Macrophages and Hemoglobin Destruction Process
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Questions and Answers

What is the normal hematocrit percentage in men?

  • 45 percent (correct)
  • 47 percent
  • 40 percent
  • 42 percent

How is the hematocrit measured?

  • By analyzing the color of erythrocytes
  • By counting the number of leukocytes
  • By centrifuging a blood sample (correct)
  • By measuring the amount of iron in the blood

What is the volume of plasma in an average-sized person with a 45 percent hematocrit?

  • 3.0 L (correct)
  • 4.0 L
  • 3.5 L
  • 2.5 L

What is the quantity of hemoglobin that red blood cells can concentrate in their cell fluid?

<p>34 grams in each 100 milliliters of cells (D)</p> Signup and view all the answers

Why is it important to understand the means by which iron is utilized in the body?

<p>To ensure the formation of myoglobin and cytochromes (C)</p> Signup and view all the answers

What is the approximate volume of blood in an average-sized person (70 kg)?

<p>5.5 L (B)</p> Signup and view all the answers

What is the primary function of hemoglobin in the body?

<p>To combine with oxygen in the peripheral tissue capillaries (B)</p> Signup and view all the answers

What determines the binding affinity of the hemoglobin for oxygen?

<p>The types of hemoglobin chains in the hemoglobin molecule (A)</p> Signup and view all the answers

What happens when reticulocytes leave the bone marrow and pass into the blood stream?

<p>They continue to form minute quantities of hemoglobin for another day or so (D)</p> Signup and view all the answers

What alteration in the hemoglobin molecule leads to sickle cell anemia?

<p>Substitution of glutamic acid for valine at one point in each of the two beta chains (C)</p> Signup and view all the answers

Where is excess iron deposited in the body?

<p>In the liver hepatocytes and reticuloendothelial cells (C)</p> Signup and view all the answers

What is the role of transferrin in iron metabolism?

<p>It transports iron to the mitochondria for heme synthesis (A)</p> Signup and view all the answers

What happens to old abnormal red cells when the spleen is removed?

<p>Their number increases considerably in the blood circulation (B)</p> Signup and view all the answers

What happens when red blood cells burst and release their hemoglobin?

<p>The hemoglobin is phagocytized immediately by macrophages (B)</p> Signup and view all the answers

What is unique about transferrin's interaction with erythroblasts?

<p>It binds with receptors in erythroblasts and forms ferritin directly (B)</p> Signup and view all the answers

What is stored as hemosiderin?

<p>Iron combined with clusters of iron radicals and apoferritin (B)</p> Signup and view all the answers

What causes severe hypochromic anemia?

<p>Failure to transport iron to erythroblasts by transferrin (B)</p> Signup and view all the answers

Where does most destruction of red blood cells occur?

<p>In the liver hepatocytes and macrophages of the spleen and bone marrow (C)</p> Signup and view all the answers

Which of the following is the primary role of transferrin in the process described?

<p>Transporting iron to the bone marrow for the production of new red blood cells (B)</p> Signup and view all the answers

In cases of chronic blood loss, why are RBCs smaller than normal and contain too little hemoglobin?

<p>Inability to absorb enough iron from the intestines (D)</p> Signup and view all the answers

What condition may lead to megaloblastic anemia due to slow reproduction of erythroblasts in the bone marrow?

<p>Inability to absorb vitamin B12 from the gastrointestinal tract (A)</p> Signup and view all the answers

What is the basic abnormality in pernicious anemia?

<p>Atrophy of the stomach mucosa (C)</p> Signup and view all the answers

What is the role of intrinsic factor in the absorption of vitamin B12 from the gastrointestinal tract?

<p>Combines with vitamin B12 in food for absorption by the gut (A)</p> Signup and view all the answers

What is the minimum amount of vitamin B12 required each day to maintain normal red cell maturation?

<p>1-3 micrograms (D)</p> Signup and view all the answers

What is a common cause of maturation failure anemia?

<p>Deficiency of folic acid and vitamin B12 absorption (D)</p> Signup and view all the answers

What leads to hemolytic anemia?

<p>Hereditary abnormalities making RBCs fragile (B)</p> Signup and view all the answers

What characterizes RBCs in hereditary spherocytosis?

<p>Small size and biconcave disc shape (B)</p> Signup and view all the answers

What causes the cells in sickle cell disease to become highly fragile?

<p>Damage to the cell membrane by the precipitated hemoglobin (D)</p> Signup and view all the answers

What event in erythroblastosis fetalis leads to rapid rupture of Rh-positive RBCs in the fetus?

<p>Attack by antibodies from an Rh-negative mother (C)</p> Signup and view all the answers

What causes the bloodforming organs to produce large quantities of extra RBCs in secondary polycythemia?

<p>Hypoxia in the tissues (A)</p> Signup and view all the answers

What is the characteristic of physiological polycythemia in individuals living at high altitudes?

<p>Ability to perform high levels of continuous work at rarefied atmosphere (A)</p> Signup and view all the answers

What distinguishes polycythemia vera from physiological polycythemia?

<p>Genetic aberration in the blood cells (C)</p> Signup and view all the answers

What is the cause of excess production of RBCs in polycythemia vera?

<p>Blast cells no longer stop producing RBCs when too many cells are already present (D)</p> Signup and view all the answers

What is the hematocrit percentage in polycythemia vera compared to the normal range?

<p>60% to 70% (C)</p> Signup and view all the answers

What effect does polycythemia vera have on the total blood volume?

<p>Increases almost twice normal (D)</p> Signup and view all the answers

What is a consequence of the entire vascular system becoming intensely engorged in polycythemia vera?

<p>Many blood capillaries become plugged (B)</p> Signup and view all the answers

What condition causes a large number of early blast forms of RBCs to be released from the bone marrow into the blood?

<p>Secondary polycythemia (B)</p> Signup and view all the answers

What type of secondary polycythemia occurs in those living at altitudes of 14,000 to 17,000 feet?

<p>Physiological polycythemia (D)</p> Signup and view all the answers

What causes sickling, ruptured RBCs, and further decrease in oxygen tension in sickle cell disease crisis?

<p>Low oxygen tension in the tissues (A)</p> Signup and view all the answers

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