Mastering Innate Immunity

CXCL8 interacts with CD31 on the endothelial cell to allow for extravsation

CXCL8 causes a conformational change in LFA-1 resulting in a high affinity binding state

CXCL8 degrades the basement membrane to allow for leukocyte passage

CXCL8 forms a gradient that the neutrophil follows to the site of infection (correct)

A defect in CD31 on the endothelial cell

A defect in CD18, the b-chain subunit of LFA-1 (correct)

A defect in ICAMs on the endothelium

A defect in CXCR1/2 on the neutrophil

CCR7 degrades the basement membrane to allow for DC passage

CCR7 causes a conformational change in LFA-1 resulting in a high affinity binding state

CCR7 interacts with CD31 on the endothelial cell to allow for extravasation

CCR7 forms a gradient that the DC follows to the T cell zone (correct)