LQTS Personalized Medicine Assessment Quiz
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Questions and Answers

Which genetic testing allows the assessment of genotype–phenotype correlations in hypertrophic cardiomyopathy?

  • TPM1 and MYH7
  • MYH7 and MYBPC3 (correct)
  • TNNT2, TNNI3, and TPM1
  • MYBPC3 and TNNT2

    • What is the estimated prevalence of hypertrophic cardiomyopathy in the general population?

  • 1 in 1000
  • 1 in 100
  • 1 in 2000
  • 1 in 500 (correct)

    • What percentage of patients with hypertrophic cardiomyopathy have a family history showing autosomal dominant inheritance?

  • 60% (correct)
  • 20%
  • 80%
  • 40%

    • Which gene mutations are the most frequent in hypertrophic cardiomyopathy?

    <p>MYH7 and MYBPC3</p> Signup and view all the answers

    What proportion of early-onset myocardial infarction patients were considered to be at polygenic high risk?

    <p>~17.3%</p> Signup and view all the answers

    Which disease is defined as diseases of the myocardium associated with cardiac dysfunction that can manifest with near-normal life expectancy without symptoms to sudden cardiac death in youth?

    <p>Hypertrophic cardiomyopathy</p> Signup and view all the answers

    What type of inheritance pattern is associated with familial hypercholesterolemia?

    <p><strong>Autosomal dominant inheritance</strong></p> Signup and view all the answers

    Which genes encoding myocardial components are accountable for 40–60% of hypertrophic cardiomyopathy cases?

    <p><strong>Genes encoding sarcomere components</strong></p> Signup and view all the answers

    How many mutations in at least how many genes are responsible for hypertrophic cardiomyopathy?

    <p>Over 1400 mutations in at least 11 genes</p> Signup and view all the answers

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