Podcast
Questions and Answers
What is the most common and deadly species of Plasmodium that causes malaria in humans?
What is the most common and deadly species of Plasmodium that causes malaria in humans?
- P. vivax
- P. falciparum (correct)
- P. malariae
- P. ovale
Which method is the main mode of transmission of malaria?
Which method is the main mode of transmission of malaria?
- Blood transfusion
- Mother to child transmission
- Bites from infected female anopheles mosquito (correct)
- Needle stick injury
What is the estimated percentage of malaria deaths in children according to WMR(2018) in 2017?
What is the estimated percentage of malaria deaths in children according to WMR(2018) in 2017?
- 25%
- 75%
- 100%
- 50% (correct)
Which species of Plasmodium causes malaria with an erythrocytic cycle of 72 hours?
Which species of Plasmodium causes malaria with an erythrocytic cycle of 72 hours?
Which type of malaria is characterized by asexual P. falciparum infection, life-threatening signs/symptoms, or vital organ dysfunction?
Which type of malaria is characterized by asexual P. falciparum infection, life-threatening signs/symptoms, or vital organ dysfunction?
What is the main characteristic of uncomplicated malaria?
What is the main characteristic of uncomplicated malaria?
What is the consequence of cytoadherence in malaria?
What is the consequence of cytoadherence in malaria?
How is malaria diagnosed through microscopy-based tests?
How is malaria diagnosed through microscopy-based tests?
What do RDTs detect in malaria diagnosis?
What do RDTs detect in malaria diagnosis?
What is the impact of some RDTs in detecting parasite antigens?
What is the impact of some RDTs in detecting parasite antigens?
What is the main feature of severe malaria?
What is the main feature of severe malaria?
What does P. falciparum do within RBCs?
What does P. falciparum do within RBCs?
What is the classification of malaria based on?
What is the classification of malaria based on?
How are non-microscopy tests for malaria diagnosis conducted?
How are non-microscopy tests for malaria diagnosis conducted?
What is the limitation of RDTs in malaria diagnosis?
What is the limitation of RDTs in malaria diagnosis?
What is the consequence of infected red cells adhering to each other and sometimes to uninfected erythrocytes?
What is the consequence of infected red cells adhering to each other and sometimes to uninfected erythrocytes?
Which of the following is NOT a preferred treatment for uncomplicated malaria?
Which of the following is NOT a preferred treatment for uncomplicated malaria?
What is the recommended initial dose of Artemether for severe malaria if artesunate injection is not available?
What is the recommended initial dose of Artemether for severe malaria if artesunate injection is not available?
What is the purpose of using two or more blood schizonticidal drugs with independent modes of action in anti-malarial combination therapy?
What is the purpose of using two or more blood schizonticidal drugs with independent modes of action in anti-malarial combination therapy?
What is the first-line anti-malarial combination therapy of choice in Nigeria?
What is the first-line anti-malarial combination therapy of choice in Nigeria?
What is the definition of treatment failure in the context of malaria treatment?
What is the definition of treatment failure in the context of malaria treatment?
What is the recommended chemoprophylaxis for special risk groups in malaria endemic regions?
What is the recommended chemoprophylaxis for special risk groups in malaria endemic regions?
Flashcards
Most common malaria species
Most common malaria species
Plasmodium falciparum
Malaria transmission method
Malaria transmission method
Mosquito bites
Malaria deaths in children (2017)
Malaria deaths in children (2017)
50% (according to WMR 2018)
P. malariae erythrocytic cycle
P. malariae erythrocytic cycle
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Severe malaria
Severe malaria
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Uncomplicated malaria symptoms
Uncomplicated malaria symptoms
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Cytoadherence consequence
Cytoadherence consequence
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Microscopy malaria diagnosis
Microscopy malaria diagnosis
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RDT detection
RDT detection
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RDT detection duration
RDT detection duration
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Severe malaria feature
Severe malaria feature
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P. falciparum in RBCs
P. falciparum in RBCs
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Malaria classification base
Malaria classification base
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Non-microscopy malaria test
Non-microscopy malaria test
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RDT limitation
RDT limitation
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Red blood cell consequence
Red blood cell consequence
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Unfavorable Malaria treatment
Unfavorable Malaria treatment
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Severe malaria Artemether dose
Severe malaria Artemether dose
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Combination therapy purpose
Combination therapy purpose
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Nigeria's first-line malaria treatment
Nigeria's first-line malaria treatment
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Treatment failure definition
Treatment failure definition
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Malaria Chemoprophylaxis
Malaria Chemoprophylaxis
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Study Notes
Malaria Pathogenesis and Classification
- P. falciparum can invade RBCs of all ages and multiply exponentially without inhibition by the host or drugs
- Infected red cells adhere to vessel walls (cytoadherence), to each other, and sometimes to uninfected erythrocytes (rosetting)
- Cytoadherence leads to sequestration of red blood cells containing mature parasites in various organs
- Malaria is classified as uncomplicated or severe based on clinical features and vital organ dysfunction
- Uncomplicated malaria presents with symptoms such as fever, chills, headaches, malaise, and nausea/vomiting
- Severe malaria is characterized by asexual P. falciparum infection, life-threatening signs/symptoms, or vital organ dysfunction
- Severe malaria features include cerebral malaria, prostration, multiple convulsions, acidosis, bleeding, hypoglycemia, severe malarial anemia, renal impairment, jaundice, pulmonary edema, and shock
- Malaria is diagnosed through history taking, physical examination, and parasite-based confirmation by microscopy or mRDT
- Microscopy-based tests for malaria diagnosis include blood film light microscopy, QBC method, and BCP procedure
- Non-microscopy tests involve identification of parasitic antigen or anti-plasmodial antibodies, such as RDTs and PCR
- RDTs detect parasite antigens, but cannot quantify the number of parasites or distinguish between active and past infections
- Some RDTs can detect parasite antigens up to 2 weeks after treatment, impacting the accuracy of the test results
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Description
Test your knowledge of malaria pathogenesis and classification with this quiz. Learn about the invasion of RBCs by P. falciparum, the classification of malaria, and the diagnosis methods including microscopy and RDTs.
