Male Reproductive System and Sperm Transport Mechanisms
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Questions and Answers

What is the primary factor that regulates the descent of the testis from the posterior abdominal wall to the lower abdomen near the inguinal ring?

  • Leydig cells
  • Calcitonin gene-related peptide (CGRP)
  • Insulin-like 3 (correct)
  • Androgens, particularly testosterone
  • Which abnormality in the descent process can result in the failure of one or both testes to descend properly?

  • Early disruption in the transabdominal phase
  • Excessive production of androgens
  • Later inguinoscrotal phase (correct)
  • Overactivity of the genitofemoral nerve
  • Where is the internal (deep) ring located in the inguinal canal?

  • Terminal end of the inguinal canal
  • At the lower abdomen near the inguinal ring
  • Just prior to the pubic tubercle
  • Above the midpoint of the inguinal ligament (correct)
  • Which tissue expresses the androgen receptors primarily in the testicular and epididymal regions?

    <p>Myoid cells</p> Signup and view all the answers

    What stimulates Leydig cells to produce androgens, predominantly testosterone, for male development?

    <p>Luteinizing hormone (LH)</p> Signup and view all the answers

    Which hormone plays a role in regulating the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland?

    <p>Gonadotropin releasing hormone (GnRH)</p> Signup and view all the answers

    What is the primary site of androgen receptors in the prostate?

    <p>Glandular secretory cells</p> Signup and view all the answers

    What is the main effect of testosterone on Sertoli cells in the testis?

    <p>Conversion to DHT</p> Signup and view all the answers

    What is the role of hypothalamus in regulating male reproduction?

    <p>Regulation of pituitary gland activity through GnRH secretion</p> Signup and view all the answers

    Which phase of testes descent is regulated by mechanical factors, pressure changes within the abdominal cavity, and androgens such as testosterone?

    <p>Inguinoscrotal Phase</p> Signup and view all the answers

    What is the legal duty of those who own or are responsible for a horse under the Animal Welfare Act (2013)?

    <p>Protect the horse from pain, injury, suffering, and disease and take records of all medical treatment</p> Signup and view all the answers

    What are some major welfare issues facing horses in the UK?

    <p>Inappropriate use of training aids and inappropriate stabling</p> Signup and view all the answers

    What tests can be performed to identify a 'rig' in horses?

    <p>Manual palpation of the scrotum and blood tests for AMH</p> Signup and view all the answers

    What is the purpose of testing for Oestrone Sulphate in horses suspected to be 'rigs'?

    <p>To differentiate between rigs and geldings</p> Signup and view all the answers

    What factors contribute to the variation in the cost of castration for horses?

    <p>Age, weight, and previous medical history of the horse</p> Signup and view all the answers

    What should be included in the cost of castration for horses under general anaesthetic?

    <p>Anaesthetic, surgery, post-operative checks, and pain relief</p> Signup and view all the answers

    What is included in the requirement for horse passports?

    <p>Description of the animal, list of all vaccinations, and microchip details</p> Signup and view all the answers

    What is the purpose of microchipping horses?

    <p>To reunite lost or stolen horses with their owners more easily</p> Signup and view all the answers

    At what age should foals have a valid passport and microchip according to legal requirements?

    <p>Before they reach six months old or before November 30 within the year they are born</p> Signup and view all the answers

    What happens if a horse does not have an up-to-date passport according to legal requirements?

    <p>The horse may be ineligible for certain veterinary treatments or procedures</p> Signup and view all the answers

    What is the purpose of using a horse weight tape?

    <p>To calculate the horse's approximate weight</p> Signup and view all the answers

    Why is it important for testes to be stored in the scrotum outside of the body cavity?

    <p>To allow spermatogenesis to occur at a lower temperature</p> Signup and view all the answers

    At what temperature does spermatogenesis cease to function in most domesticated species?

    <p>35°C</p> Signup and view all the answers

    Where do the testicles initially develop in domestic animals?

    <p>Near the kidneys and dorsal body wall</p> Signup and view all the answers

    What is the primary purpose of using a weight tape in conjunction with BCS for horses?

    <p>To provide a more comprehensive assessment of the horse's health</p> Signup and view all the answers

    What is the retroperitoneal position of the testicles?

    <p>Behind the peritoneum</p> Signup and view all the answers

    In cryptorchid animals, where may the undescended testes be located?

    <p>In the abdominal cavity</p> Signup and view all the answers

    Why is it necessary for spermatogenesis to occur at a lower temperature in domestic animals?

    <p>To facilitate genetic recombination during meiosis</p> Signup and view all the answers

    What aspect of horses' conformation is crucial for accurate measurement with a weight tape?

    <p>'Zero' point positioning</p> Signup and view all the answers

    Within which cavity do the testes normally reside in domestic animals?

    <p>The peritoneal cavity.</p> Signup and view all the answers

    Which of the following is NOT a function of the accessory sex glands in the male reproductive system?

    <p>Secretion of hormones to regulate sperm production</p> Signup and view all the answers

    What physiological mechanism leads to the filling of the cavernous spaces in the erectile tissue during penile erection?

    <p>Relaxation of the smooth muscle walls</p> Signup and view all the answers

    What is the primary mechanism for sperm transport in the male reproductive tract?

    <p>Transportation by the deferent duct</p> Signup and view all the answers

    What is the main function of the epididymis in the male reproductive system?

    <p>Maturation and storage of sperm</p> Signup and view all the answers

    Which behavioural change is most likely to be observed in a mature gelding after castration?

    <p>Aggression toward other horses</p> Signup and view all the answers

    What is a key reason for castration of male horses?

    <p>To prevent undesirable genetic traits from being passed on</p> Signup and view all the answers

    What should be taken into consideration when assessing safety implications for handlers when examining an unhandled horse?

    <p>Tense muzzle as a sign of worry in the horse</p> Signup and view all the answers

    "A horse exhibiting aggressive type behavior poses a risk of ____________ to handlers."

    <p>Collisions due to attempted escape</p> Signup and view all the answers

    "What is NOT a health and safety risk associated with handling unhandled horses?"

    <p>&quot;Increased bonding with handlers&quot;</p> Signup and view all the answers

    "What is NOT a function of prenatal androgens in masculinising the male reproductive system?"

    <p>&quot;Increasing estrogen production&quot;</p> Signup and view all the answers

    Match the major welfare issues facing horses in the UK with their descriptions:

    <p>Under or over weight = Inappropriate body condition leading to health problems Stabling 24 hours a day = Limited movement and lack of access to grazing Inappropriate use of training aids = Improper equipment causing discomfort or injury Kept in unsuitable environments = Poor living conditions affecting health and behavior</p> Signup and view all the answers

    Match the tests used to identify a 'rig' in horses with their descriptions:

    <p>Manual palpation of the scrotum = Assessment for descended testicles AMH blood test = Biomarker of testicular tissue production Oestrone Sulphate blood test = Distinguishes between rigs and geldings History of the animal and bilateral castration = Assessment of previous castration and medical background</p> Signup and view all the answers

    Match the costs involved in castration for horses with their descriptions:

    <p>Castration under general anaesthetic (up to 200kg) = Procedure, sedation, consumables included Castration under general anaesthetic (Up to 350kg) = Procedure, sedation, consumables included Castration under general anaesthetic (Over 350kg) = Procedure, sedation, consumables included Castrate Standing &lt; 6 months old = Procedure, sedation, consumables included</p> Signup and view all the answers

    Match the legal requirements for identification of horses by microchip and passport with their descriptions:

    <p>Passport = Describes the animal, lists vaccinations, includes owner's details Microchip = Includes owner's information, horse’s passport details Passport upkeep = Must be kept with the horse at all times, kept up to date Microchipping before new homes = Must be microchipped before going to new homes, details stored in CED</p> Signup and view all the answers

    It is a legal requirement to have ______ and passports for horses.

    <p>microchips</p> Signup and view all the answers

    A male horse that has no signs of external testicles but still has one or two testicles present is known as a 'rig' or has ______.

    <p>cryptorchidism</p> Signup and view all the answers

    AMH, produced by Sertoli cells, is a biomarker used to differentiate between cryptorchid and castrated horses and is tested through a ______.

    <p>blood test</p> Signup and view all the answers

    The retention of one or both testicles resulting in a true rig is known as ______.

    <p>cryptorchidism</p> Signup and view all the answers

    Horses showing rig-like behavior can be tested with blood tests for the presence of ______.

    <p>Anti-mullerian Hormone (AMH)</p> Signup and view all the answers

    Equine testes produce 10 times as much ______ as testosterone.

    <p>oestrogen</p> Signup and view all the answers

    Horses over 18 months of age should have a ______ of blood in a plain (clot) tube for a specific test.

    <p>3ml</p> Signup and view all the answers

    A single test of ______ will distinguish between rigs and geldings.

    <p>oestrone sulphate</p> Signup and view all the answers

    Horses over 3 years of age should have ______ of blood in a plain (clot) tube for a specific test.

    <p>2.5ml</p> Signup and view all the answers

    Foals should have a valid passport and microchip before they reach ______ old, according to legal requirements.

    <p>six months</p> Signup and view all the answers

    What is the purpose of using a horse weight tape?

    <p>Estimating a horse's weight when no scales are available</p> Signup and view all the answers

    Why is the scrotal location of testes important in domestic animals?

    <p>To allow spermatogenesis to occur at a lower temperature</p> Signup and view all the answers

    What is the significance of the temperature dependence of spermatogenesis in domestic animals?

    <p>Spermatogenesis will not occur normally at body temperature</p> Signup and view all the answers

    Where do the testicles initially develop in domestic animals?

    <p>Retroperitoneally within the cranial abdomen from intermediate mesoderm near the kidneys and dorsal body wall</p> Signup and view all the answers

    What is the purpose of testing for Oestrone Sulphate in horses suspected to be 'rigs'?

    <p>To differentiate between cryptorchid and castrated horses</p> Signup and view all the answers

    Where may the undescended testes be located in cryptorchid animals?

    <p>They may be located in the abdomen or inguinal canal</p> Signup and view all the answers

    What is the main effect of testosterone on Sertoli cells in the testis?

    <p>Stimulates the production of AMH</p> Signup and view all the answers

    What is the primary factor that regulates the descent of the testis from the posterior abdominal wall to the lower abdomen near the inguinal ring?

    <p>Androgens such as testosterone</p> Signup and view all the answers

    What is the role of hypothalamus in regulating male reproduction?

    <p>Regulating the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the anterior pituitary gland</p> Signup and view all the answers

    At what temperature does spermatogenesis cease to function in most domesticated species?

    <p>Above 35°C</p> Signup and view all the answers

    What ligaments are responsible for holding the testes in place during the descent process?

    <p>cranial gonadal ligament and caudal gonadal ligament (gubernaculum during development)</p> Signup and view all the answers

    What is the main role of the internal (deep) ring in the inguinal canal?

    <p>It provides a covering to the inguinal canal's content and is located above the midpoint of the inguinal ligament.</p> Signup and view all the answers

    Where are the main general locations of the androgen receptors in the male reproductive system?

    <p>testicular, epididymal, and accessory sex glands</p> Signup and view all the answers

    What is the main role of the hypothalamus in the regulation of male reproduction?

    <p>Regulating the activity of the pituitary gland and the release of hormones, particularly gonadotropin releasing hormone (GnRH).</p> Signup and view all the answers

    What is the primary effect of testosterone on Sertoli cells in the testis?

    <p>Testosterone is converted to DHT, which is vital for maintaining spermatogenesis.</p> Signup and view all the answers

    What is the main effect of androgens on male sexual behavior?

    <p>They influence male sexual behaviors like aggression and other species-specific patterns.</p> Signup and view all the answers

    What are the two phases of testes descent, and what regulates the movement during each phase?

    <p>Transabdominal Phase (regulated by testosterone) and Inguinoscrotal Phase (regulated by androgens and the genitofemoral nerve)</p> Signup and view all the answers

    What abnormality in the descent process can result in the failure of one or both testes to descend properly?

    <p>Cryptorchidism</p> Signup and view all the answers

    What is the main site of androgen receptors in the prostate?

    <p>Glandular secretory cells</p> Signup and view all the answers

    What hormone stimulates Leydig cells to produce androgens for male development?

    <p>Luteinizing hormone (LH)</p> Signup and view all the answers

    Explain the physiological mechanisms underlying penile erection.

    <p>Sympathetic nerves cause tonic contractions of the smooth muscle walls of the erectile tissue, while parasympathetic control leads to the relaxation of smooth muscle, allowing blood to fill the cavernous spaces and increase length and girth.</p> Signup and view all the answers

    Discuss the reasons for castration of male horses.

    <p>The reasons for castration of male horses include preventing undesirable genetic traits from being passed on, managing aggressive behavior caused by high testosterone, and addressing cryptorchidism, an inheritable trait that leads to lower sperm count.</p> Signup and view all the answers

    Outline the behavioural changes associated with castration in horses.

    <p>Castrated horses may exhibit reduced aggression and stallion-like behavior, but some mature geldings may still display masculine behavior and attempt to mount and breed mares in estrus.</p> Signup and view all the answers

    Describe the absorptive and secretory functions of the male reproductive tract and accessory glands.

    <p>The male reproductive tract absorbs old or unused sperm through macrophages, and the accessory sex glands produce seminal fluid to aid motility and nourish sperm.</p> Signup and view all the answers

    Describe the health and safety risks associated with handling aggressive type behavior/unhandled horses and discuss strategies for safe handling during a physical examination.

    <p>The health and safety risks include physical injuries to handlers, attempts of escape leading to collisions, and unpredictable reactions of unhandled horses. Strategies for safe handling include assessing body language, using appropriate physical restraint, and allowing time for the examination.</p> Signup and view all the answers

    Discuss the mechanisms for sperm transport in the male reproductive tract.

    <p>Sperm transport in the male reproductive tract involves spermatogenesis in the seminiferous tubules, collection into the rete testis, reabsorption and concentration of fluid in the efferent ducts, maturation and storage in the epididymis, and transportation to the pelvic urethra at ejaculation via the deferent duct.</p> Signup and view all the answers

    Explain the reabsorptive process of sperm in the male reproductive system.

    <p>The reabsorption of sperm occurs in two steps: macrophages break down old or unused sperm, and the remnants are absorbed into the membrane lining the epididymis.</p> Signup and view all the answers

    List key aspects of equine body language and behavior that should be used to assess safety implications for handlers.

    <p>Key aspects of equine body language include stance, ears, eyes, muzzle, and nostrils, which can indicate the horse's mood and help assess safety implications for handlers.</p> Signup and view all the answers

    Outline the legislation that places a duty of care on those responsible for horses in the UK.

    <p>The legislation in the UK places a duty of care on those responsible for horses, ensuring the animals' welfare needs are met, including the provision of adequate food, water, shelter, and veterinary care.</p> Signup and view all the answers

    Discuss the absorptive and secretory functions of the accessory sex glands in the male reproductive system.

    <p>The accessory sex glands in the male reproductive system produce seminal fluid to act as a transport medium aiding motility and nourishing sperm.</p> Signup and view all the answers

    What are some major welfare issues facing horses in the UK?

    <p>Some major welfare issues facing horses in the UK include being under or over weight, stabling 24 hours a day, inappropriate use of training aids, unsuitable environments, and vulnerability in the racing industry and travellers horses.</p> Signup and view all the answers

    Outline the tests that can be performed to identify a 'rig' in horses.

    <p>Tests to identify a 'rig' in horses include manual palpation of the scrotum, taking a history of the animal to check for castration, and conducting blood tests for AMH (Anti-mullerian Hormone) and Oestrone Sulphate.</p> Signup and view all the answers

    Explain the legal requirements for identification of horses by microchip and passport.

    <p>It is a legal requirement to have microchips and passports for horses. The passport should include the animal's description, vaccinations, owner's details, and the microchip details. Horses must be microchipped before going to new homes by law, and the details must be stored in the Central Equine Database.</p> Signup and view all the answers

    What factors contribute to the variation in the cost of castration for horses?

    <p>The cost of castration for horses varies based on factors such as the size and weight of the horse, the type of castration (standing or under general anaesthetic), and whether additional treatments like vaccination for tetanus are required.</p> Signup and view all the answers

    What are the costs involved in castration and where are they incurred?

    <p>The costs of castration for horses vary based on the size and weight of the horse, ranging from around £110 to £385. Costs are incurred for the procedure, sedation, consumables, drugs administered, and additional treatments like tetanus vaccination if required.</p> Signup and view all the answers

    What should be included in the cost of castration for horses under general anaesthetic?

    <p>The cost of castration for horses under general anaesthetic should cover the procedure, sedation, consumables, drugs administered, and may include additional treatments like oral antibiotics and pain relief on a case by case basis.</p> Signup and view all the answers

    What is the purpose of testing for Oestrone Sulphate in horses suspected to be 'rigs'?

    <p>The purpose of testing for Oestrone Sulphate in horses suspected to be 'rigs' is to distinguish between rigs and geldings. Equine testes produce 10 times as much oestrogen as testosterone, and this test helps differentiate between the two.</p> Signup and view all the answers

    What is the legal duty of those who own or are responsible for a horse under the Animal Welfare Act (2013)?

    <p>Under the Animal Welfare Act (2013), those who own or are responsible for a horse have a duty of care to provide suitable housing, food and water, protection from pain and suffering, normal behavior, medical treatment records, vaccination, and registration with a vet and farrier.</p> Signup and view all the answers

    What is the role of hypothalamus in regulating male reproduction?

    <p>The hypothalamus regulates male reproduction by secreting gonadotropin-releasing hormone (GnRH), which stimulates the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, thereby controlling the production of testosterone and sperm.</p> Signup and view all the answers

    Foals should have a valid passport and microchip before they reach ______ old, according to legal requirements.

    <p>Foals should have a valid passport and microchip before they reach six months old, or before the 30 November within the year they are born.</p> Signup and view all the answers

    Study Notes

    Estimating Horse Weight

    • Use a horse weight tape to calculate approximate weights for horses
    • Stand the horse square on a flat surface, placing the 'zero' end of the tape at the lowest point of the horse's withers
    • Bring the tape around the horse's girth, passing behind the elbows, and pull it up to meet the 'zero' for the approximate weight

    Scrotal Location of Testes and Temperature Dependence

    • Testes are stored in the scrotum outside of the body cavity, allowing for a lower temperature and enabling spermatogenesis
    • Spermatogenesis is highly temperature dependent and ceases to function above 35°C in most domestic species

    Descent of Testes

    • Initial intra-abdominal position: Testicles develop retroperitoneally near the kidneys and dorsal body wall
    • Descent process:
      • Transabdominal phase: Cranial gonadal ligament degenerates, and the testis begins to descend towards the scrotum
      • Inguinoscrotal phase: Testes pass through the inguinal canal to reach the scrotum, regulated by androgens and the genitofemoral nerve
    • Abnormalities in the descent process can result in cryptorchidism
    • Undescended testis (UDT) can be located in the abdominal cavity or inguinal canal

    Internal and External Inguinal Rings

    • Inguinal canal formed by two gaps: internal and external rings
    • Internal ring: formed of transversalis fascia, located above the midpoint of the inguinal ligament
    • External ring: formed by fibres of the external abdominal oblique muscle, located at the terminal end of the inguinal canal

    Extra-Testicular Androgen Receptors

    • Androgen receptors (AR) located on the X chromosome, expressed in various tissues
    • Main locations: testicular, epididymal, and accessory sex glands
    • Specific receptors in sertoli cells, myoid cells, and cells in the interstitial spaces

    Hypothalamus and Male Reproduction

    • Hypothalamus regulates male reproduction by regulating the activity of the pituitary gland and releasing hormones
    • Pulsatile secretion of gonadotropin releasing hormone (GnRH) stimulates the production of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)
    • LH stimulates Leydig cells to produce androgens, predominantly testosterone, for male development

    Effects of Androgens on Male Behaviour and Appearance

    • Androgens have masculinising effects on the male reproductive system
    • Androgen effects on cells:
      • Leydig cells: autocrine effect on cells in a short negative feedback loop
      • Myoid cells: maintains functional integrity and contractility of the seminiferous tubules
      • Sertoli cells: testosterone is converted to DHT (more biologically active), vital for maintaining spermatogenesis
    • Androgen activational effects: maintenance of spermatogenesis, erectile capacity, and secondary sexual characteristics

    Sperm Transport in the Male Reproductive Tract

    • Spermatogenesis occurs in seminiferous tubules
    • Spermatozoa collected into rete testis
    • Efferent ducts reabsorb fluid and concentrate sperm
    • Epididymis: mature and store sperm
    • Deferent duct: transports sperm to pelvic urethra at ejaculation

    Absorptive and Secretory Functions of the Male Reproductive Tract

    • Reabsorption of sperm occurs in two steps: macrophages break down old or unused sperm, and remnants are absorbed into the membrane lining the epididymis
    • Accessory sex glands produce seminal fluid to aid motility and nourish sperm

    Penile Erection

    • Sympathetic nerves cause tonic contractions of the smooth muscle walls of the erectile tissue
    • Parasympathetic control is up-regulated during erection, smooth muscle relaxes, and space fills with blood
    • Muscles in the urogenital diaphragm compress veins, causing blood to become trapped in the cavernous spaces

    Behavioural Changes Associated with Castration

    • After castration, testosterone levels decrease, and aggression towards other horses and humans may decrease
    • However, some geldings may still display masculine behaviour and aggression

    Legislation and Duty of Care

    • Legislation in the UK places a duty of care on those responsible for horses
    • Handlers must ensure the health and safety of both the horse and themselves

    Health and Safety Risks

    • Handling aggressive or unhandled horses can lead to physical injuries, attempts to escape, and unpredictable reactions
    • Safe handling involves careful assessment of body language, appropriate use of physical restraint, and consideration of licenced drugs for sedation### Prenatal Development
    • Prenatal androgens masculinize the hypothalamus, preventing positive feedback of LH characteristic of female ovarian cyclicity.
    • Testosterone production masculinizes the external genitalia, developing the penis and scrotum.

    Sperm Transport

    • Spermatogenesis occurs in seminiferous tubules.
    • Spermatozoa collect in the rete testis.
    • Efferent ducts reabsorb and concentrate fluid.
    • Epididymis matures and stores sperm.
    • Deferent duct transports sperm to the pelvic urethra at ejaculation.

    Absorptive and Secretory Functions

    • Reabsorption of sperm occurs in two steps: breakdown by macrophages and absorption into the epididymis membrane.
    • Accessory sex glands (ampulla gland, vesicular glands, prostate gland, and bulbourethral glands) produce seminal fluid for sperm motility and nourishment.

    Physiological Mechanisms of Penile Erection

    • Sympathetic nerves cause tonic contractions of smooth muscle walls in erectile tissue.
    • Parasympathetic control relaxes smooth muscle, allowing blood to fill the space.
    • Muscles in the urogenital diaphragm compress veins, trapping blood and causing erection.

    Castration in Horses

    • Castration decreases testosterone levels, reducing aggression and stallion-like behavior.
    • Some geldings (20-30%) may still display masculine behavior and aggression.
    • Castration does not guarantee elimination of stallion-like behavior.

    Reasons for Castration

    • Undesirable genetic traits
    • Behavioral issues (aggression, difficulty in training) caused by high testosterone
    • Cryptorchidism (undescended testicles) leading to undesirable traits and lower sperm count

    Equine Body Language and Behavior

    • Stance, ears, eyes, muzzle, nostrils, and mouth can indicate a horse's emotional state.
    • Spending time with a horse helps recognize normal behavior and potential safety implications.

    Health and Safety Risks

    • Handling unhandled horses poses physical injury risks to handlers (bites, kicks, strikes).
    • Correct interactions, careful assessment of body language, and appropriate physical restraint can minimize risks.

    Legislation

    • UK legislation places a duty of care on those responsible for horses.

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    Description

    This quiz covers the mechanisms for sperm transport in the male reproductive tract, including spermatogenesis in the seminiferous tubules, collection of spermatozoa into rete testis, and fluid reabsorption by efferent ducts. Test your knowledge on the processes involved in male reproductive system function.

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