30 Questions
What is the estimated prevalence of PAH globally?
15 to 50 per million
Which subtype accounts for 50-60% of all PAH cases?
IPAH
What is the gender distribution of PAH patients?
Twice as many females as males
In which age group is PAH predominantly recognized?
Younger females
Which country was the source of the study 'An epidemiological study of pulmonary arterial hypertension'?
France
Which of the following is NOT a common cause of PAH?
Infectious
What is the prevalence of PAH patients found in Saudi Arabia till now?
750 patients
What are the potential side effects of Maacy?
Headaches and hypotension
Why should individuals with lactose intolerance contact their doctor before taking Maacy?
Maacy contains lactose
What precaution is advised for pregnant women regarding Maacy?
Use a reliable form of contraception while taking Maacy
Why is it crucial for pregnant women to consult a doctor immediately if they suspect pregnancy while taking Maacy?
Maacy may cause harm to unborn babies
What precaution is advised for women who could become pregnant before starting Maacy?
Take a pregnancy test
Why is it important for breastfeeding mothers to avoid taking Maacy?
It is unknown whether Maacy is transferred into breast milk
Which type of medications are used to treat HIV infections?
Ritonavir and saquinavir
What is the purpose of cyclosporine medication?
Prevent organ rejection after transplant
What are the potential effects of Maacy on driving ability?
The symptoms of your condition can make you less fit to drive
What is the primary function of Macitentan in PAH treatment?
To reduce disease progression and hospitalization risk
Which study demonstrated that Macitentan significantly reduced the risk of morbidity and mortality by 45%?
The Seraphin Study
What are the primary benefits offered by Macitentan in PAH treatment?
Improved survival rate, functionality, quality of life, and decreased hospitalization
What did the Seraphin OL Extension Study show about Macitentan's average survival and hospitalization risk reduction?
Offers an average survival of 5.9 years and reduces hospitalization risk by 38%
What did the study reveal about the effect of Macitentan 10mg combination therapy on hospitalization risk for PAH?
Reduced the risk of hospitalization for PAH by 37% more than placebo combination with background therapy
What improvement was associated with patients on Macitentan 10mg combination therapy?
74% greater chance of improving WHO functional class status and a 22-meter increase in 6-minute walk distance
What reduction in the risk of being hospitalized for PAH was reported for patients receiving Macitentan 10mg combination therapy?
37%
What is the indication for Macitentan (Maacy) 10mg tablet?
Treatment of pulmonary arterial hypertension (PAH) in adult patients classified as WHO Functional Class II to III
How should Maacy be taken?
Once daily with a glass of water, with or without food, at the same time each day
What precaution is advised for lactating women taking Maacy?
Not to breastfeed if taking Maacy, as it is not known if Maacy passes into breast milk
What is the recommended action if a dose of Maacy is missed?
It should be taken as soon as remembered, without taking a double dose to make up for a forgotten tablet
Who should be monitored for signs of puberty when taking Maacy?
Female pediatric patients taking Maacy before reaching puberty
In which patients should caution be exercised when using Maacy due to limited experience in this age group?
Patients older than 75 years
What condition should patients with kidney problems discuss with their doctor before using Maacy?
Pulmonary veno-occlusive disease
Study Notes
Macitentan (Maacy) 10mg Tablet: Indications, Usage, and Precautions
- Macitentan (Maacy) 10mg tablet is indicated for the long-term treatment of pulmonary arterial hypertension (PAH) in adult patients classified as WHO Functional Class (FC) II to III.
- The Macitentan 10mg combination therapy significantly increased the 6-minute walk distance by 25.9 meters compared to placebo combination therapy, which showed a decrease by 7.8 meters.
- Maacy comes in the form of film-coated tablets, with each tablet containing macitentan 10 mg. It is recommended to be taken once daily with a glass of water, with or without food, at the same time each day.
- Pregnant women are advised not to take Maacy, as it can cause serious birth defects. Negative pregnancy tests are required before starting Maacy, monthly while taking it, and for one month after stopping the medication.
- Lactating women are advised not to breastfeed if taking Maacy, and it is not known if Maacy passes into breast milk.
- Female pediatric patients taking Maacy before reaching puberty should be monitored for signs of puberty, as they may reach puberty before having their first menstrual period.
- In case of overdose, symptoms may include headache, nausea, or vomiting. If a dose is missed, it should be taken as soon as remembered, without taking a double dose to make up for a forgotten tablet.
- It is advised not to take Maacy if allergic to Macitentan, soya, or any other ingredients, if pregnant, planning to become pregnant, or not using reliable contraception, if breastfeeding, or if having liver disease or very high levels of liver enzymes.
- Before taking Maacy, it is important to consult a doctor or pharmacist, as blood tests may be recommended to assess anemia and monitor liver function. Symptoms of anemia and liver dysfunction should be promptly reported to the doctor.
- Maacy should not be given to children and adolescents below 18 years, and caution should be exercised when using Maacy in patients older than 75 years due to limited experience in this age group.
- Maacy can affect other medicines and should be used cautiously with specific medications, including certain antibiotics, seizure medications, and others. It is important to inform the doctor or pharmacist about all medications being taken.
- Patients with kidney problems or pulmonary veno-occlusive disease should discuss these conditions with their doctor before using Maacy, as it may further reduce blood pressure, cause a decrease in hemoglobin levels, or lead to pulmonary edema.
Test your knowledge about Macitentan (Maacy) 10mg Tablet, its indications, usage, and precautions with this informative quiz. Learn about the long-term treatment of pulmonary arterial hypertension, dosage, potential side effects, contraindications, and important considerations for specific patient groups. Enhance your understanding of this medication and its impact on different medical conditions and drug interactions.
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