Mastering the Three Initiation Factors
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Questions and Answers

What is the role of IF1 in the 30s complex formation?

  • It blocks the initiator tRNA from entering the 'A-site' (correct)
  • It remains bound with the 30S subunit
  • It places the initiator tRNA at P-site
  • It helps in binding of the 50s subunit with 30s subunit

    • What is the role of IF2 in the 30s complex formation?

  • It remains bound with the 30S subunit
  • It blocks the initiator tRNA from entering the 'A-site'
  • It helps in binding of the 50s subunit with 30s subunit
  • It places the initiator tRNA at P-site (correct)

    • Which initiation factors remain bound with the 30S subunit during 30s complex formation?

  • IF1 and IF3 (correct)
  • IF1, IF2, and IF3
  • IF1 and IF2
  • IF2 and IF3

    • What is the role of IF3 in the 30s complex formation?

    <p>It blocks binding of the 50s subunit with 30s subunit</p> Signup and view all the answers

    What is the function of Streptomycin in inhibiting 30s complex formation?

    <p>It binds to the 16s rRNA in the 30S subunit and inhibits binding of the initiator tRNA with the start codon</p> Signup and view all the answers

    What is the consequence of Streptomycin binding to the 16s rRNA in the 30S subunit?

    <p>Mis-reading of the template causes polypeptide frame shifting</p> Signup and view all the answers

    What is the role of IF1 and IF2 in placing the Initiator tRNA to 'P-site'?

    <p>Both IF1 and IF2 help in placing the Initiator tRNA to 'P-site'</p> Signup and view all the answers

    Which initiation factor blocks the initiator tRNA from entering the 'A-site'?

    <p>IF1</p> Signup and view all the answers

    What is the consequence of mis-reading of the template during 30s complex formation?

    <p>Polypeptide frame shifting</p> Signup and view all the answers

    What is the consequence of Streptomycin inhibiting binding of the initiator tRNA with the start codon?

    <p>Initiator tRNA is placed incorrectly</p> Signup and view all the answers

    What is the function of IF1 in the 30s complex formation?

    <p>It blocks the initiator tRNA from entering the 'A-site'</p> Signup and view all the answers

    Which initiation factor remains bound with the 30S subunit during the 30s complex formation?

    <p>IF3</p> Signup and view all the answers

    What is the function of IF3 in the 30s complex formation?

    <p>It blocks binding of the 50s subunit with 30s subunit</p> Signup and view all the answers

    Which initiation factor places the initiator tRNA (fmet-tRNA) at P-site during the 30s complex formation?

    <p>IF2</p> Signup and view all the answers

    What is the role of both IF1 and IF2 in the 30s complex formation?

    <p>They place the initiator tRNA at P-site</p> Signup and view all the answers

    Which antibiotic binds to the 16s rRNA in the 30S subunit and inhibits binding of the initiator tRNA with the start codon during the 30s complex formation?

    <p>Streptomycin</p> Signup and view all the answers

    What is the consequence of streptomycin binding to the 16s rRNA during the 30s complex formation?

    <p>Initiator tRNA is placed incorrectly</p> Signup and view all the answers

    Which initiation factor(s) help in blocking the binding of the 50s subunit with 30s subunit during the 30s complex formation?

    <p>IF3</p> Signup and view all the answers

    Which initiation factor helps in placing the initiator tRNA to 'P-site' during the 30s complex formation?

    <p>IF2</p> Signup and view all the answers

    Which initiation factor blocks the initiator tRNA from entering the 'A-site' during the 30s complex formation?

    <p>IF1</p> Signup and view all the answers

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