Podcast
Questions and Answers
What is the characteristic of non-nodal mantle cell lymphoma?
What is the characteristic of non-nodal mantle cell lymphoma?
- It is associated with a very poor prognosis
- It presents with bulky lymphadenopathy characterized by lymph nodes greater than 10 cm in size
- It is associated with severe allergic reactions to mosquito bites
- It presents without lymph node swelling with circulating lymphoma cells (correct)
What is the primary factor that initiates genetic alterations in MCL?
What is the primary factor that initiates genetic alterations in MCL?
- Identifiable environmental factors
- Acquired genetic mutations in somatic cells (correct)
- Inherited genetic mutations
- Risk factors for lymphoma development
What is the characteristic growth pattern of MCL in the nodular type?
What is the characteristic growth pattern of MCL in the nodular type?
- Large nodules of MCL cells in the lymph node with no germinal centers observed (correct)
- Lymphoma cells contained within the mantle zone without expansion
- Expansion of the mantle zone around normal germinal centers
- Diffuse growth of lymphoma cells throughout the lymph node
What is the effect of MCL cells replacing normal cells in the bone marrow?
What is the effect of MCL cells replacing normal cells in the bone marrow?
What is the significance of CNS involvement in MCL?
What is the significance of CNS involvement in MCL?
What is the approximate median survival time for patients with a Ki-67 index of 5-20%?
What is the approximate median survival time for patients with a Ki-67 index of 5-20%?
What is the characteristic of blastic MCL cells compared to nodular and diffuse types?
What is the characteristic of blastic MCL cells compared to nodular and diffuse types?
What is the significance of a beta-2 microglobulin value of less than three for auto SCT patients?
What is the significance of a beta-2 microglobulin value of less than three for auto SCT patients?
What is the purpose of testing for lactate dehydrogenase in non-Hodgkin's lymphoma patients?
What is the purpose of testing for lactate dehydrogenase in non-Hodgkin's lymphoma patients?
What is the ratio of males to females affected by MCL as of 2015?
What is the ratio of males to females affected by MCL as of 2015?
What is the approximate percentage of non-Hodgkin's lymphoma cases that mantle cell lymphoma comprises?
What is the approximate percentage of non-Hodgkin's lymphoma cases that mantle cell lymphoma comprises?
In which year was the term 'mantle cell lymphoma' first adopted?
In which year was the term 'mantle cell lymphoma' first adopted?
What is the typical age range of onset for people with mantle cell lymphoma?
What is the typical age range of onset for people with mantle cell lymphoma?
What is the name of the chromosomal translocation that leads to the over-expression of cyclin D1 in MCL cells?
What is the name of the chromosomal translocation that leads to the over-expression of cyclin D1 in MCL cells?
What is the predominant race affected by mantle cell lymphoma in the United States?
What is the predominant race affected by mantle cell lymphoma in the United States?
What is the characteristic chromosomal translocation found in most cases of MCL?
What is the characteristic chromosomal translocation found in most cases of MCL?
Which of the following markers is typically overexpressed in MCL?
Which of the following markers is typically overexpressed in MCL?
What is the primary reason why the diagnosis of MCL may be complicated?
What is the primary reason why the diagnosis of MCL may be complicated?
What is the prognosis of cyclin-D1-negative MCL subtypes?
What is the prognosis of cyclin-D1-negative MCL subtypes?
What is the primary goal of enrolling in clinical trials for MCL patients?
What is the primary goal of enrolling in clinical trials for MCL patients?
What is the primary reason for not repeating chemotherapy in relapse?
What is the primary reason for not repeating chemotherapy in relapse?
Which chemotherapy regimen is becoming popular and showing promising results, especially with rituximab?
Which chemotherapy regimen is becoming popular and showing promising results, especially with rituximab?
What is the main benefit of using PEP-C regimen in relapsed patients?
What is the main benefit of using PEP-C regimen in relapsed patients?
What is the goal of using very high doses of chemotherapy, sometimes combined with total body irradiation (TBI)?
What is the goal of using very high doses of chemotherapy, sometimes combined with total body irradiation (TBI)?
What is the primary difference between 'passive' and 'active' immunotherapy?
What is the primary difference between 'passive' and 'active' immunotherapy?
What is the primary indication of brexucabtagene autoleucel approved in the United States in July 2020?
What is the primary indication of brexucabtagene autoleucel approved in the United States in July 2020?
What is the approximate 5-year survival rate for limited-stage MCL?
What is the approximate 5-year survival rate for limited-stage MCL?
What is the purpose of the Ki-67 index in MCL?
What is the purpose of the Ki-67 index in MCL?
What is the name of the index that classifies MCL patients into three risk groups?
What is the name of the index that classifies MCL patients into three risk groups?
When was pirtobrutinib (Jaypirca) approved for medical use in the United States?
When was pirtobrutinib (Jaypirca) approved for medical use in the United States?
