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Lovastatin Overview and Administration
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Lovastatin Overview and Administration

Created by
@FeatureRichHazel

Questions and Answers

What is the brand name of Lovastatin?

  • Mevacor (correct)
  • Lipitor
  • Altoprev (correct)
  • Zocor

    • What is the drug class of Lovastatin?

    HMG-CoA Reductase Inhibitor

    What are the routes of administration of Lovastatin?

    Oral Tablet: 10 mg, 20 mg, 40 mg; Oral Tablet, Extended Release: 20 mg, 40 mg, 60 mg

    What are the common indications and dosing of Lovastatin?

    <p>Coronary arteriosclerosis, hypercholesterolemia; Initial 20 mg po daily, maintenance 10-80 mg po daily with the evening meal; max 80 mg/d; extended-release tablet: 20-60 mg po qhs</p> Signup and view all the answers

    What is the Mechanism of Action of Lovastatin?

    <p>Competitively inhibit conversion of HMG-CoA to mevalonate</p> Signup and view all the answers

    What is the dose adjustment for renal impairment for Lovastatin?

    <p>CrCl 20 mg/d</p> Signup and view all the answers

    Are there pharmacogenetics for Lovastatin?

    <p>False</p> Signup and view all the answers

    What are the contraindications to Lovastatin?

    <p>Hypersensitivity to lovastatin, active liver disease, pregnancy and lactation, concomitant use with strong CYP3A4/5 inhibitors, unexplained persistent elevation of liver enzymes</p> Signup and view all the answers

    What are the black box warnings for Lovastatin?

    <p>False</p> Signup and view all the answers

    What are the drug interactions with Lovastatin?

    <p>CYP3A4/5 inhibitors, CYP3A4/5 inducers, Fibrates, Niacin</p> Signup and view all the answers

    What are common adverse reactions with Lovastatin?

    <p>NONE</p> Signup and view all the answers

    What are rare but serious adverse reactions with Lovastatin?

    <p>Rhabdomyolysis, hepatotoxicity, increased risk of diabetes</p> Signup and view all the answers

    What are the efficacy monitoring parameters for Lovastatin?

    <p>Reduction in total cholesterol, LDL-cholesterol, and triglyceride levels; increase in HDL-cholesterol levels</p> Signup and view all the answers

    What are the toxicity monitoring parameters for Lovastatin?

    <p>Signs/symptoms of rhabdomyolysis or hepatotoxicity; LFTs, blood glucose, and HbA1c</p> Signup and view all the answers

    Study Notes

    Lovastatin Overview

    • Brand names include Altoprev and Mevacor.
    • Classified as an HMG-CoA Reductase Inhibitor, used to lower cholesterol.

    Administration

    • Available in oral tablets: 10 mg, 20 mg, 40 mg.
    • Extended-release tablets: 20 mg, 40 mg, 60 mg.

    Indications and Dosing

    • Commonly prescribed for coronary arteriosclerosis and hypercholesterolemia.
    • Initial dosing is typically 20 mg per day; maintenance dosage ranges from 10-80 mg daily, max 80 mg.
    • The extended-release version is usually dosed at 20-60 mg at bedtime.

    Mechanism of Action

    • Works by competitively inhibiting the conversion of HMG-CoA to mevalonate, crucial in cholesterol synthesis.

    Renal Dose Adjustment

    • Recommended maximum dosage in patients with ≤ CrCl is 20 mg/d.

    Pharmacogenetics

    • No known pharmacogenetic factors associated with Lovastatin.

    Contraindications

    • Contraindicated in cases of hypersensitivity to the drug, active liver disease, pregnancy, and lactation.
    • Use is also restricted with strong CYP3A4/5 inhibitors and when there is unexplained persistent elevation of liver enzymes.

    Black Box Warnings

    • Lovastatin has no black box warnings.

    Drug Interactions

    • Significant interactions include:
      • CYP3A4/5 inhibitors and inducers
      • Fibrates and Niacin

    Adverse Reactions

    • Common adverse reactions are absent.
    • Rare but serious reactions can include:
      • Rhabdomyolysis
      • Hepatotoxicity
      • Increased risk of diabetes

    Efficacy Monitoring Parameters

    • Monitor reduction in total cholesterol, LDL-cholesterol, and triglycerides; observe increases in HDL-cholesterol.
    • Assessment should occur at baseline and periodically thereafter.

    Toxicity Monitoring Parameters

    • Watch for symptoms of rhabdomyolysis (myalgias, dark urine, arthralgias, fatigue) and hepatotoxicity.
    • Regular checks of liver function tests (LFTs), blood glucose, and HbA1c are recommended at baseline, 6-12 weeks after initiation, and periodically thereafter.
    • Serum creatine kinase should be measured in individuals with muscle pain or those on other myopathy-associated medications.

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    Description

    This quiz covers the essential details about Lovastatin, including its brand names, mechanism of action, and administration guidelines. It discusses indications, dosing recommendations, renal dose adjustments, contraindications, and pharmacogenetic considerations. Test your knowledge about this important cholesterol-lowering medication!

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