Mantle Cell Lymphoma (MCL) Quiz

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What is the characteristic of non-nodal mantle cell lymphoma?

It is associated with a very poor prognosis

It presents with bulky lymphadenopathy characterized by lymph nodes greater than 10 cm in size

It is associated with severe allergic reactions to mosquito bites

It presents without lymph node swelling with circulating lymphoma cells (correct)

What is the primary factor that initiates genetic alterations in MCL?

Identifiable environmental factors

Acquired genetic mutations in somatic cells (correct)

Inherited genetic mutations

Risk factors for lymphoma development

What is the characteristic growth pattern of MCL in the nodular type?

Large nodules of MCL cells in the lymph node with no germinal centers observed (correct)

Lymphoma cells contained within the mantle zone without expansion

Expansion of the mantle zone around normal germinal centers

Diffuse growth of lymphoma cells throughout the lymph node

What is the effect of MCL cells replacing normal cells in the bone marrow?

It impairs normal blood cell production Signup and view all the answers

What is the significance of CNS involvement in MCL?

It is associated with a very poor prognosis Signup and view all the answers

What is the approximate median survival time for patients with a Ki-67 index of 5-20%?

Nearly 4 years Signup and view all the answers

What is the characteristic of blastic MCL cells compared to nodular and diffuse types?

Faster growth rate Signup and view all the answers

What is the significance of a beta-2 microglobulin value of less than three for auto SCT patients?

Good prognosis Signup and view all the answers

What is the purpose of testing for lactate dehydrogenase in non-Hodgkin's lymphoma patients?

Tracking tumor burden Signup and view all the answers

What is the ratio of males to females affected by MCL as of 2015?

4:1 Signup and view all the answers

What is the approximate percentage of non-Hodgkin's lymphoma cases that mantle cell lymphoma comprises?

6% Signup and view all the answers

In which year was the term 'mantle cell lymphoma' first adopted?

1991 Signup and view all the answers

What is the typical age range of onset for people with mantle cell lymphoma?

60-70 years Signup and view all the answers

What is the name of the chromosomal translocation that leads to the over-expression of cyclin D1 in MCL cells?

t(11:14) Signup and view all the answers

What is the predominant race affected by mantle cell lymphoma in the United States?

Caucasian Signup and view all the answers

What is the characteristic chromosomal translocation found in most cases of MCL?

t(11;14)(q13;q32) Signup and view all the answers

Which of the following markers is typically overexpressed in MCL?

SOX11 Signup and view all the answers

What is the primary reason why the diagnosis of MCL may be complicated?

Similarity of MCL to other types of lymphoma Signup and view all the answers

What is the prognosis of cyclin-D1-negative MCL subtypes?

Similar to the main cyclin-D1 variant Signup and view all the answers

What is the primary goal of enrolling in clinical trials for MCL patients?

To access the latest treatments Signup and view all the answers

What is the primary reason for not repeating chemotherapy in relapse?

Due to side effects Signup and view all the answers

Which chemotherapy regimen is becoming popular and showing promising results, especially with rituximab?

HyperCVAD Signup and view all the answers

What is the main benefit of using PEP-C regimen in relapsed patients?

It has anti-angiogenetic properties Signup and view all the answers

What is the goal of using very high doses of chemotherapy, sometimes combined with total body irradiation (TBI)?

To destroy all evidence of the disease Signup and view all the answers

What is the primary difference between 'passive' and 'active' immunotherapy?

Passive immunotherapy uses monoclonal antibodies, while active immunotherapy uses cancer vaccines Signup and view all the answers

What is the primary indication of brexucabtagene autoleucel approved in the United States in July 2020?

Treatment of adults with relapsed or refractory mantle cell lymphoma Signup and view all the answers

What is the approximate 5-year survival rate for limited-stage MCL?

70% Signup and view all the answers

What is the purpose of the Ki-67 index in MCL?

To assess the proliferation rate of MCL cells Signup and view all the answers

What is the name of the index that classifies MCL patients into three risk groups?

Mantle Cell Lymphoma International Prognostic Index (MIPI) Signup and view all the answers

When was pirtobrutinib (Jaypirca) approved for medical use in the United States?

January 2023 Signup and view all the answers