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12 Questions

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Managing Cancer Genome Data

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Questions and Answers

What can paired reads yield evidence for?

Single nucleotide polymorphisms

Gene expression levels

DNA replication errors

Structural events (correct)

How is inferred insert size used to detect structural variants?

Color by nucleotide sequence

Analyze gene expression levels

Identify single nucleotide polymorphisms

Detect deletions and insertions (correct)

What do alignment coloring options help highlight based on inferred insert size and pair orientation?

DNA methylation patterns

Single nucleotide polymorphisms

Structural events (correct)

Gene expression patterns

How does the orientation of paired reads reveal structural events?

Identifying translocations Signup and view all the answers

What can paired-end sequencing detect besides deletions and insertions?

Inter-chromosomal rearrangements Signup and view all the answers

What type of genomic events can alignment coloring options help highlight?

Structural variations Signup and view all the answers

What type of information/data would be important to put in a cancer database?

Information/data about the project Signup and view all the answers

Which website provides information on cancer genomes?

<a href="http://www.sanger.ac.uk/genetics/CGP/cosmic">http://www.sanger.ac.uk/genetics/CGP/cosmic</a> Signup and view all the answers

What is the purpose of the Integrative Genomics Viewer (IGV)?

To explore large genomic datasets with an intuitive interface Signup and view all the answers

What does GDC stand for in the context of cancer research?

Genomic Data Commons Signup and view all the answers

Why is information/data about the tumor important for a cancer database?

It helps in understanding the characteristics of the tumor Signup and view all the answers

What type of information/data does ICGC DCC provide?

Information/data about cancer genomes Signup and view all the answers