Lymphatic System and Immunity

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Questions and Answers

Which tissue type is characterized by a specialized form of reticular connective tissue abundant in lymphocytes?

  • Reticular Epithelium
  • Reticular Tissue
  • Lymphatic Tissue (correct)
  • Immune Tissue

What structural feature primarily distinguishes lymphatic capillaries from blood capillaries?

  • Lymphatic capillaries have greater permeability than blood capillaries (correct)
  • Lymphatic vessels have thicker walls than veins
  • Veins have one-way valves that prevent blood from escaping
  • There is no structural difference

Which pairing of lymph duct and drainage region is mismatched?

  • Right lymphatic duct—right side of body inferior to the ribs (correct)
  • Right lymphatic duct—right jugular veins
  • Thoracic duct—the entire body inferior to the ribs
  • Thoracic duct—left jugular veins

The thoracic duct originates as the cisterna chyli, which receives lymph from which trunks?

<p>cisterna chyli; lumbar; intestinal (A)</p> Signup and view all the answers

What sequence accurately describes the flow of fluid from blood capillaries back to the bloodstream via the lymphatic system?

<p>interstitial space-lymphatic capillaries-lymphatic vessels-lymph nodes-lymphatic vessels-lymphatic ducts-junction of the internal jugular and subclavian veins (A)</p> Signup and view all the answers

What is the primary immunological role of the thymus?

<p>maturation of T cells (D)</p> Signup and view all the answers

What age-related change occurs in the thymus?

<p>it undergoes atrophy (D)</p> Signup and view all the answers

In what sequence does lymph flow through a lymph node?

<p>afferent lymphatic vessels-subcapsular sinus-trabecular sinuses-medullary sinuses-efferent lymphatic vessels (B)</p> Signup and view all the answers

What is the fate of foreign substances that enter a lymph node within the lymph?

<p>they are trapped and destroyed (C)</p> Signup and view all the answers

The innate immune system involves several components, EXCEPT which of the following?

<p>development of antibodies against invaders (C)</p> Signup and view all the answers

Which of the following is NOT an internal defense protecting against microbes that penetrate the skin and mucous membranes?

<p>lysozyme in saliva (B)</p> Signup and view all the answers

What are antimicrobial proteins that primarily target viral replication called?

<p>interferons (C)</p> Signup and view all the answers

Which type of leukocyte is classified as a natural killer cell?

<p>lymphocytes (B)</p> Signup and view all the answers

What is the correct sequence of events in phagocytosis?

<p>chemotaxis, adherence, ingestion, digestion, killing (C)</p> Signup and view all the answers

How are microbes destroyed after being ingested by a phagocyte?

<p>digestive enzymes dissolve it (C)</p> Signup and view all the answers

Where are complement proteins primarily produced?

<p>in the liver and circulating in the blood (C)</p> Signup and view all the answers

Which mechanism is NOT a part of the complement system's action against microbes?

<p>by stimulating fever which destroys microbes (A)</p> Signup and view all the answers

How is the complement system typically activated?

<p>they become activated only when split by enzymes into active fragments (C)</p> Signup and view all the answers

What does it mean when a cell is described as 'immunocompetent'?

<p>it is ready to carry out adaptive immune responses (D)</p> Signup and view all the answers

Where do T cells and B cells undergo development?

<p>T cells develop in the thymus and B cells in the bone marrow. (C)</p> Signup and view all the answers

Which outcome is NOT a function of adaptive immunity?

<p>In cell-mediated immunity, phagocytes are produced. (D)</p> Signup and view all the answers

What process involves breaking down antigenic proteins into peptide fragments that form antigen-MHC molecules, followed by the insertion of the antigen-MHC complex into the plasma membrane?

<p>processing; presentation (D)</p> Signup and view all the answers

What is the primary role of major histocompatibility complex (MHC) molecules?

<p>act as self-antigens (C)</p> Signup and view all the answers

Which of the following is not considered an example of endogenous antigens?

<p>MHC molecules on plasma membrane (A)</p> Signup and view all the answers

Which statement accurately describes the initial step in the activation of a T cell?

<p>Binding of a T cell to an antigen-MHC complex is the first signal in activation. (B)</p> Signup and view all the answers

Which type of active T cells directly attack other body cells that have been infected with an antigen?

<p>cytotoxic (A)</p> Signup and view all the answers

Besides cells infected by microbes, what other types of cells do cytotoxic T cells target?

<p>tumor cells and transplanted cells (B)</p> Signup and view all the answers

How do cytotoxic T cells induce cell death in infected target cells?

<p>by delivering a lethal hit (A)</p> Signup and view all the answers

Which type of T cell participates in both cell-mediated and antibody-mediated immune responses?

<p>helper T cells (A)</p> Signup and view all the answers

With what specific part of the antigen does an antibody combine?

<p>epitope (B)</p> Signup and view all the answers

In what aspects do the five classes of antibodies differ?

<p>chemical; biological role (A)</p> Signup and view all the answers

Through which mechanism do antibodies NOT disable antigens?

<p>inhibit complement (C)</p> Signup and view all the answers

What type of cell is described as a 'descendant of a B cell that remains after an immune response and is ready to respond rapidly and forcefully should the same antigen enter the body in the future'?

<p>memory B cell (B)</p> Signup and view all the answers

How does the secondary response to an antigen typically differ from the primary response?

<p>it is faster and stronger (B)</p> Signup and view all the answers

Which antibody type is predominantly involved in the secondary response?

<p>IgG (A)</p> Signup and view all the answers

Which complement protein is NOT directly involved in the formation of the membrane attack complex (MAC)?

<p>C3a (C)</p> Signup and view all the answers

Which substance is NOT released by cytotoxic T cells to induce cell death in target cells?

<p>lysozyme. (A)</p> Signup and view all the answers

What type of cell is responsible for producing antibodies?

<p>Plasma cells. (A)</p> Signup and view all the answers

What type of antibody primarily constitutes the serum component of a secondary immune response?

<p>IgG antibodies. (D)</p> Signup and view all the answers

Against what type of pathogens are interferons most effective?

<p>viruses. (A)</p> Signup and view all the answers

Considering the relationship between volume and pressure as described by Boyle's Law, what effect would a decrease in lung volume have on intrapulmonary pressure?

<p>Intrapulmonary pressure would increase. (D)</p> Signup and view all the answers

How would the affinity of hemoglobin for oxygen be affected in metabolically active tissues with increased carbon dioxide (CO2) levels and decreased pH?

<p>Hemoglobin's affinity for oxygen would decrease, facilitating oxygen release. (C)</p> Signup and view all the answers

Which of the following best describes the cooperative binding of oxygen to hemoglobin?

<p>The binding of one oxygen molecule enhances the affinity for subsequent oxygen molecules. (A)</p> Signup and view all the answers

What is the functional consequence of the absence of cartilage on the posterior aspect of the trachea?

<p>It enables the esophagus to expand anteriorly during swallowing. (D)</p> Signup and view all the answers

How does increased altitude affect alveolar partial pressure of oxygen ($P_{O2}$), and what is the physiological consequence for oxygen diffusion?

<p>Increased altitude leads to lower alveolar $P_{O2}$, reducing the diffusion gradient. (A)</p> Signup and view all the answers

Flashcards

Lymphatic tissue

A specialized form of reticular connective tissue that contains large numbers of lymphocytes.

Lymphatic Vessel Structure

Lymphatic capillaries have greater permeability than blood capillaries.

Lymphatic Drainage Regions

The right lymphatic duct drains the right side of the body inferior to the ribs.

Cisterna Chyli

A dilation which receives lymph from the lumbar and intestinal trunks.

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Route of Fluid Flow

Interstitial spaces → lymphatic capillaries → lymphatic vessels → lymph nodes → lymphatic ducts → junction of internal jugular and subclavian veins.

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Role of Thymus

Maturation of T cells.

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Thymus Size with Age

The thymus undergoes atrophy.

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Lymph Flow in Node

Afferent lymphatic vessels → subcapsular sinus → trabecular sinuses → medullary sinuses → efferent lymphatic vessels.

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Foreign Substances in Lymph Node

They are trapped and destroyed.

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NOT innate immunity

Development of antibodies against invaders

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Internal defenses against microbes

All provide protection against microbes except lysozyme in saliva.

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Interferons

Antimicrobial proteins that prevent viral replication.

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Natural Killer Cells

Lymphocytes.

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Phagocytosis Phases

Chemotaxis, adherence, ingestion, digestion, killing.

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Killing Microbes

Digestive enzymes dissolve it.

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Complement Proteins Production

In the liver and circulating in the blood.

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Not a function of the complement system

By stimulating fever which destroys microbes.

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Complement System Activation

They become activated only when split by enzymes into active fragments

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Immunocompetent Cell

It is ready to carry out adaptive immune responses.

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T and B Cell Development

T cells develop in the thymus and B cells in the bone marrow.

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Not a function of adaptive immunity

In cell-mediated immunity, phagocytes are produced.

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Antigen context

Processing; presentation.

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MHC Molecules

Act as self-antigens.

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Endogenous Antigens

MHC molecules on plasma membrane.

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T cell activation

Binding of a T cell to an antigen-MHC complex is the first signal in activation.

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Effector T cells

Cytotoxic.

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Cytotoxic T cell targets

Tumor cells and transplanted cells.

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How Cytotoxic T cells kill

By delivering a lethal hit.

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T Cell in Both Responses

Helper T cells.

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An antibody combines specifically with the

Epitope.

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Antibodies Differ

Chemical; biological role.

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Antibodies disable antigens in any of the following ways except:

Inhibit complement.

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Descendant of B cell...

Memory B cell.

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Secondary Response

It is faster and stronger.

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Antibody in Secondary Response

IgG.

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Membrane attack complex

C3a.

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Cytotoxic T Cells substances except

Lysozyme.

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Antibodies are produced by

Plasma cells.

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Serum Component

IgG antibodies.

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Interferons are effective against

Viruses.

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Lymphatic system.

Cisterna chili.

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Lymph node area

Germinal center.

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Splenic Parts

White pulp.

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Cell capable

Macrophages.

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The organ is the indicated organ in this figure is the

Thymus.

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Study Notes

  • Lymphatic tissue is a specialized form of reticular connective tissue with a large number of lymphocytes.
  • Lymphatic capillaries have greater permeability than blood capillaries
  • The right lymphatic duct does not drain the right side of the body inferior to the ribs.
  • The thoracic duct begins as the cisterna chyli, which receives lymph from the lumbar and intestinal trunks.
  • The route of fluid flow is: interstitial space -> lymphatic capillaries -> lymphatic vessels -> lymph nodes -> lymphatic ducts -> junction of internal jugular and subclavian veins
  • The thymus matures T cells.
  • The thymus undergoes atrophy as you age
  • As lymph travels through a lymph node, it flows through: afferent lymphatic vessels-> subcapsular sinus -> trabecular sinuses -> medullary sinuses -> efferent lymphatic vessels.
  • Foreign substances that enter a lymph node in lymph are trapped and destroyed.
  • Development of antibodies against invaders is NOT a component of innate immunity.
  • Lysozyme in saliva is NOT an internal defense that provides protection against microbes that penetrate the skin and mucous membranes
  • Interferons are antimicrobial proteins that prevent viral replication
  • Lymphocytes are natural killer cells.
  • The correct order for the phases of phagocytosis is: chemotaxis -> adherence -> ingestion -> digestion -> killing.
  • Microbes are killed following ingestion by a phagocyte by digestive enzymes dissolving it.
  • Complement proteins are produced in the liver and circulating in the blood.
  • Stimulating fever which destroys microbes is NOT a means for the complement system to destroy microbes.
  • The complement system is activated when they become activated only when split by enzymes into active fragments.
  • Immunocompetent means ready to carry out adaptive immune responses.
  • T cells develop in the thymus and B cells in the bone marrow.
  • Cell-mediated immunity, phagocytes are NOT produced, cytotoxic T cells directly attack invading antigens.
  • In antigen processing, antigenic proteins are broken down into peptide fragments that then form antigen-MHC molecules and the insertion of the antigen-MHC complex into the plasma membrane is called antigen presentation.
  • Major histocompatibility complex molecules act as self-antigens.
  • MHC molecules on the plasma membrane are NOT an example of endogenous antigens
  • Binding of a T cell to an antigen-MHC complex is the first signal in activation.
  • Cytotoxic T cells are the effector cells of a T cell clone that attack other body cells that have been infected with the antigen.
  • Cytotoxic T cells attack tumor cells and transplanted cells besides cells infected by microbes.
  • Cytotoxic T cells kill infected target cells by delivering a lethal hit.
  • Helper T cells participate in both cell-mediated and antibody-mediated immune responses.
  • An antibody combines specifically with the epitope on the antigen that triggered the antibody's production.
  • The five classes of antibodies differ in chemical structure and specific biological role.
  • Antibodies disable antigens in any of the following ways except inhibit complement.
  • Memory B cell is a descendant of a B cell that remains after immune response and is ready to respond rapidly and forcefully should the same antigen enter body in future.
  • The secondary response to an antigen is faster and stronger than the primary response.
  • The IgG antibody responds most strongly during the secondary response.
  • C3a is NOT directly involved in the formation of a membrane attack complex
  • Cytotocix T cells release perfonin, granzymes, and lymphotoxin BUT NOT lysozyme
  • Antibodies are produced by plasma cells
  • The serum component of a secondary response consists mainly of IgG antibodies.
  • Interferons are effective against viruses.
  • The indicated structure in the lymphatic system figure is the cisterna chili.
  • The indicated area in the lymph node figure is the germinal center
  • The indicated structure of the spleen is the white pulp.
  • Macrophages are capable of the immune response process
  • The indicated organ structure is the thymus
  • Air molecules enter into the nasal cavity, then into a series of groove-like passageways - the superior, middle, and inferior nasal meatuses.
  • The nose does NOT dry incoming air
  • Maxillary cartilages are NOT a cartilage of the nose.
  • Paranasal sinuses serve as a resonating chamber and produce mucus
  • The nose traps particulate matter and mucus reduces drying to moisten and clean inhaled air before it enters the rest of the respiratory tract.
  • The superior and inferior borders of the pharynx are the nasal cavity and esophagus.
  • The epiglottis is a large, leafshaped piece of elastic cartilage that can move up and down like a trap door.
  • The main function of the vocal folds is to produce sounds.
  • The benefit of not having cartilage between the trachea and the esophagus is that both increases flexibility of the trachea and prevents the tracheal wall from collapsing.
  • The path taken by air molecules into and through the bronchial tree is: trachea-> carina -> primary bronchi -> secondary bronchi -> tertiary bronchi -> bronchioles -> terminal bronchioles
  • The pleural cavity is NOT between the parietal pleura and chest wall
  • The path taken by air molecules as they travel from terminal bronchioles to alveoli is: terminal bronchioles -> respiratory bronchioles -> alveolar ducts -> alveoli
  • If the volume of the cylinder decreased from 1 liter to 1/4 liter, the pressure would increase to 4 atm
  • The most important muscle that powers breathing is the diaphragm.
  • Volume increases cause air to enter the lungs during inhalation.
  • Elastic fibers within parietal pleura do NOT produce the elastic recoil of the thoracic wall and lungs, this DOES include recoil of stretched elastic fibers, surface tension in alveoli, passive spring back of thoracic wall
  • Airflow into alveoli is greater with higher compliance of the lungs and larger bronchioles.
  • The apparatus commonly used to measure the volume of air exchanged during breathing and to measure the respiratory rate is a spirometer.
  • The anatomic dead space is air remaining in the conducting airways.
  • Inspiratory reserve volume is NOT title volume plus full inspiration
  • The quantity of a gas that will dissolve in a liquid is proportional to the partial pressure of the gas and its solubility, this is described by Henry's law AND Dalton’s law describes the pressure of a specific gas in a mixture.
  • Oxygen enters pulmonary capillaries from alveolar air and enters tissue cells from systemic capillaries due to the partial pressure differences of oxygen.
  • Blood pressure differences do NOT affect the rates of diffusion of oxygen and carbon dioxide.
  • Increased altitude causes decreased partial pressure of oxygen.
  • Oxygen transport through the blood can occur dissolved in blood plasma and bound to hemoglobin.
  • Partial pressure of oxygen is the most important factor in determining how much oxygen binds to hemoglobin.
  • It is false that in tissue capillaries, where PO2 is high, a lot of O2 binds to hemoglobin.
  • Carbon dioxide transport through the blood can occur EXCEPT when bound to chloride
  • The concentration of HCO3- is expected to be higher in blood plasma taken from a systemic vein not an artery.
  • The phrenic nerves convey impulses from the respiratory center to the diaphragm.
  • The basic rhythm of respiration is controlled by: medullary rhythmicity area.
  • The statement that apneustic area controls the pneumotaxic area regarding the apneustic and pneumotaxic areas is that its INCORRECT the pneumotaxic area controls the apneustic area..
  • Central chemoreceptors of respiration are located in the medulla oblongata.
  • The chemical chloride does not stimulate peripheral chemoreceptors.
  • The normal arterial blood PCO2 is about 40 mmHg.
  • The rate of breathing increases as depth increases when PCO2 becomes elevated.
  • The inflation reflex prevents insufficient inflation of the lungs.
  • Proteins buffer body fluids and bicarbonate ions release H+ to increase acidity in order to maintain the pH of body fluids.
  • Hyperventilation results in respiratory acidosis is a false statement about acidosis and alkalosis.
  • The nasal cavity is lined with pseudostratified columnar epithelium.
  • A bronchopulmonary segment is an area of the lung supplied by a tertiary bronchus.
  • As the volume of a specific amount of gas increases its pressure decreases, according to Boyle's Law
  • The air that remains in the noncollapsible airways is the residual volume.
  • The law that states each gas in a mixture exerts its own pressure as if no other gases were present is Dalton's law.
  • Gas exchange between systemic capillaries and tissue cells is known as internal respiration.
  • The greatest percentage of CO2 is transported in the blood as bicarbonate ions.
  • The apneustic area is located in the pons.
  • Hyperventilation will result if PCO2 is increased.
  • An increase of CO2 in body fluids increases H+ concentration and lowers pH.
  • The area indicated in the throat figure is the oropharynx.
  • The structure indicated in the laryngeal structure is the epiglottis
  • Type II alveolar cells function in surfactant secretion.
  • According to the oxygen-hemoglobin dissociation curve shown in this figure, as pH decreases oxygen binds less tightly with hemoglobin so more O2 is available to the tissues
  • The structure in the lung is the left primary bronchus.

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