Mastering Heart Failure Pathophysiology
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Questions and Answers

Which type of dysfunction is characterized by impaired cardiac contractility?

  • Diastolic dysfunction
  • Left ventricular dysfunction
  • Right ventricular dysfunction
  • Systolic dysfunction (correct)
  • What is the main determinant of pre-load?

  • Ventricular wall tension
  • Excessive afterload
  • Vascular resistance
  • Venous return (correct)
  • What is the force that the contracting heart must generate to eject blood from the heart called?

  • Pre-load
  • Ventricular wall tension
  • Afterload (correct)
  • Vascular resistance
  • Which component of afterload may impair ventricular ejection and increase wall tension?

    <p>Vascular resistance</p> Signup and view all the answers

    What is the term for the ability of the myocardium to contract?

    <p>Myocardial contractility</p> Signup and view all the answers

    Which ion influences myocardial contractility by opening L-type channels facilitated by cAMP?

    <p>Ca2+</p> Signup and view all the answers

    Which ion exchange is indirectly inhibited by cardiac glycosides, leading to increased contractility?

    <p>Na+/Ca2+ exchange</p> Signup and view all the answers

    Which NYHA class of heart failure is characterized by marked limitation of physical activity?

    <p>Class III</p> Signup and view all the answers

    Which NYHA class of heart failure is characterized by no limitation of physical activity?

    <p>Class I</p> Signup and view all the answers

    Which type of dysfunction is characterized by a decrease in ejection fraction?

    <p>Systolic dysfunction</p> Signup and view all the answers

    Which of the following is true about capillary hydrostatic pressure?

    <p>It forces fluid out of the capillaries and into the interstitium</p> Signup and view all the answers

    Which of the following is responsible for drawing fluid into the capillaries?

    <p>Plasma oncotic pressure</p> Signup and view all the answers

    Which system is important in controlling the concentration of proteins in interstitial fluids and the volume of interstitial fluid?

    <p>Lymphatic system</p> Signup and view all the answers

    What is the range of pressure in the systemic venous circulation?

    <p>Between 3-18mmHg</p> Signup and view all the answers

    What effect does sympathetic innervation of veins have on venous return to the heart?

    <p>Increases venous return</p> Signup and view all the answers

    Which of the following is true about the effect of decreased alveolar O2 on local alveolar blood flow in the lungs?

    <p>It decreases local alveolar blood flow</p> Signup and view all the answers

    What are the major routes across capillary membranes for the movement of fluids, solutes, and larger molecules/proteins?

    <p>Diffusion and bulk flow</p> Signup and view all the answers

    What is the importance of the lymphatic system in fluid homeostasis and net transcapillary movement of water across capillary beds?

    <p>It prevents fluid accumulation in tissues</p> Signup and view all the answers

    What are the factors that affect venous return and consequently determine cardiac output and blood pressure?

    <p>Blood volume and blood viscosity</p> Signup and view all the answers

    What is the term for the net movement of nutrients, oxygen, and metabolic end products through capillary membranes?

    <p>Diffusion</p> Signup and view all the answers

    Which artery supplies blood to the walls of the right atrium and right ventricle?

    <p>Right coronary artery</p> Signup and view all the answers

    Which of the following is the primary controller of coronary blood flow?

    <p>Local metabolism</p> Signup and view all the answers

    What is the main determinant of preload?

    <p>Venous return</p> Signup and view all the answers

    Which ion influences myocardial contractility by opening L-type channels facilitated by cAMP?

    <p>Calcium</p> Signup and view all the answers

    What effect does sympathetic innervation of veins have on venous return to the heart?

    <p>Increases venous return</p> Signup and view all the answers

    During strenuous exercise, the work output of the heart increases by 6-9 times. What percentage of coronary blood flow does the heart use during strenuous exercise?

    <p>70-80%</p> Signup and view all the answers

    Which of the following is responsible for vasoconstriction of skeletal muscle arterioles during sympathetic stimulation?

    <p>α1 receptors</p> Signup and view all the answers

    What is the main factor that determines venous return to the heart?

    <p>Preload</p> Signup and view all the answers

    Which of the following is true about the effect of sympathetic innervation on venous return to the heart?

    <p>Increases venous return</p> Signup and view all the answers

    What is the term for the ability of the myocardium to contract?

    <p>Contractility</p> Signup and view all the answers

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