Podcast
Questions and Answers
Which of the following histological types is the MOST common in non-small cell lung cancer?
Which of the following histological types is the MOST common in non-small cell lung cancer?
- Squamous cell carcinoma (correct)
- Small cell carcinoma
- Mesothelioma
- Adenocarcinoma
A patient presents with a hoarse voice and a chest X-ray reveals a mass in the mediastinum. Which of the following mechanisms is the MOST likely cause of the hoarseness?
A patient presents with a hoarse voice and a chest X-ray reveals a mass in the mediastinum. Which of the following mechanisms is the MOST likely cause of the hoarseness?
- Superior vena cava obstruction
- Recurrent laryngeal nerve palsy (correct)
- Horner's syndrome
- Phrenic nerve palsy
Which of the following paraneoplastic syndromes is MOST likely associated with squamous cell carcinoma of the lung?
Which of the following paraneoplastic syndromes is MOST likely associated with squamous cell carcinoma of the lung?
- Cushing’s syndrome
- Limbic encephalitis
- Syndrome of inappropriate ADH (SIADH)
- Hypercalcemia (correct)
A patient with small cell lung cancer develops muscle weakness that improves with muscle use. Which of the following conditions is the MOST likely cause?
A patient with small cell lung cancer develops muscle weakness that improves with muscle use. Which of the following conditions is the MOST likely cause?
A patient with facial swelling, shortness of breath, and distended neck veins MOST likely has which of the following complications of lung cancer?
A patient with facial swelling, shortness of breath, and distended neck veins MOST likely has which of the following complications of lung cancer?
What is the FIRST-LINE treatment offered to patients with non-small cell lung cancer if the disease is isolated to a single area?
What is the FIRST-LINE treatment offered to patients with non-small cell lung cancer if the disease is isolated to a single area?
Which of the following imaging techniques is BEST for identifying areas of metastasis in lung cancer due to its ability to visualize metabolically active tissues?
Which of the following imaging techniques is BEST for identifying areas of metastasis in lung cancer due to its ability to visualize metabolically active tissues?
A patient presents with pneumonia-like symptoms after returning from a holiday where they stayed in a hotel with a contaminated water supply. Which organism is MOST likely responsible?
A patient presents with pneumonia-like symptoms after returning from a holiday where they stayed in a hotel with a contaminated water supply. Which organism is MOST likely responsible?
Which of the following is the MOST appropriate initial antibiotic treatment for a patient with mild community-acquired pneumonia?
Which of the following is the MOST appropriate initial antibiotic treatment for a patient with mild community-acquired pneumonia?
Which of the following findings on a chest examination is MOST indicative of pneumonia?
Which of the following findings on a chest examination is MOST indicative of pneumonia?
A patient with a history of asbestos exposure is MOST at risk of developing which type of lung malignancy?
A patient with a history of asbestos exposure is MOST at risk of developing which type of lung malignancy?
A farmer develops a flu-like illness and is diagnosed with atypical pneumonia. Which organism is the MOST likely cause?
A farmer develops a flu-like illness and is diagnosed with atypical pneumonia. Which organism is the MOST likely cause?
Which of the following interventions is MOST important to consider in a patient with poorly controlled HIV and a low CD4 count who presents with a dry cough and shortness of breath?
Which of the following interventions is MOST important to consider in a patient with poorly controlled HIV and a low CD4 count who presents with a dry cough and shortness of breath?
According to NICE guidelines, what is the FIRST-LINE investigation in suspected asthma?
According to NICE guidelines, what is the FIRST-LINE investigation in suspected asthma?
A patient's FEV1/FVC ratio is greater than 75% and both FEV1 and FVC are reduced. This pattern is MOST indicative of which type of lung disease?
A patient's FEV1/FVC ratio is greater than 75% and both FEV1 and FVC are reduced. This pattern is MOST indicative of which type of lung disease?
Which of the following medications is MOST commonly used as a reliever or rescue medication during acute asthma exacerbations?
Which of the following medications is MOST commonly used as a reliever or rescue medication during acute asthma exacerbations?
A patient has a peak flow of 200 L/min, and their predicted peak flow is 400 L/min. What percentage of their BEST predicted peak flow are they currently achieving?
A patient has a peak flow of 200 L/min, and their predicted peak flow is 400 L/min. What percentage of their BEST predicted peak flow are they currently achieving?
A patient is prescribed theophylline. What monitoring is required?
A patient is prescribed theophylline. What monitoring is required?
What is the MOST appropriate next step for a patient with asthma who is using a short-acting beta 2 agonist inhaler and a low-dose inhaled corticosteroid but remains symptomatic?
What is the MOST appropriate next step for a patient with asthma who is using a short-acting beta 2 agonist inhaler and a low-dose inhaled corticosteroid but remains symptomatic?
What is the MOST common cause of community acquired penumonia?
What is the MOST common cause of community acquired penumonia?
What is the MOST appropriate course of antibiotics for moderate to severe community-acquired pneumonia?
What is the MOST appropriate course of antibiotics for moderate to severe community-acquired pneumonia?
What CURB-65 score suggests intensive care assessment?
What CURB-65 score suggests intensive care assessment?
What are the features of Horner's syndrome?
What are the features of Horner's syndrome?
What antibodies are associated with the paraneoplastic syndrome, Limbic Encephalitis?
What antibodies are associated with the paraneoplastic syndrome, Limbic Encephalitis?
What peak flow percentage indicates severe acute asthma?
What peak flow percentage indicates severe acute asthma?
Which of the following is NOT a typical trigger for asthma?
Which of the following is NOT a typical trigger for asthma?
A patient presents with pneumonia symptoms and erythema multiforme. Which organism is MOST likely responsible?
A patient presents with pneumonia symptoms and erythema multiforme. Which organism is MOST likely responsible?
Apart from pneumonia, what other condition does haemoptysis occur in?
Apart from pneumonia, what other condition does haemoptysis occur in?
What does the 'R' stand for in the CURB-65 scoring system?
What does the 'R' stand for in the CURB-65 scoring system?
If FEV1 and FVC are equally reduced, with a normal or raised FEV1:FVC ratio > 75%. This suggests...
If FEV1 and FVC are equally reduced, with a normal or raised FEV1:FVC ratio > 75%. This suggests...
A patient presents with facial congestion and cyanosis when raising their hands over their head. What is this sign known as?
A patient presents with facial congestion and cyanosis when raising their hands over their head. What is this sign known as?
The use of accessory muscles, rapid respiratory rate, and symmetrical expiratory wheezing
The use of accessory muscles, rapid respiratory rate, and symmetrical expiratory wheezing
Which investigation is the FIRST-LINE investigation in suspected lung cancer?
Which investigation is the FIRST-LINE investigation in suspected lung cancer?
Which of the following can be used as part of palliative treatment to relieve bronchial obstruction caused by lung cancer?
Which of the following can be used as part of palliative treatment to relieve bronchial obstruction caused by lung cancer?
A patient is wheezing but investigations are normal and they respond well to treatment. What is the most likely diagnosis?
A patient is wheezing but investigations are normal and they respond well to treatment. What is the most likely diagnosis?
What result from a CRB-65 scoring system indicates NICE suggest considering referring patients to hospital?
What result from a CRB-65 scoring system indicates NICE suggest considering referring patients to hospital?
Apart from lung disease, in which other condition are lung function tests particularly helpful?
Apart from lung disease, in which other condition are lung function tests particularly helpful?
What are the two key treatments for the long term management of asthma?
What are the two key treatments for the long term management of asthma?
Which pneumonia organisms won't respond to pennicillins
Which pneumonia organisms won't respond to pennicillins
A patient with a history of smoking presents with shoulder pain and Horner's syndrome. Which of the following locations is the MOST likely site of the tumor causing these symptoms?
A patient with a history of smoking presents with shoulder pain and Horner's syndrome. Which of the following locations is the MOST likely site of the tumor causing these symptoms?
A patient diagnosed with small cell lung cancer develops hyponatremia. Which of the following is the MOST likely underlying mechanism?
A patient diagnosed with small cell lung cancer develops hyponatremia. Which of the following is the MOST likely underlying mechanism?
Which of the following is the MOST appropriate initial imaging modality for a patient suspected of having lung cancer, based on their presenting symptoms?
Which of the following is the MOST appropriate initial imaging modality for a patient suspected of having lung cancer, based on their presenting symptoms?
A patient with non-small cell lung cancer undergoes surgical resection. Adjuvant chemotherapy is being considered. What is the PRIMARY goal of adjuvant chemotherapy in this scenario?
A patient with non-small cell lung cancer undergoes surgical resection. Adjuvant chemotherapy is being considered. What is the PRIMARY goal of adjuvant chemotherapy in this scenario?
Which of the following pathological changes is MOST characteristic of obstructive lung diseases like asthma and COPD?
Which of the following pathological changes is MOST characteristic of obstructive lung diseases like asthma and COPD?
A patient's spirometry results show a normal FEV1/FVC ratio but reduced FVC. Which of the following BEST describes the underlying pathophysiology?
A patient's spirometry results show a normal FEV1/FVC ratio but reduced FVC. Which of the following BEST describes the underlying pathophysiology?
Which of the following is the MOST appropriate action for a patient experiencing an acute asthma exacerbation with a peak expiratory flow rate (PEFR) of 40% of their personal best?
Which of the following is the MOST appropriate action for a patient experiencing an acute asthma exacerbation with a peak expiratory flow rate (PEFR) of 40% of their personal best?
A patient with asthma is using a short-acting beta2-agonist as needed and a low-dose inhaled corticosteroid daily, but continues to experience symptoms. According to NICE guidelines, what is the MOST appropriate next step in managing this patient's asthma?
A patient with asthma is using a short-acting beta2-agonist as needed and a low-dose inhaled corticosteroid daily, but continues to experience symptoms. According to NICE guidelines, what is the MOST appropriate next step in managing this patient's asthma?
A patient has been prescribed theophylline for asthma management. Which of the following monitoring procedures is MOST important to ensure patient safety?
A patient has been prescribed theophylline for asthma management. Which of the following monitoring procedures is MOST important to ensure patient safety?
A patient presents with a productive cough, fever, and pleuritic chest pain. Auscultation reveals bronchial breath sounds and coarse crackles in the right lower lobe. Which of the following is the MOST likely diagnosis?
A patient presents with a productive cough, fever, and pleuritic chest pain. Auscultation reveals bronchial breath sounds and coarse crackles in the right lower lobe. Which of the following is the MOST likely diagnosis?
A patient is diagnosed with community-acquired pneumonia (CAP). According to the CURB-65 scoring system, which of the following factors is included in the assessment?
A patient is diagnosed with community-acquired pneumonia (CAP). According to the CURB-65 scoring system, which of the following factors is included in the assessment?
A patient is being treated for pneumonia and develops a pleural effusion. Which of the following is the MOST concerning complication associated with a pleural effusion in this setting?
A patient is being treated for pneumonia and develops a pleural effusion. Which of the following is the MOST concerning complication associated with a pleural effusion in this setting?
A patient with a history of heavy smoking is diagnosed with squamous cell carcinoma of the lung. Which of the following electrolyte abnormalities is MOST likely associated with this type of lung cancer?
A patient with a history of heavy smoking is diagnosed with squamous cell carcinoma of the lung. Which of the following electrolyte abnormalities is MOST likely associated with this type of lung cancer?
A patient with small cell lung cancer (SCLC) presents with proximal muscle weakness that improves with repeated muscle use. This presentation is MOST suggestive of which paraneoplastic syndrome?
A patient with small cell lung cancer (SCLC) presents with proximal muscle weakness that improves with repeated muscle use. This presentation is MOST suggestive of which paraneoplastic syndrome?
A patient presents with a dry cough, shortness of breath, and a history of working in a job that involved exposure to asbestos. Which of the following conditions should be HIGHLY suspected?
A patient presents with a dry cough, shortness of breath, and a history of working in a job that involved exposure to asbestos. Which of the following conditions should be HIGHLY suspected?
In the management of asthma, which medication is used as a 'reliever' to provide immediate relief during acute bronchoconstriction?
In the management of asthma, which medication is used as a 'reliever' to provide immediate relief during acute bronchoconstriction?
A patient with a history of asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of severe asthma?
A patient with a history of asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of severe asthma?
A patient presents with pneumonia and is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?
A patient presents with pneumonia and is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?
A patient with pneumonia has a CRB-65 score of 2. According to NICE guidelines, what is the MOST appropriate next step in management?
A patient with pneumonia has a CRB-65 score of 2. According to NICE guidelines, what is the MOST appropriate next step in management?
Which of the following antibiotic classes is typically recommended for treating atypical pneumonia caused by Mycoplasma pneumoniae?
Which of the following antibiotic classes is typically recommended for treating atypical pneumonia caused by Mycoplasma pneumoniae?
A patient presents with a new diagnosis of pneumonia and is found to have a low CD4 count due to poorly controlled HIV. Which opportunistic infection is MOST likely?
A patient presents with a new diagnosis of pneumonia and is found to have a low CD4 count due to poorly controlled HIV. Which opportunistic infection is MOST likely?
A patient with known asthma has been using a short-acting beta-agonist (SABA) frequently, more than twice a week. What does this suggest about their asthma control?
A patient with known asthma has been using a short-acting beta-agonist (SABA) frequently, more than twice a week. What does this suggest about their asthma control?
What is the expected FEV1/FVC ratio in a patient diagnosed with restrictive lung disease?
What is the expected FEV1/FVC ratio in a patient diagnosed with restrictive lung disease?
A patient is suspected of having asthma. According to NICE guidelines, what is the first-line investigation to confirm the diagnosis?
A patient is suspected of having asthma. According to NICE guidelines, what is the first-line investigation to confirm the diagnosis?
After starting treatment for pneumonia a patient's CRP levels spike higher a day or two later despite the patient clinically improving on treatment. What is the MOST likely explanation for this?
After starting treatment for pneumonia a patient's CRP levels spike higher a day or two later despite the patient clinically improving on treatment. What is the MOST likely explanation for this?
Which of the following factors is MOST suggestive of asthma rather than another respiratory condition?
Which of the following factors is MOST suggestive of asthma rather than another respiratory condition?
According to BTS/SIGN guidelines regarding diagnosing Asthma, what action should a clinician take if they highly suspect a diagnosis of Asthma clinically?
According to BTS/SIGN guidelines regarding diagnosing Asthma, what action should a clinician take if they highly suspect a diagnosis of Asthma clinically?
Which of the following suggests a pneumonia diagnosis other than an infection of Streptococcus pneumoniae?
Which of the following suggests a pneumonia diagnosis other than an infection of Streptococcus pneumoniae?
What does the 'B' stand for when using the CRB-65 scoring system on a patient?
What does the 'B' stand for when using the CRB-65 scoring system on a patient?
Which of the following bacteria most commonly presents itself in patients with both pneumonia and cystic fibrosis?
Which of the following bacteria most commonly presents itself in patients with both pneumonia and cystic fibrosis?
For pneumonia patients treated in the community with a CRB score of 0 or 1, what investigation should be considered?
For pneumonia patients treated in the community with a CRB score of 0 or 1, what investigation should be considered?
Which of the following is most likely to cause pneumonia in a patient with a new parrot?
Which of the following is most likely to cause pneumonia in a patient with a new parrot?
What flow rate indicates severe asthma?
What flow rate indicates severe asthma?
What other condition can lung function tests assist with?
What other condition can lung function tests assist with?
Which of the following combinations of medications is MOST likely to be found in a Maintenance and Reliever Therapy (MART) inhaler?
Which of the following combinations of medications is MOST likely to be found in a Maintenance and Reliever Therapy (MART) inhaler?
Which of the following is NOT a restrictive lung disease?
Which of the following is NOT a restrictive lung disease?
A patient is being assessed using a peak flow meter. Which of the following instructions would be MOST appropriate to ensure an accurate reading?
A patient is being assessed using a peak flow meter. Which of the following instructions would be MOST appropriate to ensure an accurate reading?
Which of the following is the MOST common symptom of pneumonia?
Which of the following is the MOST common symptom of pneumonia?
A patient with a history of asbestos exposure presents with shortness of breath and chest pain. While mesothelioma is suspected, which initial imaging finding would be MOST indicative of this specific malignancy rather than other lung conditions?
A patient with a history of asbestos exposure presents with shortness of breath and chest pain. While mesothelioma is suspected, which initial imaging finding would be MOST indicative of this specific malignancy rather than other lung conditions?
A patient with small cell lung cancer (SCLC) develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?
A patient with small cell lung cancer (SCLC) develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?
A patient presents with new onset ptosis, miosis, and anhidrosis on the right side of their face, along with right shoulder pain. Given the likely diagnosis, where is the MOST probable location of the tumor?
A patient presents with new onset ptosis, miosis, and anhidrosis on the right side of their face, along with right shoulder pain. Given the likely diagnosis, where is the MOST probable location of the tumor?
A patient is diagnosed with community-acquired pneumonia (CAP) and has a CURB-65 score of 3. What is the MOST appropriate management strategy for this patient, according to guidelines?
A patient is diagnosed with community-acquired pneumonia (CAP) and has a CURB-65 score of 3. What is the MOST appropriate management strategy for this patient, according to guidelines?
Following initial investigations, a patient is suspected to have asthma. According to NICE guidelines, which of the following is the MOST appropriate FIRST-LINE investigation to confirm the diagnosis?
Following initial investigations, a patient is suspected to have asthma. According to NICE guidelines, which of the following is the MOST appropriate FIRST-LINE investigation to confirm the diagnosis?
A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following BEST describes the components and usage of a MART inhaler?
A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following BEST describes the components and usage of a MART inhaler?
A patient with a history of well-controlled asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a severe asthma exacerbation?
A patient with a history of well-controlled asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a severe asthma exacerbation?
A patient presents with a dry cough, shortness of breath and night sweats. They have a history of poorly controlled HIV. Which of the following is the MOST likely causative organism for their pneumonia?
A patient presents with a dry cough, shortness of breath and night sweats. They have a history of poorly controlled HIV. Which of the following is the MOST likely causative organism for their pneumonia?
A patient with a history of smoking develops hypercalcemia. What type of lung cancer is MOST likely?
A patient with a history of smoking develops hypercalcemia. What type of lung cancer is MOST likely?
A patient’s spirometry results show an FEV1/FVC ratio of 85% and reduced FVC. What does this suggest?
A patient’s spirometry results show an FEV1/FVC ratio of 85% and reduced FVC. What does this suggest?
A patient with a history of asthma presents with cough, wheeze, and shortness of breath. They use their short-acting beta2-agonist inhaler more than twice a week. What does this indicate regarding their asthma control?
A patient with a history of asthma presents with cough, wheeze, and shortness of breath. They use their short-acting beta2-agonist inhaler more than twice a week. What does this indicate regarding their asthma control?
A farmer presents with a flu-like illness and is subsequently diagnosed with atypical pneumonia. Which organism is MOST likely responsible?
A farmer presents with a flu-like illness and is subsequently diagnosed with atypical pneumonia. Which organism is MOST likely responsible?
A patient presents with a pneumonia and a rash characterised by varying sized 'target lesions' formed by pink rings with pale centres. What organism is MOST likely responsible?
A patient presents with a pneumonia and a rash characterised by varying sized 'target lesions' formed by pink rings with pale centres. What organism is MOST likely responsible?
Which of the following statements BEST describes the action of theophylline in the long-term management of asthma?
Which of the following statements BEST describes the action of theophylline in the long-term management of asthma?
A patient has been diagnosed with pneumonia. Their inflammatory markers spike higher a day or two later after treatment despite them improving clinically. What is the MOST likely explanation for this?
A patient has been diagnosed with pneumonia. Their inflammatory markers spike higher a day or two later after treatment despite them improving clinically. What is the MOST likely explanation for this?
A patient with pneumonia deteriorates and develops a pleural effusion. Which complication is MOST concerning?
A patient with pneumonia deteriorates and develops a pleural effusion. Which complication is MOST concerning?
A patient with suspected pneumonia has a CRB-65 score of 1. According to NICE guidelines, what is the MOST appropriate action for this patient?
A patient with suspected pneumonia has a CRB-65 score of 1. According to NICE guidelines, what is the MOST appropriate action for this patient?
A patient presents with signs and symptoms suggestive of pneumonia. Which of the following findings on chest examination is MOST indicative of pneumonia?
A patient presents with signs and symptoms suggestive of pneumonia. Which of the following findings on chest examination is MOST indicative of pneumonia?
A patient is commenced on Theophylline for asthma management. Which regular monitoring is required?
A patient is commenced on Theophylline for asthma management. Which regular monitoring is required?
What percentage of lung cancers are estimated to be preventable?
What percentage of lung cancers are estimated to be preventable?
Which of the following is the MOST common presenting symptom of pneumonia?
Which of the following is the MOST common presenting symptom of pneumonia?
A patient with asthma has an FEV1/FVC ratio of less than 75%. What does this suggest?
A patient with asthma has an FEV1/FVC ratio of less than 75%. What does this suggest?
Which of the following signs and symptoms are associated with superior vena cava obstruction?
Which of the following signs and symptoms are associated with superior vena cava obstruction?
A patient has been exposed to asbestos. Which malignancy is MOST associated with this?
A patient has been exposed to asbestos. Which malignancy is MOST associated with this?
What is the MOST significant risk factor for lung cancer?
What is the MOST significant risk factor for lung cancer?
Which of the following findings on a chest X-ray MOST strongly suggests lung cancer?
Which of the following findings on a chest X-ray MOST strongly suggests lung cancer?
A patient with suspected pneumonia has a CRB-65 score of 1. Which of the following factors contribute to the patients score?
A patient with suspected pneumonia has a CRB-65 score of 1. Which of the following factors contribute to the patients score?
What is the typical treatment for small cell lung cancer?
What is the typical treatment for small cell lung cancer?
What is the definition of hospital acquired pneumonia?
What is the definition of hospital acquired pneumonia?
A patient presents with a productive cough, fever and pleuritic chest pain. On examination, you note bronchial breath sounds and coarse crackles on the right side of their chest. What is the MOST likely diagnosis?
A patient presents with a productive cough, fever and pleuritic chest pain. On examination, you note bronchial breath sounds and coarse crackles on the right side of their chest. What is the MOST likely diagnosis?
Which of the following underlying mechanisms is MOST likely for the development of Cushing’s syndrome in a patient with small cell lung cancer?
Which of the following underlying mechanisms is MOST likely for the development of Cushing’s syndrome in a patient with small cell lung cancer?
A patient has been diagnosed with restrictive lung disease. What test can be used to establish objective measures of lung function?
A patient has been diagnosed with restrictive lung disease. What test can be used to establish objective measures of lung function?
In suspected lung cancer, what is the purpose of using contrast enhancement during a CT scan of the chest, abdomen, and pelvis?
In suspected lung cancer, what is the purpose of using contrast enhancement during a CT scan of the chest, abdomen, and pelvis?
What is the MOST appropriate treatment for mild community acquired pneumonia?
What is the MOST appropriate treatment for mild community acquired pneumonia?
Which of the following is MOST likely to be found in a Maintenance and Reliever Therapy (MART) inhaler?
Which of the following is MOST likely to be found in a Maintenance and Reliever Therapy (MART) inhaler?
A patient with a history of asthma presents with progressively worsening shortness of breath, a respiratory rate of 28 breaths per minute and is using accessory muscles. Peak flow is 40% of their predicted best. How would you grade the severity of their asthma?
A patient with a history of asthma presents with progressively worsening shortness of breath, a respiratory rate of 28 breaths per minute and is using accessory muscles. Peak flow is 40% of their predicted best. How would you grade the severity of their asthma?
A patient is diagnosed with pneumonia and is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?
A patient is diagnosed with pneumonia and is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?
A patient has been prescribed Theophylline. How soon after each dose change should their plasma levels should be monitored?
A patient has been prescribed Theophylline. How soon after each dose change should their plasma levels should be monitored?
What is the MOST common cause of atypical pneumonia in patients with poorly controlled HIV and a low CD4 count?
What is the MOST common cause of atypical pneumonia in patients with poorly controlled HIV and a low CD4 count?
A patient with a history of asbestos exposure presents with shortness of breath. Aside from mesothelioma, what other condition is this patient MOST at risk of developing?
A patient with a history of asbestos exposure presents with shortness of breath. Aside from mesothelioma, what other condition is this patient MOST at risk of developing?
According to NICE guidelines, what is the FIRST step in long term asthma management, after prescribing a short-acting beta 2 agonist inhaler?
According to NICE guidelines, what is the FIRST step in long term asthma management, after prescribing a short-acting beta 2 agonist inhaler?
What are some triggers for asthma?
What are some triggers for asthma?
A patient presents with proximal muscle weakness that improves with repeated muscle use. This presentation is MOST suggestive of which paraneoplastic syndrome associated with small cell lung cancer?
A patient presents with proximal muscle weakness that improves with repeated muscle use. This presentation is MOST suggestive of which paraneoplastic syndrome associated with small cell lung cancer?
A farmer presents with a flu-like illness and is diagnosed with atypical pneumonia, contracted from exposure to animals and their bodily fluids. Which organism is MOST likely responsible?
A farmer presents with a flu-like illness and is diagnosed with atypical pneumonia, contracted from exposure to animals and their bodily fluids. Which organism is MOST likely responsible?
A patient's spirometry results show an FEV1/FVC ratio of 65% and reduced FEV1. What does this pattern suggest?
A patient's spirometry results show an FEV1/FVC ratio of 65% and reduced FEV1. What does this pattern suggest?
When should you consider to intensive care assessment for a patient with pneumonia?
When should you consider to intensive care assessment for a patient with pneumonia?
A patient is suspected of having pneumonia. Which investigation is MOST likely to occur if they arrive at hospital?
A patient is suspected of having pneumonia. Which investigation is MOST likely to occur if they arrive at hospital?
Which of the following statements BEST describes the use of peak expiratory flow rate (PEFR) in asthma management?
Which of the following statements BEST describes the use of peak expiratory flow rate (PEFR) in asthma management?
A patient presents with a dry cough, shortness of breath, and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which of the following investigations would be MOST useful in confirming the suspected diagnosis?
A patient presents with a dry cough, shortness of breath, and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which of the following investigations would be MOST useful in confirming the suspected diagnosis?
A patient is diagnosed with community-acquired pneumonia (CAP) and is being treated as an outpatient. Three days later, the patient returns, reporting worsening symptoms despite adherence to the prescribed antibiotics. Which of the following is the MOST appropriate next step in management?
A patient is diagnosed with community-acquired pneumonia (CAP) and is being treated as an outpatient. Three days later, the patient returns, reporting worsening symptoms despite adherence to the prescribed antibiotics. Which of the following is the MOST appropriate next step in management?
A patient with a history of smoking presents with new onset ptosis, miosis and anhidrosis on the left side of their face, along with left shoulder pain. A mass is found on the apex of the lung. Which nerve structure is MOST likely affected?
A patient with a history of smoking presents with new onset ptosis, miosis and anhidrosis on the left side of their face, along with left shoulder pain. A mass is found on the apex of the lung. Which nerve structure is MOST likely affected?
A patient presents with a persistent dry cough, shortness of breath, and fatigue. A chest X-ray reveals bilateral hilar lymphadenopathy and reticular infiltrates. Which of the following conditions is MOST likely?
A patient presents with a persistent dry cough, shortness of breath, and fatigue. A chest X-ray reveals bilateral hilar lymphadenopathy and reticular infiltrates. Which of the following conditions is MOST likely?
A patient recently returned from a holiday, where they stayed in a cheap hotel. They now have a persistent dry cough, neurological symptoms and hyponatraemia. Which of the following organisms is MOST likely the cause?
A patient recently returned from a holiday, where they stayed in a cheap hotel. They now have a persistent dry cough, neurological symptoms and hyponatraemia. Which of the following organisms is MOST likely the cause?
A patient’s spirometry results show a normal FEV1/FVC ratio but reduced FVC. Which of the following is the MOST likely underlying cause
A patient’s spirometry results show a normal FEV1/FVC ratio but reduced FVC. Which of the following is the MOST likely underlying cause
A patient with asthma is using a short-acting beta2-agonist (SABA) more than twice a week for symptom relief. According to asthma guidelines, what does this indicate and what should the next step likely be?
A patient with asthma is using a short-acting beta2-agonist (SABA) more than twice a week for symptom relief. According to asthma guidelines, what does this indicate and what should the next step likely be?
A patient with small cell lung cancer develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?
A patient with small cell lung cancer develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?
A 60 year old patient, recently diagnosed with pneumonia, is not improving as expected on standard antibiotic treatment. Sputum and blood cultures are negative. They recall owning a pet parrot. What is the MOST likely cause?
A 60 year old patient, recently diagnosed with pneumonia, is not improving as expected on standard antibiotic treatment. Sputum and blood cultures are negative. They recall owning a pet parrot. What is the MOST likely cause?
A patient with advanced lung cancer develops new onset of short-term memory loss, hallucinations, confusion and seizures. Which antibody is MOST likely associated with this presentation?
A patient with advanced lung cancer develops new onset of short-term memory loss, hallucinations, confusion and seizures. Which antibody is MOST likely associated with this presentation?
A patient with known asthma presents with acute respiratory distress. They are diaphoretic, using accessory muscles to breathe and are only able to speak in single words. Auscultation reveals minimal wheezing and significantly reduced air entry bilaterally. Despite nebulised bronchodilators and IV corticosteroids, their condition worsens, and their PaCO2 is rising. This patient is MOST likely suffering from which of the following pathological processes?
A patient with known asthma presents with acute respiratory distress. They are diaphoretic, using accessory muscles to breathe and are only able to speak in single words. Auscultation reveals minimal wheezing and significantly reduced air entry bilaterally. Despite nebulised bronchodilators and IV corticosteroids, their condition worsens, and their PaCO2 is rising. This patient is MOST likely suffering from which of the following pathological processes?
What does an FEV1/FVC ratio of less than 75% suggest?
What does an FEV1/FVC ratio of less than 75% suggest?
Exposure to which of the following substances is MOST associated with mesothelioma?
Exposure to which of the following substances is MOST associated with mesothelioma?
Which of the following is the MOST significant risk factor for lung cancer?
Which of the following is the MOST significant risk factor for lung cancer?
A patient presents to hospital with suspected pneumonia. Which of the following CURB-65 factors contribute to a score of 1?
A patient presents to hospital with suspected pneumonia. Which of the following CURB-65 factors contribute to a score of 1?
What is the MOST appropriate antibiotic treatment for mild community acquired pneumonia?
What is the MOST appropriate antibiotic treatment for mild community acquired pneumonia?
Which of the following is NOT a typical trigger for triggering asthma?
Which of the following is NOT a typical trigger for triggering asthma?
Which of the following is a typical sign or symptom of lung cancer?
Which of the following is a typical sign or symptom of lung cancer?
What is the FIRST-LINE investigation for suspected lung cancer?
What is the FIRST-LINE investigation for suspected lung cancer?
Apart from recurrent pneumonia, which of the following is a sign or symptom of lung cancer?
Apart from recurrent pneumonia, which of the following is a sign or symptom of lung cancer?
Which of the following is the MOST common risk factor for developing lung cancer?
Which of the following is the MOST common risk factor for developing lung cancer?
Which of the following, seen on a chest X-ray, would MOST strongly suggest lung cancer?
Which of the following, seen on a chest X-ray, would MOST strongly suggest lung cancer?
Which of the following conditions is MOST associated with asbestos exposure?
Which of the following conditions is MOST associated with asbestos exposure?
What is the purpose of using contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?
What is the purpose of using contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?
What is the typical treatment approach for small cell lung cancer (SCLC)?
What is the typical treatment approach for small cell lung cancer (SCLC)?
A patient presents with new onset ptosis, miosis and anhidrosis on the left side of their face, along with left shoulder pain. A mass is found on the apex of the lung. Which nerve structure is MOST likely affected?
A patient presents with new onset ptosis, miosis and anhidrosis on the left side of their face, along with left shoulder pain. A mass is found on the apex of the lung. Which nerve structure is MOST likely affected?
Which of the following findings on a chest X-ray would be MOST suggestive of mesothelioma, rather than other lung conditions, in a patient with a history of asbestos exposure?
Which of the following findings on a chest X-ray would be MOST suggestive of mesothelioma, rather than other lung conditions, in a patient with a history of asbestos exposure?
A patient is diagnosed with small cell lung cancer (SCLC) and develops SIADH. Which mechanism BEST explains the underlying cause of hyponatremia in this patient?
A patient is diagnosed with small cell lung cancer (SCLC) and develops SIADH. Which mechanism BEST explains the underlying cause of hyponatremia in this patient?
A patient has an FEV1/FVC ratio of less than 75%. What does this suggest?
A patient has an FEV1/FVC ratio of less than 75%. What does this suggest?
Which of the following are the two key treatments for the long term management of asthma?
Which of the following are the two key treatments for the long term management of asthma?
Which of the following scenarios MOST accurately describes how hospital aquired pneumonia is developed?
Which of the following scenarios MOST accurately describes how hospital aquired pneumonia is developed?
Which antibiotic is MOST appropriate for treating mild community acquired pneumonia?
Which antibiotic is MOST appropriate for treating mild community acquired pneumonia?
According to asthma management guidelines involving the 'stepwise ladder', what is the FIRST step?
According to asthma management guidelines involving the 'stepwise ladder', what is the FIRST step?
What are some typical triggers for asthma?
What are some typical triggers for asthma?
Which of the organisms listed below is LEAST likely to respond to penicillins?
Which of the organisms listed below is LEAST likely to respond to penicillins?
A patient is diagnosed with pneumonia and has a CRB-65 score of 1. What is the MOST appropriate action for this patient?
A patient is diagnosed with pneumonia and has a CRB-65 score of 1. What is the MOST appropriate action for this patient?
Which pneumonia type is LEAST likely to be caused by Streptococcus pneumoniae?
Which pneumonia type is LEAST likely to be caused by Streptococcus pneumoniae?
Which presentation is MOST suggestive of asthma, rather than another respiratory condition?
Which presentation is MOST suggestive of asthma, rather than another respiratory condition?
When interpreting lung function tests, what does an FEV1/FVC ratio of less than 75% suggest?
When interpreting lung function tests, what does an FEV1/FVC ratio of less than 75% suggest?
Which of the following signs is associated with pneumonia?
Which of the following signs is associated with pneumonia?
Which type of lung disease is associated with having a relatively good lung volume but air is only able to move in and out of the lungs slowly, due to obstruction?
Which type of lung disease is associated with having a relatively good lung volume but air is only able to move in and out of the lungs slowly, due to obstruction?
Atypical pneumonia will NOT respond to which common medication?
Atypical pneumonia will NOT respond to which common medication?
In asthma management, what is the action of short acting beta 2 adrenergic receptor agonists?
In asthma management, what is the action of short acting beta 2 adrenergic receptor agonists?
Which is MOST likely to cause pneumonia on a patient presenting with a new parrot?
Which is MOST likely to cause pneumonia on a patient presenting with a new parrot?
Which of the following is the MOST common cause of pneumonia in patients with cystic fibrosis?
Which of the following is the MOST common cause of pneumonia in patients with cystic fibrosis?
Which of the options is MOST appropriate to treat moderate to severe community acquired pneumonia?
Which of the options is MOST appropriate to treat moderate to severe community acquired pneumonia?
A patient has a dry cough, shortness of breath and sweats with poorly controlled HIV. What is the MOST likely causative organism for pneumonia?
A patient has a dry cough, shortness of breath and sweats with poorly controlled HIV. What is the MOST likely causative organism for pneumonia?
Which statement BEST describes the underlying process of restrictive lung disease?
Which statement BEST describes the underlying process of restrictive lung disease?
What is the primary goal of adjuvant chemotherapy in a patient with non-small cell lung cancer after surgical resection?
What is the primary goal of adjuvant chemotherapy in a patient with non-small cell lung cancer after surgical resection?
What is the MOST likely underlying cause of hyponatremia in a patient with small cell lung cancer (SCLC)?
What is the MOST likely underlying cause of hyponatremia in a patient with small cell lung cancer (SCLC)?
A patient presents with pneumonia symptoms, a history of working in the construction industry with exposure to asbestos and also has an associated pleural effusion. Which malignancy should be MOST suspected?
A patient presents with pneumonia symptoms, a history of working in the construction industry with exposure to asbestos and also has an associated pleural effusion. Which malignancy should be MOST suspected?
TOM TIP: The 5 causes of atypical pneumonia mnemonic is 'Legions of psittaci MCQs'. What does the 'Qs' stand for?
TOM TIP: The 5 causes of atypical pneumonia mnemonic is 'Legions of psittaci MCQs'. What does the 'Qs' stand for?
What is the expected FEV1/FVC ratio in a patient diagnosed with restrictive lung disease, and why?
What is the expected FEV1/FVC ratio in a patient diagnosed with restrictive lung disease, and why?
A patient with a history of smoking presents with shoulder pain and Horner's syndrome, and a mass in the pulmonary apex. Which nerve structure is MOST likely compressed on the sympathetic ganglion, causing these symptoms?
A patient with a history of smoking presents with shoulder pain and Horner's syndrome, and a mass in the pulmonary apex. Which nerve structure is MOST likely compressed on the sympathetic ganglion, causing these symptoms?
A patient is diagnosed with small cell lung cancer and develops Cushing’s syndrome. What is the MOST likely underlying mechanism?
A patient is diagnosed with small cell lung cancer and develops Cushing’s syndrome. What is the MOST likely underlying mechanism?
Which is NOT a specific diagnostic criteria for acute asthma?
Which is NOT a specific diagnostic criteria for acute asthma?
Why does the trend of C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis commonly show a delayed response, spiking a day or two later despite the patient improving on their dual antibiotic treatment?
Why does the trend of C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis commonly show a delayed response, spiking a day or two later despite the patient improving on their dual antibiotic treatment?
Which combination of diagnostic findings is MOST indicative of severe acute asthma? Auscultation results will reveal what?
Which combination of diagnostic findings is MOST indicative of severe acute asthma? Auscultation results will reveal what?
A patient has been diagnosed with non-small cell lung cancer. The cancer has been isolated to a single area, and the patient is deemed suitable for surgery. Which of the following surgical procedures is typically offered FIRST-LINE?
A patient has been diagnosed with non-small cell lung cancer. The cancer has been isolated to a single area, and the patient is deemed suitable for surgery. Which of the following surgical procedures is typically offered FIRST-LINE?
Which of the following is the LEAST common histological type of non-small cell lung cancer?
Which of the following is the LEAST common histological type of non-small cell lung cancer?
Which investigation is considered FIRST-LINE in suspected lung cancer?
Which investigation is considered FIRST-LINE in suspected lung cancer?
Which of the following is NOT a recognised sign or symptom of lung cancer?
Which of the following is NOT a recognised sign or symptom of lung cancer?
What is a common finding on a chest X-ray that may suggest lung cancer?
What is a common finding on a chest X-ray that may suggest lung cancer?
Which of the following imaging modalities is BEST for identifying areas of metastasis in suspected lung cancer due to its ability to visualize metabolically active tissues?
Which of the following imaging modalities is BEST for identifying areas of metastasis in suspected lung cancer due to its ability to visualize metabolically active tissues?
Surgery is typically offered as a FIRST-LINE treatment for which type of lung cancer when the disease is isolated to a single area?
Surgery is typically offered as a FIRST-LINE treatment for which type of lung cancer when the disease is isolated to a single area?
A patient presents with facial swelling, shortness of breath, and dilated neck veins. Which complication of lung cancer is MOST likely?
A patient presents with facial swelling, shortness of breath, and dilated neck veins. Which complication of lung cancer is MOST likely?
What condition is suggested by the 'Pemberton’s sign'?
What condition is suggested by the 'Pemberton’s sign'?
Which triad of symptoms characterizes Horner's syndrome?
Which triad of symptoms characterizes Horner's syndrome?
A patient with small cell lung cancer develops hyponatremia. Which paraneoplastic syndrome is the MOST likely cause?
A patient with small cell lung cancer develops hyponatremia. Which paraneoplastic syndrome is the MOST likely cause?
A patient with squamous cell carcinoma of the lung develops hypercalcemia. What is the MOST likely underlying mechanism?
A patient with squamous cell carcinoma of the lung develops hypercalcemia. What is the MOST likely underlying mechanism?
What is one of the primary goals of adjuvant chemotherapy in patients with non-small cell lung cancer after surgical resection?
What is one of the primary goals of adjuvant chemotherapy in patients with non-small cell lung cancer after surgical resection?
Which lung malignancy is MOST strongly associated with asbestos inhalation?
Which lung malignancy is MOST strongly associated with asbestos inhalation?
Which classification BEST describes pneumonia if it develops more than 48 hours after hospital admission?
Which classification BEST describes pneumonia if it develops more than 48 hours after hospital admission?
Which of the following chest signs is MOST indicative of pneumonia?
Which of the following chest signs is MOST indicative of pneumonia?
Which CURB-65 scoring system component does the 'B' stand for?
Which CURB-65 scoring system component does the 'B' stand for?
Which is the MOST common cause of community-acquired pneumonia?
Which is the MOST common cause of community-acquired pneumonia?
Which of the following organisms is LEAST likely to respond to penicillin antibiotics?
Which of the following organisms is LEAST likely to respond to penicillin antibiotics?
A patient diagnosed with pneumonia develops a pleural effusion. Which of the following complications is MOST concerning in this setting?
A patient diagnosed with pneumonia develops a pleural effusion. Which of the following complications is MOST concerning in this setting?
A farmer develops a flu-like illness and is diagnosed with atypical pneumonia. Exposure to which organism is MOST likely?
A farmer develops a flu-like illness and is diagnosed with atypical pneumonia. Exposure to which organism is MOST likely?
What atypical pneumonia is MOST likely to be contracted from contact with infected birds such as parrots?
What atypical pneumonia is MOST likely to be contracted from contact with infected birds such as parrots?
Which of the following is MOST commonly used to treat fungal pneumonia caused by Pneumocystis jiroveci (PCP)?
Which of the following is MOST commonly used to treat fungal pneumonia caused by Pneumocystis jiroveci (PCP)?
What should patients with poorly controlled or new HIV with a low CD4 count be prescribed to protect against PCP?
What should patients with poorly controlled or new HIV with a low CD4 count be prescribed to protect against PCP?
Which organism is MOST likely responsible for pneumonia in a patient who presents with a dry cough, shortness of breath, and night sweats and has a history of poorly controlled HIV?
Which organism is MOST likely responsible for pneumonia in a patient who presents with a dry cough, shortness of breath, and night sweats and has a history of poorly controlled HIV?
Which of the following results is MOST indicative of obstructive lung disease?
Which of the following results is MOST indicative of obstructive lung disease?
Which of the following scenarios suggests a restrictive lung disease?
Which of the following scenarios suggests a restrictive lung disease?
In asthma, what is the PATHOPHYSIOLOGICAL basis of airflow obstruction is?
In asthma, what is the PATHOPHYSIOLOGICAL basis of airflow obstruction is?
What is the MOST appropriate action for a patient experiencing an acute asthma exacerbation with a peak expiratory flow rate (PEFR) of 40% of their personal best?
What is the MOST appropriate action for a patient experiencing an acute asthma exacerbation with a peak expiratory flow rate (PEFR) of 40% of their personal best?
A patient has a peak flow of 66% of their predicted best. Which severity category does this fall into?
A patient has a peak flow of 66% of their predicted best. Which severity category does this fall into?
A patient with asthma is using their short-acting beta2-agonist (SABA) inhaler more than twice a week for symptom relief. What does this suggest about their asthma control?
A patient with asthma is using their short-acting beta2-agonist (SABA) inhaler more than twice a week for symptom relief. What does this suggest about their asthma control?
What is the MOST important action for a patient who has been hospitalised with acute asthma and is about to be discharged?
What is the MOST important action for a patient who has been hospitalised with acute asthma and is about to be discharged?
Which medication, commonly used in asthma management, requires monitoring of plasma levels due to its narrow therapeutic window?
Which medication, commonly used in asthma management, requires monitoring of plasma levels due to its narrow therapeutic window?
In the context of asthma, what does the acronym MART stand for regarding inhaler therapy?
In the context of asthma, what does the acronym MART stand for regarding inhaler therapy?
Considering patients with a high pre-test probability of Asthma and are symptomatic, what is the most appropriate action a clinician should take, according to BTS/SIGN guidelines?
Considering patients with a high pre-test probability of Asthma and are symptomatic, what is the most appropriate action a clinician should take, according to BTS/SIGN guidelines?
A patient presents with pneumonia symptoms, a history of working in the construction industry with exposure to asbestos but WITHOUT an associated pleural effusion. Which malignancy should be HIGHLY suspected?
A patient presents with pneumonia symptoms, a history of working in the construction industry with exposure to asbestos but WITHOUT an associated pleural effusion. Which malignancy should be HIGHLY suspected?
Which of the following statements BEST represents the difference in treatment approach between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC)?
Which of the following statements BEST represents the difference in treatment approach between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC)?
What is the MOST likely causative organism of atypical pneumonia when a patient presents with a persistent dry cough, neurological symptoms, and hyponatraemia after recently staying in a cheap hotel?
What is the MOST likely causative organism of atypical pneumonia when a patient presents with a persistent dry cough, neurological symptoms, and hyponatraemia after recently staying in a cheap hotel?
According to the typical antibiotic course lengths, which of the following options is MOST appropriate for a patient diagnosed with moderate to severe community-acquired pneumonia?
According to the typical antibiotic course lengths, which of the following options is MOST appropriate for a patient diagnosed with moderate to severe community-acquired pneumonia?
In a patient with suspected pneumonia and a CRB-65 score of 2, with no other concerning symptoms. What is the MOST appropriate next step in management?
In a patient with suspected pneumonia and a CRB-65 score of 2, with no other concerning symptoms. What is the MOST appropriate next step in management?
A patient has been diagnosed with non-small cell lung cancer, and staging reveals the cancer has spread to distant sites. All treatments have failed, and the patient now requires end-of-life care. Which treatment is MOST appropriate?
A patient has been diagnosed with non-small cell lung cancer, and staging reveals the cancer has spread to distant sites. All treatments have failed, and the patient now requires end-of-life care. Which treatment is MOST appropriate?
A patient presents with proximal muscle weakness that improves with repeated muscle use. A diagnosis of small-cell lung cancer is suspected. What specific finding would provide further evidence of the underlying cause of Lambert-Eaton Myasthenic Syndrome
A patient presents with proximal muscle weakness that improves with repeated muscle use. A diagnosis of small-cell lung cancer is suspected. What specific finding would provide further evidence of the underlying cause of Lambert-Eaton Myasthenic Syndrome
What percentage of lung cancers are considered preventable?
What percentage of lung cancers are considered preventable?
Which investigation is typically performed FIRST-LINE if a doctor suspects a patient may have lung cancer?
Which investigation is typically performed FIRST-LINE if a doctor suspects a patient may have lung cancer?
Which small cell lung cancer manifestation presents with short term memory impairment, hallucinations, confusion and seizures?
Which small cell lung cancer manifestation presents with short term memory impairment, hallucinations, confusion and seizures?
A patient presents with a combination of cough, fever, and pleuritic chest pain. On auscultation, bronchial breath sounds and coarse crackles are observed. What condition is MOST likely?
A patient presents with a combination of cough, fever, and pleuritic chest pain. On auscultation, bronchial breath sounds and coarse crackles are observed. What condition is MOST likely?
What FEV1/FVC ratio result suggests obstructive lung disease?
What FEV1/FVC ratio result suggests obstructive lung disease?
What is the MOST likely cause of pneumonia in a patient with cystic fibrosis?
What is the MOST likely cause of pneumonia in a patient with cystic fibrosis?
According to NICE guidelines, what combination of medications should be prescribed INITIALLY for asthma management?
According to NICE guidelines, what combination of medications should be prescribed INITIALLY for asthma management?
What is the MOST appropriate first-line management for a patient with community-acquired pneumonia and a CURB-65 score of 0 or 1?
What is the MOST appropriate first-line management for a patient with community-acquired pneumonia and a CURB-65 score of 0 or 1?
A patient presents with suspected pneumonia. Which of the following chest examination findings is MOST indicative of pneumonia?
A patient presents with suspected pneumonia. Which of the following chest examination findings is MOST indicative of pneumonia?
A person with a predicted peak flow of 600 achieves a score of 300 on their best attempt using a peak expiratory flow meter. What percentage of their predicted peak flow are they currently achieving?
A person with a predicted peak flow of 600 achieves a score of 300 on their best attempt using a peak expiratory flow meter. What percentage of their predicted peak flow are they currently achieving?
Which statement BEST describes the purpose of contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?
Which statement BEST describes the purpose of contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?
In the context of asthma management, what is the difference between the British Thoracic Society (BTS)/SIGN guidelines and the NICE guidelines regarding diagnosis?
In the context of asthma management, what is the difference between the British Thoracic Society (BTS)/SIGN guidelines and the NICE guidelines regarding diagnosis?
A patient presents with a persistent dry cough, shortness of breath, and fatigue. A chest X-ray reveals bilateral hilar lymphadenopathy and reticular infiltrates. What condition is MOST likely?
A patient presents with a persistent dry cough, shortness of breath, and fatigue. A chest X-ray reveals bilateral hilar lymphadenopathy and reticular infiltrates. What condition is MOST likely?
What does the acronym 'TOM TIP' stand for in the context of atypical pneumonia causes?
What does the acronym 'TOM TIP' stand for in the context of atypical pneumonia causes?
A patient with non-small cell lung cancer develops hypercalcemia due to ectopic parathyroid hormone production. Despite treatment, the hypercalcemia persists, and the patient develops severe polyuria and polydipsia. Which of the following mechanisms BEST contributes to these renal effects?
A patient with non-small cell lung cancer develops hypercalcemia due to ectopic parathyroid hormone production. Despite treatment, the hypercalcemia persists, and the patient develops severe polyuria and polydipsia. Which of the following mechanisms BEST contributes to these renal effects?
Which of the following patients presenting with pneumonia is MOST likely to have a normal inflammatory response, and thus, normal WBC and CRP markers?
Which of the following patients presenting with pneumonia is MOST likely to have a normal inflammatory response, and thus, normal WBC and CRP markers?
What is the MOST common early symptom of lung cancer?
What is the MOST common early symptom of lung cancer?
Which investigation is MOST appropriate for suspected lung cancer?
Which investigation is MOST appropriate for suspected lung cancer?
Which tumour location is MOST likely to cause Horner's syndrome?
Which tumour location is MOST likely to cause Horner's syndrome?
What is the MOST common cause of pneumonia?
What is the MOST common cause of pneumonia?
What is the MOST likely finding of restrictive lung disease during lung function tests?
What is the MOST likely finding of restrictive lung disease during lung function tests?
What is the MOST appropriate FIRST-LINE treatment for asthma?
What is the MOST appropriate FIRST-LINE treatment for asthma?
What is the MOST common method of staging and assessment of metastasis in suspected lung cancer?
What is the MOST common method of staging and assessment of metastasis in suspected lung cancer?
Which pneumonia causing organism is MOST associated with recent travel?
Which pneumonia causing organism is MOST associated with recent travel?
A patient's asthma symptoms are not well controlled with an inhaled corticosteroid. According to NICE guidelines, what is the MOST appropriate next step?
A patient's asthma symptoms are not well controlled with an inhaled corticosteroid. According to NICE guidelines, what is the MOST appropriate next step?
What is the MOST important measure in reducing the risk of lung cancer?
What is the MOST important measure in reducing the risk of lung cancer?
What is the MOST likely result of a recurrent laryngeal nerve palsy?
What is the MOST likely result of a recurrent laryngeal nerve palsy?
What is the MOST likely action of theophylline in the treatment of asthma?
What is the MOST likely action of theophylline in the treatment of asthma?
Which description BEST describes the stepwise approach to asthma management?
Which description BEST describes the stepwise approach to asthma management?
Which condition is MOST associated with the presence of anti-Hu antibodies?
Which condition is MOST associated with the presence of anti-Hu antibodies?
A patient is diagnosed with pneumonia. What parameter is assessed in the CURB-65 score?
A patient is diagnosed with pneumonia. What parameter is assessed in the CURB-65 score?
What is the MOST likely antibiotic for mild community-acquired pneumonia?
What is the MOST likely antibiotic for mild community-acquired pneumonia?
Which is the MOST appropriate action for a patient experiencing acute asthma with a PEFR of 40%?
Which is the MOST appropriate action for a patient experiencing acute asthma with a PEFR of 40%?
What is the MOST likely reason for hyponatremia in a patient with Legionella pneumonia?
What is the MOST likely reason for hyponatremia in a patient with Legionella pneumonia?
What is the BEST method of determining an asthmatic patient's peak flow?
What is the BEST method of determining an asthmatic patient's peak flow?
Which of these causes cannot typically be tested using a gram stain?
Which of these causes cannot typically be tested using a gram stain?
Which feature is MOST indicative of pneumonia?
Which feature is MOST indicative of pneumonia?
What is the MOST likely finding of compression of the superior vena cava?
What is the MOST likely finding of compression of the superior vena cava?
A patient is diagnosed with Chlamydia psittaci. How did they MOST likely contract it?
A patient is diagnosed with Chlamydia psittaci. How did they MOST likely contract it?
What is the primary aim of surgery in non-small cell lung cancer?
What is the primary aim of surgery in non-small cell lung cancer?
Which finding would be MOST likely in a patient with poorly controlled HIV presenting with pneumonia?
Which finding would be MOST likely in a patient with poorly controlled HIV presenting with pneumonia?
A patient displays Pemberton's sign. What is the underlying cause for this?
A patient displays Pemberton's sign. What is the underlying cause for this?
Which statement BEST describes the function of a MART inhaler in asthma management?
Which statement BEST describes the function of a MART inhaler in asthma management?
Which organism is LEAST likely to respond to penicillin antibiotics?
Which organism is LEAST likely to respond to penicillin antibiotics?
A patient with a history of asbestos exposure presents with shortness of breath. Which condition is MOST associated with this exposure?
A patient with a history of asbestos exposure presents with shortness of breath. Which condition is MOST associated with this exposure?
According to NICE guidelines, what action should a clinician take if they have a high clinical suspicion of asthma?
According to NICE guidelines, what action should a clinician take if they have a high clinical suspicion of asthma?
What FEV1/FVC ratio is MOST indicative of obstructive lung disease?
What FEV1/FVC ratio is MOST indicative of obstructive lung disease?
A patient with non-small cell lung cancer (NSCLC) is being considered for adjuvant chemotherapy in addition to surgery. What is the PRIMARY goal of adjuvant chemotherapy in this scenario?
A patient with non-small cell lung cancer (NSCLC) is being considered for adjuvant chemotherapy in addition to surgery. What is the PRIMARY goal of adjuvant chemotherapy in this scenario?
A patient with untreated pneumonia develops marked hypotension and confusion despite broad-spectrum antibiotic therapy being administered. A chest X-ray demonstrates a large unilateral pleural effusion. What is the MOST likely cause of this acute deterioration?
A patient with untreated pneumonia develops marked hypotension and confusion despite broad-spectrum antibiotic therapy being administered. A chest X-ray demonstrates a large unilateral pleural effusion. What is the MOST likely cause of this acute deterioration?
What key risk is associated with Theophylline, therefore indicating the necessity for testing?
What key risk is associated with Theophylline, therefore indicating the necessity for testing?
A patient presents with pneumonia-like symptoms, neurological abnormalities and also has hyponatraemia. Which factor in their history would MOST strongly point towards Legionella as the causative organism?
A patient presents with pneumonia-like symptoms, neurological abnormalities and also has hyponatraemia. Which factor in their history would MOST strongly point towards Legionella as the causative organism?
Researchers are studying the long-term outcomes of patients diagnosed with small cell lung cancer (SCLC) who initially responded well to chemotherapy and radiotherapy. They aim to identify predictive factors for survival beyond five years. Which of the following factors, if found to be significantly associated with prolonged survival in this patient population, would be the MOST novel and practice-changing discovery?
Researchers are studying the long-term outcomes of patients diagnosed with small cell lung cancer (SCLC) who initially responded well to chemotherapy and radiotherapy. They aim to identify predictive factors for survival beyond five years. Which of the following factors, if found to be significantly associated with prolonged survival in this patient population, would be the MOST novel and practice-changing discovery?
A researcher aims to investigate the impact of a novel inhaled medication on airway hyperresponsiveness in patients with refractory asthma. To obtain the MOST direct and quantifiable measure of airway responsiveness before and after treatment, which assessment method should the researcher prioritize?
A researcher aims to investigate the impact of a novel inhaled medication on airway hyperresponsiveness in patients with refractory asthma. To obtain the MOST direct and quantifiable measure of airway responsiveness before and after treatment, which assessment method should the researcher prioritize?
Which of the following investigations allows for detailed assessment of a lung tumor and ultrasound-guided biopsy?
Which of the following investigations allows for detailed assessment of a lung tumor and ultrasound-guided biopsy?
What pathological process is indicated by an FEV1/FVC ratio of less than 75%?
What pathological process is indicated by an FEV1/FVC ratio of less than 75%?
Which of the following clinical scenarios poses the HIGHEST risk for Pneumocystis jiroveci pneumonia (PCP)?
Which of the following clinical scenarios poses the HIGHEST risk for Pneumocystis jiroveci pneumonia (PCP)?
Apart from shortness of breath, which other symptoms commonly co-occur with superior vena cava obstruction?
Apart from shortness of breath, which other symptoms commonly co-occur with superior vena cava obstruction?
Which of the following is the MOST characteristic presentation of Chlamydophila pneumoniae infection?
Which of the following is the MOST characteristic presentation of Chlamydophila pneumoniae infection?
A patient is being discharged with community acquired pneumonia but has a penicillin allergy, what antibiotic would be MOST suitable?
A patient is being discharged with community acquired pneumonia but has a penicillin allergy, what antibiotic would be MOST suitable?
What is the recommended duration of antibiotic treatment for mild community-acquired pneumonia (CAP)?
What is the recommended duration of antibiotic treatment for mild community-acquired pneumonia (CAP)?
Which combination of factors is DEFINITIVE for severe acute asthma compared to moderate asthma?
Which combination of factors is DEFINITIVE for severe acute asthma compared to moderate asthma?
Which organism is MOST closely associated with infected water supplies or air conditioning units, potentially causing hyponatremia?
Which organism is MOST closely associated with infected water supplies or air conditioning units, potentially causing hyponatremia?
According to BTS/SIGN guidelines, how should a clinician initially manage a patient with a presentation with high clinical suspicion of asthma?
According to BTS/SIGN guidelines, how should a clinician initially manage a patient with a presentation with high clinical suspicion of asthma?
What is the MOST likely finding upon auscultation of a patient's chest indicating pneumonia?
What is the MOST likely finding upon auscultation of a patient's chest indicating pneumonia?
What is the MOST common histological type of lung cancer?
What is the MOST common histological type of lung cancer?
Which of the following is the MOST appropriate first-line investigation for suspected lung cancer?
Which of the following is the MOST appropriate first-line investigation for suspected lung cancer?
Which of the following is a typical symptom that may suggest the possibility of lung cancer?
Which of the following is a typical symptom that may suggest the possibility of lung cancer?
A patient diagnosed with pneumonia develops confusion, a respiratory rate of 32, and a blood pressure of 85/55. According to the CRB-65 scoring system, what is their score?
A patient diagnosed with pneumonia develops confusion, a respiratory rate of 32, and a blood pressure of 85/55. According to the CRB-65 scoring system, what is their score?
What is the underlying cause of hoarseness associated with lung cancer?
What is the underlying cause of hoarseness associated with lung cancer?
What is the expected FEV1/FVC ratio in restrictive lung disease, and what factors may lead to a reduced overall lung capacity?
What is the expected FEV1/FVC ratio in restrictive lung disease, and what factors may lead to a reduced overall lung capacity?
Which of the following diagnostic findings is MOST indicative of severe acute asthma?
Which of the following diagnostic findings is MOST indicative of severe acute asthma?
In non-small cell lung cancer (NSCLC), what is the typical FIRST-LINE surgical treatment option for patients with localized disease?
In non-small cell lung cancer (NSCLC), what is the typical FIRST-LINE surgical treatment option for patients with localized disease?
What is the PRIMARY mechanism by which inhaled corticosteroids (ICS) help manage asthma symptoms?
What is the PRIMARY mechanism by which inhaled corticosteroids (ICS) help manage asthma symptoms?
After sending the appropriate investigations for pneumonia, why does C-reactive protein (CRP) trend show a delayed response, peaking a day or two later despite clinical improvement with antibiotics?
After sending the appropriate investigations for pneumonia, why does C-reactive protein (CRP) trend show a delayed response, peaking a day or two later despite clinical improvement with antibiotics?
What is the significance of Pemberton's sign, often observed in patients with certain mediastinal masses, and how does it manifest clinically?
What is the significance of Pemberton's sign, often observed in patients with certain mediastinal masses, and how does it manifest clinically?
What recommendation would NICE give in the context of a patient with a CRB-65 score of 2?
What recommendation would NICE give in the context of a patient with a CRB-65 score of 2?
A farmer presents with a flu-like illness and signs of pneumonia after exposure to animals. Which atypical pneumonia organism is MOST likely suspected?
A farmer presents with a flu-like illness and signs of pneumonia after exposure to animals. Which atypical pneumonia organism is MOST likely suspected?
How is the effectiveness of bronchodilator treatment BEST assessed with respect to spirometry results?
How is the effectiveness of bronchodilator treatment BEST assessed with respect to spirometry results?
What clinical triad characterises Horner's syndrome, and how is it typically associated with lung cancer?
What clinical triad characterises Horner's syndrome, and how is it typically associated with lung cancer?
What is the MOST preventable cause of lung cancer?
What is the MOST preventable cause of lung cancer?
How is hospital-acquired pneumonia defined, and what is the minimum time frame for its onset post-admission?
How is hospital-acquired pneumonia defined, and what is the minimum time frame for its onset post-admission?
In the long-term management of asthma, which medication is used to provide quick, short-term relief during acute bronchoconstriction?
In the long-term management of asthma, which medication is used to provide quick, short-term relief during acute bronchoconstriction?
What key feature differentiates restrictive lung disease from obstructive lung disease regarding airflow?
What key feature differentiates restrictive lung disease from obstructive lung disease regarding airflow?
In older smokers presenting with Lambert-Eaton syndrome, what underlying condition should be strongly suspected?
In older smokers presenting with Lambert-Eaton syndrome, what underlying condition should be strongly suspected?
Which of the following combinations of factors would give you a CRB-65 score of 1?
Which of the following combinations of factors would give you a CRB-65 score of 1?
What potential issue can Haemophilus influenzae potentially cause?
What potential issue can Haemophilus influenzae potentially cause?
According to NICE guidelines, what is the FIRST step in the long-term management of asthma after prescribing a short-acting beta 2 agonist (SABA) inhaler?
According to NICE guidelines, what is the FIRST step in the long-term management of asthma after prescribing a short-acting beta 2 agonist (SABA) inhaler?
Which of the following are typical triggers precipitating asthma symptoms?
Which of the following are typical triggers precipitating asthma symptoms?
Which paraneoplastic syndrome associated with small cell lung cancer (SCLC) leads the immune system to produce antibodies against voltage-gated calcium channels on presynaptic terminals of motor neurons?
Which paraneoplastic syndrome associated with small cell lung cancer (SCLC) leads the immune system to produce antibodies against voltage-gated calcium channels on presynaptic terminals of motor neurons?
The TOM TIP mnemonic can recall the 5 causes of atypical pneumonia 'Legions of psittaci MCQs'. Which Q is this mnemonic referring to?
The TOM TIP mnemonic can recall the 5 causes of atypical pneumonia 'Legions of psittaci MCQs'. Which Q is this mnemonic referring to?
A patient with a history of asthma presents with shortness of breath, wheezing, and a tight chest. Their peak expiratory flow (PEF) is 60% of their personal best. Should you be concerned?
A patient with a history of asthma presents with shortness of breath, wheezing, and a tight chest. Their peak expiratory flow (PEF) is 60% of their personal best. Should you be concerned?
Which of the following is a common symptom of pneumonia?
Which of the following is a common symptom of pneumonia?
According to the NICE guidelines for asthma management, what is the INITIAL step?
According to the NICE guidelines for asthma management, what is the INITIAL step?
What percentage of lung cancers are estimated to be preventable through lifestyle and environmental changes?
What percentage of lung cancers are estimated to be preventable through lifestyle and environmental changes?
In restrictive lung disease, why is the FEV1/FVC ratio typically normal or increased?
In restrictive lung disease, why is the FEV1/FVC ratio typically normal or increased?
What is the MOST likely organism responsible for pneumonia in a patient with cystic fibrosis?
What is the MOST likely organism responsible for pneumonia in a patient with cystic fibrosis?
Which of the following results from lung function tests indicates obstructive lung disease?
Which of the following results from lung function tests indicates obstructive lung disease?
Which of the following is a typical symptom of superior vena cava obstruction?
Which of the following is a typical symptom of superior vena cava obstruction?
A patient presents with a dry cough, night sweats, and shortness of breath. They have a history of poorly controlled HIV. Which pneumonia-causing organism is MOST likely?
A patient presents with a dry cough, night sweats, and shortness of breath. They have a history of poorly controlled HIV. Which pneumonia-causing organism is MOST likely?
What is the BEST description of the mechanism of action of short-acting beta 2 agonists in asthma management?
What is the BEST description of the mechanism of action of short-acting beta 2 agonists in asthma management?
What combination of medications is typically found in a Maintenance and Reliever Therapy (MART) inhaler?
What combination of medications is typically found in a Maintenance and Reliever Therapy (MART) inhaler?
What does 'Pemberton’s sign' indicate in the context of lung cancer complications?
What does 'Pemberton’s sign' indicate in the context of lung cancer complications?
What is the MOST common presenting symptom of pneumonia?
What is the MOST common presenting symptom of pneumonia?
A patient with suspected pneumonia has a CRB-65 score of 2. What would you expect the next step to be?
A patient with suspected pneumonia has a CRB-65 score of 2. What would you expect the next step to be?
Which of the following is MOST likely to lead to Q fever?
Which of the following is MOST likely to lead to Q fever?
A patient with a history of asbestos exposure presents with shortness of breath and chest pain. Why is mesothelioma suspected?
A patient with a history of asbestos exposure presents with shortness of breath and chest pain. Why is mesothelioma suspected?
A patient has pneumonia and develops hyponatraemia. Which organism is MOST likely responsible?
A patient has pneumonia and develops hyponatraemia. Which organism is MOST likely responsible?
Which antibodies are associated with Limbic Encephalitis?
Which antibodies are associated with Limbic Encephalitis?
A patient who owns parrots presents with the typical symptoms of pneumonia. The patient's pneumonia does not respond to penicillin based medications. What is the MOST likely infectious cause of the pneumonia?
A patient who owns parrots presents with the typical symptoms of pneumonia. The patient's pneumonia does not respond to penicillin based medications. What is the MOST likely infectious cause of the pneumonia?
A patient with newly diagnosed community-acquired pneumonia develops a pleural effusion. Analysis of the pleural fluid reveals a high neutrophil count, a low pH, and the presence of bacteria. This is MOST suggestive of what management change?
A patient with newly diagnosed community-acquired pneumonia develops a pleural effusion. Analysis of the pleural fluid reveals a high neutrophil count, a low pH, and the presence of bacteria. This is MOST suggestive of what management change?
Which of the following is a common symptom of lung cancer?
Which of the following is a common symptom of lung cancer?
In suspected lung cancer, which of the following is typically the initial investigation performed?
In suspected lung cancer, which of the following is typically the initial investigation performed?
Which of the following most accurately describes the purpose of contrast enhancement in CT scans for suspected lung cancer?
Which of the following most accurately describes the purpose of contrast enhancement in CT scans for suspected lung cancer?
A patient presents with facial swelling and shortness of breath. Which of the following conditions is MOST likely?
A patient presents with facial swelling and shortness of breath. Which of the following conditions is MOST likely?
What organisms are NOT typically treated using penicillins?
What organisms are NOT typically treated using penicillins?
Which of the following does the 'B' represent in the CURB-65 scoring system for pneumonia severity?
Which of the following does the 'B' represent in the CURB-65 scoring system for pneumonia severity?
In the context of community-acquired pneumonia, what CRB-65 score suggests referral to hospital should be considered?
In the context of community-acquired pneumonia, what CRB-65 score suggests referral to hospital should be considered?
What does FEV1 represent in lung function tests?
What does FEV1 represent in lung function tests?
Which finding on lung function tests is MOST indicative of obstructive lung disease?
Which finding on lung function tests is MOST indicative of obstructive lung disease?
Apart from respiratory conditions, in which other medical situation are lung function tests MOST helpful?
Apart from respiratory conditions, in which other medical situation are lung function tests MOST helpful?
What is the primary action of Theophylline?
What is the primary action of Theophylline?
What is the standard recommendation when using a peak flow meter?
What is the standard recommendation when using a peak flow meter?
Other than infection, what is a typical trigger for asthma?
Other than infection, what is a typical trigger for asthma?
According to NICE guidelines, what action should a clinician take if they highly suspect a diagnosis of Asthma clinically?
According to NICE guidelines, what action should a clinician take if they highly suspect a diagnosis of Asthma clinically?
In long-term asthma management, which of the following medications is used to reduce inflammation and reactivity in the airways?
In long-term asthma management, which of the following medications is used to reduce inflammation and reactivity in the airways?
What is the function of short acting beta 2 adrenergic receptor agonists in asthma management?
What is the function of short acting beta 2 adrenergic receptor agonists in asthma management?
What percentage of predicted peak flow is indicative of severe acute asthma?
What percentage of predicted peak flow is indicative of severe acute asthma?
Which of the following causes atypical pneumonia and may cause a rash called erythema multiforme, characterised by varying sized 'target lesions'?
Which of the following causes atypical pneumonia and may cause a rash called erythema multiforme, characterised by varying sized 'target lesions'?
What is the most common cause of pneumonia in patients with cystic fibrosis?
What is the most common cause of pneumonia in patients with cystic fibrosis?
What is suggested by a patient with asthma, using their short-acting beta2-agonist (SABA) more than twice a week?
What is suggested by a patient with asthma, using their short-acting beta2-agonist (SABA) more than twice a week?
A patient presents with pneumonia and is being investigated. Which investigation would be performed if pneumonia was caused by legionella?
A patient presents with pneumonia and is being investigated. Which investigation would be performed if pneumonia was caused by legionella?
What do episodic symptoms and diurnal variability, worse at night, suggest?
What do episodic symptoms and diurnal variability, worse at night, suggest?
A patient presents with a dry cough, night sweats and progressive shortness of breath. They have a known history of HIV. What should be your MOST suspected organism?
A patient presents with a dry cough, night sweats and progressive shortness of breath. They have a known history of HIV. What should be your MOST suspected organism?
Which of the following would be the MOST appropriate combination of medications in a MART inhaler?
Which of the following would be the MOST appropriate combination of medications in a MART inhaler?
A patient is diagnosed with community-acquired pneumonia and is being treated as an outpatient. Three days later, the patient returns. What would be the MOST appropriate step?
A patient is diagnosed with community-acquired pneumonia and is being treated as an outpatient. Three days later, the patient returns. What would be the MOST appropriate step?
A patient's spirometry results show equal reductions in FEV1 and FVC. The FEV1/FVC ratio is 80%. This pattern is MOST indicative of which type of lung disease?
A patient's spirometry results show equal reductions in FEV1 and FVC. The FEV1/FVC ratio is 80%. This pattern is MOST indicative of which type of lung disease?
In a suspected case of lung cancer, which of the following chest X-ray findings would be MOST concerning?
In a suspected case of lung cancer, which of the following chest X-ray findings would be MOST concerning?
A patient presents with cough, wheeze and shortness of breath with a history of asthma, using their SABA more than twice a week. What does this indicate?
A patient presents with cough, wheeze and shortness of breath with a history of asthma, using their SABA more than twice a week. What does this indicate?
A patient’s spirometry results show an FEV1/FVC ratio of 65%. What does this suggest?
A patient’s spirometry results show an FEV1/FVC ratio of 65%. What does this suggest?
A doctor reviews a patient who has been treated for pneumonia, and their inflammatory markers spike higher a day or two later despite the patient clinically improving on treatment. What is the MOST likely explanation for this?
A doctor reviews a patient who has been treated for pneumonia, and their inflammatory markers spike higher a day or two later despite the patient clinically improving on treatment. What is the MOST likely explanation for this?
A patient with a new parrot presents to the clinic with sudden onset of pneumonia-like symptoms, which organism is MOST likely responsible?
A patient with a new parrot presents to the clinic with sudden onset of pneumonia-like symptoms, which organism is MOST likely responsible?
A patient presents with shortness of breath, night sweats, and a dry cough. They have poorly controlled HIV. After confirming the diagnosis, what is the MOST appropriate treatment?
A patient presents with shortness of breath, night sweats, and a dry cough. They have poorly controlled HIV. After confirming the diagnosis, what is the MOST appropriate treatment?
A known smoker presents with shoulder pain and Horner’s syndrome symptoms, suggestive of lung cancer. What is the MOST likely location of the tumour?
A known smoker presents with shoulder pain and Horner’s syndrome symptoms, suggestive of lung cancer. What is the MOST likely location of the tumour?
A patient with poorly controlled asthma and a history of hay fever presents with increased wheezing, shortness of breath, and a non-productive cough for the past week, and reports that they've increased their SABA use without relief. Auscultation reveals bilateral high-pitched wheezes, despite use of their SABA inhaler just 10 minutes prior. Peak flow is at 40%. Which of the following is the MOST appropriate next step in the immediate management of this patient?
A patient with poorly controlled asthma and a history of hay fever presents with increased wheezing, shortness of breath, and a non-productive cough for the past week, and reports that they've increased their SABA use without relief. Auscultation reveals bilateral high-pitched wheezes, despite use of their SABA inhaler just 10 minutes prior. Peak flow is at 40%. Which of the following is the MOST appropriate next step in the immediate management of this patient?
A patient with a known history of well-controlled asthma presents with acute respiratory distress. They are diaphoretic, using accessory muscles to breathe, and are only able to speak in single words. Auscultation reveals minimal wheezing with significantly reduced air entry bilaterally. Nebulised bronchodilators and IV corticosteroids have been administered, but their PaCO2 is still rising. Which of the following pathological processes is MOST likely occurring in this patient?
A patient with a known history of well-controlled asthma presents with acute respiratory distress. They are diaphoretic, using accessory muscles to breathe, and are only able to speak in single words. Auscultation reveals minimal wheezing with significantly reduced air entry bilaterally. Nebulised bronchodilators and IV corticosteroids have been administered, but their PaCO2 is still rising. Which of the following pathological processes is MOST likely occurring in this patient?
A 60-year-old patient with a 40 pack-year smoking history presents with new-onset short-term memory loss, hallucinations, confusion, and seizures. MRI of the brain shows inflammation in the limbic system. Bronchoscopy reveals small cell lung cancer. Which antibody is MOST likely associated with this presentation?
A 60-year-old patient with a 40 pack-year smoking history presents with new-onset short-term memory loss, hallucinations, confusion, and seizures. MRI of the brain shows inflammation in the limbic system. Bronchoscopy reveals small cell lung cancer. Which antibody is MOST likely associated with this presentation?
Which of these symptoms would suggest a diagnosis of pneumonia?
Which of these symptoms would suggest a diagnosis of pneumonia?
What is the MOST common presenting symptom in people with penumonia?
What is the MOST common presenting symptom in people with penumonia?
What does an FEV1/FVC ratio of less than 75% suggest with lung function tests?
What does an FEV1/FVC ratio of less than 75% suggest with lung function tests?
What signs and symptoms are associated with superior vena cava obstruction?
What signs and symptoms are associated with superior vena cava obstruction?
Which of the following malignancies is MOST closely associated with asbestos exposure?
Which of the following malignancies is MOST closely associated with asbestos exposure?
What is the MOST significant risk factor for developing lung cancer?
What is the MOST significant risk factor for developing lung cancer?
Which of the following findings on a chest X-ray would MOST strongly suggest lung cancer?
Which of the following findings on a chest X-ray would MOST strongly suggest lung cancer?
What factors need to be considered to give a patient a CRB-65 score of 1?
What factors need to be considered to give a patient a CRB-65 score of 1?
What is the typical treatment approach for small cell lung cancer?
What is the typical treatment approach for small cell lung cancer?
Which of the following describes the definition of hospital acquired pneumonia?
Which of the following describes the definition of hospital acquired pneumonia?
A patient has a productive cough, fever and pleuritic chest pain. On examination their chest shows bronchial breath sounds and coarse crackles on the right side. What is the MOST likely diagnosis?
A patient has a productive cough, fever and pleuritic chest pain. On examination their chest shows bronchial breath sounds and coarse crackles on the right side. What is the MOST likely diagnosis?
What does a presentation of acute respiratory distress, diaphoresis, accessory muscle use, single-word speech, minimal wheezing and reduced air entry bilaterally suggest?
What does a presentation of acute respiratory distress, diaphoresis, accessory muscle use, single-word speech, minimal wheezing and reduced air entry bilaterally suggest?
A patient has an FEV1/FVC ratio of less than 75%. Which classification is this?
A patient has an FEV1/FVC ratio of less than 75%. Which classification is this?
Which of the following presents MOST suspect of asthma, rather than another respiratory condition?
Which of the following presents MOST suspect of asthma, rather than another respiratory condition?
A patient with long term asthma can have difficulty with exercise tolerance, so that their asthma can be controlled and allow them to continue to participate in sport, what medication can be used to combat this?
A patient with long term asthma can have difficulty with exercise tolerance, so that their asthma can be controlled and allow them to continue to participate in sport, what medication can be used to combat this?
If the inflammatory markers of WBC and CRP are not raised despite a case presenting as a severe infection, what could be the cause to this?
If the inflammatory markers of WBC and CRP are not raised despite a case presenting as a severe infection, what could be the cause to this?
Which of the following is NOT typically associated with small cell lung cancer due to its neuroendocrine properties?
Which of the following is NOT typically associated with small cell lung cancer due to its neuroendocrine properties?
A patient presents with a cough, shortness of breath, and chest pain, and is subsequently diagnosed with pneumonia. Which symptom is MOST indicative of pleuritic chest pain?
A patient presents with a cough, shortness of breath, and chest pain, and is subsequently diagnosed with pneumonia. Which symptom is MOST indicative of pleuritic chest pain?
A previously healthy patient develops a pneumonia. Atypical pneumonia is suspected. Which of the following historical details would MOST strongly suggest Mycoplasma pneumoniae as the causative organism?
A previously healthy patient develops a pneumonia. Atypical pneumonia is suspected. Which of the following historical details would MOST strongly suggest Mycoplasma pneumoniae as the causative organism?
A patient has suspected restrictive lung disease. The FEV1/FVC ratio is normal, but the FVC is reduced. This suggests that the underlying issue is that the:
A patient has suspected restrictive lung disease. The FEV1/FVC ratio is normal, but the FVC is reduced. This suggests that the underlying issue is that the:
A patient with suspected asthma has a negative response to initial spirometry. According to NICE guidelines, what is the MOST appropriate next step?
A patient with suspected asthma has a negative response to initial spirometry. According to NICE guidelines, what is the MOST appropriate next step?
Which of the following is TRUE regarding the technique for measuring peak expiratory flow rate (PEFR)?
Which of the following is TRUE regarding the technique for measuring peak expiratory flow rate (PEFR)?
A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following statements BEST describes how this inhaler should be used?
A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following statements BEST describes how this inhaler should be used?
A patient presents with a 3-day history of cough, fever, and shortness of breath. Auscultation reveals bronchial breath sounds and coarse crackles in the right lower lobe. Initial investigations reveal a CRP of 15mg/L. According to NICE guidelines, what is the MOST appropriate next step?
A patient presents with a 3-day history of cough, fever, and shortness of breath. Auscultation reveals bronchial breath sounds and coarse crackles in the right lower lobe. Initial investigations reveal a CRP of 15mg/L. According to NICE guidelines, what is the MOST appropriate next step?
Compared to non-small cell lung cancer, what is generally TRUE regarding the prognosis for small cell lung cancer (SCLC)?
Compared to non-small cell lung cancer, what is generally TRUE regarding the prognosis for small cell lung cancer (SCLC)?
Which of the following historical details would MOST suggest Coxiella burnetii (Q fever) as the cause of the patient's pneumonia?
Which of the following historical details would MOST suggest Coxiella burnetii (Q fever) as the cause of the patient's pneumonia?
In restrictive lung disease, what results would you expect to see when interpreting lung function tests?
In restrictive lung disease, what results would you expect to see when interpreting lung function tests?
A patient with a history of asbestos exposure presents with shortness of breath. Which of the following is the MOST likely diagnosis?
A patient with a history of asbestos exposure presents with shortness of breath. Which of the following is the MOST likely diagnosis?
Which statement BEST describes the typical findings of a unilateral pleural effusion caused by lung cancer?
Which statement BEST describes the typical findings of a unilateral pleural effusion caused by lung cancer?
A patient's asthma symptoms are well controlled on a low dose inhaled corticosteroid (ICS) and as-needed short-acting beta-2 agonist (SABA). At their annual review, they report using their SABA more than twice a week. What is the MOST appropriate next step in their management?
A patient's asthma symptoms are well controlled on a low dose inhaled corticosteroid (ICS) and as-needed short-acting beta-2 agonist (SABA). At their annual review, they report using their SABA more than twice a week. What is the MOST appropriate next step in their management?
How does the Theophylline help patients with asthma?
How does the Theophylline help patients with asthma?
Following a diagnosis of small cell lung cancer, a patient develops Cushing's syndrome. What is the MOST likely underlying mechanism causing this paraneoplastic syndrome?
Following a diagnosis of small cell lung cancer, a patient develops Cushing's syndrome. What is the MOST likely underlying mechanism causing this paraneoplastic syndrome?
Of the options presented, which paraneoplastic syndrome is MOST associated with small cell lung cancer?
Of the options presented, which paraneoplastic syndrome is MOST associated with small cell lung cancer?
A patient with pneumonia is admitted to hospital and treated with intravenous antibiotics. After a few days, the patient clinically improves, but their inflammatory markers (CRP & WBC) initially increase. What statement BEST describes why this happens?
A patient with pneumonia is admitted to hospital and treated with intravenous antibiotics. After a few days, the patient clinically improves, but their inflammatory markers (CRP & WBC) initially increase. What statement BEST describes why this happens?
A patient develops a lung infection following admission to hospital after 5 days? What would this be classified as?
A patient develops a lung infection following admission to hospital after 5 days? What would this be classified as?
A patient presents with signs and symptoms of acute asthma exacerbation. Which of the following indicates a life-threatening presentation of reduced peak expiratory flow rate (PEFR)?
A patient presents with signs and symptoms of acute asthma exacerbation. Which of the following indicates a life-threatening presentation of reduced peak expiratory flow rate (PEFR)?
Approximately what percentage of lung cancer cases are estimated to be preventable?
Approximately what percentage of lung cancer cases are estimated to be preventable?
TOM TIP: Legions of psittaci MCQs - which conditions are psittaci linked to?
TOM TIP: Legions of psittaci MCQs - which conditions are psittaci linked to?
What percentage of lung cancers are estimated to be preventable through lifestyle and environmental modifications?
What percentage of lung cancers are estimated to be preventable through lifestyle and environmental modifications?
Which of the following is the MOST common presenting sign or symptom of pneumonia?
Which of the following is the MOST common presenting sign or symptom of pneumonia?
What is the typical action of short-acting beta 2 agonists in the short-term management of asthma symptoms?
What is the typical action of short-acting beta 2 agonists in the short-term management of asthma symptoms?
Which of the following conditions is MOST associated with prior asbestos exposure?
Which of the following conditions is MOST associated with prior asbestos exposure?
A new diagnosis of pneumonia is confirmed in a patient. Which investigation is MOST essential to conduct?
A new diagnosis of pneumonia is confirmed in a patient. Which investigation is MOST essential to conduct?
Which set of symptoms is MOST commonly associated with superior vena cava obstruction?
Which set of symptoms is MOST commonly associated with superior vena cava obstruction?
Which of the following suggests obstructive lung disease?
Which of the following suggests obstructive lung disease?
Which of these patient descriptions is MOST suggestive of a diagnosis of asthma rather than another respiratory condition?
Which of these patient descriptions is MOST suggestive of a diagnosis of asthma rather than another respiratory condition?
According to the BTS/SIGN asthma guidelines, what is the recommended approach when there is a high clinical suspicion of asthma?
According to the BTS/SIGN asthma guidelines, what is the recommended approach when there is a high clinical suspicion of asthma?
A patient with suspected pneumonia has a CRB-65 score of 1 in the community. According to NICE guidelines, what is the MOST appropriate next step?
A patient with suspected pneumonia has a CRB-65 score of 1 in the community. According to NICE guidelines, what is the MOST appropriate next step?
What is the MOST common etiology of community-acquired pneumonia (CAP)?
What is the MOST common etiology of community-acquired pneumonia (CAP)?
Which of the following organisms causing pneumonia is LEAST likely to respond to treatment with penicillin antibiotics?
Which of the following organisms causing pneumonia is LEAST likely to respond to treatment with penicillin antibiotics?
A patient presents with features of pneumonia but has had recent contact with a parrot. Which organism is MOST likely to be responsible?
A patient presents with features of pneumonia but has had recent contact with a parrot. Which organism is MOST likely to be responsible?
What flow rate reading on a peak expiratory flow meter (PEFR) would indicate severe asthma?
What flow rate reading on a peak expiratory flow meter (PEFR) would indicate severe asthma?
A patient presents with a dry cough, shortness of breath, and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which causative organism is MOST likely responsible for pneumonia?
A patient presents with a dry cough, shortness of breath, and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which causative organism is MOST likely responsible for pneumonia?
What is the PRIMARY purpose of performing contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?
What is the PRIMARY purpose of performing contrast enhancement during a CT scan of the chest, abdomen, and pelvis in suspected lung cancer?
After starting treatment for pneumonia, a patient's CRP levels spike higher a day or two later despite clinically improving on antibiotics. What is the MOST likely explanation for this?
After starting treatment for pneumonia, a patient's CRP levels spike higher a day or two later despite clinically improving on antibiotics. What is the MOST likely explanation for this?
A patient is diagnosed with community-acquired pneumonia (CAP) and is being treated as an outpatient. Three days later, the patient returns, reporting worsening symptoms despite antibiotic adherence. What is the MOST appropriate next step?
A patient is diagnosed with community-acquired pneumonia (CAP) and is being treated as an outpatient. Three days later, the patient returns, reporting worsening symptoms despite antibiotic adherence. What is the MOST appropriate next step?
A patient presents with cough, wheeze, and shortness of breath. They use their short-acting beta2-agonist inhaler more than twice a week. What does this indicate regarding their asthma control?
A patient presents with cough, wheeze, and shortness of breath. They use their short-acting beta2-agonist inhaler more than twice a week. What does this indicate regarding their asthma control?
Which of the following sets of diagnostic results is MOST indicative of severe acute asthma?
Which of the following sets of diagnostic results is MOST indicative of severe acute asthma?
A patient has been prescribed Theophylline for their asthma. How soon after each dose change should their plasma levels be monitored?
A patient has been prescribed Theophylline for their asthma. How soon after each dose change should their plasma levels be monitored?
What is the MOST likely diagnosis in a patient presenting with facial congestion and cyanosis when raising their hands over their head?
What is the MOST likely diagnosis in a patient presenting with facial congestion and cyanosis when raising their hands over their head?
A patient has an FEV1/FVC ratio of 85% and reduced FVC. What does this suggest?
A patient has an FEV1/FVC ratio of 85% and reduced FVC. What does this suggest?
A patient is diagnosed with small cell lung cancer (SCLC) and develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?
A patient is diagnosed with small cell lung cancer (SCLC) and develops SIADH. Which of the following mechanisms BEST explains the underlying cause of hyponatremia in this patient?
What findings are associated with Horner's syndrome?
What findings are associated with Horner's syndrome?
In asthma management, what is the role of inhaled corticosteroids (ICS)?
In asthma management, what is the role of inhaled corticosteroids (ICS)?
Which of the following is the MOST likely underlying cause of Cushing’s syndrome in a patient with small cell lung cancer?
Which of the following is the MOST likely underlying cause of Cushing’s syndrome in a patient with small cell lung cancer?
A patient presents with unilateral wheezing. What does this suggest?
A patient presents with unilateral wheezing. What does this suggest?
A patient presents with a history of smoking along with shoulder pain and Horner's syndrome. Which location is the MOST likely primary site of the tumor causing these symptoms?
A patient presents with a history of smoking along with shoulder pain and Horner's syndrome. Which location is the MOST likely primary site of the tumor causing these symptoms?
A patient diagnosed with small cell lung cancer develops short term memory loss, hallucinations, confusion and seizures. Which antibody is MOST associated with this presentation?
A patient diagnosed with small cell lung cancer develops short term memory loss, hallucinations, confusion and seizures. Which antibody is MOST associated with this presentation?
Which community acquired organisms are MOST commonly associated with pneumonia in patients who have cystic fibrosis?
Which community acquired organisms are MOST commonly associated with pneumonia in patients who have cystic fibrosis?
Which of the following is the MOST likely cause of pneumonia in a patient with a new pet parrot?
Which of the following is the MOST likely cause of pneumonia in a patient with a new pet parrot?
Referring to the 'TOM TIP' mnemonic - 'Legions of psittaci MCQs', what does 'Qs' stand for?
Referring to the 'TOM TIP' mnemonic - 'Legions of psittaci MCQs', what does 'Qs' stand for?
Which lung diseases are categorised by normal or raised FEV1/FVC ratio >75, but equally reduced FEV1 and FVC?
Which lung diseases are categorised by normal or raised FEV1/FVC ratio >75, but equally reduced FEV1 and FVC?
A patient's spirometry results show FEV1 to be 2L and FVC to be 4L, so the ratio will not exceed 75%. This suggests what lung disease?
A patient's spirometry results show FEV1 to be 2L and FVC to be 4L, so the ratio will not exceed 75%. This suggests what lung disease?
What percentage of lung cancers are thought to be preventable?
What percentage of lung cancers are thought to be preventable?
Which of the following symptoms is LEAST likely to be associated with pneumonia?
Which of the following symptoms is LEAST likely to be associated with pneumonia?
What does FEV1 measure in lung function tests?
What does FEV1 measure in lung function tests?
A patient with suspected pneumonia has a CRB-65 score of 2. Which of the following is the MOST appropriate action, according to NICE guidelines?
A patient with suspected pneumonia has a CRB-65 score of 2. Which of the following is the MOST appropriate action, according to NICE guidelines?
Which of the following should be included in the advice to a patient to ensure an accurate reading when using a peak flow meter?
Which of the following should be included in the advice to a patient to ensure an accurate reading when using a peak flow meter?
A patient with a history of asbestos exposure presents with signs suggestive of a lung malignancy. Which finding would MOST specifically indicate mesothelioma rather than other common lung conditions?
A patient with a history of asbestos exposure presents with signs suggestive of a lung malignancy. Which finding would MOST specifically indicate mesothelioma rather than other common lung conditions?
A patient is prescribed Theophylline. What regular monitoring is required during their treatment, and when should it occur?
A patient is prescribed Theophylline. What regular monitoring is required during their treatment, and when should it occur?
A patient who owns a parrot presents with pneumonia-like symptoms. Which organism is MOST likely responsible?
A patient who owns a parrot presents with pneumonia-like symptoms. Which organism is MOST likely responsible?
A patient with a history of asthma presents with progressively worsening shortness of breath and is diagnosed with severe acute asthma. Which peak expiratory flow rate (PEFR) would be MOST consistent with this classification?
A patient with a history of asthma presents with progressively worsening shortness of breath and is diagnosed with severe acute asthma. Which peak expiratory flow rate (PEFR) would be MOST consistent with this classification?
After starting treatment for pneumonia, a patient's CRP levels spike higher a day or two later, despite the patient clinically improving. What is the MOST likely explanation for this?
After starting treatment for pneumonia, a patient's CRP levels spike higher a day or two later, despite the patient clinically improving. What is the MOST likely explanation for this?
A patient has been diagnosed with restrictive lung disease. Spirometry results show normal or raised FEV1/FVC ratio. Which statement explains this result?
A patient has been diagnosed with restrictive lung disease. Spirometry results show normal or raised FEV1/FVC ratio. Which statement explains this result?
A patient has been prescribed a MART inhaler, which they have been using correctly. Which of the following statements is INCORRECT regarding this regime?
A patient has been prescribed a MART inhaler, which they have been using correctly. Which of the following statements is INCORRECT regarding this regime?
What is the underlying pathophysiology that leads to the symptoms associated with Lambert-Eaton Myasthenic Syndrome?
What is the underlying pathophysiology that leads to the symptoms associated with Lambert-Eaton Myasthenic Syndrome?
In the NICE stepwise ladder for asthma management, what is the next step immediately AFTER commencing a short-acting beta 2 agonist inhaler (e.g. salbutamol) for infrequent wheezy episodes?
In the NICE stepwise ladder for asthma management, what is the next step immediately AFTER commencing a short-acting beta 2 agonist inhaler (e.g. salbutamol) for infrequent wheezy episodes?
A patient presents with pneumonia and is suspected of having Legionella infection. Which finding on initial investigations would STRONGLY support this diagnosis?
A patient presents with pneumonia and is suspected of having Legionella infection. Which finding on initial investigations would STRONGLY support this diagnosis?
The trend of C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis commonly shows a delayed response, spiking a day or two later despite the patient improving. Why is this?
The trend of C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis commonly shows a delayed response, spiking a day or two later despite the patient improving. Why is this?
A patient presents with features of pneumonia but is also suffering with neurological symptoms (confusion, seizures) as well as hyponatraemia from SIADH. From the 5 key causes of atypical pneumonia, which is MOST likely causing the patient's illness?
A patient presents with features of pneumonia but is also suffering with neurological symptoms (confusion, seizures) as well as hyponatraemia from SIADH. From the 5 key causes of atypical pneumonia, which is MOST likely causing the patient's illness?
Which of the following is the MOST accurate definition of pneumonia, particularly considering its classification and differentiation from other similar conditions?
Which of the following is the MOST accurate definition of pneumonia, particularly considering its classification and differentiation from other similar conditions?
A patient presents with a persistent dry cough, neurological symptoms and hyponatraemia. They have recently returned from a holiday which included a cheaper hotel by the coast. Which is the MOST likely organism causing the patient problems?
A patient presents with a persistent dry cough, neurological symptoms and hyponatraemia. They have recently returned from a holiday which included a cheaper hotel by the coast. Which is the MOST likely organism causing the patient problems?
A patient is being treated for pneumonia and subsequently develops a pleural effusion. Leaving empyema to one side, which of the following is the MOST concerning complication in this setting and why?
A patient is being treated for pneumonia and subsequently develops a pleural effusion. Leaving empyema to one side, which of the following is the MOST concerning complication in this setting and why?
What percentage of lung cancers are estimated to be preventable, largely due to modifiable risk factors?
What percentage of lung cancers are estimated to be preventable, largely due to modifiable risk factors?
What is the role of salbutamol in asthma management?
What is the role of salbutamol in asthma management?
A patient has been diagnosed with suspected pneumonia. What is the purpose of performing a chest X-ray on admission?
A patient has been diagnosed with suspected pneumonia. What is the purpose of performing a chest X-ray on admission?
A patient diagnosed with pneumonia is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?
A patient diagnosed with pneumonia is suspected of having Legionella infection. Which of the following findings would STRONGLY support this diagnosis?
Which of the following presentations is MOST suggestive of asthma, rather than another respiratory condition?
Which of the following presentations is MOST suggestive of asthma, rather than another respiratory condition?
What is the purpose of prescribing salbutamol for asthma?
What is the purpose of prescribing salbutamol for asthma?
Which of the following blood pressure readings would suggest that the patient has a high CURB-65 score?
Which of the following blood pressure readings would suggest that the patient has a high CURB-65 score?
What is the MOST common presenting symptom of lung cancer?
What is the MOST common presenting symptom of lung cancer?
What is the MOST likely organism causing pneumonia in a patient also presenting with hyponatraemia?
What is the MOST likely organism causing pneumonia in a patient also presenting with hyponatraemia?
What is the typical presentation of a patient with Q fever (Coxiella burnetti)?
What is the typical presentation of a patient with Q fever (Coxiella burnetti)?
A patient has a best peak flow reading of 300 L/min, and their predicted peak flow is 500 L/min. What degree of asthma does this indicate?
A patient has a best peak flow reading of 300 L/min, and their predicted peak flow is 500 L/min. What degree of asthma does this indicate?
Which of the following examination findings indicates moderate asthma exacerbation?
Which of the following examination findings indicates moderate asthma exacerbation?
Which of the following features on a chest X-ray MOST strongly suggests a diagnosis of lung cancer rather than a differential?
Which of the following features on a chest X-ray MOST strongly suggests a diagnosis of lung cancer rather than a differential?
A patient has been admitted to hospital with moderate community aquired pneumonia. What antibiotic course are they MOST likely to be prescribed?
A patient has been admitted to hospital with moderate community aquired pneumonia. What antibiotic course are they MOST likely to be prescribed?
When interpreting lung function tests, which of the following measurement patterns is indicative of obstructive lung disease?
When interpreting lung function tests, which of the following measurement patterns is indicative of obstructive lung disease?
Which of the following statements accurately describes the use of peak expiratory flow rate (PEFR) in asthma management?
Which of the following statements accurately describes the use of peak expiratory flow rate (PEFR) in asthma management?
A patient is diagnosed with lung cancer and develops the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Which underlying mechanism is MOST likely?
A patient is diagnosed with lung cancer and develops the syndrome of inappropriate antidiuretic hormone secretion (SIADH). Which underlying mechanism is MOST likely?
A patient with a history of smoking presents with shoulder pain, ptosis, miosis, and anhidrosis on one side of their face. In which location is the tumor MOST likely situated?
A patient with a history of smoking presents with shoulder pain, ptosis, miosis, and anhidrosis on one side of their face. In which location is the tumor MOST likely situated?
According to NICE guidelines, after prescribing a short-acting beta 2 agonist inhaler, which of the following is the appropriate FIRST step in long-term asthma management?
According to NICE guidelines, after prescribing a short-acting beta 2 agonist inhaler, which of the following is the appropriate FIRST step in long-term asthma management?
A patient's spirometry results show equally reduced FEV1 and FVC, that return an FEV1:FVC ratio of >75%. What diagnosis is MOST indicated based on this result?
A patient's spirometry results show equally reduced FEV1 and FVC, that return an FEV1:FVC ratio of >75%. What diagnosis is MOST indicated based on this result?
What triggers the presentation of Pemberton's sign?
What triggers the presentation of Pemberton's sign?
A patient presents with a dry cough, shortness of breath and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which investigation is the MOST useful to confirm a diagnosis of Pneumocystis jirovecii pneumonia?
A patient presents with a dry cough, shortness of breath and night sweats. They have a history of poorly controlled HIV and a low CD4 count. Which investigation is the MOST useful to confirm a diagnosis of Pneumocystis jirovecii pneumonia?
Which of the following statements BEST describes how community-acquired pneumonia is defined?
Which of the following statements BEST describes how community-acquired pneumonia is defined?
A patient with a history of well-controlled asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a life-threatening asthma exacerbation?
A patient with a history of well-controlled asthma presents to the emergency department with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a life-threatening asthma exacerbation?
In a patient using dual therapy with amoxicillin and clarithromycin for pneumonia, which organism is LEAST likely to respond?
In a patient using dual therapy with amoxicillin and clarithromycin for pneumonia, which organism is LEAST likely to respond?
A patient has been started on Theophylline as part of their asthma management. Blood plasma levels of the medication should be tested how long after a dose change?
A patient has been started on Theophylline as part of their asthma management. Blood plasma levels of the medication should be tested how long after a dose change?
A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following BEST describes the components and usage of this?
A patient with asthma is prescribed a Maintenance and Reliever Therapy (MART) inhaler. Which of the following BEST describes the components and usage of this?
A patient being investigated for suspected lung cancer undergoes a CT scan of the chest, abdomen and pelvis. Why is it important that this scan includes contrast enhancement?
A patient being investigated for suspected lung cancer undergoes a CT scan of the chest, abdomen and pelvis. Why is it important that this scan includes contrast enhancement?
Which statement BEST describes the underlying process of restrictive lung disease that will cause reduced FVC on spirometry?
Which statement BEST describes the underlying process of restrictive lung disease that will cause reduced FVC on spirometry?
Which of the following investigations is MOST appropriate when a junior clinician highly suspects asthma, according to BTS/SIGN guidelines?
Which of the following investigations is MOST appropriate when a junior clinician highly suspects asthma, according to BTS/SIGN guidelines?
A patient is being treated for pneumonia as an outpatient. Three days later, the patient returns with worsening symptoms despite taking their medication. What next step is MOST appropriate?
A patient is being treated for pneumonia as an outpatient. Three days later, the patient returns with worsening symptoms despite taking their medication. What next step is MOST appropriate?
A patient with suspected pneumonia deteriorates and develops a pleural effusion. Which of the following is the MOST concerning complication to be aware of?
A patient with suspected pneumonia deteriorates and develops a pleural effusion. Which of the following is the MOST concerning complication to be aware of?
Which statement is LEAST accurate regarding expected findings in a case of severe acute asthma?
Which statement is LEAST accurate regarding expected findings in a case of severe acute asthma?
Which condition must be present to refer a patient to intensive care, according to the CURB-65 scoring system guide?
Which condition must be present to refer a patient to intensive care, according to the CURB-65 scoring system guide?
A 50 year old woman with a history of well-managed asthma controlled with occasional use of a SABA presents to her GP complaining of increasing nocturnal symptoms. She has been experiencing a cough, wheeze, and shortness of breath more than four nights a week. She denies any recent infections or changes in her environment. What is the MOST appropriate next step in managing her asthma?
A 50 year old woman with a history of well-managed asthma controlled with occasional use of a SABA presents to her GP complaining of increasing nocturnal symptoms. She has been experiencing a cough, wheeze, and shortness of breath more than four nights a week. She denies any recent infections or changes in her environment. What is the MOST appropriate next step in managing her asthma?
A patient with advanced lung cancer develops new onset of short-term memory loss, hallucinations, confusion and seizures. Which antibody is MOST likely associated with this paraneoplastic syndrome?
A patient with advanced lung cancer develops new onset of short-term memory loss, hallucinations, confusion and seizures. Which antibody is MOST likely associated with this paraneoplastic syndrome?
Following a pneumonia diagnosis, inflammatory markers can show varying patterns. Which statement BEST describes the expected trend of C-reactive protein (CRP)?
Following a pneumonia diagnosis, inflammatory markers can show varying patterns. Which statement BEST describes the expected trend of C-reactive protein (CRP)?
A patient with a history of asbestos exposure presents with progressively worsening dyspnea and chest pain. While mesothelioma is suspected, which initial imaging finding would be MOST indicative of this specific malignancy rather than other asbestos-related lung conditions?
A patient with a history of asbestos exposure presents with progressively worsening dyspnea and chest pain. While mesothelioma is suspected, which initial imaging finding would be MOST indicative of this specific malignancy rather than other asbestos-related lung conditions?
What factors are present in the CURB-65 scoring system that indicate a score of 1?
What factors are present in the CURB-65 scoring system that indicate a score of 1?
In the mnemonic 'Legions of psittaci MCQs' - what do the 'Qs' stand for?
In the mnemonic 'Legions of psittaci MCQs' - what do the 'Qs' stand for?
Which of the following diagnostic challenges presents the GREATEST difficulty in accurately determining the underlying cause of shortness of breath?
Which of the following diagnostic challenges presents the GREATEST difficulty in accurately determining the underlying cause of shortness of breath?
Which of the following lung function test changes is MOST likely in a well-controlled asthmatic with mild intermittent symptoms between exacerbations?
Which of the following lung function test changes is MOST likely in a well-controlled asthmatic with mild intermittent symptoms between exacerbations?
Which clinical presentation is MOST suggestive of Lambert-Eaton myasthenic syndrome?
Which clinical presentation is MOST suggestive of Lambert-Eaton myasthenic syndrome?
What initial diagnostic finding is MOST indicative of mesothelioma?
What initial diagnostic finding is MOST indicative of mesothelioma?
A patient presents with new disorientation in time and place due to pneumonia. According to the CRB-65 scoring system, what score does the confusion add?
A patient presents with new disorientation in time and place due to pneumonia. According to the CRB-65 scoring system, what score does the confusion add?
A patient with suspected pneumonia is prescribed amoxicillin and clarithromycin. What type of pneumonia is this dual therapy MOST likely targetting?
A patient with suspected pneumonia is prescribed amoxicillin and clarithromycin. What type of pneumonia is this dual therapy MOST likely targetting?
Which of the following best describes the function of inhaled corticosteroids (ICS) in asthma management?
Which of the following best describes the function of inhaled corticosteroids (ICS) in asthma management?
Which of the following inhaled medications is MOST commonly used as a reliever medication during acute asthma exacerbations?
Which of the following inhaled medications is MOST commonly used as a reliever medication during acute asthma exacerbations?
A patient develops a pleural effusion from a pneumonia. Which is the MOST concerning complication?
A patient develops a pleural effusion from a pneumonia. Which is the MOST concerning complication?
What combination of medications is contained within a Maintenance and Reliever Therapy (MART) inhaler?
What combination of medications is contained within a Maintenance and Reliever Therapy (MART) inhaler?
Which finding is MOST suggestive of a new diagnosis of pneumonia caused by Mycoplasma pneumoniae?
Which finding is MOST suggestive of a new diagnosis of pneumonia caused by Mycoplasma pneumoniae?
Which type of treatment is offered first-line in patients with non-small cell lung cancer when the disease is isolated to a single area?
Which type of treatment is offered first-line in patients with non-small cell lung cancer when the disease is isolated to a single area?
A patient with a history of well-controlled asthma presents with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a severe asthma exacerbation?
A patient with a history of well-controlled asthma presents with acute respiratory distress. Which of the following clinical signs would be MOST indicative of a severe asthma exacerbation?
A patient presents with pneumonia alongside hyponatraemia and neurological symptoms during their assessment. Which cause of pneumonia is MOST likely, going by this information?
A patient presents with pneumonia alongside hyponatraemia and neurological symptoms during their assessment. Which cause of pneumonia is MOST likely, going by this information?
Which statement describes why C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis may show a delayed response, spiking a day or two later despite the patient clinically improving on treatment?
Which statement describes why C-reactive protein (CRP) inflammatory markers following a pneumonia diagnosis may show a delayed response, spiking a day or two later despite the patient clinically improving on treatment?
A patient receives a diagnosis of pneumonia during their assessment, and a sputum sample is collected as part of the diagnostic process. What investigation is MOST likely to occur next with this sample?
A patient receives a diagnosis of pneumonia during their assessment, and a sputum sample is collected as part of the diagnostic process. What investigation is MOST likely to occur next with this sample?
Which lung sounds are MOST associated with pneumonia?
Which lung sounds are MOST associated with pneumonia?
What is the MOST likely underlying cause of Cushing’s syndrome in a patient with small cell lung cancer?
What is the MOST likely underlying cause of Cushing’s syndrome in a patient with small cell lung cancer?
Which statement is MOST accurate regarding NICE guidelines and a diagnosis of asthma?
Which statement is MOST accurate regarding NICE guidelines and a diagnosis of asthma?
Flashcards
Lung Cancer
Lung Cancer
Third most common cancer in the UK; smoking is the biggest cause.
Non-Small Cell Lung Cancer (NSCLC)
Non-Small Cell Lung Cancer (NSCLC)
Includes squamous cell carcinoma and adenocarcinoma.
Small Cell Lung Cancer (SCLC)
Small Cell Lung Cancer (SCLC)
Releases neuroendocrine hormones, causes paraneoplastic syndromes.
Lung Cancer Symptoms
Lung Cancer Symptoms
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Lung Cancer on Chest X-ray
Lung Cancer on Chest X-ray
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CT Scan for Lung Cancer
CT Scan for Lung Cancer
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PET-CT Scan
PET-CT Scan
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Bronchoscopy with EBUS
Bronchoscopy with EBUS
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Lobectomy
Lobectomy
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Segmentectomy/Wedge Resection
Segmentectomy/Wedge Resection
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Recurrent Laryngeal Nerve Palsy
Recurrent Laryngeal Nerve Palsy
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Phrenic Nerve Palsy
Phrenic Nerve Palsy
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Superior Vena Cava Obstruction
Superior Vena Cava Obstruction
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Horner’s Syndrome
Horner’s Syndrome
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SIADH in Lung Cancer
SIADH in Lung Cancer
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Cushing’s Syndrome
Cushing’s Syndrome
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Limbic Encephalitis
Limbic Encephalitis
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Lambert-Eaton Syndrome
Lambert-Eaton Syndrome
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Mesothelioma
Mesothelioma
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Pneumonia
Pneumonia
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Community Acquired Pneumonia (CAP)
Community Acquired Pneumonia (CAP)
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Hospital Acquired Pneumonia (HAP)
Hospital Acquired Pneumonia (HAP)
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Aspiration Pneumonia
Aspiration Pneumonia
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Pneumonia Symptoms
Pneumonia Symptoms
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Tachypnoea
Tachypnoea
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Tachycardia
Tachycardia
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Hypoxia
Hypoxia
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Hypotension
Hypotension
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Bronchial Breath Sounds
Bronchial Breath Sounds
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Focal Coarse Crackles
Focal Coarse Crackles
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Dullness to Percussion
Dullness to Percussion
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CRB-65/CURB-65
CRB-65/CURB-65
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CURB-65 components
CURB-65 components
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Common Pneumonia Cause
Common Pneumonia Cause
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Atypical Pneumonia
Atypical Pneumonia
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Legionella pneumophila Source
Legionella pneumophila Source
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Mycoplasma pneumoniae
Mycoplasma pneumoniae
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Chlamydophila pneumoniae
Chlamydophila pneumoniae
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Coxiella burnetii (Q fever)
Coxiella burnetii (Q fever)
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Chlamydia psittaci
Chlamydia psittaci
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Pneumocystis jiroveci (PCP)
Pneumocystis jiroveci (PCP)
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FEV1
FEV1
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FVC
FVC
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Obstructive Lung Disease
Obstructive Lung Disease
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Restrictive Lung Disease
Restrictive Lung Disease
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Peak Flow
Peak Flow
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Asthma
Asthma
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Asthma Symptoms
Asthma Symptoms
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Short Acting Beta 2 Agonists
Short Acting Beta 2 Agonists
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Inhaled Corticosteroids (ICS)
Inhaled Corticosteroids (ICS)
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Hypercalcaemia
Hypercalcaemia
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Legionella pneumophila
Legionella pneumophila
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Chest Xray
Chest Xray
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Maintenance and Reliever Therapy
Maintenance and Reliever Therapy
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Acute Asthma Exacerbation
Acute Asthma Exacerbation
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Pneumocystis jiroveci (PCP) pneumonia
Pneumocystis jiroveci (PCP) pneumonia
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Pneumonia management in the community
Pneumonia management in the community
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Spirometry
Spirometry
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Obstructive Lung Disease Diagnosis
Obstructive Lung Disease Diagnosis
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Asthma: Monitoring
Asthma: Monitoring
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Salbutamol Mechanism
Salbutamol Mechanism
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Lung Cancer MDT
Lung Cancer MDT
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Radiotherapy for lung cancer
Radiotherapy for lung cancer
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Adjuvant chemotherapy
Adjuvant chemotherapy
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Palliative chemotherapy
Palliative chemotherapy
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Endobronchial treatment
Endobronchial treatment
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Extrapulmonary Manifestations
Extrapulmonary Manifestations
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Pemberton’s sign
Pemberton’s sign
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Lambert-Eaton Syndrome Mechanism
Lambert-Eaton Syndrome Mechanism
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Pneumonia Description
Pneumonia Description
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Pneumonia Complications
Pneumonia Complications
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Treatment for Pneumocystis Pneumonia
Treatment for Pneumocystis Pneumonia
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Spirometry function
Spirometry function
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Inflammatory response
Inflammatory response
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NICE vs SIGN
NICE vs SIGN
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Acute Asthma
Acute Asthma
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What is Mesothelioma?
What is Mesothelioma?
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What is Aspiration Pneumonia?
What is Aspiration Pneumonia?
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MDT meeting
MDT meeting
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Pneumonia Antibiotics
Pneumonia Antibiotics
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What is Limbic encephalitis
What is Limbic encephalitis
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Long-acting muscarinic antagonists (LAMA)
Long-acting muscarinic antagonists (LAMA)
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Reversibility testing
Reversibility testing
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Leukotrienes
Leukotrienes
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Bronchoconstriction
Bronchoconstriction
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CRB-65
CRB-65
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CURB-65
CURB-65
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Theophylline
Theophylline
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How to measure peak expiratory flow rate
How to measure peak expiratory flow rate
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Maintenance and Reliever Therapy (MART)
Maintenance and Reliever Therapy (MART)
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What are SABAs (e.g. salbutamol)?
What are SABAs (e.g. salbutamol)?
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What is LABA (e.g. salmeterol)?
What is LABA (e.g. salmeterol)?
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The stepwise ladder principles
The stepwise ladder principles
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Paraneoplastic Syndromes
Paraneoplastic Syndromes
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CRP
CRP
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Bronchodilation
Bronchodilation
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LAMA MOA
LAMA MOA
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Leukotriene Receptor Antagonists MOA
Leukotriene Receptor Antagonists MOA
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Asthma Control
Asthma Control
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Diurnal Variability
Diurnal Variability
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NICE on Asthma
NICE on Asthma
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Acute Asthma Presentation
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Short acting beta 2 agonist function
Short acting beta 2 agonist function
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Study Notes
Lung Cancer Overview
- Lung cancer is the third most prevalent cancer in the UK, following breast and prostate cancer.
- Cigarette smoking stands as the primary cause, with approximately 80% of cases deemed preventable.
Lung Cancer Histology
- NSCLC subtypes include squamous cell carcinoma (35%) and adenocarcinoma (25%).
- SCLC constitutes 20% of lung cancer cases.
Small Cell Lung Cancer Specifics
- SCLC cells contain neurosecretory granules, facilitating the release of neuroendocrine hormones.
- It frequently causes paraneoplastic syndromes due to hormone release.
Lung Cancer Signs and Symptoms
- Shortness of breath is a common symptom.
- Cough is frequently observed.
- Haemoptysis (coughing up blood) may occur.
- Finger clubbing can be a sign.
- Recurrent pneumonia may indicate lung cancer.
- Weight loss is a common symptom
- Lymphadenopathy, particularly in the supraclavicular nodes, is often the first sign found on examination.
Lung Cancer Investigations
- Chest X-ray is the initial investigation, revealing hilar enlargement, peripheral opacity (visible lesion), unilateral pleural effusion, and collapse suggesting cancer.
- Contrast-enhanced CT scans of the chest, abdomen, and pelvis are conducted for staging and to check for lymph node involvement and metastasis; contrast enhancement provides detailed tissue information.
- PET-CT uses radioactive tracers attached to glucose molecules, visualizing metabolically active tissues to identify cancer spread through areas of increased metabolic activity.
- Bronchoscopy with EBUS allows detailed tumor assessment and ultrasound-guided biopsy.
- Histological diagnosis requires a biopsy, obtained via bronchoscopy or percutaneously, to check the cancer cell type.
Lung Cancer Treatment Options
- Treatment plans are decided in MDT meetings, involving pathologists, surgeons, oncologists, and radiologists, to determine the most suitable options.
- Surgery (lobectomy, segmentectomy, or wedge resection) is first-line for localized NSCLC with the aim of curing the cancer; lobectomy involves removing the lung lobe containing the tumour.
- Radiotherapy can be curative for early-stage NSCLC.
- Chemotherapy can be adjuvant after surgery or radiotherapy or palliative for advanced NSCLC.
- SCLC treatment primarily involves chemotherapy and radiotherapy; prognosis is typically worse than NSCLC.
- Endobronchial treatments like stents relieve bronchial obstruction palliatively.
Extrapulmonary Manifestations of Lung Cancer
- Recurrent laryngeal nerve palsy causes a hoarse voice due to nerve compression in the mediastinum.
- Phrenic nerve palsy results in diaphragm weakness and shortness of breath due to nerve compression.
- Superior vena cava obstruction presents with facial swelling, breathing difficulty, and distended neck veins due to tumor compression.
- Pemberton’s sign involves facial congestion and cyanosis when raising arms overhead, indicating a medical emergency.
- Horner’s syndrome, a triad of partial ptosis, anhidrosis, and miosis, results from a Pancoast tumor pressing on the sympathetic ganglion.
- SIADH is caused by ectopic ADH secretion by SCLC, leading to hyponatremia.
- Cushing’s syndrome is caused by ectopic ACTH secretion by SCLC.
- Hypercalcemia is caused by ectopic parathyroid hormone production from squamous cell carcinoma.
- Limbic encephalitis involves an autoimmune response causing short-term memory impairment, hallucinations, confusion, and seizures, and is associated with anti-Hu antibodies.
Lambert-Eaton Myasthenic Syndrome
- Autoantibodies against small cell lung cancer cells damage voltage-gated calcium channels on presynaptic motor neurons.
- Proximal muscle weakness, diplopia, ptosis, slurred speech, and dysphagia occur.
- Symptoms worsen with muscle use and are similar to myasthenia gravis.
- In older smokers, consider small cell lung cancer with these symptoms.
Mesothelioma
- Lung malignancy affects mesothelial cells of the pleura and is linked to asbestos inhalation.
- A long latency period (up to 45 years) exists between asbestos exposure and development; prognosis is poor.
- Chemotherapy provides palliative benefits.
Pneumonia Classifications
- Community Acquired Pneumonia (CAP) develops outside of a hospital.
- Hospital Acquired Pneumonia (HAP) develops >48 hours after hospital admission.
- Aspiration Pneumonia results from inhaling foreign material.
- Causes inflammation of the lung tissue and production of sputum that fills the airways and alveoli.
- Can be seen as consolidation on a chest X-ray.
Pneumonia Presentation
- Shortness of breath
- Productive cough
- Fever
- Coughing up blood (haemoptysis)
- Pleuritic chest pain (sharp chest pain worse on inspiration)
- Delirium (acute confusion associated with infection)
- Sepsis
Pneumonia Signs
- Changes in vital signs (tachypnoea, tachycardia, hypoxia, hypotension, fever, confusion).
- Bronchial breath sounds.
- Focal coarse crackles.
- Dullness to percussion.
Pneumonia Severity Assessment
- CRB-65 (outpatient) assesses confusion, respiratory rate, blood pressure, and age ≥ 65.
- CURB-65 (inpatient) includes urea in addition to the CRB-65 variables and predicts mortality risk.
- CURB-65 score predicts mortality risk.
- Score 0/1: Treatment at home
- Score ≥ 2: Hospital admission
- Score ≥ 3: Intensive care assessment
Pneumonia Common Causes
- Streptococcus pneumoniae: 50%.
- Haemophilus influenzae: 20%.
- Moraxella catarrhalis: Common in immunocompromised or chronic pulmonary disease patients.
- Pseudomonas aeruginosa: Common in cystic fibrosis or bronchiectasis patients.
- Staphylococcus aureus: Common in cystic fibrosis patients.
Atypical Pneumonia
- Definition is pneumonia caused by an organism that cannot be cultured in the normal way or detected using a Gram stain.
- Does not respond to penicillins, macrolides, fluoroquinolones and tetracyclines are suitable treatments.
- Macrolides, fluoroquinolones, and tetracyclines are suitable treatments in place of penicillins.
- Specific causes:
- Legionella pneumophila (Legionnaires’ disease): Occurs from infected water supplies or air conditioning units, causes hyponatremia by causing SIADH.
- Mycoplasma pneumoniae: Milder pneumonia, can cause erythema multiforme and neurological symptoms.
- Chlamydophila pneumoniae: Mild, chronic pneumonia and wheeze in school-aged children.
- Coxiella burnetii (Q fever): Exposure to animals and their bodily fluids.
- Chlamydia psittaci: Contact with infected birds.
- Mnemonic for atypical pneumonias "Legions of psittaci MCQs” can assist with remembering the 5 causes:
- Legionella pneumophila
- Chlamydia psittaci
- Mycoplasma pneumoniae
- Chlamydophila pneumoniae
- Q fever (coxiella burnetii)
Pneumocystis jiroveci (PCP) Pneumonia
- Occurs in immunocompromised patients, particularly those with poorly controlled HIV.
- Symptoms: Dry cough, shortness of breath on exertion, and night sweats.
- Treatment: Co-trimoxazole (trimethoprim/sulfamethoxazole).
- Prophylactic co-trimoxazole for HIV patients with low CD4 counts.
Pneumonia Investigations
- Community patients with CRB-65 0 or 1 may not need investigations.
- Recommended inpatient investigations include:
- Chest X-ray.
- FBC (raised white cells).
- U&Es (for urea).
- CRP (raised in inflammation and infection).
- Further investigations for moderate/severe cases:
- Sputum cultures.
- Blood cultures.
- Legionella and pneumococcal urinary antigens.
- Inflammatory markers: Magnitude reflects infection severity.
- Patients that are immunocompromised may not show an inflammatory response and may not have raised inflammatory markers despite severe infection.
- NICE suggest considering a “point of care” test in primary care for CRP level to help guide management, however this is not widely available.
Pneumonia Antibiotics
- Follow local guidelines due to regional antibiotic resistance variations.
- Typically, IV antibiotics are started for moderate/severe/septic cases and then switched to oral.
- Typical durations:
- Mild CAP: 5 days oral amoxicillin or a macrolide.
- Moderate to severe CAP: 7-10 days dual antibiotics (amoxicillin and macrolide).
Pneumonia Complications
- Sepsis
- Pleural effusion
- Empyema
- Lung abscess
- Death
Lung Function Tests Overview
- Used to diagnose lung diseases.
- Helpful in identifying obstructive and restrictive lung diseases.
Spirometry
- Measures lung function through breathing exercises.
- Measures air volumes and flow rates.
- Reversibility testing uses a bronchodilator (salbutamol) to assess changes in results.
- FEV1: Forced expiratory volume in 1 second.
- Reflects ease of airflow out of the lungs; reduced with airway obstruction.
- FVC: Forced vital capacity.
- Total air exhaled after full inhalation; reduced with lung capacity restriction.
Obstructive Lung Disease
- Indicated by FEV1:FVC ratio < 75%.
- Signifies airway obstruction.
- Asthma: Narrowed airways due to bronchoconstriction.
- COPD: Chronic airway and lung damage.
- Reversibility testing: Asthma obstruction is typically reversible, COPD is not.
Restrictive Lung Disease
- FEV1 and FVC are equally reduced, FEV1:FVC ratio > 75%.
- Restriction limits lung expansion.
- Causes inadequate alveolar ventilation and blood oxygenation.
- FEV1/FVC ratio is normal or raised.
Causes of Restrictive Lung Disease
- Interstitial lung disease (pulmonary fibrosis).
- Sarcoidosis.
- Obesity.
- Motor neurone disease.
- Scoliosis.
- Anything that affects how well the chest wall and lungs can forcefully expand to draw air in.
Peak Flow Measurement
- Measures the fastest point of expiratory flow (PEFR).
- Assess obstruction to airflow using a peak flow meter.
- Useful for managing obstructive lung disease, especially asthma.
- Recorded as a percentage of predicted PEFR, taking into account patient's sex, height and age
- Stand tall, take a deep breath in, make a good seal around the device with the lips and blow as fast and hard as possible into the device, take three attempts and record the best result.
Asthma Overview
- Chronic inflammatory condition causing episodic bronchoconstriction.
- Reversible airway obstruction responding to bronchodilators.
- Airway hypersensitivity triggered by environmental factors.
- Bronchoconstriction is where the smooth muscles of the airways (the bronchi) contract, causing a reduction in the diameter of the airways.
- Narrowing of the airways causes an obstruction to airflow.
Asthma Triggers
- Infection
- Night time or early morning
- Exercise
- Animals
- Cold, damp or dusty air
- Strong emotions
Asthma Presentation
- Episodic symptoms.
- Diurnal variability, worse at night.
- Dry cough, wheeze, and shortness of breath.
- History of atopic conditions.
- Family history.
- Bilateral widespread wheeze.
Non-Asthma Presentations
- Wheeze related to colds.
- Isolated or productive cough.
- Normal investigations.
- No response to treatment.
- Unilateral wheeze (suggests a focal lesion or infection).
Asthma Diagnosis Guidelines
- BTS/SIGN guidelines advise clinical diagnosis for high suspicion; testing for intermediate/low suspicion.
- NICE guidelines require definitive testing; discourages clinical diagnosis alone.
BTS/Sign Guidelines on Diagnosis
- High probability of asthma clinically: Try treatment.
- Intermediate probability of asthma: Perform spirometry with reversibility testing.
- Low probability of asthma: Consider referral and investigating for other causes.
NICE Guidelines on Diagnosis
- Assessment and testing occur at a diagnostic hub.
- First-line investigations:
- Fractional exhaled nitric oxide (FeNO).
- Spirometry with bronchodilator reversibility.
- Follow-up tests for diagnostic uncertainty:
- Peak flow variability diary (2-4 weeks).
- Direct bronchial challenge test.
Long Term Management of asthma
- Short-acting beta 2 agonists (e.g., salbutamol):
- Act on airway smooth muscles to cause relaxation, quick relief during acute exacerbations.
- Inhaled corticosteroids (ICS) (e.g., beclometasone):
- Reduce inflammation and reactivity, used regularly as "preventer" medications.
- Long-acting beta 2 agonists (LABA) (e.g., salmeterol):
- Same mechanism as SABAs but longer-lasting.
- Long-acting muscarinic antagonists (LAMA) (e.g., tiotropium):
- Block acetylcholine receptors, causing bronchodilation.
- Leukotriene receptor antagonists (e.g., montelukast):
- Block leukotrienes, reducing inflammation, bronchoconstriction, and mucus secretion.
- Theophylline:
- Relaxes bronchial smooth muscle and reduces inflammation; requires blood level monitoring.
- Monitoring plasma theophylline levels in the blood is required 5 days after starting treatment and 3 days after each dose changes.
- Maintenance and Reliever Therapy (MART):
- Combination inhaler (ICS + fast-acting LABA) for both regular prevention and symptom relief.
Stepwise Ladder
- BTS/SIGN and NICE guidelines have different steps.
- Both start with SABA and low-dose ICS.
- Next step: leukotriene receptor antagonist or inhaled LABA.
- Principles:
- Start at appropriate step.
- Review regularly.
- Step up/down based on symptoms.
- Aim for symptom control on lowest dose.
- Check inhaler technique and adherence.
BTS/SIGN Stepwise Ladder
- Add a short-acting beta 2 agonist inhaler (e.g. salbutamol) as required for infrequent wheezy episodes.
- Add a regular low dose corticosteroid inhaler.
- Add LABA inhaler (e.g. salmeterol). Continue the LABA only if the patient has a good response.
- Consider a trial of an oral leukotriene receptor antagonist (i.e. montelukast), oral beta 2 agonist (i.e. oral salbutamol), oral theophylline or an inhaled LAMA (i.e. tiotropium).
- Titrate the inhaled corticosteroid up to “high dose". Combine additional treatments from step 4. Refer to a specialist.
- Add oral steroids at the lowest dose possible to achieve good control.
NICE Guidelines
- Add a short-acting beta 2 agonist inhaler (e.g. salbutamol) as required for infrequent wheezy episodes.
- Add a regular low dose inhaled corticosteroid.
- Add an oral leukotriene receptor antagonist (i.e. montelukast).
- Add LABA inhaler (e.g. salmeterol). Continue the LABA only if the patient has a good response.
- Consider changing to a maintenance and reliever therapy (MART) regime.
- Increase the inhaled corticosteroid to a “moderate dose”.
- Consider increasing the inhaled corticosteroid dose to “high dose” or oral theophylline or an inhaled LAMA (e.g. tiotropium).
- Refer to a specialist.
Additional Asthma Management
- Individual asthma self-management plan.
- Yearly flu jab.
- Yearly asthma review.
- Encourage exercise and smoking cessation.
Acute Asthma Presentation
- Rapid deterioration of symptoms.
- Use of accessory muscles.
- Tachypnoea.
- Symmetrical expiratory wheeze.
- Reduced air entry.
- The chest can sound "tight" on auscultation with reduced air entry
Acute Asthma Grading
- Moderate: PEFR 50 – 75% predicted.
- Severe: PEFR 33-50% predicted, Resp rate >25, Heart rate >110, Unable to complete sentences.
- Life-threatening: PEFR <33% predicted.
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