L1. Histology - Male Reproductive System
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Questions and Answers

Which structure in the male reproductive system is classified as an exocrine gland?

  • Seminal vesicle
  • Testis (correct)
  • Ductus deferens
  • Epididymal duct
  • What is the role of the Sertoli cell within the seminiferous tubule?

  • Transporting sperm
  • Secreting testosterone
  • Spermatogenesis
  • Nourishing spermatogenic cells (correct)
  • Which phase of spermatogenesis involves the first meiotic division?

  • Spermatid phase
  • Spermatogonial phase
  • Spermatocyte phase
  • Primary spermatocyte phase (correct)
  • What is the primary function of the epididymal duct's principal cells?

    <p>Sperm maturation (B)</p> Signup and view all the answers

    How does the histology of the ampulla of the ductus deferens compare to that of the seminal vesicle?

    <p>The seminal vesicle has secretory glands (C)</p> Signup and view all the answers

    What type of cells are located at the adluminal compartment created by Sertoli cells?

    <p>Spermatids (A)</p> Signup and view all the answers

    What is the major secretory molecule produced by the seminal vesicle?

    <p>Fructose (A)</p> Signup and view all the answers

    Which component is involved in establishing haploid gametes during spermatogenesis?

    <p>First meiotic division (C)</p> Signup and view all the answers

    What role does nitric oxide (NO) play in the mechanism of producing an erection?

    <p>It relaxes the smooth muscle by increasing cGMP production. (C)</p> Signup and view all the answers

    Which neurotransmitter is involved in the initial signal that leads to the production of nitric oxide in the erectile tissue?

    <p>Acetylcholine (C)</p> Signup and view all the answers

    What is the effect of phosphodiesterase on cGMP in the context of erectile dysfunction?

    <p>It breaks down cGMP, reducing smooth muscle relaxation. (B)</p> Signup and view all the answers

    How do phosphodiesterase inhibitors, such as sildenafil citrate, assist men with erectile dysfunction?

    <p>By enhancing the action of cGMP through preventing its breakdown. (B)</p> Signup and view all the answers

    What physiological change occurs when cGMP levels are increased in the smooth muscle of the erectile tissue?

    <p>Increased blood flow through the helicine arteries. (B)</p> Signup and view all the answers

    What type of epithelium lines the straight tubules?

    <p>Simple cuboidal epithelium (D)</p> Signup and view all the answers

    What is the primary function of the straight tubules and the rete testis?

    <p>To transport spermatozoa (C)</p> Signup and view all the answers

    Where are the intratesticular ducts located?

    <p>At the ends of seminiferous tubules (B)</p> Signup and view all the answers

    What structure does the rete testis merge to form?

    <p>Efferent ductules (B)</p> Signup and view all the answers

    What type of channel system is the rete testis classified as?

    <p>Intrateesticular duct system (A)</p> Signup and view all the answers

    What is the connective tissue surrounding the rete testis known as?

    <p>Mediastinum testis (C)</p> Signup and view all the answers

    Which of these is true about the epithelial lining of the rete testis?

    <p>It is simple cuboidal (C)</p> Signup and view all the answers

    Which fluid is responsible for moving sperm through the ducts?

    <p>Testicular fluid (D)</p> Signup and view all the answers

    What happens if the Sertoli-Sertoli cell junctions are compromised?

    <p>The immune system may identify sperm proteins as foreign. (D)</p> Signup and view all the answers

    How long does spermatogenesis take to complete in humans?

    <p>65-75 days (C)</p> Signup and view all the answers

    What are the three phases of spermatogenesis?

    <p>Spermatogonial, Spermatocyte, and Spermatid (C)</p> Signup and view all the answers

    What is the primary function of the bulbourethral glands?

    <p>Secrete mucous (D)</p> Signup and view all the answers

    Which portion of the penis contains the urethra?

    <p>Corpus spongiosum (C)</p> Signup and view all the answers

    What is the role of Type Ad spermatogonia?

    <p>Divide mitotically to produce more Type Ad or Type Ap. (A)</p> Signup and view all the answers

    What type of epithelium is commonly found in the male urethra?

    <p>Stratified or pseudostratified columnar (D)</p> Signup and view all the answers

    What is a characteristic feature of all spermatogonia?

    <p>They are found near the basal lamina. (A)</p> Signup and view all the answers

    What are the vascular spaces in erectile tissue called?

    <p>Lacunæ (A)</p> Signup and view all the answers

    Which statement best describes the differentiating function of spermatids?

    <p>They differentiate into mature sperm. (D)</p> Signup and view all the answers

    Which structure surrounds the cylinders of erectile tissue in the penis?

    <p>Tunica albuginea (D)</p> Signup and view all the answers

    What type of cells can be classified as spermatogonia?

    <p>Ad, Ap, and B spermatogonia (C)</p> Signup and view all the answers

    Where do the ducts of the bulbourethral glands open?

    <p>Penile urethra (B)</p> Signup and view all the answers

    What occurs during the spermatocyte phase of spermatogenesis?

    <p>Meiotic divisions reduce the DNA content. (B)</p> Signup and view all the answers

    What is the role of the trabecculae in erectile tissues?

    <p>Provide structural support (C)</p> Signup and view all the answers

    What are the glands that secrete mucous in the male urethra called?

    <p>Glands of Littré (D)</p> Signup and view all the answers

    What structural change occurs to the nucleus during the acrosome phase of sperm development?

    <p>It condenses and elongates. (A)</p> Signup and view all the answers

    What characterizes the middle piece of the spermatozoan?

    <p>It consists of mitochondria wrapped around the axoneme. (A)</p> Signup and view all the answers

    What happens to the excess cytoplasm during the maturation phase of sperm development?

    <p>It is extruded into a residual body. (A)</p> Signup and view all the answers

    How are late spermatids typically recognized?

    <p>By their small, dense triangular head. (C)</p> Signup and view all the answers

    What is the status of newly shed spermatozoa immediately after they are released?

    <p>They remain stagnant and cannot fertilize. (B)</p> Signup and view all the answers

    What aids in the movement of spermatozoa within the seminiferous tubules?

    <p>Flow of fluid secreted by Sertoli cells. (C)</p> Signup and view all the answers

    Which structure is the first component of the excretory duct system?

    <p>Straight tubules. (A)</p> Signup and view all the answers

    What is the primary function of the Sertoli cells in relation to sperm?

    <p>They provide nutrients and support for developing sperm. (B)</p> Signup and view all the answers

    Flashcards

    Testis as an Exocrine Gland

    The testes are considered an exocrine gland due to their production and secretion of sperm, which are released into the duct system for external transport.

    Spermatogenesis

    The process of sperm cell formation, involving a series of cell divisions and transformations from spermatogonial cells to mature spermatozoa.

    Sertoli Cells

    Special cells within the seminiferous tubules that support and nurture developing sperm cells. They are responsible for providing nutrients, growth factors, and other essential components for spermatogenesis.

    Spermatogonial Phase

    The initial stage of spermatogenesis where spermatogonial cells undergo mitotic divisions, increasing their number and preparing for further development.

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    Spermatid Phase

    Round spermatids, the first stage after meiosis, undergo a series of transformations to develop the distinct head, midpiece, and tail of mature sperm.

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    First Meiotic Division

    The first meiotic division (reductional division) of the spermatocyte phase reduces the chromosome number from diploid to haploid, ensuring that each sperm cell receives a single set of chromosomes.

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    Second Meiotic Division

    The second meiotic division (equatorial division) of the spermatocyte phase ensures that each sperm cell receives a complete set of genetic information, even though they have half the original number of chromosomes.

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    Epididymis Function

    The epididymis is a coiled tube where sperm cells mature and gain the ability to fertilize an egg. Principal cells of the epididymal duct play a crucial role in this process, providing nourishment, removing waste products, and aiding in the development of sperm's motility.

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    What is Spermatogenesis?

    The process of sperm cell formation involving a series of cell divisions and transformations from spermatogonial cells to mature spermatozoa.

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    Late Spermatids

    Changes in the morphology of the nucleus during the acrosome phase results in the formation of the late (elongated) spermatids. The small dense triangular head of the late or elongated spermatids makes them easy to recognize. They are often located very close to the lumen of the seminiferous tubules.

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    What is a Spermatozoan?

    The late (elongated) spermatid is shed from the seminiferous epithelium to become a sperm (spermatozoan).

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    What is the 'Middle Piece'?

    The process of mitochondria migrating to the initial portion of the axoneme adjacent to the neck to form a spiral wrapping to constitute the "middle piece" of the spermatozoan.

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    Newly-shed sperm & Fertilization

    Although morphologically mature, the newly-shed sperm are nonmotile and incapable of fertilization.

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    How is sperm moved?

    Spermatozoa are moved passively along the seminiferous tube lumen by the flow of the fluid secreted by the Sertoli cells and by contractions of the myoid cells of the tunica propria.

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    Sertoli Cell Fluid

    The fluid secreted by the Sertoli cells that moves sperm along the seminiferous tube lumen.

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    Myoid Cell Contraction

    Contractions by the myoid cells of the tunica propria, which help move the sperm cells along the seminiferous tube lumen.

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    Spermatocytes

    Spermatocytes are germ cells that undergo meiotic divisions during the spermatocyte phase, reducing the chromosome number by half to produce haploid cells.

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    Type Ad Spermatogonia

    Type Ad spermatogonia are the stem cells of spermatogenesis. They divide by mitosis to produce either more type Ad cells or type Ap spermatogonia.

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    Type Ap Spermatogonia

    Type Ap spermatogonia are derived from type Ad cells and continue to divide by mitosis, ultimately leading to the formation of type B spermatogonia.

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    Type B Spermatogonia

    Type B spermatogonia are the final type of spermatogonia. They undergo further divisions to produce primary spermatocytes.

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    Straight tubules

    These are tiny tubes located at the ends of the seminiferous tubules where they connect with the mediastinum testis.

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    Rete Testis

    A network of interconnected channels within the connective tissue mediastinum testis.

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    Simple Cuboidal Epithelium

    The epithelial lining of the straight tubules and rete testis is similar and helps transport sperm efficiently.

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    Transporting Sperm

    The straight tubules and rete testis work together to move sperm from the seminiferous tubules to the epididymal duct.

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    Efferent ductules

    These ducts connect the rete testis to the epididymis.

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    Merging of the rete testis

    The efferent ductules are formed by the merging of the rete testis.

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    Function of straight tubules and rete testis

    The straight tubules and rete testis are involved in transporting sperm from the seminiferous tubules to the epididymal duct.

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    Testicular fluid for sperm transport

    The fluid within the straight tubules and rete testis helps in transporting sperm by moving them along the ducts.

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    How does sildenafil citrate help with erectile dysfunction?

    Sildenafil citrate, a phosphodiesterase inhibitor, prevents the breakdown of cGMP, allowing smooth muscle relaxation and increased blood flow to the penis, leading to an erection.

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    What is the role of nitric oxide (NO) in erections?

    Nitric oxide (NO) is released from the endothelium of the erectile tissue, causing smooth muscle relaxation and increased blood flow, leading to an erection.

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    How does acetylcholine contribute to erections?

    Acetylcholine, a neurotransmitter released by parasympathetic nerves in the penis, triggers the production of nitric oxide (NO), which leads to smooth muscle relaxation and an erection.

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    What does cyclic GMP (cGMP) do in the erectile process?

    Cyclic GMP (cGMP) relaxes the smooth muscle of the erectile tissue, increasing blood flow and leading to an erection.

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    What is the role of phosphodiesterase in erections?

    The enzyme phosphodiesterase breaks down cGMP, leading to smooth muscle contraction and decreased blood flow, contributing to the termination of an erection.

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    What are the bulbourethral glands?

    The bulbourethral glands are small, pea-sized glands located in the urogenital diaphragm (area between the pelvic floor and the penis). They produce a clear, viscous fluid that is secreted into the urethra during sexual arousal, prior to ejaculation.

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    Where do the ducts of the bulbourethral glands open?

    The penile urethra is the final portion of the male urethra that travels through the penis and opens at the external urethral orifice.

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    What are the main components of the penis?

    The penis is made up of three cylindrical structures: two corpora cavernosa (dorsal cylinders) and one corpus spongiosum (ventral cylinder). These erectile tissues contain spaces that fill with blood during arousal, causing the penis to become erect.

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    What is the tunica albuginea?

    The tunica albuginea is a tough, fibrous layer surrounding the cylinders of erectile tissue in the penis. It helps maintain the shape of the penis and contains blood vessels and nerves.

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    How is the male urethra divided?

    The male urethra has three main parts: prostatic, membranous, and penile. The penile urethra is contained within the corpus spongiosum, the ventral cylinder of the penis.

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    What type of epithelium lines the penile urethra?

    The lining of the penile urethra can vary in appearance but is often stratified or pseudostratified columnar epithelium. This means it consists of multiple layers of cells.

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    What are glands off Littré?

    Glands of Littré are small, mucous-secreting glands that are found lining the urethra. They help lubricate the urethra during urination and sexual activity.

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    What is erectile tissue made of?

    Erectile tissue is found in the penis and is composed of two main components: trabeculae and lacunae. The trabeculae are a network of connective tissue and smooth muscle, while the lacunae are spaces lined with endothelium (inner layer of blood vessels).

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    Study Notes

    Male Reproductive System

    • Testes: Classified as an exocrine gland by morphology and secretion
      • Covered by coverings, lobular organization, and interstitium
      • Contains an endocrine component
      • Seminiferous tubules are the histological organization
      • Sertoli cells create basal and adluminal compartments in the seminiferous epithelium
      • Sertoli cells have functions
    • Spermatogenic cells: Involved in spermatogenesis
      • Spermatogonial cells: Location, function, and histology
      • Primary spermatocytes: Location and histology; first meiotic division (reductional)
      • Second meiotic division (equatorial) of spermatocyte phase, role in establishing haploid gametes
      • Spermatids: DNA, chromosome content, location and histology of round/elongated spermatids, Golgi, cap, acrosome, and maturational phases
    • Excretory Ducts of the Male Reproductive System:
      • Straight tubules: Location, histological features, and function
      • Rete testis: Location, histological features, and function
      • Efferent ductules: Location, histological features, and function
      • Epididymal duct: Location, histological features, function of principal cells
      • Ductus deferens: Histological features
      • Ampulla function, comparison with seminal vesicles
    • Accessory Glands of the Male Reproductive System:
      • Seminal vesicle: Histological organization, typical secretory epithelium classification, major secretory molecules
      • Prostate gland: Organization, secretory epithelium, secretions and function
      • Role of testosterone in accessory gland function
    • Penis: Microanatomy and function
      • Histological organization of corpora cavernosa, corpus spongiosum and penile urethra
      • Connective tissue and vascular components of erectile (cavernous) tissues
    • Testes (Detailed):
      • Endocrine gland (Leydig cells) producing testosterone
      • Exocrine organ producing spermatozoa
      • A compound tubular gland utilizing a holocrine mechanism
      • Surrounded by the tunica albuginea, with an inner layer, the tunica vasculosa
      • Posteriorly thickened into the mediastinum testis, the connective tissue creating lobules, each containing seminiferous tubules.
    • Sertoli Cells:
      • Columnar epithelium stretching from the basal lamina to the lumen
      • Indistinct plasma membrane boundaries, indented, vesiculated nucleus, and prominent nucleolus
      • Create microenvironments for spermatogenic cell development
    • Spermatogenesis:
      • Spermatogonial phase: Production of spermatocytes from spermatogonial cells (gonial cells) - 3 main types Ad (dark), Ap (pale) and B
      • Spermatocyte phase: Meiotic divisions of spermatocytes, reducing DNA to one copy per cell
    • Spermatid Phase:
      • Undifferentiated cells undergoing biochemical and morphological changes (spermiogenesis)
      • Golgi, cap, acrosome, and maturation stages
        • Acrosomal vesicle production
        • Tail formation, nuclear condensation
      • Mitochondria migration
      • Extrusion of residual body
      • Efferent ductules: Passageway from rete testis to epididymis; Facilitate sperm movement
      • Epididymis: Sperm storage; Important in maturation
      • Ductus deferens: Transport sperm; Muscular walls
      • Seminal vesicles: Secrete majority of semen volume, e.g., fructose; Produce prostaglandins, proteins, bicarbonate
      • Prostate, seminal vesicles and bulbourethral glands: Important for sperm motility and nutrition
      • Penis: Consists of erectile tissue (corpora cavernosa and corpus spongiosum); Urethra runs through; Enables copulation.

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