Podcast
Questions and Answers
What is malondialdehyde (MDA) known to impact?
What is malondialdehyde (MDA) known to impact?
Endothelial function
Which patient groups had higher median concentrations of salivary and serum MDA?
Which patient groups had higher median concentrations of salivary and serum MDA?
CRP was not a significant predictor of serum and salivary MDA levels.
CRP was not a significant predictor of serum and salivary MDA levels.
False
What percentage of adults aged over 30 years in the USA are reported to have periodontitis?
What percentage of adults aged over 30 years in the USA are reported to have periodontitis?
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Match the following conditions with their relationships to periodontitis:
Match the following conditions with their relationships to periodontitis:
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What is one of the main features in the pathogenesis of both periodontitis and CHD?
What is one of the main features in the pathogenesis of both periodontitis and CHD?
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Study Notes
Overview
- Malondialdehyde (MAA) is a significant marker in lipid metabolism, affecting endothelial function in periodontitis and coronary heart disease (CHD).
- This study investigates the effects of periodontitis, CHD, and their combination on MAA levels in serum and saliva.
Study Design
- Participants: 32 healthy subjects, 34 with periodontitis, 33 with CHD, and 34 with both periodontitis and CHD.
- Measurements: Assessment of periodontal health, serum, and salivary samples for MAA and C-reactive protein (CRP) levels.
Key Findings
- Higher MAA concentrations were found in periodontitis and periodontitis + CHD groups compared to CHD and healthy controls.
- Serum MAA levels:
- Periodontitis: 3.92 µmol/L
- Periodontitis + CHD: 4.34 µmol/L
- CHD: 3.72 µmol/L
- Healthy control: 3.14 µmol/L
- Salivary MAA levels:
- Periodontitis: 1.81 µmol/g protein
- Periodontitis + CHD: 1.96 µmol/g protein
- CHD: 1.59 µmol/g protein
- Healthy control: 1.41 µmol/g protein
- Statistical significance found with p-values indicating marked differences (p < 0.01 for most comparisons).
Correlations and Predictors
- Univariate models indicated significant associations between periodontitis, CHD, CRP, and MAA levels (CRP: p < 0.001).
- In multivariate analysis, CRP remained a significant predictor for both salivary and serum MAA levels.
Clinical Context
- Periodontitis is a prevalent chronic inflammatory disease, potentially affecting over 50% of adults over 30 in the USA.
- Strong associations exist between periodontitis and increased risk for CHD, including serious conditions like stroke and myocardial infarction.
- The study highlights elevated inflammatory markers, which may contribute to the pathogenesis of both periodontitis and CHD.
Conclusion
- Patients suffering from periodontitis, and those with both periodontitis and CHD, exhibit significantly elevated MAA levels compared to those with CHD alone and healthy individuals.
- C-reactive protein is identified as a critical predictor of MAA levels, emphasizing its role in the inflammatory responses linked to these diseases.
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Description
Explore the significant findings from a study measuring malondialdehyde (MAA) levels in serum and saliva among participants with periodontitis, coronary heart disease (CHD), and those with both conditions. The results indicate that higher MAA concentrations are associated with periodontal disease, providing insights into lipid metabolism and endothelial function in these conditions.
