Podcast
Questions and Answers
The cross bridge cycle starts when ________.
The cross bridge cycle starts when ________.
Ca2+ from the sarcoplasmic reticulum binds to troponin
Place the steps that occur during a single cross bridge cycle in the correct order from left to right.
Place the steps that occur during a single cross bridge cycle in the correct order from left to right.
- Activated myosin head binds to actin, forming a cross bridge. (correct)
- ATP is hydrolyzed to ADP and Pi and the energy released re-cocks the myosin head. (correct)
- ATP binds to the myosin head and detaches it from actin. (correct)
- ADP is released and myosin slides the thin filament toward the center of the sarcomere. (correct)
What is myosin?
What is myosin?
Myofilament with a knob-like head
What is actin?
What is actin?
What is sarcoplasm?
What is sarcoplasm?
What is a fascicle?
What is a fascicle?
What is the sarcolemma?
What is the sarcolemma?
What blocks myosin-binding sites on actin?
What blocks myosin-binding sites on actin?
What are skeletal muscle fibers?
What are skeletal muscle fibers?
What is a sarcomere?
What is a sarcomere?
What are myofibrils?
What are myofibrils?
In the event that a muscle cell runs out of ATP, what step of the cross bridge cycle is most directly inhibited or terminated?
In the event that a muscle cell runs out of ATP, what step of the cross bridge cycle is most directly inhibited or terminated?
What best explains rigor mortis after death?
What best explains rigor mortis after death?
Flashcards
Cross Bridge Cycle Initiation
Cross Bridge Cycle Initiation
Starts when Ca2+ binds to troponin.
Role of Calcium
Role of Calcium
Elevated Ca2+ causes troponin to move tropomyosin away from actin's binding sites.
Cross Bridge Formation
Cross Bridge Formation
Myosin heads bind to actin, forming a link between filaments.
Power Stroke
Power Stroke
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Cross Bridge Detachment
Cross Bridge Detachment
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Myosin Head Re-cocking
Myosin Head Re-cocking
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Myosin
Myosin
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Actin
Actin
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Sarcoplasm
Sarcoplasm
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Fascicle
Fascicle
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Sarcolemma
Sarcolemma
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Sarcomere
Sarcomere
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Tropomyosin
Tropomyosin
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Study Notes
Cross Bridge Cycle Initiation
- The cross bridge cycle begins when Ca2+ from the sarcoplasmic reticulum binds to troponin.
- Elevated Ca2+ levels cause a conformational change in troponin, moving tropomyosin away from actin's myosin-binding sites.
Steps in the Cross Bridge Cycle
- Myosin heads bind to actin, forming a cross bridge.
- Release of ADP results in the "power stroke," sliding the thin filament towards the sarcomere's center.
- ATP binds to myosin, prompting detachment from actin.
- ATP is hydrolyzed into ADP and inorganic phosphate (Pi), re-cocking the myosin head.
- The cycle continues as long as calcium ions and ATP are present, leading to muscle contraction.
Muscle Fiber Structure
- Myosin: Myofilament characterized by a knob-like head, essential for muscle contraction.
- Actin: Myofilament that is stabilized by tropomyosin, forming the structure of thin filaments.
- Sarcoplasm: The cytoplasm within skeletal muscle fibers, containing necessary organelles and proteins.
- Fascicle: Bundles of muscle fibers encased in connective tissue known as perimysium.
- Sarcolemma: The plasma membrane surrounding muscle cells, crucial for maintaining ionic gradients.
Sarcomere and Myofilaments
- Sarcomere: The fundamental contractile unit of striated muscle, comprising alternating thick (myosin) and thin (actin) filaments.
- Myofibrils: Structures made of aligned sarcomeres that run the length of the muscle fiber, facilitating contraction.
Tropomyosin and Muscle Contraction
- Tropomyosin blocks the myosin-binding sites on actin when muscle fibers are relaxed, preventing contraction.
Physiological Responses
- Cross bridge detachment is significantly hindered when ATP levels drop, leading to muscle stiffness.
- In rigor mortis, calcium leaks into the cytoplasm post-mortem, resulting in sustained contraction due to the absence of ATP for detachment.
Important Facts About Cross Bridge Cycling
- Detachment requires ATP, thus lacking ATP halts the cycle and maintains cross bridges.
- During cycling, only half of myosin heads detach at any time while calcium is available.
- Myosin is in an energized state with ADP and Pi bound before the cross bridge cycle initiates.
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Description
Test your knowledge on the cross bridge cycle and muscle physiology with this quiz based on Chapter 9 of Mastering Anatomy & Physiology. Understand key concepts including calcium ion dynamics and muscle contraction. Perfect for students seeking to reinforce their understanding of this essential topic.