H&H modules 5:6
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Questions and Answers

A patient presents with a persistent cough, weight loss, and chest pain. Imaging reveals a centrally located lung tumor strongly associated with smoking. Which type of lung cancer is MOST likely?

  • Large cell carcinoma
  • Small cell lung cancer
  • Squamous cell carcinoma (correct)
  • Adenocarcinoma

Why is distinguishing between small cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) significant in clinical practice?

  • Because treatment strategies and prognoses differ significantly between the two types. (correct)
  • Because the types have different appearances under a microscope.
  • Because NSCLC is always curable, whereas SCLC is not.
  • Because SCLC only occurs in smokers, while NSCLC does not.

Which diagnostic procedure involves examining a sample of coughed-up material under a microscope to detect cancerous cells?

  • Mediastinoscopy
  • Bronchoscopy
  • Sputum cytology (correct)
  • Needle biopsy

A patient with no history of smoking is diagnosed with lung cancer. Which subtype of non-small cell lung cancer is MOST likely?

<p>Adenocarcinoma (A)</p> Signup and view all the answers

Which of the following is the MOST critical factor contributing to the development of small cell lung cancer (SCLC)?

<p>Smoking history (C)</p> Signup and view all the answers

Why is staging performed after a lung cancer diagnosis?

<p>To assess the extent of the cancer's spread and guide treatment decisions. (A)</p> Signup and view all the answers

Which of the following symptoms, if experienced by a patient, would warrant further investigation for potential lung cancer, even in the absence of other risk factors?

<p>A persistent cough with blood-tinged sputum (A)</p> Signup and view all the answers

Which of the following imaging techniques is LEAST likely to be used in the initial diagnosis of lung cancer?

<p>Ultrasound (A)</p> Signup and view all the answers

A patient is diagnosed with lung cancer that has spread to nearby lymph nodes but not to distant organs. According to the TNM staging system, which component is directly addressed by the presence of cancer in the lymph nodes?

<p>N (Nodes) (A)</p> Signup and view all the answers

Which of the following is a factor that does not directly determine the treatment approach for lung cancer?

<p>The patient's personal hobbies (A)</p> Signup and view all the answers

Which intervention provides the most significant reduction in lung cancer risk for an individual who is a current smoker?

<p>Quitting smoking entirely (D)</p> Signup and view all the answers

An individual with a 30 pack-year smoking history quit smoking 10 years ago. They are currently 58 years old. According to the guidelines, are they a candidate for lung cancer screening?

<p>Yes, because they are between 50 and 80 years old, have a history of heavy smoking, and quit within the past 15 years. (C)</p> Signup and view all the answers

Which of the following complications of lung cancer is characterized by fluid build up in the space between the lungs and chest wall?

<p>Pleural effusion (A)</p> Signup and view all the answers

A patient undergoing chemotherapy for lung cancer experiences a severe drop in white blood cell count. Which of the following treatment modalities would best address this specific complication?

<p>Administering growth factors (A)</p> Signup and view all the answers

What is the primary goal of palliative care in the treatment of lung cancer?

<p>Providing relief from symptoms and improving quality of life (A)</p> Signup and view all the answers

Which of the following statements best describes the relationship between lung cancer stage at diagnosis and prognosis?

<p>Earlier stages at diagnosis generally lead to improved chances of survival compared to later stages. (C)</p> Signup and view all the answers

A patient undergoing chemotherapy for leukemia reports sudden muscle cramps, nausea, and diarrhea. Initial lab results show elevated potassium and uric acid levels. Which oncologic emergency is MOST likely occurring?

<p>Tumor lysis syndrome (TLS) (C)</p> Signup and view all the answers

A patient with lymphoma is starting chemotherapy. To prevent a potential complication, the physician prescribes allopurinol. What is the MOST likely rationale for this prescription?

<p>To prevent hyperuricemia. (D)</p> Signup and view all the answers

A patient with acute leukemia has a critically low platelet count and is at high risk for bleeding. What nursing intervention is MOST appropriate?

<p>Use a soft-bristled toothbrush for oral care. (D)</p> Signup and view all the answers

A patient receiving chemotherapy for lymphoma develops mucositis. The patient reports severe pain when eating. Which intervention is MOST appropriate?

<p>Administer a topical anesthetic before meals. (D)</p> Signup and view all the answers

A patient undergoing treatment for leukemia is prescribed filgrastim. What laboratory value should the nurse monitor to evaluate the effectiveness of this medication?

<p>White blood cell count (B)</p> Signup and view all the answers

What is the MOST important instruction to provide a patient with neutropenia who is undergoing chemotherapy for acute leukemia?

<p>Avoid crowds and people who are sick. (A)</p> Signup and view all the answers

A patient receiving chemotherapy for lymphoma expresses concern about hair loss. Which nursing intervention is MOST appropriate?

<p>Educate the patient about wigs, scarves, and other head coverings. (D)</p> Signup and view all the answers

A patient undergoing treatment for acute leukemia is scheduled for a platelet transfusion. What assessment finding would MOST directly indicate the need for this intervention?

<p>Platelet count of 15,000/µL (D)</p> Signup and view all the answers

A patient with lymphoma reports persistent fatigue that is interfering with daily activities. What is the MOST appropriate nursing recommendation?

<p>Suggest the patient cluster activities and prioritize tasks. (A)</p> Signup and view all the answers

A patient undergoing chemotherapy for leukemia expresses feelings of sadness and hopelessness. What is the MOST appropriate initial nursing action?

<p>Provide a safe and supportive environment for the patient to express their feelings. (C)</p> Signup and view all the answers

A patient reports a change in bowel habits, rectal bleeding, and persistent abdominal discomfort. Which nursing intervention is MOST appropriate as an initial step?

<p>Performing a thorough assessment of the patient's symptoms and medical history. (B)</p> Signup and view all the answers

When educating a patient about colorectal cancer screening options, which statement accurately describes the key difference between a colonoscopy and a flexible sigmoidoscopy?

<p>A colonoscopy examines the entire colon, while a flexible sigmoidoscopy examines only the rectum and lower colon. (C)</p> Signup and view all the answers

A patient undergoing chemotherapy for colorectal cancer develops mucositis. Which dietary modification is MOST appropriate to recommend?

<p>Offer soft, bland foods and avoid acidic or spicy items. (B)</p> Signup and view all the answers

A patient with advanced colorectal cancer is experiencing significant pain. Besides administering analgesics, what non-pharmacological intervention could a nurse implement to enhance pain management?

<p>Applying heat or cold packs and teaching relaxation techniques. (D)</p> Signup and view all the answers

A patient is scheduled for a colonoscopy. Which instruction regarding bowel preparation should the nurse emphasize?

<p>Maintain a clear liquid diet for 1-2 days before the procedure and take the prescribed bowel preparation as directed. (C)</p> Signup and view all the answers

A patient who underwent colorectal cancer resection with an ostomy is concerned about body image. Which nursing intervention is MOST appropriate?

<p>Provide education on ostomy care, appliance options, and connect them with support resources. (D)</p> Signup and view all the answers

During a follow-up appointment, a colorectal cancer survivor reports persistent fatigue. What should the nurse prioritize?

<p>Assessing for underlying causes of fatigue and promoting energy conservation techniques. (C)</p> Signup and view all the answers

What is the BEST approach for a nurse to provide emotional support to a patient newly diagnosed with colorectal cancer?

<p>Actively listening, acknowledging feelings, and providing accurate information. (B)</p> Signup and view all the answers

A patient with colorectal cancer is considering participating in an advance care planning session. What key aspect of palliative care should the nurse emphasize when explaining the purpose of this session?

<p>Advance care planning facilitates discussions about goals of care and ensures the patient's wishes are honored. (A)</p> Signup and view all the answers

A nurse is reviewing the care plan for a patient receiving palliative care for colorectal cancer. Which intervention is MOST aligned with the goals of palliative care?

<p>Focusing on maximizing the patient's comfort and quality of life through symptom management. (D)</p> Signup and view all the answers

What is the MOST important information to emphasize when educating patients about modifiable risk factors for colorectal cancer?

<p>Diet, exercise, smoking, and alcohol consumption are modifiable factors that can influence colorectal cancer risk. (A)</p> Signup and view all the answers

A patient's screening colonoscopy reveals several precancerous polyps, which are removed. What follow-up recommendation should the nurse reinforce?

<p>Follow-up colonoscopies will be scheduled at intervals determined by the number and type of polyps found. (A)</p> Signup and view all the answers

A patient with colorectal cancer develops chemotherapy-induced peripheral neuropathy. Which intervention is MOST appropriate to recommend?

<p>Recommend regular gentle exercise, protective footwear, and fall prevention strategies. (A)</p> Signup and view all the answers

What is the primary goal of survivorship care for patients who have completed treatment for colorectal cancer?

<p>To monitor for recurrence, manage long-term side effects, and promote a healthy lifestyle. (D)</p> Signup and view all the answers

A patient undergoing treatment for colorectal cancer expresses concerns about the cost of medications. Which nursing action is MOST appropriate?

<p>Collaborating with the healthcare team to explore options such as patient assistance programs or generic alternatives. (B)</p> Signup and view all the answers

A patient undergoing hormonal therapy for breast cancer reports experiencing frequent hot flashes and night sweats. What is the MOST appropriate nursing recommendation?

<p>Suggest the patient wear layered clothing and use a fan to stay cool, especially at night. (B)</p> Signup and view all the answers

A patient who underwent a mastectomy is at risk of developing lymphedema in the affected arm. Which intervention is MOST crucial for the nurse to include in the patient's discharge teaching to prevent this complication?

<p>Educating the patient on proper skin care, avoiding injury, and performing gentle range-of-motion exercises. (A)</p> Signup and view all the answers

A patient receiving chemotherapy for breast cancer develops neutropenia. What is the MOST important instruction the nurse should provide to prevent infection?

<p>Avoid crowded places and people who are sick, and practice meticulous hand hygiene. (D)</p> Signup and view all the answers

A breast cancer patient reports persistent fatigue that interferes with performing daily activities. What strategy should the nurse recommend to help the patient manage this fatigue?

<p>Engage in regular, light exercise as tolerated and prioritize rest periods. (C)</p> Signup and view all the answers

A patient undergoing radiation therapy for breast cancer experiences skin irritation and burns in the treatment area. What should the nurse advise the patient to do?

<p>Use a mild, fragrance-free soap and apply prescribed topical corticosteroids or emollients. (A)</p> Signup and view all the answers

A patient who has completed treatment for breast cancer expresses concerns about body image and self-esteem due to surgical changes. What is the MOST appropriate nursing intervention?

<p>Encourage the patient to express feelings, provide emotional support, and offer resources for counseling and support groups. (C)</p> Signup and view all the answers

A patient on targeted therapy for breast cancer develops diarrhea. Which dietary modification should the nurse suggest to help manage this side effect?

<p>Eat small, frequent meals and avoid fatty, spicy, and gas-producing foods. (B)</p> Signup and view all the answers

During a routine follow-up appointment, a breast cancer survivor reports experiencing anxiety and difficulty sleeping. Which of the following nursing interventions is MOST appropriate?

<p>Assessing the patient's stress levels, providing stress management techniques, and offering referrals to mental health services. (D)</p> Signup and view all the answers

A patient receiving chemotherapy is scheduled to receive education regarding potential side effects. Which statement BEST describes the information the nurse should prioritize?

<p>Providing a comprehensive overview of all potential side effects, including strategies for their prevention and management. (B)</p> Signup and view all the answers

A patient who had a mastectomy is preparing to go home. What information ensuring continuity of care should the nurse emphasize during discharge teaching?

<p>Details regarding who to contact for durable medical equipment needs, wound care, follow-up and signs of potential complications. (A)</p> Signup and view all the answers

What is the most important role a nurse plays in the early detection of prostate cancer?

<p>Educating men about the risks and benefits of PSA testing and DRE. (A)</p> Signup and view all the answers

Which of the following topics is most important for a nurse to include when educating a prostate cancer patient newly prescribed hormone therapy?

<p>Potential side effects such as hot flashes, erectile dysfunction, and decreased libido. (B)</p> Signup and view all the answers

Which intervention is most appropriate for a nurse to recommend to a prostate cancer patient experiencing persistent fatigue related to their treatment?

<p>Implementing energy conservation techniques and regular, moderate exercise. (A)</p> Signup and view all the answers

A patient who underwent a radical prostatectomy is now reporting urinary leakage. What should the nurse recommend?

<p>Start pelvic floor exercises immediately and consistently. (B)</p> Signup and view all the answers

A prostate cancer patient reports constipation following treatment. What should the nurse recommend?

<p>Dietary modifications, increased hydration, and stool softeners. (B)</p> Signup and view all the answers

What is the most important pre-operative teaching point a nurse should emphasize to a patient scheduled for a radical prostatectomy?

<p>The process of bowel preparation, catheter care, and pain management. (A)</p> Signup and view all the answers

A nurse is caring for a prostate cancer patient experiencing pain. What should the nurse do first?

<p>Assess the patient's pain using a validated pain scale. (B)</p> Signup and view all the answers

A patient is considering active surveillance as a treatment option for prostate cancer. What information is most important for the nurse to convey?

<p>Active surveillance involves regular monitoring and may delay definitive treatment. (A)</p> Signup and view all the answers

What information is most important for the nurse to include when teaching a patient about skin care during external beam radiation therapy (EBRT)?

<p>Use mild, unscented soap and water to gently cleanse the treatment area and pat dry. (D)</p> Signup and view all the answers

A patient undergoing hormone therapy for prostate cancer reports experiencing hot flashes that are interfering with their daily life. Which of the following nursing recommendations is MOST appropriate?

<p>Wear layered clothing and avoid triggers such as spicy foods and hot environments. (B)</p> Signup and view all the answers

A patient receiving chemotherapy for advanced prostate cancer develops a decreased white blood cell count. What should the nurse prioritize when educating the patient?

<p>Avoid crowds and contact with people who are sick, and report any signs of infection immediately. (D)</p> Signup and view all the answers

A patient is considering active surveillance for low-risk prostate cancer and asks the nurse about the purpose of frequent PSA tests. What is the MOST appropriate response?

<p>Frequent PSA tests help track the cancer's growth and determine if treatment is needed. (C)</p> Signup and view all the answers

A patient diagnosed with prostate cancer expresses feelings of anxiety and fear about the impact of the disease on his sexual function. What is the nurse's MOST appropriate initial intervention?

<p>Provide the patient with information about potential treatment-related sexual side effects and offer resources for counseling and support. (A)</p> Signup and view all the answers

Which of the following assessment findings would be MOST important for the nurse to report to the healthcare provider when caring for a patient receiving brachytherapy for prostate cancer?

<p>New onset of urinary retention or difficulty voiding. (B)</p> Signup and view all the answers

How should the nurse individualize care for a patient who has body image concerns related to hormone therapy-induced gynecomastia?

<p>Acknowledge the patient's concerns, provide information about managing gynecomastia, and offer resources such as support groups or counseling. (D)</p> Signup and view all the answers

What is the MOST important aspect for the nurse to assess when evaluating the effectiveness of pain management interventions for a patient with prostate cancer?

<p>The patient's ability to perform activities of daily living and maintain quality of life. (B)</p> Signup and view all the answers

Which intervention should the nurse prioritize for a patient on long-term hormone therapy to minimize the risk of osteoporosis?

<p>Providing education on calcium and vitamin D supplementation, as well as weight-bearing exercise. (B)</p> Signup and view all the answers

What is the MOST appropriate nursing action to support a patient who is having difficulty adhering to the active surveillance schedule?

<p>Re-educate on the goals, risks, and benefits of active survelience and address barriers of adherence. (C)</p> Signup and view all the answers

Which of the following is NOT a typical administration method for intraperitoneal chemotherapy?

<p>Direct injection into a peripheral vein (C)</p> Signup and view all the answers

A patient receiving intraperitoneal chemotherapy reports increased abdominal pain and fever. What is the MOST likely immediate concern?

<p>Developing a catheter-related infection (A)</p> Signup and view all the answers

Why is intrathecal chemotherapy often preferred over systemic chemotherapy for treating cancers that have spread to the central nervous system (CNS)?

<p>The blood-brain barrier limits the penetration of many systemic drugs. (B)</p> Signup and view all the answers

An Ommaya reservoir is implanted to facilitate which type of chemotherapy administration?

<p>Intrathecal/Intraventricular (A)</p> Signup and view all the answers

Which route of chemotherapy administration is designed to directly target cancer cells within the abdominal cavity, commonly used for ovarian and colorectal cancers?

<p>Intraperitoneal chemotherapy (D)</p> Signup and view all the answers

A patient with leukemia is receiving intrathecal methotrexate. What is the PRIMARY rationale for choosing this route of administration?

<p>To bypass the blood-brain barrier and target leukemic cells in the CNS. (B)</p> Signup and view all the answers

When evaluating a patient receiving targeted cancer therapy, what factor should be considered a key indicator of treatment effectiveness?

<p>A decrease in tumor size or disease markers (A)</p> Signup and view all the answers

Which statement BEST describes the purpose of using targeted cancer therapies?

<p>Specifically attacking cancer cells while minimizing harm to normal cells (A)</p> Signup and view all the answers

Which of the following is the MOST accurate description of how intra-arterial chemotherapy reduces systemic toxicity compared to traditional chemotherapy?

<p>It delivers a higher dose of chemotherapy directly to the tumor, requiring lower overall dosages. (D)</p> Signup and view all the answers

A patient with osteogenic sarcoma is being considered for intra-arterial chemotherapy. What is the PRIMARY advantage of using intra-arterial chemotherapy over systemic chemotherapy in this scenario?

<p>It minimizes systemic side effects, allowing for higher local drug concentrations at the tumor site. (A)</p> Signup and view all the answers

A patient is scheduled to receive intra-arterial chemotherapy for liver cancer via an implanted infusion pump. What is the PRIMARY nursing responsibility related to the implanted pump?

<p>Monitoring the insertion site for signs of infection and ensuring proper pump function. (A)</p> Signup and view all the answers

Which type of cancer is LEAST likely to be treated with intra-arterial chemotherapy, based on arterial access and tumor location?

<p>Gastric cancer (C)</p> Signup and view all the answers

Which of the following statements BEST describes the role of regular physical activity in cancer prevention?

<p>It reduces the risk of cancer by helping to maintain a healthy weight and modulating hormone levels. (A)</p> Signup and view all the answers

A community health nurse is designing an educational program on cancer prevention. Which of the following strategies would be MOST effective in reducing cancer risk related to sun exposure?

<p>Promoting the use of broad-spectrum sunscreen and protective clothing during peak sun hours. (B)</p> Signup and view all the answers

A nutritionist is advising a patient on dietary changes to reduce cancer risk. Which dietary recommendation reflects the MOST current guidelines for cancer prevention?

<p>Emphasizing a balanced diet rich in fruits, vegetables, fiber, and omega-3 fatty acids. (B)</p> Signup and view all the answers

A patient reports noticing a new, irregular mole on their skin. According to the recommendations for early cancer detection, what is the MOST appropriate initial action?

<p>Scheduling an appointment with a healthcare provider for evaluation. (B)</p> Signup and view all the answers

What is a primary advantage of using an Ommaya reservoir for intraventricular chemotherapy administration compared to repeated lumbar punctures?

<p>It ensures more uniform drug distribution in the CNS and avoids repeated painful procedures. (C)</p> Signup and view all the answers

A patient undergoing intrathecal chemotherapy suddenly develops a severe headache, fever, and neck stiffness. What is the MOST likely complication?

<p>Meningitis (C)</p> Signup and view all the answers

Which of the following is a PRIMARY goal of intravesical bladder chemotherapy?

<p>To destroy cancer cells within the bladder and reduce the recurrence of superficial bladder cancer. (A)</p> Signup and view all the answers

A patient receiving intravesical chemotherapy reports experiencing painful urination and increased urinary frequency. Which of the following interventions is MOST appropriate?

<p>Administer medication to alleviate bladder spasms and encourage increased fluid intake. (D)</p> Signup and view all the answers

What is the MAIN advantage of intravesical chemotherapy over systemic chemotherapy for superficial bladder cancer?

<p>Intravesical chemotherapy minimizes systemic side effects because the drug is instilled directly into the bladder. (B)</p> Signup and view all the answers

A patient undergoing intravesical chemotherapy for bladder cancer develops hematuria. What is the initial nursing intervention?

<p>Monitor the patient for signs of worsening bleeding and notify the physician. (A)</p> Signup and view all the answers

A patient is scheduled to receive external beam radiation therapy. What teaching point is MOST important for the nurse to include?

<p>Radiation is delivered from a machine outside the body, targeting the tumor site. (C)</p> Signup and view all the answers

What is the PRIMARY difference between external beam radiation and brachytherapy (internal radiation)?

<p>External radiation directs radiation from outside the body, while brachytherapy involves placing radioactive material internally near the treatment area. (B)</p> Signup and view all the answers

Which of the following pathophysiological processes in septic shock contributes MOST directly to the development of lactic acidosis?

<p>Impaired tissue oxygenation, causing cellular hypoxia and anaerobic metabolism (B)</p> Signup and view all the answers

A patient in septic shock is exhibiting hypotension despite aggressive fluid resuscitation. What is the MOST likely combination of factors contributing to this persistent hypotension?

<p>Hypovolemia, vasodilation and myocardial dysfunction (C)</p> Signup and view all the answers

In septic shock, the balance between pro-inflammatory and anti-inflammatory responses is disrupted. Which statement best describes the imbalance that occurs?

<p>The pro-inflammatory response overwhelms the anti-inflammatory response (A)</p> Signup and view all the answers

A patient with a confirmed infection is suspected of developing septic shock. Which cluster of vital sign abnormalities would MOST strongly suggest the early stages of septic shock?

<p>Hypotension, tachycardia, tachypnea, and fever (A)</p> Signup and view all the answers

Which of the following mechanisms directly leads to widespread edema formation in patients with septic shock?

<p>Endothelial damage leading to increased vascular permeability. (B)</p> Signup and view all the answers

Flashcards

Cancer in situ

Describes cancer confined to its place of origin.

T (Tumor) in TNM Staging

Used to describe the size and extent of the primary tumor.

N (Nodes) in TNM Staging

Indicates if cancer has spread to nearby lymph nodes.

M (Metastasis) in TNM Staging

Indicates if cancer has spread to distant organs.

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Chemotherapy

Drugs to kill cancer cells, usually administered intravenously or orally.

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Targeted Therapy

Drugs that target specific abnormalities in cancer cells.

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Palliative Care

Relief from symptoms and improving quality of life.

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Pleural Effusion

Fluid buildup in the space between the lungs and chest wall.

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Lung Cancer

Cancer that begins in the lungs, the leading cause of cancer deaths worldwide.

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Types of Lung Cancer

The two main categories are Small Cell Lung Cancer (SCLC) and Non-Small Cell Lung Cancer (NSCLC).

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Non-Small Cell Lung Cancer (NSCLC)

More common type (80-85%) divided into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

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Adenocarcinoma

Begins in mucus-producing gland cells; most common in non-smokers and women.

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Squamous Cell Carcinoma

Related to smoking history; typically found in the central part of the lungs.

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Small Cell Lung Cancer (SCLC)

Accounts for 10-15% of lung cancers; strongly associated with smoking; known for aggressive growth.

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Leading cause of Lung Cancer

Primarily through smoking, including direct and secondhand exposure.

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Lung Cancer Diagnosis Methods

Imaging (X-rays, CT Scans), Sputum Cytology, and Biopsy (bronchoscopy, mediastinoscopy, needle biopsy).

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Hematologic Cancers

Cancers affecting blood cells (leukemia) or the lymphatic system (lymphomas).

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Common Symptoms

Includes fatigue, weakness, recurrent infections, bleeding, and bone pain.

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Neutropenia

Low white blood cell count, increasing infection risk.

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Antiemetics

Medications to prevent or reduce nausea and vomiting.

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Mucositis

Inflammation of the mucous membranes, often in the mouth.

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Alopecia

Hair loss due to chemotherapy.

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Neutropenic Precautions

Precautions taken to prevent infection in patients with low neutrophil counts.

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Tumor Lysis Syndrome (TLS)

A condition caused by the breakdown of cancer cells, releasing intracellular contents into the bloodstream.

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Colorectal Cancer (CRC)

Cancer that starts in the colon or rectum.

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Colorectal Polyps

Abnormal growths in the colon or rectum that can turn into cancer.

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CRC Symptoms

Changes in bowel habits, rectal bleeding, abdominal discomfort, fatigue, unexplained weight loss.

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Pain Management

Administering analgesics, relaxation techniques, heat/cold applications.

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Bowel Management

Monitoring and managing bowel movements with stool softeners or laxatives.

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Nausea/Vomiting Management

Administering antiemetics, small frequent meals, avoiding strong odors.

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Fatigue Management

Rest periods, energy conservation, addressing underlying causes like anemia.

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Nutritional Support

Nutritional counseling, monitoring intake, considering enteral/parenteral nutrition.

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Modifiable Risk Factors

Diet, exercise, smoking, and alcohol consumption.

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CRC Screening Options

Colonoscopy, sigmoidoscopy, stool-based tests.

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CRC Treatment Options

Surgery, chemotherapy, radiation therapy, and targeted therapy.

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Follow-Up Care

Regular appointments and tests to check for recurrence.

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Nursing Assessment

Conducting physical, emotional, and psychosocial assessments.

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Palliative Pain Management

Using various approaches to alleviate cancer pain.

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Spiritual Care

Addressing spiritual needs and helping find meaning/peace.

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Breast Cancer

A malignant tumor that develops in breast cells.

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Breast Self-Exam

Examine breasts monthly to detect changes early.

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Symptom Management

Techniques for reducing cancer treatment discomfort.

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Lymphedema

Swelling due to lymph node blockage, often in the arm.

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Psychosocial Support

Providing emotional support and counseling.

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Breast Assessment

Inspecting and touching breasts to identify abnormalities.

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Pneumonitis

Inflammation of the lungs after radiation therapy.

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Prostate Cancer

Cancer affecting the prostate gland, common in aging men.

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Prostate Cancer Screening

Crucial for early detection; includes PSA tests and DREs.

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DRE and PSA Testing

PSA blood test and physical exam of the prostate.

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Urinary Symptoms

Frequency, urgency, nocturia, hesitancy, weak stream, incomplete emptying.

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Radical Prostatectomy

Complete removal of the prostate gland; can cause incontinence and ED.

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Urinary Incontinence

Difficulty controlling urine after surgery.

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Pelvic Floor Exercises

Exercises to strengthen muscles for urinary control.

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EBRT

Radiation delivered from an external source to the prostate.

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Brachytherapy

Implanting radioactive seeds directly into the prostate gland.

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Hormone Therapy (ADT)

Therapy to lower testosterone levels to slow prostate cancer growth.

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Anti-Androgens

Drugs that block the effects of testosterone on prostate cancer cells.

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Active Surveillance

Close monitoring of prostate cancer with regular PSA tests and biopsies.

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Psychosocial impact of prostate cancer

Anxiety, depression, distress.

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Sexual Dysfunction Resources

Assessing and addressing sexual health concerns of patients.

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Medical History in Assessment

Comprehensive review of past illnesses and treatments.

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Pain Assessment Scales

Using scales to determine pain intensity and characteristics.

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Functional Status Assessment

Evaluating capacity to perform daily tasks.

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Carcinogens

Physical, chemical, or viral agents that cause cancer.

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Canada's Dietary Guidelines

Following guidelines helps ensure a balanced intake of essential nutrients.

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Physical Activity & Cancer Prevention

Regular activity helps maintain a healthy weight, reducing cancer risk.

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Cancer Screening

Early detection increases survival rates.

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Seven Warning Signs of Cancer

General signs that requires medical attention.

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Intra-arterial Chemotherapy

Chemotherapy drugs delivered directly to the tumor via arteries.

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Advantage of Intra-arterial Chemo

Reduced overall side effects due to targeted drug delivery.

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Intra-arterial chemotherapy

This specialized method delivers cancer treatment directly to tumors through the arteries that supply them.

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Chemotherapy Side Effects

Toxic effects from chemotherapy depend on the drug's properties and tumor location.

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Intraperitoneal Chemotherapy

Chemotherapy delivered directly into the abdominal cavity to target cancers there.

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Targets of Intraperitoneal Chemo

Colorectal and ovarian cancers that have spread to the peritoneum; also malignant ascites.

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IP Chemo Administration

Temporary (catheters) or long-term (implanted ports) methods for delivering drugs into the peritoneal cavity.

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IP Chemo Risks

Abdominal pain, catheter issues (blockage, dislodgement), and infections.

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Intrathecal/Intraventricular Chemo

Chemotherapy delivered directly into the CNS to treat cancers that have spread there.

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Cancers Treated with IT/IV Chemo

Breast, lung, GI cancers, leukemia, and lymphoma that have spread to the CNS.

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Challenge to CNS Chemotherapy

The blood-brain barrier prevents many drugs from reaching the CNS effectively.

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Intrathecal/Intraventricular Chemo Benefits

Direct drug delivery to CNS, bypassing the blood-brain barrier for better treatment efficacy.

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Ommaya Reservoir

A reservoir that allows convenient administration of treatments over time.

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Chemo Complications (Intrathecal/Intraventricular)

Meningitis and leukoencephalopathy.

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Intravesical Bladder Chemotherapy

Treatment for superficial transitional cell cancer of the bladder.

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Purpose of Intravesical Chemo

Destroys cancer cells and reduces the recurrence of bladder cancer.

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How Intravesical Chemo is given

Directly instilled into the bladder through a urinary catheter for 1-3 hours.

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Potential Complications of Intravesical Chemo

Dysuria, increased urinary frequency, hematuria, bladder spasms.

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External Radiation

Direct radiation from outside the body to target cancer cells.

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Septic Shock

Life-threatening condition from a dysregulated response to infection, leading to organ dysfunction.

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Cytokines in Septic Shock

Pro-inflammatory substances (like TNF-α, IL-1, IL-6) released during infection.

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Endothelial Damage in Septic Shock

Increased vascular permeability causing fluid shift from blood vessels to tissues.

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Coagulation Cascade in Septic Shock

Activation leading to small clots, impaired tissue perfusion, and reduced oxygen delivery.

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Hypotension in Septic Shock

Low blood pressure despite fluid resuscitation; a key indicator of septic shock.

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Study Notes

  • Cancer is more common among women between 20-59, especially breast and thyroid cancer.
  • Nearly 40% of breast cancer cases are diagnosed in women aged 30-59.
  • In all other age groups, cancer is more common in men.

Prevalence, Incidence, and Death Rates of Cancer in Canada

  • Prevalence means the number of people living with a cancer diagnosis.
  • Prevalence is often defined as patients alive 10 years post-diagnosis.
  • Nearly one in two Canadians (45% male, 45% female) will develop cancer.
  • One in four Canadians (26% male, 23% female) will die from cancer.
  • Cancer was the leading cause of death in Canada in 2017, accounting for 30% of deaths.
  • In 2019, the top 5 cancer death causes (lung, colorectal, pancreas, breast, prostate) were over 50% of all cancer deaths.
  • Lung cancer is still the leading cause of premature death from cancer.
  • Known risk factors, besides tobacco, are excessive body weight, physical inactivity, unhealthy eating habits, alcohol, and sun exposure.
  • Pancreatic cancer is expected to be the third deadliest cancer in Canada, surpassing breast cancer.
  • Lung cancer incidence and death rates for females are decreasing.
  • Female breast cancer death rates have decreased approximately 48% since peaking in 1986.
  • Survival rates for blood-related cancers have greatly increased since the 1990s.

Biological Processes in Cancer

  • Two major dysfunctions in cancer are defective cellular proliferation and differentiation.
  • Cell proliferation starts in the stem cell and begins when it enters the cell cycle.
  • Cancer cells in tissue culture show loss of contact inhibition, breaching boundaries to grow abnormally.
  • Cancer cells proliferate at the same rate as normal cells but respond differently to intracellular signals.
  • Cell division in cancer is dysregulated and haphazard, leading to continuous proliferation.
  • Tumour mass doubles with each cell division, i.e. pyramid effect; doubling time is the time required for the tumour to double.
  • After cell mutation, the cell can die (apoptosis), repair itself, or survive and pass on damage, potentially becoming malignant.
  • Cancer cells produce telomerase, preventing telomere shortening, enabling cells to bypass senescence & death, promoting immortalization.
  • Cellular differentiation involves stable and orderly phasing out of cellular potential; differentiated cells don’t dedifferentiate under normal conditions.
  • Proto-oncogenes encourage growth, while tumor suppressor genes, like tumor protein 53, suppress growth.
  • Tumors are either benign or malignant; benign neoplasms are well-differentiated & malignant neoplasms are undifferentiated. Malignant cells can invade and metastasize.

Benign vs Malignant Neoplasms

  • Benign neoplasms are usually encapsulated, normally differentiated, metastasis is absent, recurrence is rare, vascularity is slight, mode of growth is expansive, cell characteristics are normal to the parent cells.
  • Malignant neoplasms are rarely encapsulated, undifferentiated, metastasis is frequently present, possible recurrence, vascularity is moderate to market, mode of growth is infiltrative and expansive, cell characteristics bear resemblance to the parent cells.

Cancer Development Stages

  • Initiation involves a cell's genetic mutation from inheritance, DNA replication errors, or carcinogen/radiation exposure; women with BRCA1 or BRCA2 genes have a 40-85% breast cancer risk.
  • Promotion is reversible proliferation of altered cells, with a 1 to 40-year latency period.
  • Progression is the final stage characterized by increased tumor growth rate, invasiveness, and metastasis.

Immune System's Role

  • The immune system can distinguish normal from abnormal cells.
  • The immune system may reject infected organs.
  • Lymphocytes check cell surface antigens, detecting and destroying cells with abnormal antigenic determinants.
  • Cytotoxic T cells play a dominant role resisting tumor growth.
  • NK cells directly lyse tumor cells spontaneously.
  • Monocytes and macrophages are important in tumor immunity.
  • TNF causes hemorrhagic necrosis of tumors and exerts cytocidal/cytostatic actions.
  • B lymphocytes produce antibodies, destroying tumor cells via complement fixation & lysis.

Classification Systems for Cancer

  • Anatomical classification: tumors are identified by tissue of origin, anatomical site, and behavior.
  • Carcinomas originate from embryonal ectoderm (skin, glands) and endoderm (mucous membrane linings of respiratory, GI, genitourinary tracts).
  • Sarcomas originate in connective tissue (fat, muscle, blood vessels, nerves, bones, cartilage).
  • Lymphomas and leukemias originate from the hematopoietic system.
  • Historical Analysis: cell appearance and differentiation degree (4 grades):
    • Grade 1: Cells slightly differ from normal, well differentiated
    • Grade 2: Cells are more abnormal, moderately differentiated.
    • Grade 3: Cells are very abnormal, poorly differentiated
    • Grade 4: Cells are immature, primitive, undifferentiated; difficult to determine cell origin.
  • Extent of disease - a classification is termed staging:
    • Stage 0: cancer in situ.
    • Stage I: tumor limited to tissue of origin; localized tumor growth.
    • Stage II: limited local spread.
    • Stage III: extensive local and regional spread.
    • Stage IV: metastasis.
  • TNM classification system represents clinical staging, using Tumor size (T), spread to lymph Nodes (N), and Metastasis (M).
  • Nurses play a role in cancer prevention and detection; early intervention increases survival rates.
  • Nurses use surgery, radiation, chemotherapy, and biological therapy to treat cancer.
  • Reduce/eliminate carcinogen exposure (cigarette smoke, sun), eat well (Canada's Dietary Guidelines), get regular exercise (30 min, 5x/week), maintain healthy weight, limit alcohol (1-2 drinks/day), know your body, follow screening guidelines, and know warning signs.

Seven Warning Signs of Cancer

  • Remember the acronym CAUTION
  • Change in bowel or bladder habits
  • A sore that does not heal
  • Unusual bleeding or discharge
  • Thickening or lump
  • Indigestion or difficulty swallowing
  • Obvious change in wart or mole
  • Nagging cough or hoarseness

Chemotherapy

  • Chemotherapy methods include oral, intramuscular intravenous, intracavitary(pleural, peritoneal), intrathecal, intra-arterial, perfusion, continuous infusion and subcutaneous delivery
  • Chemotherapy types
    • Alkylating Agents: Damage DNA, causing cell death or inhibited division
    • Antimetabolites: Interfere with synthesis of DNA, inhibiting enzymes.
    • Antitumor antibiotics: affect DNA function & transcription.
    • Plant alkaloids (Mitotic inhibitors): interrupt cell replications in Mitosis.
    • Nitrosoureas: Break DNA helix and interferes with DNA Replication.
    • Cortiocosteriods: Disrupt the cell membrane and inhibit synthesis of protein; decreases circulating lymphocytes.
    • Hormone Therapy: interfere with hormone receptors and proteins, inhibiting tumour growth. Aromatase inhibitors inhibit estrogen and Selective Estrogen Receptor Modulator (SERM) selectively modulates estrogen receptors
    • Miscellaneous: Destroys exogenous supply of L-asparagine. Anti-estrogens used in breast cancer and suppresses mitosis ant interphase.

Specialized Chemotherapy

  • Intra-arterial chemotherapy delivers treatment directly to tumors via feeding arteries to treat osteogenic sarcoma, and head, neck, brain, bladder, liver, and cervical cancers.
  • The common administration technique involves surgically placing a catheter that is connected to either an external infusion pump, or an implanted infusion pump.
  • Benefits include reduced systemic toxicity, and side effects.
  • Side effects depend on agent/tumor location and the patient.
  • Intraperitoneal Chemotherapy delivers agents into the peritoneal cavity, and targets peritoneal metastases, and malignant ascites
  • Short-term delivery is via Silastic catheters (Tenckhoff, Hickman, or Groshong catheters) inserted percutaneously or surgically in the peritoneal cavity; the long-term is via Implanted port for repeated chemotherapy drug administration
  • Potential Complications: - Abdominal Pain - Catheter-Related Issues: Occlusion (Blockage), Dislodgement, or Migration - Infection
  • Intrathecal and Intraventricular Chemotherapy is used to treat cancers metastasized to the CNS (breast, lung, gastrointestinal, leukemia, lymphoma) as the blood-brain barrier prevents conventional chemotherapy drugs from reaching the CNS effectively.
  • Intrathecal Involves a Lumbar Puncture (Spinal Tap) and injecting chemotherapy drugs directly into the subarachnoid space
  • Ommaya reservoir: is surgically implanted through the skull into a lateral ventricle of the brain, ensuring better drug distribution, eliminating repeated lumbar punctures, and bypassing the blood-brain barrier
  • Complications of intrathecal or intraventricular chemotherapy include meningitis and leukoencephalopathy
  • Intravesical bladder chemoterapy helps patient with superfical transisional cell bladder cancert that experience reoccurence, which promotes destruction, reduces dysfunction and improves sexual dysfunction
  • It delivers the drugs directly to the bladder using an urinary catheter, and retained for 1-3 hours
  • potential complications are painful or difficult urination, increased urinary frequency, hematuria (blood in urine) - bladder spasms

Radiation

  • Radiation is the emission and distribution of energy, which produces ionization and excitation when absorped,
  • That results in generation of free radicals that break chemical bonds in DNA, which may lead to lethal or sublethal damage.
  • Cancers are vulnerable to such due to the effects of cumulative radiation doses because they are less capable of repairing sublethal damage than are normal cells.
  • Cellular death related to radiation is defined as an irreversible loss of proliferative capacity.
  • External radiation (external beam radiation therapy) directs beams from outside the body to target cancer; internal (brachytherapy) places radioactive material inside body near cancer.
  • Tumour radiosensitivity is defined as highly radiosensitive, moderate radiosensitivity, mild radiosensitivity, poor radiosensitivity. High is Hodgkin's disease or Non-Hodgkin's lymphoma, moderate is breast or skin carcinoma, mild is colon adenocarcinoma, poor is malignant tumours
  • Radiation is measured using Unit, Cuire (Ci), Roentgen (R), measurement and Gray (Gy).
  • Some common manageable conditions or systems are Gastrointestinal System, Hematological system, ntegumentary system or Skin reactions

Nursing Management of Conditions Caused by Radiation Therapy

  • Stomatitis, mucositis, esophagitis may use artificial salvia to increase the occurance/ reduce the severity of oral mucositis/ Apply topical anaesthetics
  • Nausea and Vomiting should administer antiemetics, and use diversional activities
  • Anorexia should encourage small and more frequent meals.
  • Haemetological System includes moninting hemoglobin and hematocrit levels and WBC counts
  • integmentary system should suggest ways to cope with hair loss
  • Genitourinary system should moniter mannifestations such as frequency or haematuria
  • Nervous system may administer steroids and pain medications

Biological and Targeted Therapy

  • They come in the form of Cytokines, immunomodulators, tyrosine kinase inhibitors, monoclonal antibody to CD20 and Angiogensis onhibitor

Diagnostic Criteria for Sepsis

  • Requires infection detected with alterations to mental status, fever, heart rate above 90 beats/min, hyperglycaemia, hyoptherima, significant endema and tachypnea or elevated C-protein, procalcitonin or white blood cell count

Sepsis

  • Life-threatening syndrome that injures tissues and exaggeration to microogrnaisms

Septic Shock

  • A subset of Sepsis with persistant hypotensions and clinical criteria
  • Requires quick diagnosis and promote treatment through fluids/antibiotics

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Overview of lung cancer, a leading cause of cancer deaths worldwide. Categorized into small cell (SCLC) and non-small cell (NSCLC) types, with NSCLC being more common. NSCLC subtypes include adenocarcinoma, squamous cell carcinoma, and large cell carcinoma.

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