Mastering IgM Antibody Production
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Questions and Answers

Which antibody class is best for opsonizing bacteria and viruses?

  • IgG3
  • IgE
  • IgG1 (correct)
  • IgM
  • Which antibody class is best for eliminating helminths?

  • IgE (correct)
  • IgG3
  • IgM
  • IgG1
  • Isotype switching broadens the functional capabilities of humoral immune responses by changing the heavy-chain isotypes of antibodies. True or False?

  • False
  • True (correct)
  • Which receptor is responsible for the transfer of maternal IgG to the fetus?

    <p>FcRn</p> Signup and view all the answers

    What is the consequence of isotype switching in the production of IgG antibodies?

    <p>Increased half-life in the blood</p> Signup and view all the answers

    Which ligand-receptor pair is essential for isotype switching?

    <p>CD40-CD40L</p> Signup and view all the answers

    What is the cause of X-linked hyper-IgM syndrome?

    <p>Mutations in the CD40L gene</p> Signup and view all the answers

    Which antibody is the major isotype produced in mucosal lymphoid tissues?

    <p>IgA</p> Signup and view all the answers

    Which cytokine promotes switching to IgA?

    <p>Transforming growth factor (TGF)–β</p> Signup and view all the answers

    Which cells are important sources of IgA antibody in mucosal tissues, especially against nonprotein antigens?

    <p>B-1 cells</p> Signup and view all the answers

    Which enzyme alters nucleotides in the switch regions to allow for immunoglobulin heavy-chain isotype switching?

    <p>Activation-induced deaminase (AID)</p> Signup and view all the answers

    Which enzyme plays a key role in the switch recombination process?

    <p>Activation-induced deaminase (AID)</p> Signup and view all the answers

    Which antibody is produced first by B cells?

    <p>IgM</p> Signup and view all the answers

    Which cytokine stimulates the production of opsonizing IgG antibodies in humans?

    <p>Interleukin-10 (IL-10)</p> Signup and view all the answers

    Which cell type is activated by IL-5 and plays a role in eliminating helminths?

    <p>Eosinophils</p> Signup and view all the answers

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