Mastering Zonula Occludens

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Questions and Answers

Which proteins are responsible for creating the seal in the tight junction?

  • Outer leaflets
  • Transmembrane proteins
  • Occludins and claudins (correct)
  • Actin filaments

What is the function of the tight junction?

  • Allows diffusion of membrane proteins between the apical and lateral membrane domains
  • Fuses the outer leaflets of adjoined plasma membranes
  • Controls the free molecular movement between the cells (correct)
  • Attaches to actin filaments

Where do the occludins/claudins attach in the intercellular space?

  • To the neighboring cells (correct)
  • To the outer leaflets of the cells
  • To the apical and lateral membrane domains
  • To the actin filaments

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