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Questions and Answers

Which of the following histological types is the MOST common in non-small cell lung cancer?

  • Squamous cell carcinoma (correct)
  • Small cell carcinoma
  • Mesothelioma
  • Adenocarcinoma

A patient presents with a hoarse voice and a chest X-ray reveals a mass in the mediastinum. Which of the following mechanisms is the MOST likely cause of the hoarseness?

  • Superior vena cava obstruction
  • Recurrent laryngeal nerve palsy (correct)
  • Horner's syndrome
  • Phrenic nerve palsy

Which of the following paraneoplastic syndromes is MOST likely associated with squamous cell carcinoma of the lung?

  • Cushing’s syndrome
  • Limbic encephalitis
  • Syndrome of inappropriate ADH (SIADH)
  • Hypercalcemia (correct)

A patient with small cell lung cancer develops muscle weakness that improves with muscle use. Which of the following conditions is the MOST likely cause?

<p>Lambert-Eaton myasthenic syndrome (C)</p> Signup and view all the answers

A patient with facial swelling, shortness of breath, and distended neck veins MOST likely has which of the following complications of lung cancer?

<p>Superior vena cava obstruction (D)</p> Signup and view all the answers

What is the FIRST-LINE treatment offered to patients with non-small cell lung cancer if the disease is isolated to a single area?

<p>Surgery (D)</p> Signup and view all the answers

Which of the following imaging techniques is BEST for identifying areas of metastasis in lung cancer due to its ability to visualize metabolically active tissues?

<p>PET-CT scan (B)</p> Signup and view all the answers

A patient presents with pneumonia-like symptoms after returning from a holiday where they stayed in a hotel with a contaminated water supply. Which organism is MOST likely responsible?

<p>Legionella pneumophila (D)</p> Signup and view all the answers

Which of the following is the MOST appropriate initial antibiotic treatment for a patient with mild community-acquired pneumonia?

<p>Oral amoxicillin (C)</p> Signup and view all the answers

Which of the following findings on a chest examination is MOST indicative of pneumonia?

<p>Bronchial breath sounds (B)</p> Signup and view all the answers

A patient with a history of asbestos exposure is MOST at risk of developing which type of lung malignancy?

<p>Mesothelioma (B)</p> Signup and view all the answers

A farmer develops a flu-like illness and is diagnosed with atypical pneumonia. Which organism is the MOST likely cause?

<p>Coxiella burnetii (D)</p> Signup and view all the answers

Which of the following interventions is MOST important to consider in a patient with poorly controlled HIV and a low CD4 count who presents with a dry cough and shortness of breath?

<p>Testing for Pneumocystis jiroveci pneumonia (PCP) (C)</p> Signup and view all the answers

According to NICE guidelines, what is the FIRST-LINE investigation in suspected asthma?

<p>Fractional exhaled nitric oxide (FeNO) (A)</p> Signup and view all the answers

A patient's FEV1/FVC ratio is greater than 75% and both FEV1 and FVC are reduced. This pattern is MOST indicative of which type of lung disease?

<p>Restrictive lung disease (A)</p> Signup and view all the answers

Which of the following medications is MOST commonly used as a reliever or rescue medication during acute asthma exacerbations?

<p>Short-acting beta 2 adrenergic receptor agonists (D)</p> Signup and view all the answers

A patient has a peak flow of 200 L/min, and their predicted peak flow is 400 L/min. What percentage of their BEST predicted peak flow are they currently achieving?

<p>50% (A)</p> Signup and view all the answers

A patient is prescribed theophylline. What monitoring is required?

<p>Monitoring plasma theophylline levels (C)</p> Signup and view all the answers

What is the MOST appropriate next step for a patient with asthma who is using a short-acting beta 2 agonist inhaler and a low-dose inhaled corticosteroid but remains symptomatic?

<p>Add a long-acting beta 2 agonist (LABA) (D)</p> Signup and view all the answers

What is the MOST common cause of community acquired penumonia?

<p>Streptococcus pneumoniae (A)</p> Signup and view all the answers

What is the MOST appropriate course of antibiotics for moderate to severe community-acquired pneumonia?

<p>7-10 day course of dual antibiotics (D)</p> Signup and view all the answers

What CURB-65 score suggests intensive care assessment?

<p>5 (A)</p> Signup and view all the answers

What are the features of Horner's syndrome?

<p>Partial ptosis, anhidrosis and miosis (C)</p> Signup and view all the answers

What antibodies are associated with the paraneoplastic syndrome, Limbic Encephalitis?

<p>Anti-Hu antibodies (A)</p> Signup and view all the answers

What peak flow percentage indicates severe acute asthma?

<p>33-50% predicted (D)</p> Signup and view all the answers

Which of the following is NOT a typical trigger for asthma?

<p>High humidity (B)</p> Signup and view all the answers

A patient presents with pneumonia symptoms and erythema multiforme. Which organism is MOST likely responsible?

<p>Mycoplasma pneumoniae (C)</p> Signup and view all the answers

Apart from pneumonia, what other condition does haemoptysis occur in?

<p>Lung cancer (A)</p> Signup and view all the answers

What does the 'R' stand for in the CURB-65 scoring system?

<p>Respiratory rate (A)</p> Signup and view all the answers

If FEV1 and FVC are equally reduced, with a normal or raised FEV1:FVC ratio > 75%. This suggests...

<p>Restrictive lung disease (A)</p> Signup and view all the answers

A patient presents with facial congestion and cyanosis when raising their hands over their head. What is this sign known as?

<p>Pemberton’s sign (B)</p> Signup and view all the answers

The use of accessory muscles, rapid respiratory rate, and symmetrical expiratory wheezing

<p>Are indicative of an acute asthma exacerbation (B)</p> Signup and view all the answers

Which investigation is the FIRST-LINE investigation in suspected lung cancer?

<p>Chest X-Ray (D)</p> Signup and view all the answers

Which of the following can be used as part of palliative treatment to relieve bronchial obstruction caused by lung cancer?

<p>Endobronchial treatment with stents or debulking (B)</p> Signup and view all the answers

A patient is wheezing but investigations are normal and they respond well to treatment. What is the most likely diagnosis?

<p>Asthma (D)</p> Signup and view all the answers

What result from a CRB-65 scoring system indicates NICE suggest considering referring patients to hospital?

<p>anything other than 0 (C)</p> Signup and view all the answers

Apart from lung disease, in which other condition are lung function tests particularly helpful?

<p>Obesity (A)</p> Signup and view all the answers

What are the two key treatments for the long term management of asthma?

<p>Short acting beta 2 agonist, for example salbutamol (A), Inhaled corticosteroids (ICS), for example beclometasone (D)</p> Signup and view all the answers

Which pneumonia organisms won't respond to pennicillins

<p>Atypical pneumonia (C)</p> Signup and view all the answers

A patient with a history of smoking presents with shoulder pain and Horner's syndrome. Which of the following locations is the MOST likely site of the tumor causing these symptoms?

<p>Apex of the lung (D)</p> Signup and view all the answers

A patient diagnosed with small cell lung cancer develops hyponatremia. Which of the following is the MOST likely underlying mechanism?

<p>Ectopic secretion of antidiuretic hormone (ADH) (A)</p> Signup and view all the answers

Which of the following is the MOST appropriate initial imaging modality for a patient suspected of having lung cancer, based on their presenting symptoms?

<p>Chest X-ray (B)</p> Signup and view all the answers

A patient with non-small cell lung cancer undergoes surgical resection. Adjuvant chemotherapy is being considered. What is the PRIMARY goal of adjuvant chemotherapy in this scenario?

<p>To reduce the risk of cancer recurrence. (A)</p> Signup and view all the answers

Which of the following pathological changes is MOST characteristic of obstructive lung diseases like asthma and COPD?

<p>Airflow limitation (D)</p> Signup and view all the answers

A patient's spirometry results show a normal FEV1/FVC ratio but reduced FVC. Which of the following BEST describes the underlying pathophysiology?

<p>Restriction in lung volume (B)</p> Signup and view all the answers

Which of the following is the MOST appropriate action for a patient experiencing an acute asthma exacerbation with a peak expiratory flow rate (PEFR) of 40% of their personal best?

<p>Administering a short-acting beta-agonist (B)</p> Signup and view all the answers

A patient with asthma is using a short-acting beta2-agonist as needed and a low-dose inhaled corticosteroid daily, but continues to experience symptoms. According to NICE guidelines, what is the MOST appropriate next step in managing this patient's asthma?

<p>Add a long-acting beta2-agonist (LABA) (B)</p> Signup and view all the answers

A patient has been prescribed theophylline for asthma management. Which of the following monitoring procedures is MOST important to ensure patient safety?

<p>Monitoring plasma theophylline levels (B)</p> Signup and view all the answers

A patient presents with a productive cough, fever, and pleuritic chest pain. Auscultation reveals bronchial breath sounds and coarse crackles in the right lower lobe. Which of the following is the MOST likely diagnosis?

<p>Pneumonia (B)</p> Signup and view all the answers

A patient is diagnosed with community-acquired pneumonia (CAP). According to the CURB-65 scoring system, which of the following factors is included in the assessment?

<p>Confusion (B)</p> Signup and view all the answers

A patient is being treated for pneumonia and develops a pleural effusion. Which of the following is the MOST concerning complication associated with a pleural effusion in this setting?

<p>Empyema (C)</p> Signup and view all the answers

A patient with a history of heavy smoking is diagnosed with squamous cell carcinoma of the lung. Which of the following electrolyte abnormalities is MOST likely associated with this type of lung cancer?

<p>Hypercalcemia (C)</p> Signup and view all the answers

A patient with small cell lung cancer (SCLC) presents with proximal muscle weakness that improves with repeated muscle use. This presentation is MOST suggestive of which paraneoplastic syndrome?

<p>Lambert-Eaton Myasthenic Syndrome (C)</p> Signup and view all the answers

A patient presents with a dry cough, shortness of breath, and a history of working in a job that involved exposure to asbestos. Which of the following conditions should be HIGHLY suspected?

<p>Mesothelioma (D)</p> Signup and view all the answers

In the management of asthma, which medication is used as a 'reliever' to provide immediate relief during acute bronchoconstriction?

<p>Short-acting beta2-agonists (SABA) (C)</p> Signup and view all the answers

A patient with a history of asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of severe asthma?

<p>PEFR 45% of predicted, respiratory rate of 30/min, inability to complete sentences (B)</p> Signup and view all the answers

A patient presents with pneumonia and is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?

<p>Hyponatremia (D)</p> Signup and view all the answers

A patient with pneumonia has a CRB-65 score of 2. According to NICE guidelines, what is the MOST appropriate next step in management?

<p>Consider hospital admission (B)</p> Signup and view all the answers

Which of the following antibiotic classes is typically recommended for treating atypical pneumonia caused by Mycoplasma pneumoniae?

<p>Macrolides (A)</p> Signup and view all the answers

A patient presents with a new diagnosis of pneumonia and is found to have a low CD4 count due to poorly controlled HIV. Which opportunistic infection is MOST likely?

<p>Pneumocystis jirovecii (D)</p> Signup and view all the answers

A patient with known asthma has been using a short-acting beta-agonist (SABA) frequently, more than twice a week. What does this suggest about their asthma control?

<p>Poorly controlled asthma (D)</p> Signup and view all the answers

What is the expected FEV1/FVC ratio in a patient diagnosed with restrictive lung disease?

<p>Normal or increased (B)</p> Signup and view all the answers

A patient is suspected of having asthma. According to NICE guidelines, what is the first-line investigation to confirm the diagnosis?

<p>Spirometry with bronchodilator reversibility (D)</p> Signup and view all the answers

After starting treatment for pneumonia a patient's CRP levels spike higher a day or two later despite the patient clinically improving on treatment. What is the MOST likely explanation for this?

<p>Delayed CRP response (B)</p> Signup and view all the answers

Which of the following factors is MOST suggestive of asthma rather than another respiratory condition?

<p>Symptom variability (B)</p> Signup and view all the answers

According to BTS/SIGN guidelines regarding diagnosing Asthma, what action should a clinician take if they highly suspect a diagnosis of Asthma clinically?

<p>Try treatment. (D)</p> Signup and view all the answers

Which of the following suggests a pneumonia diagnosis other than an infection of Streptococcus pneumoniae?

<p>Lack of a response to Pennicillins (D)</p> Signup and view all the answers

What does the 'B' stand for when using the CRB-65 scoring system on a patient?

<p>Blood pressure (D)</p> Signup and view all the answers

Which of the following bacteria most commonly presents itself in patients with both pneumonia and cystic fibrosis?

<p>Staphylococcus aureus (B)</p> Signup and view all the answers

For pneumonia patients treated in the community with a CRB score of 0 or 1, what investigation should be considered?

<p>CRP level 'point of care' test (C)</p> Signup and view all the answers

Which of the following is most likely to cause pneumonia in a patient with a new parrot?

<p>Chlamydia psittaci (A)</p> Signup and view all the answers

What flow rate indicates severe asthma?

<p>&lt; 33% predicted (B)</p> Signup and view all the answers

What other condition can lung function tests assist with?

<p>Neuromuscular disorders (D)</p> Signup and view all the answers

Which of the following combinations of medications is MOST likely to be found in a Maintenance and Reliever Therapy (MART) inhaler?

<p>A low dose inhaled corticosteroid and a fast acting LABA. (C)</p> Signup and view all the answers

Which of the following is NOT a restrictive lung disease?

<p>Asthma (A)</p> Signup and view all the answers

A patient is being assessed using a peak flow meter. Which of the following instructions would be MOST appropriate to ensure an accurate reading?

<p>Stand tall, take a deep breath in, seal your lips around the mouthpiece, and blow as hard and fast as possible. (B)</p> Signup and view all the answers

Which of the following is the MOST common symptom of pneumonia?

<p>Cough productive of sputum (D)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with shortness of breath and chest pain. While mesothelioma is suspected, which initial imaging finding would be MOST indicative of this specific malignancy rather than other lung conditions?

<p>Pleural thickening and effusion on chest X-ray. (D)</p> Signup and view all the answers

A patient with small cell lung cancer (SCLC) develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?

<p>Ectopic secretion of antidiuretic hormone (ADH) by the tumor cells. (B)</p> Signup and view all the answers

A patient presents with new onset ptosis, miosis, and anhidrosis on the right side of their face, along with right shoulder pain. Given the likely diagnosis, where is the MOST probable location of the tumor?

<p>Pulmonary apex of the right lung. (B)</p> Signup and view all the answers

A patient is diagnosed with community-acquired pneumonia (CAP) and has a CURB-65 score of 3. What is the MOST appropriate management strategy for this patient, according to guidelines?

<p>Intensive care assessment. (A)</p> Signup and view all the answers

Following initial investigations, a patient is suspected to have asthma. According to NICE guidelines, which of the following is the MOST appropriate FIRST-LINE investigation to confirm the diagnosis?

<p>Spirometry with bronchodilator reversibility. (D)</p> Signup and view all the answers

A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following BEST describes the components and usage of a MART inhaler?

<p>A combination of an inhaled corticosteroid and a long-acting beta2-agonist, used both regularly for maintenance and as needed for symptom relief. (C)</p> Signup and view all the answers

A patient with a history of well-controlled asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a severe asthma exacerbation?

<p>Inability to complete full sentences in one breath. (C)</p> Signup and view all the answers

A patient presents with a dry cough, shortness of breath and night sweats. They have a history of poorly controlled HIV. Which of the following is the MOST likely causative organism for their pneumonia?

<p>Pneumocystis jirovecii (A)</p> Signup and view all the answers

A patient with a history of smoking develops hypercalcemia. What type of lung cancer is MOST likely?

<p>Squamous cell carcinoma (C)</p> Signup and view all the answers

A patient’s spirometry results show an FEV1/FVC ratio of 85% and reduced FVC. What does this suggest?

<p>Restrictive lung disease (A)</p> Signup and view all the answers

A patient with a history of asthma presents with cough, wheeze, and shortness of breath. They use their short-acting beta2-agonist inhaler more than twice a week. What does this indicate regarding their asthma control?

<p>Poorly controlled asthma (C)</p> Signup and view all the answers

A farmer presents with a flu-like illness and is subsequently diagnosed with atypical pneumonia. Which organism is MOST likely responsible?

<p>Coxiella burnetii (A)</p> Signup and view all the answers

A patient presents with a pneumonia and a rash characterised by varying sized 'target lesions' formed by pink rings with pale centres. What organism is MOST likely responsible?

<p>Mycoplasma pneumoniae (D)</p> Signup and view all the answers

Which of the following statements BEST describes the action of theophylline in the long-term management of asthma?

<p>It relaxes bronchial smooth muscle and reduces inflammation. (B)</p> Signup and view all the answers

A patient has been diagnosed with pneumonia. Their inflammatory markers spike higher a day or two later after treatment despite them improving clinically. What is the MOST likely explanation for this?

<p>CRP commonly shows a delayed response. (A)</p> Signup and view all the answers

A patient with pneumonia deteriorates and develops a pleural effusion. Which complication is MOST concerning?

<p>Development of an empyema (B)</p> Signup and view all the answers

A patient with suspected pneumonia has a CRB-65 score of 1. According to NICE guidelines, what is the MOST appropriate action for this patient?

<p>Consider hospital referral (B)</p> Signup and view all the answers

A patient presents with signs and symptoms suggestive of pneumonia. Which of the following findings on chest examination is MOST indicative of pneumonia?

<p>Dullness to percussion and bronchial breath sounds. (C)</p> Signup and view all the answers

A patient is commenced on Theophylline for asthma management. Which regular monitoring is required?

<p>Regular blood tests to check levels of Theophylline (B)</p> Signup and view all the answers

What percentage of lung cancers are estimated to be preventable?

<p>80% (A)</p> Signup and view all the answers

Which of the following is the MOST common presenting symptom of pneumonia?

<p>Productive cough (C)</p> Signup and view all the answers

A patient with asthma has an FEV1/FVC ratio of less than 75%. What does this suggest?

<p>Obstructive lung disease (A)</p> Signup and view all the answers

Which of the following signs and symptoms are associated with superior vena cava obstruction?

<p>Facial swelling, shortness of breath, and distended neck veins (C)</p> Signup and view all the answers

A patient has been exposed to asbestos. Which malignancy is MOST associated with this?

<p>Mesothelioma (D)</p> Signup and view all the answers

What is the MOST significant risk factor for lung cancer?

<p>Cigarette smoking (D)</p> Signup and view all the answers

Which of the following findings on a chest X-ray MOST strongly suggests lung cancer?

<p>Hilar enlargement (A)</p> Signup and view all the answers

A patient with suspected pneumonia has a CRB-65 score of 1. Which of the following factors contribute to the patients score?

<p>Confusion, Respiratory rate ≥ 30, Blood pressure &lt; 90 systolic or ≤ 60 diastolic, Age ≥ 65 (B)</p> Signup and view all the answers

What is the typical treatment for small cell lung cancer?

<p>Chemotherapy and radiotherapy (D)</p> Signup and view all the answers

What is the definition of hospital acquired pneumonia?

<p>Pneumonia that develops more than 48 hours after hospital admission (B)</p> Signup and view all the answers

A patient presents with a productive cough, fever and pleuritic chest pain. On examination, you note bronchial breath sounds and coarse crackles on the right side of their chest. What is the MOST likely diagnosis?

<p>Pneumonia (B)</p> Signup and view all the answers

Which of the following underlying mechanisms is MOST likely for the development of Cushing’s syndrome in a patient with small cell lung cancer?

<p>Ectopic ACTH secretion (D)</p> Signup and view all the answers

A patient has been diagnosed with restrictive lung disease. What test can be used to establish objective measures of lung function?

<p>Spirometry (D)</p> Signup and view all the answers

In suspected lung cancer, what is the purpose of using contrast enhancement during a CT scan of the chest, abdomen, and pelvis?

<p>To improve visualization of lymph node involvement and metastasis (A)</p> Signup and view all the answers

What is the MOST appropriate treatment for mild community acquired pneumonia?

<p>5 day course of oral antibiotics (D)</p> Signup and view all the answers

Which of the following is MOST likely to be found in a Maintenance and Reliever Therapy (MART) inhaler?

<p>A low dose inhaled corticosteroid and a fast acting LABA (C)</p> Signup and view all the answers

A patient with a history of asthma presents with progressively worsening shortness of breath, a respiratory rate of 28 breaths per minute and is using accessory muscles. Peak flow is 40% of their predicted best. How would you grade the severity of their asthma?

<p>Severe (B)</p> Signup and view all the answers

A patient is diagnosed with pneumonia and is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?

<p>Hyponatraemia (B)</p> Signup and view all the answers

A patient has been prescribed Theophylline. How soon after each dose change should their plasma levels should be monitored?

<p>3 days after the change (C)</p> Signup and view all the answers

What is the MOST common cause of atypical pneumonia in patients with poorly controlled HIV and a low CD4 count?

<p>Pneumocystis jiroveci (PCP) (C)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with shortness of breath. Aside from mesothelioma, what other condition is this patient MOST at risk of developing?

<p>Adenocarcinoma (D)</p> Signup and view all the answers

According to NICE guidelines, what is the FIRST step in long term asthma management, after prescribing a short-acting beta 2 agonist inhaler?

<p>Add a regular low dose inhaled corticosteroid (C)</p> Signup and view all the answers

What are some triggers for asthma?

<p>Exercise, animals and strong emotions (C)</p> Signup and view all the answers

A patient presents with proximal muscle weakness that improves with repeated muscle use. This presentation is MOST suggestive of which paraneoplastic syndrome associated with small cell lung cancer?

<p>Lambert-Eaton myasthenic syndrome (D)</p> Signup and view all the answers

A farmer presents with a flu-like illness and is diagnosed with atypical pneumonia, contracted from exposure to animals and their bodily fluids. Which organism is MOST likely responsible?

<p>Coxiella burnetii (Q fever) (D)</p> Signup and view all the answers

A patient's spirometry results show an FEV1/FVC ratio of 65% and reduced FEV1. What does this pattern suggest?

<p>Obstructive lung disease (B)</p> Signup and view all the answers

When should you consider to intensive care assessment for a patient with pneumonia?

<p>CURB-65 score of ≥ 3 (A)</p> Signup and view all the answers

A patient is suspected of having pneumonia. Which investigation is MOST likely to occur if they arrive at hospital?

<p>Chest Xray (A)</p> Signup and view all the answers

Which of the following statements BEST describes the use of peak expiratory flow rate (PEFR) in asthma management?

<p>It is used to measure how well asthma is controlled and how severe an acute exacerbation is. (A)</p> Signup and view all the answers

A patient presents with a dry cough, shortness of breath, and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which of the following investigations would be MOST useful in confirming the suspected diagnosis?

<p>Bronchoalveolar lavage with PCR for Pneumocystis jiroveci (B)</p> Signup and view all the answers

A patient is diagnosed with community-acquired pneumonia (CAP) and is being treated as an outpatient. Three days later, the patient returns, reporting worsening symptoms despite adherence to the prescribed antibiotics. Which of the following is the MOST appropriate next step in management?

<p>Admit the patient to the hospital for intravenous antibiotics and further evaluation. (D)</p> Signup and view all the answers

A patient with a history of smoking presents with new onset ptosis, miosis and anhidrosis on the left side of their face, along with left shoulder pain. A mass is found on the apex of the lung. Which nerve structure is MOST likely affected?

<p>Sympathetic ganglion (D)</p> Signup and view all the answers

A patient presents with a persistent dry cough, shortness of breath, and fatigue. A chest X-ray reveals bilateral hilar lymphadenopathy and reticular infiltrates. Which of the following conditions is MOST likely?

<p>Sarcoidosis (C)</p> Signup and view all the answers

A patient recently returned from a holiday, where they stayed in a cheap hotel. They now have a persistent dry cough, neurological symptoms and hyponatraemia. Which of the following organisms is MOST likely the cause?

<p>Legionella pneumophila (C)</p> Signup and view all the answers

A patient’s spirometry results show a normal FEV1/FVC ratio but reduced FVC. Which of the following is the MOST likely underlying cause

<p>Pulmonary fibrosis (A)</p> Signup and view all the answers

A patient with asthma is using a short-acting beta2-agonist (SABA) more than twice a week for symptom relief. According to asthma guidelines, what does this indicate and what should the next step likely be?

<p>Poor asthma control; step up to a low-dose inhaled corticosteroid. (B)</p> Signup and view all the answers

A patient with small cell lung cancer develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?

<p>Ectopic production of ADH by the tumor cells (A)</p> Signup and view all the answers

A 60 year old patient, recently diagnosed with pneumonia, is not improving as expected on standard antibiotic treatment. Sputum and blood cultures are negative. They recall owning a pet parrot. What is the MOST likely cause?

<p>Chlamydia psittaci (B)</p> Signup and view all the answers

A patient with advanced lung cancer develops new onset of short-term memory loss, hallucinations, confusion and seizures. Which antibody is MOST likely associated with this presentation?

<p>Anti-Hu antibodies (A)</p> Signup and view all the answers

A patient with known asthma presents with acute respiratory distress. They are diaphoretic, using accessory muscles to breathe and are only able to speak in single words. Auscultation reveals minimal wheezing and significantly reduced air entry bilaterally. Despite nebulised bronchodilators and IV corticosteroids, their condition worsens, and their PaCO2 is rising. This patient is MOST likely suffering from which of the following pathological processes?

<p>Silent chest (C)</p> Signup and view all the answers

What does an FEV1/FVC ratio of less than 75% suggest?

<p>Obstructive lung disease (D)</p> Signup and view all the answers

Exposure to which of the following substances is MOST associated with mesothelioma?

<p>Asbestos (B)</p> Signup and view all the answers

Which of the following is the MOST significant risk factor for lung cancer?

<p>Cigarette smoking (A)</p> Signup and view all the answers

A patient presents to hospital with suspected pneumonia. Which of the following CURB-65 factors contribute to a score of 1?

<p>Confusion, respiratory rate of 30, blood pressure 90/60, age 65 (A)</p> Signup and view all the answers

What is the MOST appropriate antibiotic treatment for mild community acquired pneumonia?

<p>5 day course of oral antibiotics (amoxicillin or macrolide) (B)</p> Signup and view all the answers

Which of the following is NOT a typical trigger for triggering asthma?

<p>Lack of sleep (A)</p> Signup and view all the answers

Which of the following is a typical sign or symptom of lung cancer?

<p>Finger clubbing (D)</p> Signup and view all the answers

What is the FIRST-LINE investigation for suspected lung cancer?

<p>Chest X-ray (B)</p> Signup and view all the answers

Apart from recurrent pneumonia, which of the following is a sign or symptom of lung cancer?

<p>Haemoptysis (B)</p> Signup and view all the answers

Which of the following is the MOST common risk factor for developing lung cancer?

<p>Cigarette smoking (C)</p> Signup and view all the answers

Which of the following, seen on a chest X-ray, would MOST strongly suggest lung cancer?

<p>Hilar enlargement (D)</p> Signup and view all the answers

Which of the following conditions is MOST associated with asbestos exposure?

<p>Mesothelioma (A)</p> Signup and view all the answers

What is the purpose of using contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?

<p>To improve visualisation of blood vessels and tissues (D)</p> Signup and view all the answers

What is the typical treatment approach for small cell lung cancer (SCLC)?

<p>Chemotherapy and radiotherapy (D)</p> Signup and view all the answers

A patient presents with new onset ptosis, miosis and anhidrosis on the left side of their face, along with left shoulder pain. A mass is found on the apex of the lung. Which nerve structure is MOST likely affected?

<p>Sympathetic ganglion (B)</p> Signup and view all the answers

Which of the following findings on a chest X-ray would be MOST suggestive of mesothelioma, rather than other lung conditions, in a patient with a history of asbestos exposure?

<p>Pleural thickening and effusion (B)</p> Signup and view all the answers

A patient is diagnosed with small cell lung cancer (SCLC) and develops SIADH. Which mechanism BEST explains the underlying cause of hyponatremia in this patient?

<p>Ectopic ADH production by the tumor (C)</p> Signup and view all the answers

A patient has an FEV1/FVC ratio of less than 75%. What does this suggest?

<p>Obstructive lung disease (A)</p> Signup and view all the answers

Which of the following are the two key treatments for the long term management of asthma?

<p>Inhaled corticosteroid and short acting beta 2 agonist (C)</p> Signup and view all the answers

Which of the following scenarios MOST accurately describes how hospital aquired pneumonia is developed?

<p>After 48 hours of being admitted to hospital, the patient develops pneumonia (B)</p> Signup and view all the answers

Which antibiotic is MOST appropriate for treating mild community acquired pneumonia?

<p>Amoxicillin or a macrolide (A)</p> Signup and view all the answers

According to asthma management guidelines involving the 'stepwise ladder', what is the FIRST step?

<p>Add a short acting beta 2 agonist inhaler (D)</p> Signup and view all the answers

What are some typical triggers for asthma?

<p>All of the above (D)</p> Signup and view all the answers

Which of the organisms listed below is LEAST likely to respond to penicillins?

<p>Mycoplasma pneumoniae (D)</p> Signup and view all the answers

A patient is diagnosed with pneumonia and has a CRB-65 score of 1. What is the MOST appropriate action for this patient?

<p>Consider hospital referral (D)</p> Signup and view all the answers

Which pneumonia type is LEAST likely to be caused by Streptococcus pneumoniae?

<p>Aspiration pneumonia (B)</p> Signup and view all the answers

Which presentation is MOST suggestive of asthma, rather than another respiratory condition?

<p>Diurnal variability. Typically worse at night. (D)</p> Signup and view all the answers

When interpreting lung function tests, what does an FEV1/FVC ratio of less than 75% suggest?

<p>Obstructive lung disease (A)</p> Signup and view all the answers

Which of the following signs is associated with pneumonia?

<p>Dullness to percussion (A)</p> Signup and view all the answers

Which type of lung disease is associated with having a relatively good lung volume but air is only able to move in and out of the lungs slowly, due to obstruction?

<p>Obstructive lung disease (A)</p> Signup and view all the answers

Atypical pneumonia will NOT respond to which common medication?

<p>Penicillins (A)</p> Signup and view all the answers

In asthma management, what is the action of short acting beta 2 adrenergic receptor agonists?

<p>Cause relaxation in the smooth muscles of the airway. (C)</p> Signup and view all the answers

Which is MOST likely to cause pneumonia on a patient presenting with a new parrot?

<p>Chlamydia psittaci (B)</p> Signup and view all the answers

Which of the following is the MOST common cause of pneumonia in patients with cystic fibrosis?

<p>Pseudomonas aeruginosa (A)</p> Signup and view all the answers

Which of the options is MOST appropriate to treat moderate to severe community acquired pneumonia?

<p>7-10 day course of dual antibiotics (amoxicillin and macrolide) (C)</p> Signup and view all the answers

A patient has a dry cough, shortness of breath and sweats with poorly controlled HIV. What is the MOST likely causative organism for pneumonia?

<p>Pneumocystis jiroveci (A)</p> Signup and view all the answers

Which statement BEST describes the underlying process of restrictive lung disease?

<p>Restriction in the ability of the lungs to expand and fill with air (C)</p> Signup and view all the answers

What is the primary goal of adjuvant chemotherapy in a patient with non-small cell lung cancer after surgical resection?

<p>To eliminate any remaining cancer cells and reduce the risk of recurrence (B)</p> Signup and view all the answers

What is the MOST likely underlying cause of hyponatremia in a patient with small cell lung cancer (SCLC)?

<p>Ectopic ADH secretion (C)</p> Signup and view all the answers

A patient presents with pneumonia symptoms, a history of working in the construction industry with exposure to asbestos and also has an associated pleural effusion. Which malignancy should be MOST suspected?

<p>Mesothelioma (D)</p> Signup and view all the answers

TOM TIP: The 5 causes of atypical pneumonia mnemonic is 'Legions of psittaci MCQs'. What does the 'Qs' stand for?

<p>Q fever (coxiella burnetii) (B)</p> Signup and view all the answers

What is the expected FEV1/FVC ratio in a patient diagnosed with restrictive lung disease, and why?

<p>Greater than 75%, due to equally reduced FEV1 and FVC (C)</p> Signup and view all the answers

A patient with a history of smoking presents with shoulder pain and Horner's syndrome, and a mass in the pulmonary apex. Which nerve structure is MOST likely compressed on the sympathetic ganglion, causing these symptoms?

<p>Cervical sympathetic ganglion (D)</p> Signup and view all the answers

A patient is diagnosed with small cell lung cancer and develops Cushing’s syndrome. What is the MOST likely underlying mechanism?

<p>Ectopic secretion of adrenocorticotropic hormone (ACTH) (C)</p> Signup and view all the answers

Which is NOT a specific diagnostic criteria for acute asthma?

<p>SPO2 &gt; 92% (A)</p> Signup and view all the answers

Why does the trend of C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis commonly show a delayed response, spiking a day or two later despite the patient improving on their dual antibiotic treatment?

<p>CRP has a longer half-life than white blood cells (WBC) (A)</p> Signup and view all the answers

Which combination of diagnostic findings is MOST indicative of severe acute asthma? Auscultation results will reveal what?

<p>Minimal wheezing and significantly reduced air entry bilaterally, alongside peak flow results of (C)</p> Signup and view all the answers

A patient has been diagnosed with non-small cell lung cancer. The cancer has been isolated to a single area, and the patient is deemed suitable for surgery. Which of the following surgical procedures is typically offered FIRST-LINE?

<p>Lobectomy (removing the lung lobe containing the tumour) (C)</p> Signup and view all the answers

Which of the following is the LEAST common histological type of non-small cell lung cancer?

<p>Large cell carcinoma (B)</p> Signup and view all the answers

Which investigation is considered FIRST-LINE in suspected lung cancer?

<p>Chest X-ray (A)</p> Signup and view all the answers

Which of the following is NOT a recognised sign or symptom of lung cancer?

<p>Weight gain (C)</p> Signup and view all the answers

What is a common finding on a chest X-ray that may suggest lung cancer?

<p>Hilar enlargement (A)</p> Signup and view all the answers

Which of the following imaging modalities is BEST for identifying areas of metastasis in suspected lung cancer due to its ability to visualize metabolically active tissues?

<p>PET-CT scan (positron emission tomography-computed tomography) (D)</p> Signup and view all the answers

Surgery is typically offered as a FIRST-LINE treatment for which type of lung cancer when the disease is isolated to a single area?

<p>Non-small cell lung cancer (B)</p> Signup and view all the answers

A patient presents with facial swelling, shortness of breath, and dilated neck veins. Which complication of lung cancer is MOST likely?

<p>Superior vena cava obstruction (A)</p> Signup and view all the answers

What condition is suggested by the 'Pemberton’s sign'?

<p>Superior vena cava obstruction (B)</p> Signup and view all the answers

Which triad of symptoms characterizes Horner's syndrome?

<p>Ptosis, miosis, and anhydrosis (C)</p> Signup and view all the answers

A patient with small cell lung cancer develops hyponatremia. Which paraneoplastic syndrome is the MOST likely cause?

<p>SIADH (syndrome of inappropriate antidiuretic hormone secretion) (C)</p> Signup and view all the answers

A patient with squamous cell carcinoma of the lung develops hypercalcemia. What is the MOST likely underlying mechanism?

<p>Ectopic parathyroid hormone production (D)</p> Signup and view all the answers

What is one of the primary goals of adjuvant chemotherapy in patients with non-small cell lung cancer after surgical resection?

<p>To prevent recurrence by eliminating remaining microscopic disease (A)</p> Signup and view all the answers

Which lung malignancy is MOST strongly associated with asbestos inhalation?

<p>Mesothelioma (A)</p> Signup and view all the answers

Which classification BEST describes pneumonia if it develops more than 48 hours after hospital admission?

<p>Hospital-acquired pneumonia (D)</p> Signup and view all the answers

Which of the following chest signs is MOST indicative of pneumonia?

<p>Bronchial breath sounds (A)</p> Signup and view all the answers

Which CURB-65 scoring system component does the 'B' stand for?

<p>Blood pressure (C)</p> Signup and view all the answers

Which is the MOST common cause of community-acquired pneumonia?

<p>Streptococcus pneumoniae (B)</p> Signup and view all the answers

Which of the following organisms is LEAST likely to respond to penicillin antibiotics?

<p>Mycoplasma pneumoniae (B)</p> Signup and view all the answers

A patient diagnosed with pneumonia develops a pleural effusion. Which of the following complications is MOST concerning in this setting?

<p>Empyema (C)</p> Signup and view all the answers

A farmer develops a flu-like illness and is diagnosed with atypical pneumonia. Exposure to which organism is MOST likely?

<p>Coxiella burnetii (C)</p> Signup and view all the answers

What atypical pneumonia is MOST likely to be contracted from contact with infected birds such as parrots?

<p>Chlamydia psittaci (D)</p> Signup and view all the answers

Which of the following is MOST commonly used to treat fungal pneumonia caused by Pneumocystis jiroveci (PCP)?

<p>Co-trimoxazole (D)</p> Signup and view all the answers

What should patients with poorly controlled or new HIV with a low CD4 count be prescribed to protect against PCP?

<p>Co-trimoxazole (A)</p> Signup and view all the answers

Which organism is MOST likely responsible for pneumonia in a patient who presents with a dry cough, shortness of breath, and night sweats and has a history of poorly controlled HIV?

<p>Pneumocystis jiroveci (A)</p> Signup and view all the answers

Which of the following results is MOST indicative of obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (B)</p> Signup and view all the answers

Which of the following scenarios suggests a restrictive lung disease?

<p>Normal FEV1/FVC ratio with reduced FVC (A)</p> Signup and view all the answers

In asthma, what is the PATHOPHYSIOLOGICAL basis of airflow obstruction is?

<p>Bronchoconstriction (A)</p> Signup and view all the answers

What is the MOST appropriate action for a patient experiencing an acute asthma exacerbation with a peak expiratory flow rate (PEFR) of 40% of their personal best?

<p>Administer oxygen and bronchodilators (A)</p> Signup and view all the answers

A patient has a peak flow of 66% of their predicted best. Which severity category does this fall into?

<p>Moderate (C)</p> Signup and view all the answers

A patient with asthma is using their short-acting beta2-agonist (SABA) inhaler more than twice a week for symptom relief. What does this suggest about their asthma control?

<p>Their asthma is poorly controlled (B)</p> Signup and view all the answers

What is the MOST important action for a patient who has been hospitalised with acute asthma and is about to be discharged?

<p>Provide them with a written asthma action plan (B)</p> Signup and view all the answers

Which medication, commonly used in asthma management, requires monitoring of plasma levels due to its narrow therapeutic window?

<p>Theophylline (B)</p> Signup and view all the answers

In the context of asthma, what does the acronym MART stand for regarding inhaler therapy?

<p>Maintenance and Reliever Therapy (A)</p> Signup and view all the answers

Considering patients with a high pre-test probability of Asthma and are symptomatic, what is the most appropriate action a clinician should take, according to BTS/SIGN guidelines?

<p>Trial treatment (A)</p> Signup and view all the answers

A patient presents with pneumonia symptoms, a history of working in the construction industry with exposure to asbestos but WITHOUT an associated pleural effusion. Which malignancy should be HIGHLY suspected?

<p>Squamous cell carcinoma (B)</p> Signup and view all the answers

Which of the following statements BEST represents the difference in treatment approach between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC)?

<p>SCLC is usually treated with chemotherapy and radiation, whereas surgery is often the first-line treatment for NSCLC when feasible. (C)</p> Signup and view all the answers

What is the MOST likely causative organism of atypical pneumonia when a patient presents with a persistent dry cough, neurological symptoms, and hyponatraemia after recently staying in a cheap hotel?

<p>Legionella pneumophila (D)</p> Signup and view all the answers

According to the typical antibiotic course lengths, which of the following options is MOST appropriate for a patient diagnosed with moderate to severe community-acquired pneumonia?

<p>7-10 day course of dual antibiotics (amoxicillin and macrolide) (C)</p> Signup and view all the answers

In a patient with suspected pneumonia and a CRB-65 score of 2, with no other concerning symptoms. What is the MOST appropriate next step in management?

<p>Consider admitting the patient to hospital for further management (A)</p> Signup and view all the answers

A patient has been diagnosed with non-small cell lung cancer, and staging reveals the cancer has spread to distant sites. All treatments have failed, and the patient now requires end-of-life care. Which treatment is MOST appropriate?

<p>Endobronchial treatment with stents or debulking (B)</p> Signup and view all the answers

A patient presents with proximal muscle weakness that improves with repeated muscle use. A diagnosis of small-cell lung cancer is suspected. What specific finding would provide further evidence of the underlying cause of Lambert-Eaton Myasthenic Syndrome

<p>Antibodies against voltage-gated calcium channels (B)</p> Signup and view all the answers

What percentage of lung cancers are considered preventable?

<p>80% (B)</p> Signup and view all the answers

Which investigation is typically performed FIRST-LINE if a doctor suspects a patient may have lung cancer?

<p>Chest X-ray (D)</p> Signup and view all the answers

Which small cell lung cancer manifestation presents with short term memory impairment, hallucinations, confusion and seizures?

<p>Limbic encephalitis (B)</p> Signup and view all the answers

A patient presents with a combination of cough, fever, and pleuritic chest pain. On auscultation, bronchial breath sounds and coarse crackles are observed. What condition is MOST likely?

<p>Pneumonia (D)</p> Signup and view all the answers

What FEV1/FVC ratio result suggests obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (A)</p> Signup and view all the answers

What is the MOST likely cause of pneumonia in a patient with cystic fibrosis?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

According to NICE guidelines, what combination of medications should be prescribed INITIALLY for asthma management?

<p>Short-acting beta 2 agonist (SABA) and low-dose inhaled corticosteroid (ICS) (A)</p> Signup and view all the answers

What is the MOST appropriate first-line management for a patient with community-acquired pneumonia and a CURB-65 score of 0 or 1?

<p>Oral antibiotics at home (B)</p> Signup and view all the answers

A patient presents with suspected pneumonia. Which of the following chest examination findings is MOST indicative of pneumonia?

<p>Bronchial breath sounds and coarse crackles (C)</p> Signup and view all the answers

A person with a predicted peak flow of 600 achieves a score of 300 on their best attempt using a peak expiratory flow meter. What percentage of their predicted peak flow are they currently achieving?

<p>50% (C)</p> Signup and view all the answers

Which statement BEST describes the purpose of contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?

<p>To differentiate between benign and malignant lesions and assess lymph node involvement (C)</p> Signup and view all the answers

In the context of asthma management, what is the difference between the British Thoracic Society (BTS)/SIGN guidelines and the NICE guidelines regarding diagnosis?

<p>BTS/SIGN guidelines advise making a clinical diagnosis when there is a high clinical suspicion of asthma, while NICE guidelines advise against making a diagnosis without definitive testing. (B)</p> Signup and view all the answers

A patient presents with a persistent dry cough, shortness of breath, and fatigue. A chest X-ray reveals bilateral hilar lymphadenopathy and reticular infiltrates. What condition is MOST likely?

<p>Sarcoidosis (D)</p> Signup and view all the answers

What does the acronym 'TOM TIP' stand for in the context of atypical pneumonia causes?

<p>It is just a name with no meaning (A)</p> Signup and view all the answers

A patient with non-small cell lung cancer develops hypercalcemia due to ectopic parathyroid hormone production. Despite treatment, the hypercalcemia persists, and the patient develops severe polyuria and polydipsia. Which of the following mechanisms BEST contributes to these renal effects?

<p>Inhibition of aquaporin-2 channels in the collecting duct (B)</p> Signup and view all the answers

Which of the following patients presenting with pneumonia is MOST likely to have a normal inflammatory response, and thus, normal WBC and CRP markers?

<p>A patient immunocompromised due to poorly controlled HIV (B)</p> Signup and view all the answers

What is the MOST common early symptom of lung cancer?

<p>Persistent cough (A)</p> Signup and view all the answers

Which investigation is MOST appropriate for suspected lung cancer?

<p>Chest X-ray (C)</p> Signup and view all the answers

Which tumour location is MOST likely to cause Horner's syndrome?

<p>Pancoast tumour (B)</p> Signup and view all the answers

What is the MOST common cause of pneumonia?

<p>Streptococcus pneumoniae (C)</p> Signup and view all the answers

What is the MOST likely finding of restrictive lung disease during lung function tests?

<p>Normal or increased FEV1/FVC ratio with reduced FVC (B)</p> Signup and view all the answers

What is the MOST appropriate FIRST-LINE treatment for asthma?

<p>Short-acting beta 2 agonist (C)</p> Signup and view all the answers

What is the MOST common method of staging and assessment of metastasis in suspected lung cancer?

<p>PET-CT Scan (C)</p> Signup and view all the answers

Which pneumonia causing organism is MOST associated with recent travel?

<p>Legionella pneumophila (D)</p> Signup and view all the answers

A patient's asthma symptoms are not well controlled with an inhaled corticosteroid. According to NICE guidelines, what is the MOST appropriate next step?

<p>Add a leukotriene receptor antagonist. (D)</p> Signup and view all the answers

What is the MOST important measure in reducing the risk of lung cancer?

<p>Smoking cessation (A)</p> Signup and view all the answers

What is the MOST likely result of a recurrent laryngeal nerve palsy?

<p>Hoarse voice (A)</p> Signup and view all the answers

What is the MOST likely action of theophylline in the treatment of asthma?

<p>Reducing inflammation and relaxing bronchial smooth muscle (D)</p> Signup and view all the answers

Which description BEST describes the stepwise approach to asthma management?

<p>Adjusting medications according to symptom control. (A)</p> Signup and view all the answers

Which condition is MOST associated with the presence of anti-Hu antibodies?

<p>Limbic encephalitis (A)</p> Signup and view all the answers

A patient is diagnosed with pneumonia. What parameter is assessed in the CURB-65 score?

<p>Blood pressure (A)</p> Signup and view all the answers

What is the MOST likely antibiotic for mild community-acquired pneumonia?

<p>Amoxicillin or macrolide (B)</p> Signup and view all the answers

Which is the MOST appropriate action for a patient experiencing acute asthma with a PEFR of 40%?

<p>Initiating oxygen therapy and nebulized bronchodilators (B)</p> Signup and view all the answers

What is the MOST likely reason for hyponatremia in a patient with Legionella pneumonia?

<p>Syndrome of inappropriate ADH (SIADH) (A)</p> Signup and view all the answers

What is the BEST method of determining an asthmatic patient's peak flow?

<p>Take three attempts and record the best result. (C)</p> Signup and view all the answers

Which of these causes cannot typically be tested using a gram stain?

<p>Atypical Pneumonia (C)</p> Signup and view all the answers

Which feature is MOST indicative of pneumonia?

<p>Coarse crackles (D)</p> Signup and view all the answers

What is the MOST likely finding of compression of the superior vena cava?

<p>Facial swelling and distended neck veins (D)</p> Signup and view all the answers

A patient is diagnosed with Chlamydia psittaci. How did they MOST likely contract it?

<p>Exposure to birds (A)</p> Signup and view all the answers

What is the primary aim of surgery in non-small cell lung cancer?

<p>Curative (A)</p> Signup and view all the answers

Which finding would be MOST likely in a patient with poorly controlled HIV presenting with pneumonia?

<p>Pneumocystis jiroveci (PCP) (C)</p> Signup and view all the answers

A patient displays Pemberton's sign. What is the underlying cause for this?

<p>Superior vena cava obstruction (D)</p> Signup and view all the answers

Which statement BEST describes the function of a MART inhaler in asthma management?

<p>It replaces all other inhalers and is used both regularly and as needed. (A)</p> Signup and view all the answers

Which organism is LEAST likely to respond to penicillin antibiotics?

<p>Mycoplasma pneumoniae (B)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with shortness of breath. Which condition is MOST associated with this exposure?

<p>Mesothelioma (A)</p> Signup and view all the answers

According to NICE guidelines, what action should a clinician take if they have a high clinical suspicion of asthma?

<p>Trial treatment (A)</p> Signup and view all the answers

What FEV1/FVC ratio is MOST indicative of obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (C)</p> Signup and view all the answers

A patient with non-small cell lung cancer (NSCLC) is being considered for adjuvant chemotherapy in addition to surgery. What is the PRIMARY goal of adjuvant chemotherapy in this scenario?

<p>To prevent recurrence by eliminating micrometastatic disease. (B)</p> Signup and view all the answers

A patient with untreated pneumonia develops marked hypotension and confusion despite broad-spectrum antibiotic therapy being administered. A chest X-ray demonstrates a large unilateral pleural effusion. What is the MOST likely cause of this acute deterioration?

<p>Bacterial Empyema with Resultant Sepsis. (A)</p> Signup and view all the answers

What key risk is associated with Theophylline, therefore indicating the necessity for testing?

<p>Narrow therapeutic window (D)</p> Signup and view all the answers

A patient presents with pneumonia-like symptoms, neurological abnormalities and also has hyponatraemia. Which factor in their history would MOST strongly point towards Legionella as the causative organism?

<p>Recent travel with a stay in a hotel (B)</p> Signup and view all the answers

Researchers are studying the long-term outcomes of patients diagnosed with small cell lung cancer (SCLC) who initially responded well to chemotherapy and radiotherapy. They aim to identify predictive factors for survival beyond five years. Which of the following factors, if found to be significantly associated with prolonged survival in this patient population, would be the MOST novel and practice-changing discovery?

<p>Persistent expression of PD-L1 on circulating tumor cells over time. (B)</p> Signup and view all the answers

A researcher aims to investigate the impact of a novel inhaled medication on airway hyperresponsiveness in patients with refractory asthma. To obtain the MOST direct and quantifiable measure of airway responsiveness before and after treatment, which assessment method should the researcher prioritize?

<p>Bronchial challenge test with methacholine. (C)</p> Signup and view all the answers

Which of the following investigations allows for detailed assessment of a lung tumor and ultrasound-guided biopsy?

<p>Bronchoscopy with endobronchial ultrasound (EBUS) (A)</p> Signup and view all the answers

What pathological process is indicated by an FEV1/FVC ratio of less than 75%?

<p>Obstructive lung disease (C)</p> Signup and view all the answers

Which of the following clinical scenarios poses the HIGHEST risk for Pneumocystis jiroveci pneumonia (PCP)?

<p>A patient with poorly controlled HIV and a low CD4 count. (A)</p> Signup and view all the answers

Apart from shortness of breath, which other symptoms commonly co-occur with superior vena cava obstruction?

<p>Facial swelling and distended veins in the neck and upper chest. (B)</p> Signup and view all the answers

Which of the following is the MOST characteristic presentation of Chlamydophila pneumoniae infection?

<p>A school-aged child with a mild to moderate chronic pneumonia and wheeze. (D)</p> Signup and view all the answers

A patient is being discharged with community acquired pneumonia but has a penicillin allergy, what antibiotic would be MOST suitable?

<p>Clarithromycin (C)</p> Signup and view all the answers

What is the recommended duration of antibiotic treatment for mild community-acquired pneumonia (CAP)?

<p>5 days (D)</p> Signup and view all the answers

Which combination of factors is DEFINITIVE for severe acute asthma compared to moderate asthma?

<p>PEFR 40% predicted, respiratory rate &gt;25, heart rate &gt;110, unable to complete sentences (A)</p> Signup and view all the answers

Which organism is MOST closely associated with infected water supplies or air conditioning units, potentially causing hyponatremia?

<p>Legionella pneumophila (C)</p> Signup and view all the answers

According to BTS/SIGN guidelines, how should a clinician initially manage a patient with a presentation with high clinical suspicion of asthma?

<p>Start treatment (B)</p> Signup and view all the answers

What is the MOST likely finding upon auscultation of a patient's chest indicating pneumonia?

<p>Bronchial breath sounds and focal coarse crackles (D)</p> Signup and view all the answers

What is the MOST common histological type of lung cancer?

<p>Squamous cell carcinoma (A)</p> Signup and view all the answers

Which of the following is the MOST appropriate first-line investigation for suspected lung cancer?

<p>Chest X-ray (D)</p> Signup and view all the answers

Which of the following is a typical symptom that may suggest the possibility of lung cancer?

<p>Recurrent pneumonia (B)</p> Signup and view all the answers

A patient diagnosed with pneumonia develops confusion, a respiratory rate of 32, and a blood pressure of 85/55. According to the CRB-65 scoring system, what is their score?

<p>3 (B)</p> Signup and view all the answers

What is the underlying cause of hoarseness associated with lung cancer?

<p>Pressure on or damage to the recurrent laryngeal nerve (C)</p> Signup and view all the answers

What is the expected FEV1/FVC ratio in restrictive lung disease, and what factors may lead to a reduced overall lung capacity?

<p>Greater than 75%; due to interstitial lung disease or scoliosis. (B)</p> Signup and view all the answers

Which of the following diagnostic findings is MOST indicative of severe acute asthma?

<p>A peak expiratory flow rate (PEFR) of 40% of predicted and inability to complete sentences. (C)</p> Signup and view all the answers

In non-small cell lung cancer (NSCLC), what is the typical FIRST-LINE surgical treatment option for patients with localized disease?

<p>Lobectomy (C)</p> Signup and view all the answers

What is the PRIMARY mechanism by which inhaled corticosteroids (ICS) help manage asthma symptoms?

<p>Reducing inflammation and reactivity of the airways (C)</p> Signup and view all the answers

After sending the appropriate investigations for pneumonia, why does C-reactive protein (CRP) trend show a delayed response, peaking a day or two later despite clinical improvement with antibiotics?

<p>CRP production has a delayed response, so may be low on first presentation, and spike later despite the patient improving on treatment. (B)</p> Signup and view all the answers

What is the significance of Pemberton's sign, often observed in patients with certain mediastinal masses, and how does it manifest clinically?

<p>Facial congestion and cyanosis when raising the hands over the head; associated with superior vena cava obstruction. (B)</p> Signup and view all the answers

What recommendation would NICE give in the context of a patient with a CRB-65 score of 2?

<p>Consider hospital admission (C)</p> Signup and view all the answers

A farmer presents with a flu-like illness and signs of pneumonia after exposure to animals. Which atypical pneumonia organism is MOST likely suspected?

<p>Coxiella burnetii (A)</p> Signup and view all the answers

How is the effectiveness of bronchodilator treatment BEST assessed with respect to spirometry results?

<p>Comparing FEV1 before and after bronchodilator administration. (B)</p> Signup and view all the answers

What clinical triad characterises Horner's syndrome, and how is it typically associated with lung cancer?

<p>Partial ptosis, anhidrosis, and miosis, caused by a tumor pressing on the sympathetic ganglion. (D)</p> Signup and view all the answers

What is the MOST preventable cause of lung cancer?

<p>Cigarette smoking (A)</p> Signup and view all the answers

How is hospital-acquired pneumonia defined, and what is the minimum time frame for its onset post-admission?

<p>Pneumonia developing more than 48 hours after hospital admission. (D)</p> Signup and view all the answers

In the long-term management of asthma, which medication is used to provide quick, short-term relief during acute bronchoconstriction?

<p>Short acting beta 2 adrenergic receptor agonists (C)</p> Signup and view all the answers

What key feature differentiates restrictive lung disease from obstructive lung disease regarding airflow?

<p>Reduced lung volume but air is able to move in and out of the lungs easily (C)</p> Signup and view all the answers

In older smokers presenting with Lambert-Eaton syndrome, what underlying condition should be strongly suspected?

<p>Small cell lung cancer (B)</p> Signup and view all the answers

Which of the following combinations of factors would give you a CRB-65 score of 1?

<p>Blood pressure 92/62, respiratory rate of 31, aged 66 and alert (D)</p> Signup and view all the answers

What potential issue can Haemophilus influenzae potentially cause?

<p>Community Acquired Pneumonia (B)</p> Signup and view all the answers

According to NICE guidelines, what is the FIRST step in the long-term management of asthma after prescribing a short-acting beta 2 agonist (SABA) inhaler?

<p>Add a regular low dose inhaled corticosteroid (C)</p> Signup and view all the answers

Which of the following are typical triggers precipitating asthma symptoms?

<p>Infection, exercise, and cold, damp or dusty air (C)</p> Signup and view all the answers

Which paraneoplastic syndrome associated with small cell lung cancer (SCLC) leads the immune system to produce antibodies against voltage-gated calcium channels on presynaptic terminals of motor neurons?

<p>Lambert-Eaton myasthenic syndrome (B)</p> Signup and view all the answers

The TOM TIP mnemonic can recall the 5 causes of atypical pneumonia 'Legions of psittaci MCQs'. Which Q is this mnemonic referring to?

<p>Q fever (Coxiella burnetii) (B)</p> Signup and view all the answers

A patient with a history of asthma presents with shortness of breath, wheezing, and a tight chest. Their peak expiratory flow (PEF) is 60% of their personal best. Should you be concerned?

<p>Moderate Asthma (D)</p> Signup and view all the answers

Which of the following is a common symptom of pneumonia?

<p>Productive cough (C)</p> Signup and view all the answers

According to the NICE guidelines for asthma management, what is the INITIAL step?

<p>Add a short-acting beta 2 agonist (SABA) inhaler (A)</p> Signup and view all the answers

What percentage of lung cancers are estimated to be preventable through lifestyle and environmental changes?

<p>80% (C)</p> Signup and view all the answers

In restrictive lung disease, why is the FEV1/FVC ratio typically normal or increased?

<p>Due to the absence of airway obstruction (D)</p> Signup and view all the answers

What is the MOST likely organism responsible for pneumonia in a patient with cystic fibrosis?

<p>Pseudomonas aeruginosa (B)</p> Signup and view all the answers

Which of the following results from lung function tests indicates obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (C)</p> Signup and view all the answers

Which of the following is a typical symptom of superior vena cava obstruction?

<p>Facial swelling (D)</p> Signup and view all the answers

A patient presents with a dry cough, night sweats, and shortness of breath. They have a history of poorly controlled HIV. Which pneumonia-causing organism is MOST likely?

<p>Pneumocystis jiroveci (C)</p> Signup and view all the answers

What is the BEST description of the mechanism of action of short-acting beta 2 agonists in asthma management?

<p>Relaxing the smooth muscles of the airways, causing bronchodilation (B)</p> Signup and view all the answers

What combination of medications is typically found in a Maintenance and Reliever Therapy (MART) inhaler?

<p>Inhaled corticosteroid and fast-acting long-acting beta 2 agonist (C)</p> Signup and view all the answers

What does 'Pemberton’s sign' indicate in the context of lung cancer complications?

<p>Superior vena cava obstruction (C)</p> Signup and view all the answers

What is the MOST common presenting symptom of pneumonia?

<p>Productive cough (C)</p> Signup and view all the answers

A patient with suspected pneumonia has a CRB-65 score of 2. What would you expect the next step to be?

<p>Consider hospital admission (C)</p> Signup and view all the answers

Which of the following is MOST likely to lead to Q fever?

<p>Exposure to animals and their bodily fluids (D)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with shortness of breath and chest pain. Why is mesothelioma suspected?

<p>Affects the mesothelial cells of the pleura (D)</p> Signup and view all the answers

A patient has pneumonia and develops hyponatraemia. Which organism is MOST likely responsible?

<p>Legionella pneumophila (B)</p> Signup and view all the answers

Which antibodies are associated with Limbic Encephalitis?

<p>Anti-Hu antibodies (A)</p> Signup and view all the answers

A patient who owns parrots presents with the typical symptoms of pneumonia. The patient's pneumonia does not respond to penicillin based medications. What is the MOST likely infectious cause of the pneumonia?

<p>Chlamydia psittaci (A)</p> Signup and view all the answers

A patient with newly diagnosed community-acquired pneumonia develops a pleural effusion. Analysis of the pleural fluid reveals a high neutrophil count, a low pH, and the presence of bacteria. This is MOST suggestive of what management change?

<p>Performing a therapeutic thoracentesis or chest drain insertion (B)</p> Signup and view all the answers

Which of the following is a common symptom of lung cancer?

<p>Finger clubbing (C)</p> Signup and view all the answers

In suspected lung cancer, which of the following is typically the initial investigation performed?

<p>Chest X-ray (B)</p> Signup and view all the answers

Which of the following most accurately describes the purpose of contrast enhancement in CT scans for suspected lung cancer?

<p>To improve the visibility of blood vessels and tissues (A)</p> Signup and view all the answers

A patient presents with facial swelling and shortness of breath. Which of the following conditions is MOST likely?

<p>Superior vena cava obstruction (B)</p> Signup and view all the answers

What organisms are NOT typically treated using penicillins?

<p>Atypical pneumonia organisms (D)</p> Signup and view all the answers

Which of the following does the 'B' represent in the CURB-65 scoring system for pneumonia severity?

<p>Blood pressure (D)</p> Signup and view all the answers

In the context of community-acquired pneumonia, what CRB-65 score suggests referral to hospital should be considered?

<p>1 (A)</p> Signup and view all the answers

What does FEV1 represent in lung function tests?

<p>Forced Expiratory Volume in 1 second (C)</p> Signup and view all the answers

Which finding on lung function tests is MOST indicative of obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (C)</p> Signup and view all the answers

Apart from respiratory conditions, in which other medical situation are lung function tests MOST helpful?

<p>Neuromuscular disorders (C)</p> Signup and view all the answers

What is the primary action of Theophylline?

<p>Dilating bronchial smooth muscle (B)</p> Signup and view all the answers

What is the standard recommendation when using a peak flow meter?

<p>Record the best of three attempts (C)</p> Signup and view all the answers

Other than infection, what is a typical trigger for asthma?

<p>Exercise (D)</p> Signup and view all the answers

According to NICE guidelines, what action should a clinician take if they highly suspect a diagnosis of Asthma clinically?

<p>Refer to a 'diagnostic hub' for assessment and testing (A)</p> Signup and view all the answers

In long-term asthma management, which of the following medications is used to reduce inflammation and reactivity in the airways?

<p>Beclometasone (C)</p> Signup and view all the answers

What is the function of short acting beta 2 adrenergic receptor agonists in asthma management?

<p>They cause smooth muscles of the airways to relax (C)</p> Signup and view all the answers

What percentage of predicted peak flow is indicative of severe acute asthma?

<p>Between 33% and 50% (A)</p> Signup and view all the answers

Which of the following causes atypical pneumonia and may cause a rash called erythema multiforme, characterised by varying sized 'target lesions'?

<p>Mycoplasma pneumoniae (B)</p> Signup and view all the answers

What is the most common cause of pneumonia in patients with cystic fibrosis?

<p>Pseudomonas aeruginosa (A)</p> Signup and view all the answers

What is suggested by a patient with asthma, using their short-acting beta2-agonist (SABA) more than twice a week?

<p>Inadequate asthma control (A)</p> Signup and view all the answers

A patient presents with pneumonia and is being investigated. Which investigation would be performed if pneumonia was caused by legionella?

<p>Legionella and pneumococcal urinary antigens (D)</p> Signup and view all the answers

What do episodic symptoms and diurnal variability, worse at night, suggest?

<p>Asthma (C)</p> Signup and view all the answers

A patient presents with a dry cough, night sweats and progressive shortness of breath. They have a known history of HIV. What should be your MOST suspected organism?

<p>Pneumocystis jirovecii (A)</p> Signup and view all the answers

Which of the following would be the MOST appropriate combination of medications in a MART inhaler?

<p>Salmeterol and fluticasone (A)</p> Signup and view all the answers

A patient is diagnosed with community-acquired pneumonia and is being treated as an outpatient. Three days later, the patient returns. What would be the MOST appropriate step?

<p>Consider an alternative diagnosis (A)</p> Signup and view all the answers

A patient's spirometry results show equal reductions in FEV1 and FVC. The FEV1/FVC ratio is 80%. This pattern is MOST indicative of which type of lung disease?

<p>Restrictive lung disease (C)</p> Signup and view all the answers

In a suspected case of lung cancer, which of the following chest X-ray findings would be MOST concerning?

<p>Hilar enlargement (D)</p> Signup and view all the answers

A patient presents with cough, wheeze and shortness of breath with a history of asthma, using their SABA more than twice a week. What does this indicate?

<p>Inadequate asthma control (C)</p> Signup and view all the answers

A patient’s spirometry results show an FEV1/FVC ratio of 65%. What does this suggest?

<p>Obstructive lung disease (A)</p> Signup and view all the answers

A doctor reviews a patient who has been treated for pneumonia, and their inflammatory markers spike higher a day or two later despite the patient clinically improving on treatment. What is the MOST likely explanation for this?

<p>Normal inflammatory response (A)</p> Signup and view all the answers

A patient with a new parrot presents to the clinic with sudden onset of pneumonia-like symptoms, which organism is MOST likely responsible?

<p>Chlamydia psittaci (B)</p> Signup and view all the answers

A patient presents with shortness of breath, night sweats, and a dry cough. They have poorly controlled HIV. After confirming the diagnosis, what is the MOST appropriate treatment?

<p>Trimethoprim/sulfamethoxazole (D)</p> Signup and view all the answers

A known smoker presents with shoulder pain and Horner’s syndrome symptoms, suggestive of lung cancer. What is the MOST likely location of the tumour?

<p>Pulmonary apex (A)</p> Signup and view all the answers

A patient with poorly controlled asthma and a history of hay fever presents with increased wheezing, shortness of breath, and a non-productive cough for the past week, and reports that they've increased their SABA use without relief. Auscultation reveals bilateral high-pitched wheezes, despite use of their SABA inhaler just 10 minutes prior. Peak flow is at 40%. Which of the following is the MOST appropriate next step in the immediate management of this patient?

<p>Administer nebulized ipratropium bromide in addition to repeated salbutamol (B)</p> Signup and view all the answers

A patient with a known history of well-controlled asthma presents with acute respiratory distress. They are diaphoretic, using accessory muscles to breathe, and are only able to speak in single words. Auscultation reveals minimal wheezing with significantly reduced air entry bilaterally. Nebulised bronchodilators and IV corticosteroids have been administered, but their PaCO2 is still rising. Which of the following pathological processes is MOST likely occurring in this patient?

<p>Worsening respiratory muscle fatigue with subsequent alveolar hypoventilation. (A)</p> Signup and view all the answers

A 60-year-old patient with a 40 pack-year smoking history presents with new-onset short-term memory loss, hallucinations, confusion, and seizures. MRI of the brain shows inflammation in the limbic system. Bronchoscopy reveals small cell lung cancer. Which antibody is MOST likely associated with this presentation?

<p>Anti-Hu antibodies (A)</p> Signup and view all the answers

Which of these symptoms would suggest a diagnosis of pneumonia?

<p>Sharp chest pain worse on inspiration (D)</p> Signup and view all the answers

What is the MOST common presenting symptom in people with penumonia?

<p>Cough (A)</p> Signup and view all the answers

What does an FEV1/FVC ratio of less than 75% suggest with lung function tests?

<p>Obstructive lung disease (C)</p> Signup and view all the answers

What signs and symptoms are associated with superior vena cava obstruction?

<p>Facial swelling, shortness of breath and distended veins in the neck and upper chest (B)</p> Signup and view all the answers

Which of the following malignancies is MOST closely associated with asbestos exposure?

<p>Mesothelioma (B)</p> Signup and view all the answers

What is the MOST significant risk factor for developing lung cancer?

<p>Cigarette smoking (B)</p> Signup and view all the answers

Which of the following findings on a chest X-ray would MOST strongly suggest lung cancer?

<p>Hilar enlargement (B)</p> Signup and view all the answers

What factors need to be considered to give a patient a CRB-65 score of 1?

<p>Blood pressure &lt; 90 systolic (D)</p> Signup and view all the answers

What is the typical treatment approach for small cell lung cancer?

<p>Chemotherapy and radiotherapy (A)</p> Signup and view all the answers

Which of the following describes the definition of hospital acquired pneumonia?

<p>Pneumonia diagnosed more than 48 hours after hospital admission (C)</p> Signup and view all the answers

A patient has a productive cough, fever and pleuritic chest pain. On examination their chest shows bronchial breath sounds and coarse crackles on the right side. What is the MOST likely diagnosis?

<p>Pneumonia (C)</p> Signup and view all the answers

What does a presentation of acute respiratory distress, diaphoresis, accessory muscle use, single-word speech, minimal wheezing and reduced air entry bilaterally suggest?

<p>Acute exacerbation of asthma with impending respiratory failure (D)</p> Signup and view all the answers

A patient has an FEV1/FVC ratio of less than 75%. Which classification is this?

<p>Obstructive Lung Disease (D)</p> Signup and view all the answers

Which of the following presents MOST suspect of asthma, rather than another respiratory condition?

<p>Episodic symptoms (D)</p> Signup and view all the answers

A patient with long term asthma can have difficulty with exercise tolerance, so that their asthma can be controlled and allow them to continue to participate in sport, what medication can be used to combat this?

<p>LABA (A)</p> Signup and view all the answers

If the inflammatory markers of WBC and CRP are not raised despite a case presenting as a severe infection, what could be the cause to this?

<p>The patient is immunocompromised (A)</p> Signup and view all the answers

Which of the following is NOT typically associated with small cell lung cancer due to its neuroendocrine properties?

<p>Pleural effusion (D)</p> Signup and view all the answers

A patient presents with a cough, shortness of breath, and chest pain, and is subsequently diagnosed with pneumonia. Which symptom is MOST indicative of pleuritic chest pain?

<p>A sharp chest pain that worsens on inspiration (B)</p> Signup and view all the answers

A previously healthy patient develops a pneumonia. Atypical pneumonia is suspected. Which of the following historical details would MOST strongly suggest Mycoplasma pneumoniae as the causative organism?

<p>The presence of target lesions on the skin (B)</p> Signup and view all the answers

A patient has suspected restrictive lung disease. The FEV1/FVC ratio is normal, but the FVC is reduced. This suggests that the underlying issue is that the:

<p>lungs cannot fully expand, limiting the total volume of air. (C)</p> Signup and view all the answers

A patient with suspected asthma has a negative response to initial spirometry. According to NICE guidelines, what is the MOST appropriate next step?

<p>Refer the patient to a specialist for further investigations such as peak flow variability testing (B)</p> Signup and view all the answers

Which of the following is TRUE regarding the technique for measuring peak expiratory flow rate (PEFR)?

<p>The patient should stand tall, seal their lips around the mouthpiece, and blow as hard and fast as possible. (C)</p> Signup and view all the answers

A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following statements BEST describes how this inhaler should be used?

<p>Use regularly every day as a preventer, and also use for quick relief of symptoms. (B)</p> Signup and view all the answers

A patient presents with a 3-day history of cough, fever, and shortness of breath. Auscultation reveals bronchial breath sounds and coarse crackles in the right lower lobe. Initial investigations reveal a CRP of 15mg/L. According to NICE guidelines, what is the MOST appropriate next step?

<p>Commence a 5 day course of oral amoxicillin (C)</p> Signup and view all the answers

Compared to non-small cell lung cancer, what is generally TRUE regarding the prognosis for small cell lung cancer (SCLC)?

<p>Prognosis is generally worse for small cell lung cancer compared with non-small cell lung cancer. (D)</p> Signup and view all the answers

Which of the following historical details would MOST suggest Coxiella burnetii (Q fever) as the cause of the patient's pneumonia?

<p>Exposure to farm animals. (C)</p> Signup and view all the answers

In restrictive lung disease, what results would you expect to see when interpreting lung function tests?

<p>A normal or raised FEV1/FVC ratio with a reduced FVC. (B)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with shortness of breath. Which of the following is the MOST likely diagnosis?

<p>Mesothelioma (A)</p> Signup and view all the answers

Which statement BEST describes the typical findings of a unilateral pleural effusion caused by lung cancer?

<p>The effusion is typically exudative. (C)</p> Signup and view all the answers

A patient's asthma symptoms are well controlled on a low dose inhaled corticosteroid (ICS) and as-needed short-acting beta-2 agonist (SABA). At their annual review, they report using their SABA more than twice a week. What is the MOST appropriate next step in their management?

<p>Add a leukotriene receptor antagonist (LTRA). (C)</p> Signup and view all the answers

How does the Theophylline help patients with asthma?

<p>By causing bronchodilation and reducing inflammation (C)</p> Signup and view all the answers

Following a diagnosis of small cell lung cancer, a patient develops Cushing's syndrome. What is the MOST likely underlying mechanism causing this paraneoplastic syndrome?

<p>Ectopic secretion of adrenocorticotropic hormone (ACTH) (D)</p> Signup and view all the answers

Of the options presented, which paraneoplastic syndrome is MOST associated with small cell lung cancer?

<p>Ectopic ACTH secretion (B)</p> Signup and view all the answers

A patient with pneumonia is admitted to hospital and treated with intravenous antibiotics. After a few days, the patient clinically improves, but their inflammatory markers (CRP & WBC) initially increase. What statement BEST describes why this happens?

<p>CRP commonly shows a delayed response so may be low on first presentation then spike very high a day or two later despite the patient improving on treatment. (A)</p> Signup and view all the answers

A patient develops a lung infection following admission to hospital after 5 days? What would this be classified as?

<p>Hospital Acquired Pneumonia (B)</p> Signup and view all the answers

A patient presents with signs and symptoms of acute asthma exacerbation. Which of the following indicates a life-threatening presentation of reduced peak expiratory flow rate (PEFR)?

<p>32% of predicted (D)</p> Signup and view all the answers

Approximately what percentage of lung cancer cases are estimated to be preventable?

<p>80% (A)</p> Signup and view all the answers

TOM TIP: Legions of psittaci MCQs - which conditions are psittaci linked to?

<p>Parrot owner (D)</p> Signup and view all the answers

What percentage of lung cancers are estimated to be preventable through lifestyle and environmental modifications?

<p>80% (D)</p> Signup and view all the answers

Which of the following is the MOST common presenting sign or symptom of pneumonia?

<p>Productive cough (C)</p> Signup and view all the answers

What is the typical action of short-acting beta 2 agonists in the short-term management of asthma symptoms?

<p>Relaxing bronchial smooth muscle to cause bronchodilation (A)</p> Signup and view all the answers

Which of the following conditions is MOST associated with prior asbestos exposure?

<p>Mesothelioma (D)</p> Signup and view all the answers

A new diagnosis of pneumonia is confirmed in a patient. Which investigation is MOST essential to conduct?

<p>Chest X-ray (C)</p> Signup and view all the answers

Which set of symptoms is MOST commonly associated with superior vena cava obstruction?

<p>Facial swelling, shortness of breath, and distended neck veins (D)</p> Signup and view all the answers

Which of the following suggests obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (B)</p> Signup and view all the answers

Which of these patient descriptions is MOST suggestive of a diagnosis of asthma rather than another respiratory condition?

<p>A persistent dry cough that worsens after exercise, accompanied with wheezing (A)</p> Signup and view all the answers

According to the BTS/SIGN asthma guidelines, what is the recommended approach when there is a high clinical suspicion of asthma?

<p>A trial of treatment is commenced (A)</p> Signup and view all the answers

A patient with suspected pneumonia has a CRB-65 score of 1 in the community. According to NICE guidelines, what is the MOST appropriate next step?

<p>Suggest considering referral to the hospital (B)</p> Signup and view all the answers

What is the MOST common etiology of community-acquired pneumonia (CAP)?

<p>Streptococcus pneumoniae (A)</p> Signup and view all the answers

Which of the following organisms causing pneumonia is LEAST likely to respond to treatment with penicillin antibiotics?

<p>Mycoplasma pneumoniae (C)</p> Signup and view all the answers

A patient presents with features of pneumonia but has had recent contact with a parrot. Which organism is MOST likely to be responsible?

<p>Chlamydia psittaci (D)</p> Signup and view all the answers

What flow rate reading on a peak expiratory flow meter (PEFR) would indicate severe asthma?

<p>33-50% of predicted (B)</p> Signup and view all the answers

A patient presents with a dry cough, shortness of breath, and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which causative organism is MOST likely responsible for pneumonia?

<p>Pneumocystis jiroveci (PCP) (B)</p> Signup and view all the answers

What is the PRIMARY purpose of performing contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?

<p>To improve the visualization of blood vessels and tissues (C)</p> Signup and view all the answers

After starting treatment for pneumonia, a patient's CRP levels spike higher a day or two later despite clinically improving on antibiotics. What is the MOST likely explanation for this?

<p>CRP commonly shows a delayed response despite clinical improvement (A)</p> Signup and view all the answers

A patient is diagnosed with community-acquired pneumonia (CAP) and is being treated as an outpatient. Three days later, the patient returns, reporting worsening symptoms despite antibiotic adherence. What is the MOST appropriate next step?

<p>Admit the patient to the hospital for intravenous antibiotics and further evaluation (C)</p> Signup and view all the answers

A patient presents with cough, wheeze, and shortness of breath. They use their short-acting beta2-agonist inhaler more than twice a week. What does this indicate regarding their asthma control?

<p>Their asthma is partly controlled and requires a step-up in therapy (C)</p> Signup and view all the answers

Which of the following sets of diagnostic results is MOST indicative of severe acute asthma?

<p>Accessory muscle use with minimal wheezing and significantly reduced air entry on auscultation (D)</p> Signup and view all the answers

A patient has been prescribed Theophylline for their asthma. How soon after each dose change should their plasma levels be monitored?

<p>3 days (B)</p> Signup and view all the answers

What is the MOST likely diagnosis in a patient presenting with facial congestion and cyanosis when raising their hands over their head?

<p>Pemberton's sign (B)</p> Signup and view all the answers

A patient has an FEV1/FVC ratio of 85% and reduced FVC. What does this suggest?

<p>Restrictive lung Defect (C)</p> Signup and view all the answers

A patient is diagnosed with small cell lung cancer (SCLC) and develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?

<p>Ectopic secretion of ADH by the tumour cells (C)</p> Signup and view all the answers

What findings are associated with Horner's syndrome?

<p>Partial ptosis, anhydrosis and miosis (C)</p> Signup and view all the answers

In asthma management, what is the role of inhaled corticosteroids (ICS)?

<p>To reduce inflammation and reactivity of the airways (A)</p> Signup and view all the answers

Which of the following is the MOST likely underlying cause of Cushing’s syndrome in a patient with small cell lung cancer?

<p>Ectopic secretion of adrenocorticotropic hormone (ACTH) (D)</p> Signup and view all the answers

A patient presents with unilateral wheezing. What does this suggest?

<p>Focal lesion or infection (D)</p> Signup and view all the answers

A patient presents with a history of smoking along with shoulder pain and Horner's syndrome. Which location is the MOST likely primary site of the tumor causing these symptoms?

<p>Pulmonary apex (B)</p> Signup and view all the answers

A patient diagnosed with small cell lung cancer develops short term memory loss, hallucinations, confusion and seizures. Which antibody is MOST associated with this presentation?

<p>Anti-Hu antibodies (D)</p> Signup and view all the answers

Which community acquired organisms are MOST commonly associated with pneumonia in patients who have cystic fibrosis?

<p>Pseudomonas aeruginosa (C)</p> Signup and view all the answers

Which of the following is the MOST likely cause of pneumonia in a patient with a new pet parrot?

<p>Chlamydia psittaci (A)</p> Signup and view all the answers

Referring to the 'TOM TIP' mnemonic - 'Legions of psittaci MCQs', what does 'Qs' stand for?

<p>Q fever (Coxiella burnetii) (B)</p> Signup and view all the answers

Which lung diseases are categorised by normal or raised FEV1/FVC ratio >75, but equally reduced FEV1 and FVC?

<p>Restrictive Lung Disease (C)</p> Signup and view all the answers

A patient's spirometry results show FEV1 to be 2L and FVC to be 4L, so the ratio will not exceed 75%. This suggests what lung disease?

<p>Obstructive Lung Defect (C)</p> Signup and view all the answers

What percentage of lung cancers are thought to be preventable?

<p>80% (A)</p> Signup and view all the answers

Which of the following symptoms is LEAST likely to be associated with pneumonia?

<p>Weight gain (A)</p> Signup and view all the answers

What does FEV1 measure in lung function tests?

<p>Volume of air exhaled in one second (D)</p> Signup and view all the answers

A patient with suspected pneumonia has a CRB-65 score of 2. Which of the following is the MOST appropriate action, according to NICE guidelines?

<p>Consider hospital admission (D)</p> Signup and view all the answers

Which of the following should be included in the advice to a patient to ensure an accurate reading when using a peak flow meter?

<p>Stand tall, take a deep breath, seal lips around the device, and blow as hard and fast as possible. (C)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with signs suggestive of a lung malignancy. Which finding would MOST specifically indicate mesothelioma rather than other common lung conditions?

<p>Pleural thickening (D)</p> Signup and view all the answers

A patient is prescribed Theophylline. What regular monitoring is required during their treatment, and when should it occur?

<p>Plasma Theophylline levels, 5 days after treatment initiation and 3 days after each dose change (A)</p> Signup and view all the answers

A patient who owns a parrot presents with pneumonia-like symptoms. Which organism is MOST likely responsible?

<p>Chlamydia psittaci (D)</p> Signup and view all the answers

A patient with a history of asthma presents with progressively worsening shortness of breath and is diagnosed with severe acute asthma. Which peak expiratory flow rate (PEFR) would be MOST consistent with this classification?

<p>40% of predicted (D)</p> Signup and view all the answers

After starting treatment for pneumonia, a patient's CRP levels spike higher a day or two later, despite the patient clinically improving. What is the MOST likely explanation for this?

<p>Delayed inflammatory response (A)</p> Signup and view all the answers

A patient has been diagnosed with restrictive lung disease. Spirometry results show normal or raised FEV1/FVC ratio. Which statement explains this result?

<p>The FEV1/FVC ratio is unaffected or raised because there is no obstructive pathology to affect airflow. (B)</p> Signup and view all the answers

A patient has been prescribed a MART inhaler, which they have been using correctly. Which of the following statements is INCORRECT regarding this regime?

<p>Replaces the need for all other inhalers including short acting beta 2 agonists (C)</p> Signup and view all the answers

What is the underlying pathophysiology that leads to the symptoms associated with Lambert-Eaton Myasthenic Syndrome?

<p>Antibodies target voltage-gated calcium channels on presynaptic motor neurones. (D)</p> Signup and view all the answers

In the NICE stepwise ladder for asthma management, what is the next step immediately AFTER commencing a short-acting beta 2 agonist inhaler (e.g. salbutamol) for infrequent wheezy episodes?

<p>Add a regular low dose inhaled corticosteroid (ICS) (C)</p> Signup and view all the answers

A patient presents with pneumonia and is suspected of having Legionella infection. Which finding on initial investigations would STRONGLY support this diagnosis?

<p>Hyponatraemia (C)</p> Signup and view all the answers

The trend of C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis commonly shows a delayed response, spiking a day or two later despite the patient improving. Why is this?

<p>CRP commonly shows a delayed response so may be low on first presentation then spike very high a day or two later despite the patient improving on treatment (D)</p> Signup and view all the answers

A patient presents with features of pneumonia but is also suffering with neurological symptoms (confusion, seizures) as well as hyponatraemia from SIADH. From the 5 key causes of atypical pneumonia, which is MOST likely causing the patient's illness?

<p>Legionella pneumophila (C)</p> Signup and view all the answers

Which of the following is the MOST accurate definition of pneumonia, particularly considering its classification and differentiation from other similar conditions?

<p>Primarily, pneumonia is an inflammatory condition of the lung parenchyma that usually occurs due to infection from bacteria, viruses, or fungi, leading to alveolar consolidation evident on imaging and impaired gas exchange, classified based on origin such as community-acquired, hospital-acquired, or aspiration pneumonia. (D)</p> Signup and view all the answers

A patient presents with a persistent dry cough, neurological symptoms and hyponatraemia. They have recently returned from a holiday which included a cheaper hotel by the coast. Which is the MOST likely organism causing the patient problems?

<p>Legionella pneumophila (C)</p> Signup and view all the answers

A patient is being treated for pneumonia and subsequently develops a pleural effusion. Leaving empyema to one side, which of the following is the MOST concerning complication in this setting and why?

<p>The effusion is likely to be linked to decreased lung compliance, making ventilation more difficult and increasing the risk of needing invasive interventions (A)</p> Signup and view all the answers

What percentage of lung cancers are estimated to be preventable, largely due to modifiable risk factors?

<p>80% (C)</p> Signup and view all the answers

What is the role of salbutamol in asthma management?

<p>A reliever medication that acts as a bronchodilator. (D)</p> Signup and view all the answers

A patient has been diagnosed with suspected pneumonia. What is the purpose of performing a chest X-ray on admission?

<p>To confirm the diagnosis and identify consolidations (C)</p> Signup and view all the answers

A patient diagnosed with pneumonia is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?

<p>Hyponatraemia (C)</p> Signup and view all the answers

Which of the following presentations is MOST suggestive of asthma, rather than another respiratory condition?

<p>Episodic symptoms (D)</p> Signup and view all the answers

What is the purpose of prescribing salbutamol for asthma?

<p>Dilate the bronchioles (A)</p> Signup and view all the answers

Which of the following blood pressure readings would suggest that the patient has a high CURB-65 score?

<p>95/55 (C)</p> Signup and view all the answers

What is the MOST common presenting symptom of lung cancer?

<p>Cough (C)</p> Signup and view all the answers

What is the MOST likely organism causing pneumonia in a patient also presenting with hyponatraemia?

<p>Legionella pneumophila (A)</p> Signup and view all the answers

What is the typical presentation of a patient with Q fever (Coxiella burnetti)?

<p>Farmer with a flu like illness (B)</p> Signup and view all the answers

A patient has a best peak flow reading of 300 L/min, and their predicted peak flow is 500 L/min. What degree of asthma does this indicate?

<p>Severe (C)</p> Signup and view all the answers

Which of the following examination findings indicates moderate asthma exacerbation?

<p>PEFR 50-75% predicted (B)</p> Signup and view all the answers

Which of the following features on a chest X-ray MOST strongly suggests a diagnosis of lung cancer rather than a differential?

<p>Hilar enlargement (A)</p> Signup and view all the answers

A patient has been admitted to hospital with moderate community aquired pneumonia. What antibiotic course are they MOST likely to be prescribed?

<p>7-10 day course of IV amoxicillin and macrolide (C)</p> Signup and view all the answers

When interpreting lung function tests, which of the following measurement patterns is indicative of obstructive lung disease?

<p>FEV1/FVC ratio &lt; 75% (B)</p> Signup and view all the answers

Which of the following statements accurately describes the use of peak expiratory flow rate (PEFR) in asthma management?

<p>It is used to measure the degree of airway obstruction (D)</p> Signup and view all the answers

A patient is diagnosed with lung cancer and develops the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Which underlying mechanism is MOST likely?

<p>Ectopic ADH production by the tumor (D)</p> Signup and view all the answers

A patient with a history of smoking presents with shoulder pain, ptosis, miosis, and anhidrosis on one side of their face. In which location is the tumor MOST likely situated?

<p>Pulmonary apex (A)</p> Signup and view all the answers

According to NICE guidelines, after prescribing a short-acting beta 2 agonist inhaler, which of the following is the appropriate FIRST step in long-term asthma management?

<p>Add a low-dose inhaled corticosteroid (D)</p> Signup and view all the answers

A patient's spirometry results show equally reduced FEV1 and FVC, that return an FEV1:FVC ratio of >75%. What diagnosis is MOST indicated based on this result?

<p>Restrictive lung disease (B)</p> Signup and view all the answers

What triggers the presentation of Pemberton's sign?

<p>Raising the hands above the head (A)</p> Signup and view all the answers

A patient presents with a dry cough, shortness of breath and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which investigation is the MOST useful to confirm a diagnosis of Pneumocystis jirovecii pneumonia?

<p>Bronchial washings (A)</p> Signup and view all the answers

Which of the following statements BEST describes how community-acquired pneumonia is defined?

<p>Pneumonia that develops outside of a hospital setting (B)</p> Signup and view all the answers

A patient with a history of well-controlled asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a life-threatening asthma exacerbation?

<p>Agitation and confusion along with a silent chest on auscultation. (B)</p> Signup and view all the answers

In a patient using dual therapy with amoxicillin and clarithromycin for pneumonia, which organism is LEAST likely to respond?

<p>Staphylococcus aureus (C)</p> Signup and view all the answers

A patient has been started on Theophylline as part of their asthma management. Blood plasma levels of the medication should be tested how long after a dose change?

<p>3 days (C)</p> Signup and view all the answers

A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following BEST describes the components and usage of this?

<p>A combination inhaler containing a low-dose inhaled corticosteroid and a fast-acting LABA used both regularly and for symptom relief. (C)</p> Signup and view all the answers

A patient being investigated for suspected lung cancer undergoes a CT scan of the chest, abdomen and pelvis. Why is it important that this scan includes contrast enhancement?

<p>To improve visualization of lymph node involvement and assess tissue vascularity (A)</p> Signup and view all the answers

Which statement BEST describes the underlying process of restrictive lung disease that will cause reduced FVC on spirometry?

<p>Decreased lung compliance and restriction in lung expansion (A)</p> Signup and view all the answers

Which of the following investigations is MOST appropriate when a junior clinician highly suspects asthma, according to BTS/SIGN guidelines?

<p>Commence empirical treatment (B)</p> Signup and view all the answers

A patient is being treated for pneumonia as an outpatient. Three days later, the patient returns with worsening symptoms despite taking their medication. What next step is MOST appropriate?

<p>Admit the patient to the hospital for intravenous antibiotics and further evaluation. (C)</p> Signup and view all the answers

A patient with suspected pneumonia deteriorates and develops a pleural effusion. Which of the following is the MOST concerning complication to be aware of?

<p>Empyema (D)</p> Signup and view all the answers

Which statement is LEAST accurate regarding expected findings in a case of severe acute asthma?

<p>Inflammatory markers will be markedly raised. (D)</p> Signup and view all the answers

Which condition must be present to refer a patient to intensive care, according to the CURB-65 scoring system guide?

<p>Score of 3 (D)</p> Signup and view all the answers

A 50 year old woman with a history of well-managed asthma controlled with occasional use of a SABA presents to her GP complaining of increasing nocturnal symptoms. She has been experiencing a cough, wheeze, and shortness of breath more than four nights a week. She denies any recent infections or changes in her environment. What is the MOST appropriate next step in managing her asthma?

<p>Add a regular low-dose inhaled corticosteroid (ICS) to her current regimen. (B)</p> Signup and view all the answers

A patient with advanced lung cancer develops new onset of short-term memory loss, hallucinations, confusion and seizures. Which antibody is MOST likely associated with this paraneoplastic syndrome?

<p>Anti-Hu (A)</p> Signup and view all the answers

Following a pneumonia diagnosis, inflammatory markers can show varying patterns. Which statement BEST describes the expected trend of C-reactive protein (CRP)?

<p>CRP exhibits a delayed response, often peaking a day or two after initial presentation, despite commencing antibiotic treatment. (C)</p> Signup and view all the answers

A patient with a history of asbestos exposure presents with progressively worsening dyspnea and chest pain. While mesothelioma is suspected, which initial imaging finding would be MOST indicative of this specific malignancy rather than other asbestos-related lung conditions?

<p>Diffuse pleural thickening with associated effusion and restriction (B)</p> Signup and view all the answers

What factors are present in the CURB-65 scoring system that indicate a score of 1?

<p>Age ≥ 65, confusion (D)</p> Signup and view all the answers

In the mnemonic 'Legions of psittaci MCQs' - what do the 'Qs' stand for?

<p>Q fever (B)</p> Signup and view all the answers

Which of the following diagnostic challenges presents the GREATEST difficulty in accurately determining the underlying cause of shortness of breath?

<p>Differentiating asthma from COPD in a smoker &lt;40 years old (B)</p> Signup and view all the answers

Which of the following lung function test changes is MOST likely in a well-controlled asthmatic with mild intermittent symptoms between exacerbations?

<p>Normal lung function tests. (B)</p> Signup and view all the answers

Which clinical presentation is MOST suggestive of Lambert-Eaton myasthenic syndrome?

<p>Muscle weakness that improves with repeated use (C)</p> Signup and view all the answers

What initial diagnostic finding is MOST indicative of mesothelioma?

<p>Pleural thickening or effusion (C)</p> Signup and view all the answers

A patient presents with new disorientation in time and place due to pneumonia. According to the CRB-65 scoring system, what score does the confusion add?

<p>1 (B)</p> Signup and view all the answers

A patient with suspected pneumonia is prescribed amoxicillin and clarithromycin. What type of pneumonia is this dual therapy MOST likely targetting?

<p>Moderate to severe community-acquired pneumonia (B)</p> Signup and view all the answers

Which of the following best describes the function of inhaled corticosteroids (ICS) in asthma management?

<p>Reduction of airway inflammation and reactivity. (D)</p> Signup and view all the answers

Which of the following inhaled medications is MOST commonly used as a reliever medication during acute asthma exacerbations?

<p>Salbutamol (D)</p> Signup and view all the answers

A patient develops a pleural effusion from a pneumonia. Which is the MOST concerning complication?

<p>Empyema (D)</p> Signup and view all the answers

What combination of medications is contained within a Maintenance and Reliever Therapy (MART) inhaler?

<p>Long acting beta 2 agonist and inhaled corticosteroid (D)</p> Signup and view all the answers

Which finding is MOST suggestive of a new diagnosis of pneumonia caused by Mycoplasma pneumoniae?

<p>A rash with target-like lesions (C)</p> Signup and view all the answers

Which type of treatment is offered first-line in patients with non-small cell lung cancer when the disease is isolated to a single area?

<p>Surgery (A)</p> Signup and view all the answers

A patient with a history of well-controlled asthma presents with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a severe asthma exacerbation?

<p>PEFR 40% predicted, respiratory rate of 30 breaths per minute, unable to complete sentences (D)</p> Signup and view all the answers

A patient presents with pneumonia alongside hyponatraemia and neurological symptoms during their assessment. Which cause of pneumonia is MOST likely, going by this information?

<p>Legionella pneumophila (A)</p> Signup and view all the answers

Which statement describes why C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis may show a delayed response, spiking a day or two later despite the patient clinically improving on treatment?

<p>CRP commonly shows a delayed response and may be low on first presentation then spike very high a day or two later (B)</p> Signup and view all the answers

A patient receives a diagnosis of pneumonia during their assessment, and a sputum sample is collected as part of the diagnostic process. What investigation is MOST likely to occur next with this sample?

<p>Gram staining (C)</p> Signup and view all the answers

Which lung sounds are MOST associated with pneumonia?

<p>Bronchial breath sounds and coarse crackles (C)</p> Signup and view all the answers

What is the MOST likely underlying cause of Cushing’s syndrome in a patient with small cell lung cancer?

<p>Ectopic ACTH secretion by the tumour (A)</p> Signup and view all the answers

Which statement is MOST accurate regarding NICE guidelines and a diagnosis of asthma?

<p>Should not make a diagnosis clinically and require investigations (D)</p> Signup and view all the answers

Flashcards

Lung Cancer

Third most common cancer in the UK; smoking is the biggest cause.

Non-Small Cell Lung Cancer (NSCLC)

Includes squamous cell carcinoma and adenocarcinoma.

Small Cell Lung Cancer (SCLC)

Releases neuroendocrine hormones, causes paraneoplastic syndromes.

Lung Cancer Symptoms

Shortness of breath, cough, coughing up blood (haemoptysis), finger clubbing.

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Lung Cancer on Chest X-ray

Enlarged hilum of lung, visible lesion, fluid accumulation, lung collapse.

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CT Scan for Lung Cancer

Uses contrast to show detailed tissue information and check lymph nodes.

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PET-CT Scan

Identifies areas of increased metabolic activity, indicating cancer spread.

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Bronchoscopy with EBUS

Endoscopy with ultrasound for detailed tumor assessment and biopsy.

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Lobectomy

Removing the lung lobe containing the tumor is the primary treatment.

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Segmentectomy/Wedge Resection

Removing a segment or wedge of lung to remove tumor.

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Recurrent Laryngeal Nerve Palsy

Hoarse voice due to nerve compression in the mediastinum.

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Phrenic Nerve Palsy

Diaphragm weakness leading to shortness of breath due to nerve compression.

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Superior Vena Cava Obstruction

Facial swelling, breathing difficulty, and distended veins due to tumor compression.

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Horner’s Syndrome

Caused by tumor pressing on sympathetic ganglion; triad of ptosis, anhidrosis, miosis.

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SIADH in Lung Cancer

Ectopic ADH secretion leading to low sodium levels.

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Cushing’s Syndrome

Ectopic ACTH secretion.

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Limbic Encephalitis

Cancer causes immune system to attack brain, causing memory loss, hallucinations.

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Lambert-Eaton Syndrome

Antibodies damage calcium channels in motor neurons, causing muscle weakness.

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Mesothelioma

Malignancy of the pleura, linked to asbestos exposure.

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Pneumonia

Infection of the lung tissue, causing inflammation and sputum production.

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Community Acquired Pneumonia (CAP)

Developed outside of hospital.

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Hospital Acquired Pneumonia (HAP)

Developed more than 48 hours after hospital admission.

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Aspiration Pneumonia

Resulting from inhaling foreign material.

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Pneumonia Symptoms

Shortness of breath, cough with sputum, fever, chest pain, confusion.

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Tachypnoea

Raised respiratory rate.

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Tachycardia

Raised heart rate.

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Hypoxia

Low oxygen level.

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Hypotension

Low blood pressure.

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Bronchial Breath Sounds

Harsh breath sounds equally loud on inspiration and expiration.

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Focal Coarse Crackles

Air passing through sputum in the airways.

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Dullness to Percussion

Collapse and/or consolidation of lung tissue

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CRB-65/CURB-65

Tool used to assess pneumonia severity.

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CURB-65 components

Confusion, Urea > 7, Respiratory rate ≥ 30, Blood pressure < 90/60, Age ≥ 65.

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Common Pneumonia Cause

Streptococcus pneumoniae.

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Atypical Pneumonia

Cannot be cultured or detected using Gram stain; doesn't respond to penicillins.

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Legionella pneumophila Source

Infected water supplies or air conditioning.

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Mycoplasma pneumoniae

Milder pneumonia, erythema multiforme (target lesions), neurological symptoms.

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Chlamydophila pneumoniae

School aged child with chronic pneumonia and wheeze?

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Coxiella burnetii (Q fever)

Linked to exposure to animals, flu-like illness.

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Chlamydia psittaci

Contracted from contact with infected birds.

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Pneumocystis jiroveci (PCP)

Pneumonia in immunocompromised patients, dry cough, shortness of breath.

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FEV1

Fraction exhaled in 1 second.

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FVC

Forced Vital Capacity.

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Obstructive Lung Disease

FEV1/FVC ratio < 75%.

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Restrictive Lung Disease

Equally reduced FEV1 and FVC; FEV1/FVC ratio > 75%.

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Peak Flow

Measure of the fastest point of expiratory flow of air.

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Asthma

Chronic inflammatory condition of airways episodic bronchoconstriction.

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Asthma Symptoms

Wheeze, shortness of breath, dry cough, diurnal variation.

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Short Acting Beta 2 Agonists

Adrenalin acts on airway smooth muscles to cause relaxation.

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Inhaled Corticosteroids (ICS)

Reduce inflammation and reactivity of the airways.

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Hypercalcaemia

Ectopic parathyroid hormone from squamous cell carcinoma.

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Legionella pneumophila

Atypical pneumonia cause by infected water supplies or air conditioning units causing low sodium levels.

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Chest Xray

First line investigation that indicates hilar enlargement peripheral opacity, pleural effusion or collapse.

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Maintenance and Reliever Therapy

Combination inhaler containing a low dose inhaled corticosteroid and a fast acting LABA.

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Acute Asthma Exacerbation

Rapid deterioration in symptoms triggered by infection, exercise or cold weather.

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Pneumocystis jiroveci (PCP) pneumonia

Infection with PCP occurs in immunocompromised patients and usually presents subtly with a dry cough without sputum, shortness of breath on exertion and night sweats

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Pneumonia management in the community

Patients in the community with CRB 0 or 1 pneumonia do not necessarily need investigations. NICE suggest considering a “point of care” test in primary care for CRP level to help guide management, however this is not widely available

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Spirometry

Spirometry measures lung function by recording volumes/flow rates during breathing exercises; Reversibility testing involves bronchodilator use before repeating the test.

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Obstructive Lung Disease Diagnosis

An obstructive lung disease can be diagnosed when the FEV1 is less than 75% of the FVC (FEV1:FVC ratio < 75%).

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Asthma: Monitoring

Measure how well the asthma is controlled and how severe an acute exacerbation is.

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Salbutamol Mechanism

Short acting beta 2 adrenergic receptor agonists. They work quickly but the effect only lasts for an hour or two. Adrenalin acts on the smooth muscles of the airways to cause relaxation.

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Lung Cancer MDT

Lung cancer treatment involving a multi-disciplinary team.

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Radiotherapy for lung cancer

Treatment using high-energy rays to kill cancer cells, curative in early NSCLC.

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Adjuvant chemotherapy

Treatment in addition to surgery or radiotherapy to improve outcomes.

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Palliative chemotherapy

Treatment to improve survival and quality of life in advanced NSCLC.

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Endobronchial treatment

Relieves bronchial obstruction caused by lung cancer.

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Extrapulmonary Manifestations

Manifestations linked to lung cancer outside the lungs.

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Pemberton’s sign

Raising arms over head causes facial congestion and cyanosis due to SVC obstruction.

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Lambert-Eaton Syndrome Mechanism

Autoantibodies damage calcium channels, causing proximal muscle weakness.

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Pneumonia Description

An infection of the lung tissue.

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Pneumonia Complications

Sepsis, pleural effusion, lung abscess and death.

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Treatment for Pneumocystis Pneumonia

Infection with PCP; treatment is with co-trimoxazole.

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Spirometry function

Measure lung function by recording volumes/flow rates during breathing exercises.

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Inflammatory response

Inflammatory markers such as white blood cells and CRP are raised in proportion to the severity of the infection.

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NICE vs SIGN

The treatment are the same but the medication they recommend varies on what point to use.

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Acute Asthma

Progressively worsening shortness of breath, accessory muscles and fast respiratory rate.

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What is Mesothelioma?

Cancer affecting mesothelial cells, strongly linked to asbestos inhalation.

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What is Aspiration Pneumonia?

This relates to pneumonia developing after inhaling foreign material.

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MDT meeting

A lung cancer MDT makes a joint decision about the most suitable options for the individual patient

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Pneumonia Antibiotics

Antibiotics that should be used following guidelines and cultures.

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What is Limbic encephalitis

Caused by a small cell lung cancer, anti-bodies are produced to tissues in the brain, specifically the limbic system, causing inflammation in these areas, symptoms such as short term memory impairment, hallucinations, confusion and seizures. It is associated with anti-Hu antibodies.

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Long-acting muscarinic antagonists (LAMA)

These block the acetylcholine receptors that are stimulated by the parasympathetic nervous system and cause contraction of the bronchial smooth muscles.

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Reversibility testing

Involves giving a bronchodilator prior to repeating the spirometry to see the impact this has on the results.

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Leukotrienes

Are produced by the immune system and cause inflammation, bronchoconstriction and mucus secretion in the airways.

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Bronchoconstriction

The narrowing of the airways causes an obstruction to airflow going in and out of the lungs.

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CRB-65

Pneumonia has a scoring system where you dont count urea

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CURB-65

Pneumonia has a scoring system where you count urea

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Theophylline

This works by relaxing bronchial smooth muscle and reducing inflammation. Monitoring plasma levels in the blood is required

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How to measure peak expiratory flow rate

The technique is to stand tall, take a deep breath in, make a good seal around the device with the lips and blow as fast and hard as possible into the device. Take three attempts and record the best result.

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Maintenance and Reliever Therapy (MART)

Combination inhaler containing a low dose inhaled corticosteroid and a fast-acting LABA. Replacing all other as a “preventer and reliever”,

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What are SABAs (e.g. salbutamol)?

These are short acting beta 2 adrenergic receptor agonists that act on airway smooth muscles to cause relaxation.

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What is LABA (e.g. salmeterol)?

Long-acting beta 2 agonists that work in the same way as short acting beta 2 agonists but have a much longer action.

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The stepwise ladder principles

The most appropriate step for the severity of the symptoms, review at regular intervals based on severity and Step up and down the ladder based on symptoms.

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Paraneoplastic Syndromes

Ectopic hormone secretion from lung cancer cells, causing various systemic effects.

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CRP

An inflammatory marker that is typically raised in proportion to the severity of pneumonia.

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Bronchodilation

Bronchial dilation caused by medications.

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LAMA MOA

Medications blocking acetylcholine receptors to cause bronchodilation.

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Leukotriene Receptor Antagonists MOA

Medications blocking effects of leukotrienes to prevent bronchoconstriction and reduce mucus.

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Asthma Control

Measure how well the asthma is controlled and how severe an acute exacerbation is by airway limitations

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Diurnal Variability

Asthma is typically worse at night.

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NICE on Asthma

First line investigations include Fractional exhaled nitric oxide and Spirometry with bronchodilator reversibility

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Acute Asthma Presentation

Rapid deterioration in symptoms triggered by infection, exercise, or cold weather.

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Short acting beta 2 agonist function

Short acting beta 2 adrenergic receptor agonists dilate the Bronchioles and improves the bronchoconstriction present in asthma.

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Study Notes

Lung Cancer Overview

  • Lung cancer is the third most prevalent cancer in the UK, following breast and prostate cancer.
  • Cigarette smoking stands as the primary cause, with approximately 80% of cases deemed preventable.

Lung Cancer Histology

  • NSCLC subtypes include squamous cell carcinoma (35%) and adenocarcinoma (25%).
  • SCLC constitutes 20% of lung cancer cases.

Small Cell Lung Cancer Specifics

  • SCLC cells contain neurosecretory granules, facilitating the release of neuroendocrine hormones.
  • It frequently causes paraneoplastic syndromes due to hormone release.

Lung Cancer Signs and Symptoms

  • Shortness of breath is a common symptom.
  • Cough is frequently observed.
  • Haemoptysis (coughing up blood) may occur.
  • Finger clubbing can be a sign.
  • Recurrent pneumonia may indicate lung cancer.
  • Weight loss is a common symptom
  • Lymphadenopathy, particularly in the supraclavicular nodes, is often the first sign found on examination.

Lung Cancer Investigations

  • Chest X-ray is the initial investigation, revealing hilar enlargement, peripheral opacity (visible lesion), unilateral pleural effusion, and collapse suggesting cancer.
  • Contrast-enhanced CT scans of the chest, abdomen, and pelvis are conducted for staging and to check for lymph node involvement and metastasis; contrast enhancement provides detailed tissue information.
  • PET-CT uses radioactive tracers attached to glucose molecules, visualizing metabolically active tissues to identify cancer spread through areas of increased metabolic activity.
  • Bronchoscopy with EBUS allows detailed tumor assessment and ultrasound-guided biopsy.
  • Histological diagnosis requires a biopsy, obtained via bronchoscopy or percutaneously, to check the cancer cell type.

Lung Cancer Treatment Options

  • Treatment plans are decided in MDT meetings, involving pathologists, surgeons, oncologists, and radiologists, to determine the most suitable options.
  • Surgery (lobectomy, segmentectomy, or wedge resection) is first-line for localized NSCLC with the aim of curing the cancer; lobectomy involves removing the lung lobe containing the tumour.
  • Radiotherapy can be curative for early-stage NSCLC.
  • Chemotherapy can be adjuvant after surgery or radiotherapy or palliative for advanced NSCLC.
  • SCLC treatment primarily involves chemotherapy and radiotherapy; prognosis is typically worse than NSCLC.
  • Endobronchial treatments like stents relieve bronchial obstruction palliatively.

Extrapulmonary Manifestations of Lung Cancer

  • Recurrent laryngeal nerve palsy causes a hoarse voice due to nerve compression in the mediastinum.
  • Phrenic nerve palsy results in diaphragm weakness and shortness of breath due to nerve compression.
  • Superior vena cava obstruction presents with facial swelling, breathing difficulty, and distended neck veins due to tumor compression.
  • Pemberton’s sign involves facial congestion and cyanosis when raising arms overhead, indicating a medical emergency.
  • Horner’s syndrome, a triad of partial ptosis, anhidrosis, and miosis, results from a Pancoast tumor pressing on the sympathetic ganglion.
  • SIADH is caused by ectopic ADH secretion by SCLC, leading to hyponatremia.
  • Cushing’s syndrome is caused by ectopic ACTH secretion by SCLC.
  • Hypercalcemia is caused by ectopic parathyroid hormone production from squamous cell carcinoma.
  • Limbic encephalitis involves an autoimmune response causing short-term memory impairment, hallucinations, confusion, and seizures, and is associated with anti-Hu antibodies.

Lambert-Eaton Myasthenic Syndrome

  • Autoantibodies against small cell lung cancer cells damage voltage-gated calcium channels on presynaptic motor neurons.
  • Proximal muscle weakness, diplopia, ptosis, slurred speech, and dysphagia occur.
  • Symptoms worsen with muscle use and are similar to myasthenia gravis.
  • In older smokers, consider small cell lung cancer with these symptoms.

Mesothelioma

  • Lung malignancy affects mesothelial cells of the pleura and is linked to asbestos inhalation.
  • A long latency period (up to 45 years) exists between asbestos exposure and development; prognosis is poor.
  • Chemotherapy provides palliative benefits.

Pneumonia Classifications

  • Community Acquired Pneumonia (CAP) develops outside of a hospital.
  • Hospital Acquired Pneumonia (HAP) develops >48 hours after hospital admission.
  • Aspiration Pneumonia results from inhaling foreign material.
  • Causes inflammation of the lung tissue and production of sputum that fills the airways and alveoli.
  • Can be seen as consolidation on a chest X-ray.

Pneumonia Presentation

  • Shortness of breath
  • Productive cough
  • Fever
  • Coughing up blood (haemoptysis)
  • Pleuritic chest pain (sharp chest pain worse on inspiration)
  • Delirium (acute confusion associated with infection)
  • Sepsis

Pneumonia Signs

  • Changes in vital signs (tachypnoea, tachycardia, hypoxia, hypotension, fever, confusion).
  • Bronchial breath sounds.
  • Focal coarse crackles.
  • Dullness to percussion.

Pneumonia Severity Assessment

  • CRB-65 (outpatient) assesses confusion, respiratory rate, blood pressure, and age ≥ 65.
  • CURB-65 (inpatient) includes urea in addition to the CRB-65 variables and predicts mortality risk.
  • CURB-65 score predicts mortality risk.
    • Score 0/1: Treatment at home
    • Score ≥ 2: Hospital admission
    • Score ≥ 3: Intensive care assessment

Pneumonia Common Causes

  • Streptococcus pneumoniae: 50%.
  • Haemophilus influenzae: 20%.
  • Moraxella catarrhalis: Common in immunocompromised or chronic pulmonary disease patients.
  • Pseudomonas aeruginosa: Common in cystic fibrosis or bronchiectasis patients.
  • Staphylococcus aureus: Common in cystic fibrosis patients.

Atypical Pneumonia

  • Definition is pneumonia caused by an organism that cannot be cultured in the normal way or detected using a Gram stain.
  • Does not respond to penicillins, macrolides, fluoroquinolones and tetracyclines are suitable treatments.
  • Macrolides, fluoroquinolones, and tetracyclines are suitable treatments in place of penicillins.
  • Specific causes:
    • Legionella pneumophila (Legionnaires’ disease): Occurs from infected water supplies or air conditioning units, causes hyponatremia by causing SIADH.
    • Mycoplasma pneumoniae: Milder pneumonia, can cause erythema multiforme and neurological symptoms.
    • Chlamydophila pneumoniae: Mild, chronic pneumonia and wheeze in school-aged children.
    • Coxiella burnetii (Q fever): Exposure to animals and their bodily fluids.
    • Chlamydia psittaci: Contact with infected birds.
  • Mnemonic for atypical pneumonias "Legions of psittaci MCQs” can assist with remembering the 5 causes:
    • Legionella pneumophila
    • Chlamydia psittaci
    • Mycoplasma pneumoniae
    • Chlamydophila pneumoniae
    • Q fever (coxiella burnetii)

Pneumocystis jiroveci (PCP) Pneumonia

  • Occurs in immunocompromised patients, particularly those with poorly controlled HIV.
  • Symptoms: Dry cough, shortness of breath on exertion, and night sweats.
  • Treatment: Co-trimoxazole (trimethoprim/sulfamethoxazole).
  • Prophylactic co-trimoxazole for HIV patients with low CD4 counts.

Pneumonia Investigations

  • Community patients with CRB-65 0 or 1 may not need investigations.
  • Recommended inpatient investigations include:
    • Chest X-ray.
    • FBC (raised white cells).
    • U&Es (for urea).
    • CRP (raised in inflammation and infection).
  • Further investigations for moderate/severe cases:
    • Sputum cultures.
    • Blood cultures.
    • Legionella and pneumococcal urinary antigens.
  • Inflammatory markers: Magnitude reflects infection severity.
  • Patients that are immunocompromised may not show an inflammatory response and may not have raised inflammatory markers despite severe infection.
  • NICE suggest considering a “point of care” test in primary care for CRP level to help guide management, however this is not widely available.

Pneumonia Antibiotics

  • Follow local guidelines due to regional antibiotic resistance variations.
  • Typically, IV antibiotics are started for moderate/severe/septic cases and then switched to oral.
  • Typical durations:
    • Mild CAP: 5 days oral amoxicillin or a macrolide.
    • Moderate to severe CAP: 7-10 days dual antibiotics (amoxicillin and macrolide).

Pneumonia Complications

  • Sepsis
  • Pleural effusion
  • Empyema
  • Lung abscess
  • Death

Lung Function Tests Overview

  • Used to diagnose lung diseases.
  • Helpful in identifying obstructive and restrictive lung diseases.

Spirometry

  • Measures lung function through breathing exercises.
  • Measures air volumes and flow rates.
  • Reversibility testing uses a bronchodilator (salbutamol) to assess changes in results.
  • FEV1: Forced expiratory volume in 1 second.
    • Reflects ease of airflow out of the lungs; reduced with airway obstruction.
  • FVC: Forced vital capacity.
    • Total air exhaled after full inhalation; reduced with lung capacity restriction.

Obstructive Lung Disease

  • Indicated by FEV1:FVC ratio < 75%.
  • Signifies airway obstruction.
  • Asthma: Narrowed airways due to bronchoconstriction.
  • COPD: Chronic airway and lung damage.
  • Reversibility testing: Asthma obstruction is typically reversible, COPD is not.

Restrictive Lung Disease

  • FEV1 and FVC are equally reduced, FEV1:FVC ratio > 75%.
  • Restriction limits lung expansion.
  • Causes inadequate alveolar ventilation and blood oxygenation.
  • FEV1/FVC ratio is normal or raised.

Causes of Restrictive Lung Disease

  • Interstitial lung disease (pulmonary fibrosis).
  • Sarcoidosis.
  • Obesity.
  • Motor neurone disease.
  • Scoliosis.
  • Anything that affects how well the chest wall and lungs can forcefully expand to draw air in.

Peak Flow Measurement

  • Measures the fastest point of expiratory flow (PEFR).
  • Assess obstruction to airflow using a peak flow meter.
  • Useful for managing obstructive lung disease, especially asthma.
  • Recorded as a percentage of predicted PEFR, taking into account patient's sex, height and age
  • Stand tall, take a deep breath in, make a good seal around the device with the lips and blow as fast and hard as possible into the device, take three attempts and record the best result.

Asthma Overview

  • Chronic inflammatory condition causing episodic bronchoconstriction.
  • Reversible airway obstruction responding to bronchodilators.
  • Airway hypersensitivity triggered by environmental factors.
  • Bronchoconstriction is where the smooth muscles of the airways (the bronchi) contract, causing a reduction in the diameter of the airways.
  • Narrowing of the airways causes an obstruction to airflow.

Asthma Triggers

  • Infection
  • Night time or early morning
  • Exercise
  • Animals
  • Cold, damp or dusty air
  • Strong emotions

Asthma Presentation

  • Episodic symptoms.
  • Diurnal variability, worse at night.
  • Dry cough, wheeze, and shortness of breath.
  • History of atopic conditions.
  • Family history.
  • Bilateral widespread wheeze.

Non-Asthma Presentations

  • Wheeze related to colds.
  • Isolated or productive cough.
  • Normal investigations.
  • No response to treatment.
  • Unilateral wheeze (suggests a focal lesion or infection).

Asthma Diagnosis Guidelines

  • BTS/SIGN guidelines advise clinical diagnosis for high suspicion; testing for intermediate/low suspicion.
  • NICE guidelines require definitive testing; discourages clinical diagnosis alone.

BTS/Sign Guidelines on Diagnosis

  • High probability of asthma clinically: Try treatment.
  • Intermediate probability of asthma: Perform spirometry with reversibility testing.
  • Low probability of asthma: Consider referral and investigating for other causes.

NICE Guidelines on Diagnosis

  • Assessment and testing occur at a diagnostic hub.
  • First-line investigations:
    • Fractional exhaled nitric oxide (FeNO).
    • Spirometry with bronchodilator reversibility.
  • Follow-up tests for diagnostic uncertainty:
    • Peak flow variability diary (2-4 weeks).
    • Direct bronchial challenge test.

Long Term Management of asthma

  • Short-acting beta 2 agonists (e.g., salbutamol):
    • Act on airway smooth muscles to cause relaxation, quick relief during acute exacerbations.
  • Inhaled corticosteroids (ICS) (e.g., beclometasone):
    • Reduce inflammation and reactivity, used regularly as "preventer" medications.
  • Long-acting beta 2 agonists (LABA) (e.g., salmeterol):
    • Same mechanism as SABAs but longer-lasting.
  • Long-acting muscarinic antagonists (LAMA) (e.g., tiotropium):
    • Block acetylcholine receptors, causing bronchodilation.
  • Leukotriene receptor antagonists (e.g., montelukast):
    • Block leukotrienes, reducing inflammation, bronchoconstriction, and mucus secretion.
  • Theophylline:
    • Relaxes bronchial smooth muscle and reduces inflammation; requires blood level monitoring.
    • Monitoring plasma theophylline levels in the blood is required 5 days after starting treatment and 3 days after each dose changes.
  • Maintenance and Reliever Therapy (MART):
    • Combination inhaler (ICS + fast-acting LABA) for both regular prevention and symptom relief.

Stepwise Ladder

  • BTS/SIGN and NICE guidelines have different steps.
  • Both start with SABA and low-dose ICS.
  • Next step: leukotriene receptor antagonist or inhaled LABA.
  • Principles:
    • Start at appropriate step.
    • Review regularly.
    • Step up/down based on symptoms.
    • Aim for symptom control on lowest dose.
    • Check inhaler technique and adherence.

BTS/SIGN Stepwise Ladder

  • Add a short-acting beta 2 agonist inhaler (e.g. salbutamol) as required for infrequent wheezy episodes.
  • Add a regular low dose corticosteroid inhaler.
  • Add LABA inhaler (e.g. salmeterol). Continue the LABA only if the patient has a good response.
  • Consider a trial of an oral leukotriene receptor antagonist (i.e. montelukast), oral beta 2 agonist (i.e. oral salbutamol), oral theophylline or an inhaled LAMA (i.e. tiotropium).
  • Titrate the inhaled corticosteroid up to “high dose". Combine additional treatments from step 4. Refer to a specialist.
  • Add oral steroids at the lowest dose possible to achieve good control.

NICE Guidelines

  • Add a short-acting beta 2 agonist inhaler (e.g. salbutamol) as required for infrequent wheezy episodes.
  • Add a regular low dose inhaled corticosteroid.
  • Add an oral leukotriene receptor antagonist (i.e. montelukast).
  • Add LABA inhaler (e.g. salmeterol). Continue the LABA only if the patient has a good response.
  • Consider changing to a maintenance and reliever therapy (MART) regime.
  • Increase the inhaled corticosteroid to a “moderate dose”.
  • Consider increasing the inhaled corticosteroid dose to “high dose” or oral theophylline or an inhaled LAMA (e.g. tiotropium).
  • Refer to a specialist.

Additional Asthma Management

  • Individual asthma self-management plan.
  • Yearly flu jab.
  • Yearly asthma review.
  • Encourage exercise and smoking cessation.

Acute Asthma Presentation

  • Rapid deterioration of symptoms.
  • Use of accessory muscles.
  • Tachypnoea.
  • Symmetrical expiratory wheeze.
  • Reduced air entry.
  • The chest can sound "tight" on auscultation with reduced air entry

Acute Asthma Grading

  • Moderate: PEFR 50 – 75% predicted.
  • Severe: PEFR 33-50% predicted, Resp rate >25, Heart rate >110, Unable to complete sentences.
  • Life-threatening: PEFR <33% predicted.

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