28 Questions
Which hormone is responsible for negative feedback in the hypothalamus?
Estrogen
What is the primary hormone secreted by the testis?
Testosterone
Which enzyme converts testosterone to DHT in certain tissues?
5alpha-reductase
What is the main function of inhibin secreted by Sertoli cells?
Negative feedback to FSH release
Which hormone drives the process of spermatogenesis?
Testosterone
What are the secondary sex characteristics in males primarily influenced by?
Testosterone
Which hormone is responsible for the release of gonadotropins from the anterior pituitary?
GnRH
What is the main function of LH in males?
Stimulate testosterone production
Which hormone provides negative feedback to LH release and GnRH release?
Testosterone
What percentage of testosterone is bound to SHBG?
65%
Which of the following is a key target organ for the effects of testosterone?
Brain
What is the main use of androgen replacement therapy in men?
Treatment of hypogonadism
Which of the following is an adverse effect of androgen suppression with finasteride?
Gynecomastia
What is the main difference between bicalutamide and enzalutamide?
Bicalutamide is a partial agonist, while enzalutamide is a full antagonist
What is the main adverse effect of androgen receptor antagonists used for prostate cancer?
Hot flashes
What is the main symptom of erectile dysfunction?
Inability to maintain penile erection
What is the main effect of testosterone on muscle?
Increase in strength and volume
What is the main effect of testosterone on bone?
Closure of epiphyses
What is the main effect of testosterone on the liver?
Synthesis of serum proteins
Which type of erectile tissue surrounds the urethra and expands to form the bulb of the penis?
Corpus spongiosum
What causes the enlargement and stiffening of the penis during an erection?
All of the above
Which of the following is NOT a side effect of older ED therapy using alprostadil (PGE1)?
Nasal congestion
Which oral PDE inhibitor has the longest duration of action according to the text?
Tadalafil
Which of the following is NOT a common side effect of oral PDE inhibitors?
Abdominal pain/GI distress
Which of the following drugs is contraindicated with organic nitrates according to the text?
Sildenafil
Which oral PDE inhibitor has the shortest time to peak concentration according to the text?
Avanafil
Which of the following is NOT a food interaction with oral PDE inhibitors according to the text?
Tadalafil
Which type of erectile tissue forms the paired dorsal erectile bodies?
Corpora cavernosa
Test your knowledge on male hormones, BPH, and ED in this pharmacology quiz. Explore the intricacies of the Hypothalamic-Pituitary-Testis axis and understand the role of pulsatile secretions of GnRH, LH, and FSH in testosterone secretion and spermatogenesis. Challenge yourself with questions on inhibin and enhance your understanding of these crucial aspects of male reproductive health.
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