Marginal Zone Lymphoma: Classification and Etiology

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What is the characteristic feature of MGUS?

Presence of bone lesions

Less than 10% of plasma cells in the marrow (correct)

More than 10% of plasma cells in the marrow

High levels of M spike

What is the primary mechanism of bone destruction in myeloma?

Direct damage by plasma cells

Osteoclast activation due to RANK-ligand upregulation (correct)

Inflammation due to immune response

Osteoblast inactivation due to parathyroid hormone

What is the characteristic histological feature of myeloma?

Bone marrow replaced by sheets of plasma cells (correct)

Follicular lymphoma with B cell proliferation

Reactive lymph node hyperplasia

Granulomatous inflammation

What is the primary clinical manifestation of renal involvement in myeloma?

Proteinuria Signup and view all the answers

What is the most common type of lymphoma related to myeloma?

IgM-secreting B cell lymphoma Signup and view all the answers

What is the median survival of untreated myeloma?

4-7 years Signup and view all the answers

What is a characteristic of B cells in non-Hodgkin lymphomas?

They undergo somatic hypermutation Signup and view all the answers

What is the primary site of manifestation for non-Hodgkin lymphomas, with few exceptions?

Lymph nodes Signup and view all the answers

What is a common symptom of non-Hodgkin lymphomas?

Painless lymphadenopathy Signup and view all the answers

What is the term for unexplained weight loss, fever, or night sweats in non-Hodgkin lymphomas?

B symptoms Signup and view all the answers

What is the term for a tumor that is widely disseminated at diagnosis?

Disseminated tumor Signup and view all the answers

What is the association between Pylori and gastric MALToma?

Pylori causes gastric MALToma Signup and view all the answers

What is the primary treatment for MALT lymphoma?

Local excision followed by radiotherapy Signup and view all the answers

Which of the following is a characteristic histological feature of Mantle Cell Lymphoma?

Diffuse or vaguely nodular pattern Signup and view all the answers

What is the primary etiological factor in endemic Burkitt lymphoma?

EBV infection Signup and view all the answers

Which type of lymphoma is commonly associated with skin lesions?

Mycosis Fungoides Signup and view all the answers

What is the primary clinical manifestation of Small Lymphocytic Lymphoma (SLL/CLL)?

Generalized lymphadenopathy and hepatosplenomegaly Signup and view all the answers

Which of the following is a characteristic feature of Mantle Cell Lymphoma?

Cyclin D1 overexpression Signup and view all the answers

What is the primary treatment for Adult T-Cell Leukemia/Lymphoma (ATLL)?

Aggressive chemotherapy Signup and view all the answers

Which type of lymphoma is commonly associated with a t(11;18) translocation?

MALT lymphoma Signup and view all the answers

What is the primary clinical manifestation of Mycosis Fungoides?

Rash and plaques Signup and view all the answers

Which of the following is a characteristic feature of Burkitt lymphoma?

Monotonous intermediate size with 2-5 nucleoli Signup and view all the answers