Malaria Treatment and Vaccine
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Questions and Answers

Which of the following medications is effective against primary and latent liver stages as well as gametocytes?

  • Atovaquone
  • Proguanil
  • Quinine
  • Primaquine (correct)
  • What percentage of deaths in the region are accounted for by children under 5?

  • 70 %
  • 90 %
  • 60 %
  • 80 % (correct)
  • What is the target of the RTS,S vaccine?

  • P. falciparum (correct)
  • P. malariae
  • P. ovale
  • P. vivax
  • What is the name of the vaccine approved by the WHO in October 2021?

    <p>RTS,S/AS01 vaccine</p> Signup and view all the answers

    What is the percentage of all malaria cases worldwide accounted for by the majority of countries in Africa?

    <p>95 %</p> Signup and view all the answers

    What is the category of drugs that includes Artemisinins, chloroquine, mefloquine, quinine, and quinidine?

    <p>General categories</p> Signup and view all the answers

    What is quinine effective against in terms of blood stages of malaria?

    <p>All four species of malaria</p> Signup and view all the answers

    What is the rare hypersensitivity reaction to quinine that can lead to anuria and renal failure?

    <p>Blackwater fever</p> Signup and view all the answers

    What is the mechanism of quinine-induced hypoglycemia?

    <p>Stimulation of insulin release</p> Signup and view all the answers

    What is a contraindication for quinine use?

    <p>Underlying cardiac abnormalities</p> Signup and view all the answers

    What is a potential interaction between quinine and another medication?

    <p>Quinine raises the plasma levels of warfarin and digoxin</p> Signup and view all the answers

    What is the first-line therapy for Babesia microti infection, in combination with clindamycin?

    <p>Quinine</p> Signup and view all the answers

    What was the initial diagnosis of the 31-year-old woman who presented with a fever and chills after returning from a trip to Brazil?

    <p>Mixed infection of P. malariae and P. falciparum</p> Signup and view all the answers

    Why was the infant not treated with primaquine?

    <p>The infant was not exposed to the sporozoite</p> Signup and view all the answers

    What was the reason for inducing labor in the 31-year-old woman?

    <p>Fetal distress</p> Signup and view all the answers

    What was the diagnosis of the 40-year-old Nigerian woman who was admitted at 36 weeks of pregnancy?

    <p>Placental malaria</p> Signup and view all the answers

    What is the purpose of terminal prophylaxis in the treatment of malaria?

    <p>To prevent relapse</p> Signup and view all the answers

    Which of the following medications was used to treat the 31-year-old woman after the revised diagnosis of P. vivax?

    <p>Chloroquine</p> Signup and view all the answers

    What is the common tick-borne disease that can cause hemolytic anemia and fever in the Northeastern United States?

    <p>Babesiosis</p> Signup and view all the answers

    What is the mechanism of action of mefloquine?

    <p>Unknown</p> Signup and view all the answers

    Which of the following is NOT a common adverse effect of mefloquine?

    <p>Hypoglycemia</p> Signup and view all the answers

    What is the half-life of mefloquine?

    <p>Long, several days</p> Signup and view all the answers

    What is the primary route of excretion for mefloquine metabolites?

    <p>Fecal excretion</p> Signup and view all the answers

    What is the primary use of mefloquine in malaria treatment and prevention?

    <p>Treatment of chloroquine-resistant P. falciparum</p> Signup and view all the answers

    What is the approved indication for Tafenoquine?

    <p>Prevention of relapse of P.vivax or P.ovale malaria</p> Signup and view all the answers

    What is a common adverse effect of Primaquine?

    <p>Nausea and epigastric pain</p> Signup and view all the answers

    Why is Primaquine contraindicated in pregnancy?

    <p>The fetus is relatively G6PD-deficient and thus at risk of hemolysis</p> Signup and view all the answers

    What is the mechanism of action of Atovaquone?

    <p>It acts selectively on the mitochondrial cytochrome bc1 complex</p> Signup and view all the answers

    What laboratory test should be performed before administering Primaquine?

    <p>Glucose-6-Phosphate Dehydrogenase (G6PD) deficiency test</p> Signup and view all the answers

    What is the indication for the combination of Primaquine with clindamycin?

    <p>P.jiroveci pneumonia</p> Signup and view all the answers

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