Mastering IgM Antibody Production
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Questions and Answers

Which antibody class is best for opsonizing bacteria and viruses?

  • IgG3
  • IgE
  • IgG1 (correct)
  • IgM

Which antibody class is best for eliminating helminths?

  • IgE (correct)
  • IgG3
  • IgM
  • IgG1

Isotype switching broadens the functional capabilities of humoral immune responses by changing the heavy-chain isotypes of antibodies. True or False?

  • False
  • True (correct)

Which receptor is responsible for the transfer of maternal IgG to the fetus?

<p>FcRn (A)</p> Signup and view all the answers

What is the consequence of isotype switching in the production of IgG antibodies?

<p>Increased half-life in the blood (B)</p> Signup and view all the answers

Which ligand-receptor pair is essential for isotype switching?

<p>CD40-CD40L (C)</p> Signup and view all the answers

What is the cause of X-linked hyper-IgM syndrome?

<p>Mutations in the CD40L gene (A)</p> Signup and view all the answers

Which antibody is the major isotype produced in mucosal lymphoid tissues?

<p>IgA (C)</p> Signup and view all the answers

Which cytokine promotes switching to IgA?

<p>Transforming growth factor (TGF)–β (C)</p> Signup and view all the answers

Which cells are important sources of IgA antibody in mucosal tissues, especially against nonprotein antigens?

<p>B-1 cells (D)</p> Signup and view all the answers

Which enzyme alters nucleotides in the switch regions to allow for immunoglobulin heavy-chain isotype switching?

<p>Activation-induced deaminase (AID) (C)</p> Signup and view all the answers

Which enzyme plays a key role in the switch recombination process?

<p>Activation-induced deaminase (AID) (B)</p> Signup and view all the answers

Which antibody is produced first by B cells?

<p>IgM (C)</p> Signup and view all the answers

Which cytokine stimulates the production of opsonizing IgG antibodies in humans?

<p>Interleukin-10 (IL-10) (C)</p> Signup and view all the answers

Which cell type is activated by IL-5 and plays a role in eliminating helminths?

<p>Eosinophils (C)</p> Signup and view all the answers

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