Marginal Zone Lymphoma: Classification and Etiology
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Questions and Answers

What is the characteristic feature of MGUS?

  • Presence of bone lesions
  • Less than 10% of plasma cells in the marrow (correct)
  • More than 10% of plasma cells in the marrow
  • High levels of M spike

What is the primary mechanism of bone destruction in myeloma?

  • Direct damage by plasma cells
  • Osteoclast activation due to RANK-ligand upregulation (correct)
  • Inflammation due to immune response
  • Osteoblast inactivation due to parathyroid hormone

What is the characteristic histological feature of myeloma?

  • Bone marrow replaced by sheets of plasma cells (correct)
  • Follicular lymphoma with B cell proliferation
  • Reactive lymph node hyperplasia
  • Granulomatous inflammation

What is the primary clinical manifestation of renal involvement in myeloma?

<p>Proteinuria (A)</p> Signup and view all the answers

What is the most common type of lymphoma related to myeloma?

<p>IgM-secreting B cell lymphoma (C)</p> Signup and view all the answers

What is the median survival of untreated myeloma?

<p>4-7 years (D)</p> Signup and view all the answers

What is a characteristic of B cells in non-Hodgkin lymphomas?

<p>They undergo somatic hypermutation (A)</p> Signup and view all the answers

What is the primary site of manifestation for non-Hodgkin lymphomas, with few exceptions?

<p>Lymph nodes (D)</p> Signup and view all the answers

What is a common symptom of non-Hodgkin lymphomas?

<p>Painless lymphadenopathy (D)</p> Signup and view all the answers

What is the term for unexplained weight loss, fever, or night sweats in non-Hodgkin lymphomas?

<p>B symptoms (C)</p> Signup and view all the answers

What is the term for a tumor that is widely disseminated at diagnosis?

<p>Disseminated tumor (B)</p> Signup and view all the answers

What is the association between Pylori and gastric MALToma?

<p>Pylori causes gastric MALToma (A)</p> Signup and view all the answers

What is the primary treatment for MALT lymphoma?

<p>Local excision followed by radiotherapy (B)</p> Signup and view all the answers

Which of the following is a characteristic histological feature of Mantle Cell Lymphoma?

<p>Diffuse or vaguely nodular pattern (C)</p> Signup and view all the answers

What is the primary etiological factor in endemic Burkitt lymphoma?

<p>EBV infection (A)</p> Signup and view all the answers

Which type of lymphoma is commonly associated with skin lesions?

<p>Mycosis Fungoides (B)</p> Signup and view all the answers

What is the primary clinical manifestation of Small Lymphocytic Lymphoma (SLL/CLL)?

<p>Generalized lymphadenopathy and hepatosplenomegaly (A)</p> Signup and view all the answers

Which of the following is a characteristic feature of Mantle Cell Lymphoma?

<p>Cyclin D1 overexpression (A)</p> Signup and view all the answers

What is the primary treatment for Adult T-Cell Leukemia/Lymphoma (ATLL)?

<p>Aggressive chemotherapy (D)</p> Signup and view all the answers

Which type of lymphoma is commonly associated with a t(11;18) translocation?

<p>MALT lymphoma (C)</p> Signup and view all the answers

What is the primary clinical manifestation of Mycosis Fungoides?

<p>Rash and plaques (D)</p> Signup and view all the answers

Which of the following is a characteristic feature of Burkitt lymphoma?

<p>Monotonous intermediate size with 2-5 nucleoli (D)</p> Signup and view all the answers

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