Untitled Quiz

Disease-modifying antirheumatic drugs (DMARDs) are medications used to treat arthritis by slowing or stopping the progression of the disease.

A DMARD used to treat arthritis, often severe skin inflammation.

A DMARD used to treat arthritis.

Biological response modifiers used to treat arthritis. These agents target specific inflammatory pathways.

Corticosteroids can be injected into inflamed joints to reduce inflammation quickly.

A surgical procedure used to remove inflamed synovial tissue from a joint.

A surgical procedure to replace a damaged joint with an artificial one.

Surgical procedures to fuse or replace a joint.

A rehabilitation program to improve mobility, function, and reduce pain and disability in patients with arthritis.

Essential for reducing inflammation, pain, and joint stress. Local or systemic

Crucial for improving joint mobility, strength, and endurance.

Heat or cold therapies used to manage pain and inflammation.

Important for patients to understand their condition and manage it effectively

Studies show genetic links on chromosomes 17q, 4q, and 6p, with strongest evidence on 6p, suggesting genes influence psoriasis.

Certain immunoglobulin genes may be linked with psoriatic arthritis (PsA).

Serum levels of immunoglobulin A (IgA) and IgG are higher in PsA patients compared to others.

Finding specific genes related to psoriasis can help understand the disease's cause, potentially leading to new treatments.

Several biological pathways are involved in psoriasis development, including skin barrier function, the Th17 pathway, innate immunity with interferon signaling, beta-defensin and Th2 immune responses.

ERAP1 gene variants show increased psoriasis susceptibility only in people with a particular HLA-C gene variant suggesting an interplay between these immune system genes.

Psoriatic arthritis inflammation involves similar inflammatory processes as rheumatoid arthritis (RA), but with key differences in cytokine profiles.

Psoriatic arthritis demonstrates different cytokine levels (types of immune signaling proteins) compared to RA, particularly regarding Th1 helper cells and their associated factors like TNF-alpha and IL-10.

Genes like LCE3B and LCE3C are associated with the integrity of the skin barrier, an important component in psoriasis.

The Th17 pathway, a type of immune response, plays a part in psoriasis through genes such as IL12B, IL23A, and IL23R.

Inflammation of the uvea, the middle layer of the eye.

Inflammation of the sacroiliac joints.

A specific human leukocyte antigen.

A type of arthritis that causes joint pain and inflammation, often associated with psoriasis.

Inflammation of the sclera (white part of the eye).

Dry eyes and cornea.

Inflammation of the iris, a colored part of the eye.

Damage to the root of the aortic valve, leading to leakage.

Amyloid build up that results from another medical condition.

Arthritis related to inflammatory bowel disease.

A blood test measuring how quickly red blood cells settle.

A blood protein produced in response to inflammation.

Personalized treatment programs starting early in the disease that target various aspects of the condition.

Important for pain management; however, prolonged rest should be avoided to prevent immobility.

Crucial, encompassing passive, active, stretching, strengthening, and endurance exercises.

Temporary pain and swelling relief through warm tubs, compresses, or cold packs.

Support devices for upper/lower extremities and spinal care.

Tools for activities of daily living and movement, including home/vehicle modifications.

Teaching patients about psoriatic arthritis, its management, and self-care strategies.

Can reduce stress on joints, improve mobility, and may enhance medication effectiveness.

Clinicians should recommend smoking cessation strategies to patients.

Rest is prioritized, with controlled passive movements.

Gradual progression of exercises including isometric exercises and range-of-motion exercises, avoiding forced movements.

Heat therapy should be administered just before range-of-motion (ROM) exercises to improve the effectiveness of the therapy.

Gait activities involving weight-bearing (with or without assistive devices) are important for patients to maintain mobility.

If pain persists more than 2 hours after therapies, reduce the intensity.

Avoid full range of motion (ROM) resistive exercises if a joint is swollen.

Spine extension exercises enhance flexibility and strength for patients with axial spine issues.

Avoid ROM exercises if pain increases during the exercises.

Extra-depth shoes with a high toe box are crucial for patients with sausage-toes; rocker-bottom shoes support toes with pain.

Arch supports can be helpful in managing plantar fasciitis.

Arthroscopic synovectomy is used to treat severe, chronic, monoarticular synovitis, but can cause fibrosis.

Anti-inflammatory measures and physical therapy are crucial adjuncts to improve range-of-motion (ROM) after synovectomy to reduce fibrosis.

Joint replacement surgery, like hip and knee replacements, is often successful for patients with psoriatic arthritis.

Arthrodesis and arthroplasty can be used in various joints to treat different joint issues.

Wrist fusion can spontaneously occur, sometimes easing pain without surgery.

Psoriatic arthritis often results in joint contractures, particularly in the hand, after surgical releases.

For arthritis mutilans, surgery targets saving the hand, usually by combining arthrodesis, arthroplasty, and bone grafts to reconstruct the affected digits.

If a doctor isn't comfortable prescribing medication for psoriatic arthritis, a rheumatologist with more experience is recommended.

Physiatrists focus on restoring the patient's functionality.

Annual eye exams are crucial for patients with juvenile psoriatic arthritis to check for eye inflammation.

Patients with psoriatic arthritis need care from multiple specialists, especially if more than one part of the disease is active.

Patients with joint deformities in psoriatic arthritis need an orthopedic specialist for potential procedures like joint replacement or contracture release.

Some medications can worsen psoriasis by causing flares.

Lithium and withdrawal from systemic corticosteroids are known to cause psoriasis flare-ups.

Beta-blockers, antimalarials (except hydroxychloroquine), and NSAIDs may also worsen psoriasis in some cases.

If skin lesions worsen with one NSAID, try a different type of NSAID.

Rest, exercise, and joint supports are key for prevention, but a definite prevention isn't possible due to the chronic nature of the disease.

Psoriatic arthritis is often linked with other health problems such as cardiovascular disease, metabolic syndrome, inflammatory bowel disease, osteoporosis, malignancy, ophthalmic disease, and liver disease.

Psoriatic arthritis can lead to reduced bone density and deterioration of bone structure, particularly over time.