Podcast
Questions and Answers
What is the estimated prevalence of PAH globally?
What is the estimated prevalence of PAH globally?
- 100 to 150 per million
- 15 to 50 per million (correct)
- 50 to 100 per million
- Less than 15 per million
Which subtype accounts for 50-60% of all PAH cases?
Which subtype accounts for 50-60% of all PAH cases?
- PAH associated with congenital heart disease
- IPAH (correct)
- Heritable PAH
- Drug-induced PAH
What is the gender distribution of PAH patients?
What is the gender distribution of PAH patients?
- Twice as many females as males (correct)
- Twice as many males as females
- Three times as many females as males
- Equal distribution among males and females
In which age group is PAH predominantly recognized?
In which age group is PAH predominantly recognized?
Which country was the source of the study 'An epidemiological study of pulmonary arterial hypertension'?
Which country was the source of the study 'An epidemiological study of pulmonary arterial hypertension'?
Which of the following is NOT a common cause of PAH?
Which of the following is NOT a common cause of PAH?
What is the prevalence of PAH patients found in Saudi Arabia till now?
What is the prevalence of PAH patients found in Saudi Arabia till now?
What are the potential side effects of Maacy?
What are the potential side effects of Maacy?
Why should individuals with lactose intolerance contact their doctor before taking Maacy?
Why should individuals with lactose intolerance contact their doctor before taking Maacy?
What precaution is advised for pregnant women regarding Maacy?
What precaution is advised for pregnant women regarding Maacy?
Why is it crucial for pregnant women to consult a doctor immediately if they suspect pregnancy while taking Maacy?
Why is it crucial for pregnant women to consult a doctor immediately if they suspect pregnancy while taking Maacy?
What precaution is advised for women who could become pregnant before starting Maacy?
What precaution is advised for women who could become pregnant before starting Maacy?
Why is it important for breastfeeding mothers to avoid taking Maacy?
Why is it important for breastfeeding mothers to avoid taking Maacy?
Which type of medications are used to treat HIV infections?
Which type of medications are used to treat HIV infections?
What is the purpose of cyclosporine medication?
What is the purpose of cyclosporine medication?
What are the potential effects of Maacy on driving ability?
What are the potential effects of Maacy on driving ability?
What is the primary function of Macitentan in PAH treatment?
What is the primary function of Macitentan in PAH treatment?
Which study demonstrated that Macitentan significantly reduced the risk of morbidity and mortality by 45%?
Which study demonstrated that Macitentan significantly reduced the risk of morbidity and mortality by 45%?
What are the primary benefits offered by Macitentan in PAH treatment?
What are the primary benefits offered by Macitentan in PAH treatment?
What did the Seraphin OL Extension Study show about Macitentan's average survival and hospitalization risk reduction?
What did the Seraphin OL Extension Study show about Macitentan's average survival and hospitalization risk reduction?
What did the study reveal about the effect of Macitentan 10mg combination therapy on hospitalization risk for PAH?
What did the study reveal about the effect of Macitentan 10mg combination therapy on hospitalization risk for PAH?
What improvement was associated with patients on Macitentan 10mg combination therapy?
What improvement was associated with patients on Macitentan 10mg combination therapy?
What reduction in the risk of being hospitalized for PAH was reported for patients receiving Macitentan 10mg combination therapy?
What reduction in the risk of being hospitalized for PAH was reported for patients receiving Macitentan 10mg combination therapy?
What is the indication for Macitentan (Maacy) 10mg tablet?
What is the indication for Macitentan (Maacy) 10mg tablet?
How should Maacy be taken?
How should Maacy be taken?
What precaution is advised for lactating women taking Maacy?
What precaution is advised for lactating women taking Maacy?
What is the recommended action if a dose of Maacy is missed?
What is the recommended action if a dose of Maacy is missed?
Who should be monitored for signs of puberty when taking Maacy?
Who should be monitored for signs of puberty when taking Maacy?
In which patients should caution be exercised when using Maacy due to limited experience in this age group?
In which patients should caution be exercised when using Maacy due to limited experience in this age group?
What condition should patients with kidney problems discuss with their doctor before using Maacy?
What condition should patients with kidney problems discuss with their doctor before using Maacy?
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Study Notes
Macitentan (Maacy) 10mg Tablet: Indications, Usage, and Precautions
- Macitentan (Maacy) 10mg tablet is indicated for the long-term treatment of pulmonary arterial hypertension (PAH) in adult patients classified as WHO Functional Class (FC) II to III.
- The Macitentan 10mg combination therapy significantly increased the 6-minute walk distance by 25.9 meters compared to placebo combination therapy, which showed a decrease by 7.8 meters.
- Maacy comes in the form of film-coated tablets, with each tablet containing macitentan 10 mg. It is recommended to be taken once daily with a glass of water, with or without food, at the same time each day.
- Pregnant women are advised not to take Maacy, as it can cause serious birth defects. Negative pregnancy tests are required before starting Maacy, monthly while taking it, and for one month after stopping the medication.
- Lactating women are advised not to breastfeed if taking Maacy, and it is not known if Maacy passes into breast milk.
- Female pediatric patients taking Maacy before reaching puberty should be monitored for signs of puberty, as they may reach puberty before having their first menstrual period.
- In case of overdose, symptoms may include headache, nausea, or vomiting. If a dose is missed, it should be taken as soon as remembered, without taking a double dose to make up for a forgotten tablet.
- It is advised not to take Maacy if allergic to Macitentan, soya, or any other ingredients, if pregnant, planning to become pregnant, or not using reliable contraception, if breastfeeding, or if having liver disease or very high levels of liver enzymes.
- Before taking Maacy, it is important to consult a doctor or pharmacist, as blood tests may be recommended to assess anemia and monitor liver function. Symptoms of anemia and liver dysfunction should be promptly reported to the doctor.
- Maacy should not be given to children and adolescents below 18 years, and caution should be exercised when using Maacy in patients older than 75 years due to limited experience in this age group.
- Maacy can affect other medicines and should be used cautiously with specific medications, including certain antibiotics, seizure medications, and others. It is important to inform the doctor or pharmacist about all medications being taken.
- Patients with kidney problems or pulmonary veno-occlusive disease should discuss these conditions with their doctor before using Maacy, as it may further reduce blood pressure, cause a decrease in hemoglobin levels, or lead to pulmonary edema.
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