cdot 5 + 2 \cdot 7 & 1 \cdot 6 + 2 \cdot 8 \ 3 \cdot 5 + 4 \cdot 7 & 3 \cdot 6 + 4 \cdot 8 \end{pmatrix} = \begin{pmatrix} 19 & 22 \ 43 & 50 \end{pmatrix}$
- $B \cdot A = \begin{pmatrix} 5 \cdot 1 + 6 \cdot 3 & 5 \cdot 2 + 6 \cdot 4 \ 7 \cdot 1 + 8 \cdot 3 & 7 \cdot 2 + 8 \cdot 4 \end{pmatrix} = \begin{pmatrix} 23 & 34 \ 31 & 46 \end{pmatrix}$
Inverse Matrix
- A square matrix $A \in \mathbb{R}^{n \times n}$ is invertible if there exists a matrix $A^{-1} \in \mathbb{R}^{n \times n}$
- Condition for invertibility: $A \cdot A^{-1} = A^{-1} \cdot A = I_n$
- $A^{-1}$ is the inverse matrix of $A$
Inverse Matrix Calculation
- The inverse matrix can be computed using:
- Gauss-Jordan elimination
- Cramer's rule
Inverse Matrix Properties
- $(A^{-1})^{-1} = A$
- $(A \cdot B)^{-1} = B^{-1} \cdot A^{-1}$
- $(A^T)^{-1} = (A^{-1})^T$
Determinant
- The determinant of a square matrix $A \in \mathbb{R}^{n \times n}$ is a scalar value, denoted as $\det(A)$ or $|A|$
Determinant Calculation
- $2 \times 2$ matrix: $\det(A) = a_{11} a_{22} - a_{12} a_{21}$
- $3 \times 3$ matrix: Use the Rule of Sarrus
- $n \times n$ matrix: Use the Laplace expansion
Determinant Properties
- $\det(A^T) = \det(A)$
- $\det(A \cdot B) = \det(A) \cdot \det(B)$
- $\det(A^{-1}) = \frac{1}{\det(A)}$
- $\det(I_n) = 1$
- $\det(A) = 0$ if $A$ has linearly dependent rows or columns
Linear Equation Systems (LES)
- A linear equation system is a set of linear equations: $a_{11} x_1 + a_{12} x_2 + \cdots + a_{1n} x_n = b_1$ $a_{21} x_1 + a_{22} x_2 + \cdots + a_{2n} x_n = b_2$ $\vdots$ $a_{m1} x_1 + a_{m2} x_2 + \cdots + a_{mn} x_n = b_m$
- Where $a_{ij}, b_i \in \mathbb{R}$ or $\mathbb{C}$
Matrix Notation for LES
- The linear equation system can be expressed in matrix form as: $A \cdot x = b$
- Where:
- $A = \begin{pmatrix} a_{11} & a_{12} & \cdots & a_{1n} \ a_{21} & a_{22} & \cdots & a_{2n} \ \vdots & \vdots & \ddots & \vdots \ a_{m1} & a_{m2} & \cdots & a_{mn} \end{pmatrix}$
- $x = \begin{pmatrix} x_1 \ x_2 \ \vdots \ x_n \end{pmatrix}$
- $b = \begin{pmatrix} b_1 \ b_2 \ \vdots \ b_m \end{pmatrix}$
Methods for Solving LES
- Methods to solve linear equation systems:
- Gaussian Elimination
- Cramer's Rule
- Inverse Matrix Method
Number of Solutions for LES
- A linear equation system can have:
- No solution
- A unique solution
- Infinitely many solutions
Eigenvalues and Eigenvectors
- For a square matrix $A \in \mathbb{R}^{n \times n}$, a non-zero vector $v \in \mathbb{R}^n$ is an eigenvector of $A$
- Condition: There exists a scalar $\lambda \in \mathbb{R}$ such that $A \cdot v = \lambda v$
- $\lambda$ is the eigenvalue of $A$ corresponding to the eigenvector $v$
Eigenvalue Calculation
- The eigenvalues can be found using the characteristic polynomial: $\det(A - \lambda I_n) = 0$
Eigenvector Calculation
- Eigenvectors are found by solving the linear equation system: $(A - \lambda I_n) \cdot v = 0$
Properties of Eigenvalues and Eigenvectors
- Eigenvectors corresponding to distinct eigenvalues are linearly independent
- The sum of the eigenvalues is equal to the trace of the matrix
- The product of the eigenvalues is equal to the determinant of the matrix
Vector Operations
Scalars and Vectors
- Scalar: A quantity characterized by a numerical value.
- Vector: A quantity with both magnitude and direction in space.
Vector Operations
Vector Multiplication by a Scalar
- (\vec{B} = a\vec{A}), where (\vec{A}) is a vector and a is a scalar.
- Magnitude: (|B| = |aA|)
- Direction:
- Same as (\vec{A}) if a is positive.
- Opposite to (\vec{A}) if a is negative.
Vector Addition
Triangle Rule
- (\vec{R} = \vec{A} + \vec{B})
- "Tip-to-tail" method where the tail of the second vector is placed at the tip of the first vector.
Parallelogram Law
- Method:
- Join the tails of (\vec{A}) and (\vec{B}).
- Draw a line from the head of each vector parallel to the other vector.
- The resultant (\vec{R}) is the diagonal of the parallelogram.
Vector Subtraction
- (\vec{R} = \vec{A} - \vec{B} = \vec{A} + (-\vec{B}))
- Defined as the addition of a negative vector.
Cartesian Vectors
Right-Handed Coordinate System
- Direction: Curl the fingers of the right hand from the x-axis toward the y-axis; the thumb points along the positive z-axis.
Rectangular Components of a Vector
- (\vec{A} = A_x\hat{\imath} + A_y\hat{\jmath} + A_z\hat{k})
- (A_x), (A_y), (A_z) are the scalar components in the x, y, z directions.
- (\hat{\imath}), (\hat{\jmath}), (\hat{k}) are the unit vectors in the x, y, z directions.
Magnitude of Cartesian Vector
- (A = \sqrt{A_x^2 + A_y^2 + A_z^2})
Direction of a Cartesian Vector
- Defined by the coordinate direction angles (\alpha), (\beta), (\gamma).
- (\cos{\alpha} = \frac{A_x}{A}), (\cos{\beta} = \frac{A_y}{A}), (\cos{\gamma} = \frac{A_z}{A})
- (\cos{\alpha}), (\cos{\beta}), (\cos{\gamma}) are the direction cosines of (\vec{A}).
- Relationship: (\cos^2{\alpha} + \cos^2{\beta} + \cos^2{\gamma} = 1)
Unit Vector
- Unit vector in the direction of (\vec{A}):
- (\hat{u}_A = \frac{\vec{A}}{A} = \frac{A_x}{A}\hat{\imath} + \frac{A_y}{A}\hat{\jmath} + \frac{A_z}{A}\hat{k} = \cos{\alpha}\hat{\imath} + \cos{\beta}\hat{\jmath} + \cos{\gamma}\hat{k})
Addition of Cartesian Vectors
- (\vec{R} = \vec{A} + \vec{B} = (A_x + B_x)\hat{\imath} + (A_y + B_y)\hat{\jmath} + (A_z + B_z)\hat{k})
Dot Product (Scalar Product)
- (\vec{A} \cdot \vec{B} = A B \cos{\theta})
- (\theta) is the angle between vectors (\vec{A}) and (\vec{B}).
- The dot product results in a scalar value.
Laws of Operation
- Commutative law: (\vec{A} \cdot \vec{B} = \vec{B} \cdot \vec{A})
- Multiplication by a scalar: (a (\vec{A} \cdot \vec{B}) = (\alpha \vec{A}) \cdot \vec{B} = \vec{A} \cdot (\alpha \vec{B}))
- Distributive law: (\vec{A} \cdot (\vec{B} + \vec{C}) = \vec{A} \cdot \vec{B} + \vec{A} \cdot \vec{C})
Cartesian Vector Formulation
- (\vec{A} \cdot \vec{B} = (A_x\hat{\imath} + A_y\hat{\jmath} + A_z\hat{k}) \cdot (B_x\hat{\imath} + B_y\hat{\jmath} + B_z\hat{k}))
- (\vec{A} \cdot \vec{B} = A_x B_x + A_y B_y + A_z B_z)
Applications
Angle Between Two Vectors
- (\cos{\theta} = \frac{\vec{A} \cdot \vec{B}}{AB} = \frac{A_x B_x + A_y B_y + A_z B_z}{AB})
Projection of a Vector
- (A' = A \cos{\theta} = \vec{A} \cdot \hat{u}_B), where (A') is the projection of (\vec{A}) onto (\vec{B}).
Cross Product (Vector Product)
- (\vec{C} = \vec{A} \times \vec{B})
- Magnitude: (C = AB \sin{\theta})
- Direction: (\vec{C}) is perpendicular to the plane containing (\vec{A}) and (\vec{B}) (right-hand rule).
- The cross product results in a vector.
Laws of Operation
- Commutative law: (\vec{A} \times \vec{B} = - \vec{B} \times \vec{A})
- Multiplication by a scalar: (a (\vec{A} \times \vec{B}) = (\alpha \vec{A}) \times \vec{B} = \vec{A} \times (\alpha \vec{B}))
- Distributive law: (\vec{A} \times (\vec{B} + \vec{C}) = \vec{A} \times \vec{B} + \vec{A} \times \vec{C})
Cartesian Vector Formulation
- (\vec{A} \times \vec{B} = \begin{vmatrix} \hat{\imath} & \hat{\jmath} & \hat{k} \ A_x & A_y & A_z \ B_x & B_y & B_z \end{vmatrix} = (A_y B_z - A_z B_y)\hat{\imath} - (A_x B_z - A_z B_x)\hat{\jmath} + (A_x B_y - A_y B_x)\hat{k})
Algorithmic Game Theory
- Algorithmic Game Theory examines the connections between game theory and computer science.
Scope
- Algorithmic issues in game theory focus on the design and analysis of algorithms for solving game-theoretic problems like computing Nash equilibria or finding optimal auctions.
- Game-theoretic issues in algorithms concentrate on designing systems with strategic agents, such as mechanism design or creating networks robust to selfish actions.
Routing Games Example
- Each agent $i$ chooses a path $P_i$ from $s_i$ to $t_i$
- Each edge $e$ has a cost or latency $l_e(x)$, which is a function of the number of agents $x$ using $e$.
- The cost to agent $i$ is: $c_i = \sum_{e \in P_i} l_e(x_e)$ where $x_e$ is number of agents using edge $e$
Nash Equilibrium
- A state where no agent benefits by unilaterally changing their strategy, assuming other agents' strategies remain constant.
Braess Paradox Example
- A network with two paths from s to t, each having two edges: one with latency x and one with latency 1
- Adding a zero-latency edge from u to v (middle nodes on each path) causes all agents to switch to the path s->u->v->t
- The total cost for each agent increases, even though network capacity has increased.
Price of Anarchy (PoA)
- A measure of inefficiency in a Nash equilibrium
- $PoA = \frac{\text{cost of the worstcase Nash equilibrium}}{\text{optimal social cost}}$
- Social cost is the sum of all agents' costs
- Optimal social cost is the minimum social cost, assuming no selfish behavior
- In the Braess paradox where $l_e(x) = a_e x + b_e$ is less than or equal to 4/3
Torsional Vibration
Causes
- Diesel engines, reciprocating compressors, generators etc cause Torsional Vibration
Effects
- Torsional Vibration results in Noise, gear tooth wear, and coupling/shaft failure
Methods to Reduce
- Torsional Vibration Damper and Tuned Absorber can reduce vibration
Types of Torsional Vibration Damper
- Viscous Damper, Pendulum Damper, and Elastomeric Damper
Viscous Damper
- This consists of a housing, viscous fluid, and inertia ring. Vibration causes the inertia ring to lag, providing damping.
Viscous Damper Advantages
- Simple, reliable and effective over a wide range of frequencies. Also relatively inexpensive.
Viscous Damper Disadvantages
- Viscous Dampers can be bulky/heavy and affected by temperature
Pendulum Damper
- This consists of a pendulum attached to the rotating shaft and the out-of-phase oscillation provides damping.
Pendulum Damper Advantages
- Effective at reducing vibration at a specific frequency and is relatively small/lightweight.
Pendulum Damper Disadvantages
- Complicated and expensive. Performance is sensitive to changes in frequency.
Elastomeric Damper
- This consists of an elastomeric material bonded to the shaft and an inertia ring. Deformation of the elastomeric material provides damping.
Elastomeric Damper Advantages
- Simple and relatively inexpensive; effective over a wide range of frequencies
Elastomeric Damper Disadvantages
- Performance affected by temperature/frequency and can be bulky.
Tuned Absorber
- This reduces torsional vibration at specific frequencies.
Types of Tuned Absorber
- Harmonic Absorber and Lanchester Damper are types of Tuned Absorber
Harmonic Absorber
- Harmonic Absorbers consist of a mass and spring system tuned to the vibration frequency and provides damping.
Harmonic Absorber Advantages
- Effective at reducing vibration at a specific frequency and is relatively small/lightweight.
Harmonic Absorber Disadvantages
- Performance is sensitive to changes in frequency and can be complex/expensive.
Lanchester Damper
- This consists of two discs with friction material in between and the friction provides damping.
Lanchester Damper Advantages
- Simple and relatively inexpensive and effective over a wide range of frequencies.
Lanchester Damper Disadvantages
- Performance is affected by the friction material and can be noisy.
The Euclidean Algorithm
- Theorem: If $a, b \in \mathbb{Z}$, then $\exists x, y \in \mathbb{Z}$ such that $ax + by = gcd(a, b)$.
Method
- Given $a > b > 0$ as integers
- $a = q_1b + r_1$, $0 \leq r_1 < b$
- $b = q_2r_1 + r_2$, $0 \leq r_2 < r_1$
- $r_1 = q_3r_2 + r_3$, $0 \leq r_3 < r_2$
- $r_{n-2} = q_nr_{n-1} + r_n$, $0 \leq r_n < r_{n-1}$
- $r_{n-1} = q_{n+1}r_n + 0$
- The greatest common divisor of $a$ and $b$ is then $gcd(a, b) = r_n$.
- The Euclidean Algorithm provides $x, y$ such that $ax + by = gcd(a, b)$
Example
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Find the GCD (greatest common divisor) of 1001 and 330
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$1001 = 3 \cdot 330 + 11$
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$330 = 30 \cdot 11 + 0$
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The GCD is therefore $gcd(1001, 330) = 11$
Example
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Express 11 as the result of a linear combination of 1001 and 330
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$11 = 1001 - 3 \cdot 330 = 1001(1) + 330(-3)$
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So $x = 1$, $y = -3$.
The Fundamental Theorem of Arithmetic
- Every integer $n > 1$ has a unique prime factorization.
- A number $n > 1$, that is not prime can be written as $n = ab$ where $1 < a, b < n$.
- The factors ,$a$ and $b$ may be further factored. The final result will be a product of primes.
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