Mastering Innate Immunity

• CXCL8 interacts with CD31 on the endothelial cell to allow for extravsation
• CXCL8 causes a conformational change in LFA-1 resulting in a high affinity binding state
• CXCL8 degrades the basement membrane to allow for leukocyte passage
• CXCL8 forms a gradient that the neutrophil follows to the site of infection (correct)

• A defect in CD31 on the endothelial cell
• A defect in CD18, the b-chain subunit of LFA-1 (correct)
• A defect in ICAMs on the endothelium
• A defect in CXCR1/2 on the neutrophil

• CCR7 degrades the basement membrane to allow for DC passage
• CCR7 causes a conformational change in LFA-1 resulting in a high affinity binding state
• CCR7 interacts with CD31 on the endothelial cell to allow for extravasation
• CCR7 forms a gradient that the DC follows to the T cell zone (correct)