30 Questions
What is the characteristic of non-nodal mantle cell lymphoma?
It presents without lymph node swelling with circulating lymphoma cells
What is the primary factor that initiates genetic alterations in MCL?
Acquired genetic mutations in somatic cells
What is the characteristic growth pattern of MCL in the nodular type?
Large nodules of MCL cells in the lymph node with no germinal centers observed
What is the effect of MCL cells replacing normal cells in the bone marrow?
It impairs normal blood cell production
What is the significance of CNS involvement in MCL?
It is associated with a very poor prognosis
What is the approximate median survival time for patients with a Ki-67 index of 5-20%?
Nearly 4 years
What is the characteristic of blastic MCL cells compared to nodular and diffuse types?
Faster growth rate
What is the significance of a beta-2 microglobulin value of less than three for auto SCT patients?
Good prognosis
What is the purpose of testing for lactate dehydrogenase in non-Hodgkin's lymphoma patients?
Tracking tumor burden
What is the ratio of males to females affected by MCL as of 2015?
4:1
What is the approximate percentage of non-Hodgkin's lymphoma cases that mantle cell lymphoma comprises?
6%
In which year was the term 'mantle cell lymphoma' first adopted?
1991
What is the typical age range of onset for people with mantle cell lymphoma?
60-70 years
What is the name of the chromosomal translocation that leads to the over-expression of cyclin D1 in MCL cells?
t(11:14)
What is the predominant race affected by mantle cell lymphoma in the United States?
Caucasian
What is the characteristic chromosomal translocation found in most cases of MCL?
t(11;14)(q13;q32)
Which of the following markers is typically overexpressed in MCL?
SOX11
What is the primary reason why the diagnosis of MCL may be complicated?
Similarity of MCL to other types of lymphoma
What is the prognosis of cyclin-D1-negative MCL subtypes?
Similar to the main cyclin-D1 variant
What is the primary goal of enrolling in clinical trials for MCL patients?
To access the latest treatments
What is the primary reason for not repeating chemotherapy in relapse?
Due to side effects
Which chemotherapy regimen is becoming popular and showing promising results, especially with rituximab?
HyperCVAD
What is the main benefit of using PEP-C regimen in relapsed patients?
It has anti-angiogenetic properties
What is the goal of using very high doses of chemotherapy, sometimes combined with total body irradiation (TBI)?
To destroy all evidence of the disease
What is the primary difference between 'passive' and 'active' immunotherapy?
Passive immunotherapy uses monoclonal antibodies, while active immunotherapy uses cancer vaccines
What is the primary indication of brexucabtagene autoleucel approved in the United States in July 2020?
Treatment of adults with relapsed or refractory mantle cell lymphoma
What is the approximate 5-year survival rate for limited-stage MCL?
70%
What is the purpose of the Ki-67 index in MCL?
To assess the proliferation rate of MCL cells
What is the name of the index that classifies MCL patients into three risk groups?
Mantle Cell Lymphoma International Prognostic Index (MIPI)
When was pirtobrutinib (Jaypirca) approved for medical use in the United States?
January 2023
Test your knowledge about Mantle Cell Lymphoma, a type of non-Hodgkin's lymphoma that develops in the mantle zone of the lymph nodes. Learn about its diagnosis, symptoms, and treatment options. This quiz is perfect for medical students and healthcare professionals.
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