Mastering Heart Failure Pathophysiology
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Questions and Answers

Which type of dysfunction is characterized by impaired cardiac contractility?

  • Diastolic dysfunction
  • Left ventricular dysfunction
  • Right ventricular dysfunction
  • Systolic dysfunction (correct)

What is the main determinant of pre-load?

  • Ventricular wall tension
  • Excessive afterload
  • Vascular resistance
  • Venous return (correct)

What is the force that the contracting heart must generate to eject blood from the heart called?

  • Pre-load
  • Ventricular wall tension
  • Afterload (correct)
  • Vascular resistance

Which component of afterload may impair ventricular ejection and increase wall tension?

<p>Vascular resistance (D)</p> Signup and view all the answers

What is the term for the ability of the myocardium to contract?

<p>Myocardial contractility (D)</p> Signup and view all the answers

Which ion influences myocardial contractility by opening L-type channels facilitated by cAMP?

<p>Ca2+ (C)</p> Signup and view all the answers

Which ion exchange is indirectly inhibited by cardiac glycosides, leading to increased contractility?

<p>Na+/Ca2+ exchange (A)</p> Signup and view all the answers

Which NYHA class of heart failure is characterized by marked limitation of physical activity?

<p>Class III (B)</p> Signup and view all the answers

Which NYHA class of heart failure is characterized by no limitation of physical activity?

<p>Class I (D)</p> Signup and view all the answers

Which type of dysfunction is characterized by a decrease in ejection fraction?

<p>Systolic dysfunction (B)</p> Signup and view all the answers

Which of the following is true about capillary hydrostatic pressure?

<p>It forces fluid out of the capillaries and into the interstitium (B)</p> Signup and view all the answers

Which of the following is responsible for drawing fluid into the capillaries?

<p>Plasma oncotic pressure (C)</p> Signup and view all the answers

Which system is important in controlling the concentration of proteins in interstitial fluids and the volume of interstitial fluid?

<p>Lymphatic system (B)</p> Signup and view all the answers

What is the range of pressure in the systemic venous circulation?

<p>Between 3-18mmHg (B)</p> Signup and view all the answers

What effect does sympathetic innervation of veins have on venous return to the heart?

<p>Increases venous return (D)</p> Signup and view all the answers

Which of the following is true about the effect of decreased alveolar O2 on local alveolar blood flow in the lungs?

<p>It decreases local alveolar blood flow (B)</p> Signup and view all the answers

What are the major routes across capillary membranes for the movement of fluids, solutes, and larger molecules/proteins?

<p>Diffusion and bulk flow (C)</p> Signup and view all the answers

What is the importance of the lymphatic system in fluid homeostasis and net transcapillary movement of water across capillary beds?

<p>It prevents fluid accumulation in tissues (B)</p> Signup and view all the answers

What are the factors that affect venous return and consequently determine cardiac output and blood pressure?

<p>Blood volume and blood viscosity (A)</p> Signup and view all the answers

What is the term for the net movement of nutrients, oxygen, and metabolic end products through capillary membranes?

<p>Diffusion (C)</p> Signup and view all the answers

Which artery supplies blood to the walls of the right atrium and right ventricle?

<p>Right coronary artery (D)</p> Signup and view all the answers

Which of the following is the primary controller of coronary blood flow?

<p>Local metabolism (B)</p> Signup and view all the answers

What is the main determinant of preload?

<p>Venous return (C)</p> Signup and view all the answers

Which ion influences myocardial contractility by opening L-type channels facilitated by cAMP?

<p>Calcium (B)</p> Signup and view all the answers

What effect does sympathetic innervation of veins have on venous return to the heart?

<p>Increases venous return (B)</p> Signup and view all the answers

During strenuous exercise, the work output of the heart increases by 6-9 times. What percentage of coronary blood flow does the heart use during strenuous exercise?

<p>70-80% (C)</p> Signup and view all the answers

Which of the following is responsible for vasoconstriction of skeletal muscle arterioles during sympathetic stimulation?

<p>α1 receptors (B)</p> Signup and view all the answers

What is the main factor that determines venous return to the heart?

<p>Preload (C)</p> Signup and view all the answers

Which of the following is true about the effect of sympathetic innervation on venous return to the heart?

<p>Increases venous return (A)</p> Signup and view all the answers

What is the term for the ability of the myocardium to contract?

<p>Contractility (B)</p> Signup and view all the answers

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