Loop Diuretics and Diuretic Resistance
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Questions and Answers

Which of the following is a determinant for cardiac output?

  • Heart rate
  • Stroke volume
  • Preload
  • All of the above (correct)
  • Which of the following is NOT an initial insult that can lead to heart failure?

  • Genetic disorders
  • Ischemic cardiomyopathy
  • Valvular disease
  • Hypertension (correct)
  • What is the formula for cardiac output?

  • CO = HR / SV
  • CO = HR - SV
  • CO = HR * SV (correct)
  • CO = HR + SV
  • Which type of heart failure is characterized by thin heart walls?

    <p>Systolic failure</p> Signup and view all the answers

    Which type of heart failure is characterized by thick heart walls?

    <p>Diastolic failure</p> Signup and view all the answers

    What is the definition of heart failure?

    <p>A syndrome caused by cardiac dysfunction resulting in symptoms such as fluid retention and shortness of breath</p> Signup and view all the answers

    Which stage of heart failure is characterized by severe symptoms at rest and requires advanced treatment options like transplantation?

    <p>Stage D</p> Signup and view all the answers

    Which hormone stimulates the conversion of Angiotensin 1 to Angiotensin 2 via ACE?

    <p>Renin</p> Signup and view all the answers

    Which of the following hormones increases volume by retention of sodium and water in the kidneys?

    <p>Vasopressin</p> Signup and view all the answers

    Which neurohormone is responsible for down regulation of the beta receptor and can cause arrhythmias?

    <p>Norepinephrine</p> Signup and view all the answers

    Which hormone causes loss of flow-mediated vasodilation, thickening and rigidity of arteries, and increased afterload?

    <p>Angiotensin 2</p> Signup and view all the answers

    Which of the following is the preferred initial treatment for Stage C heart failure with reduced ejection fraction (HFrEF)?

    <p>ARNI</p> Signup and view all the answers

    Which drug should be considered for persistently symptomatic black patients with HFrEF despite ARNI, beta-blocker, and aldosterone antagonist therapy?

    <p>Hydralazine + isosorbide dinitrate</p> Signup and view all the answers

    What is the target daily dose of carvedilol for HFrEF?

    <p>50 mg</p> Signup and view all the answers

    What is the target daily dose of metoprolol succinate (ER) for HFrEF?

    <p>200 mg</p> Signup and view all the answers

    Which medication has demonstrated reductions in cardiovascular death and hospitalizations due to HF, including additive benefit with MRAs and ARNi?

    <p>SGLT2i</p> Signup and view all the answers

    Which medication has the highest reduction in mortality according to the guideline?

    <p>Beta-blocker</p> Signup and view all the answers

    Which medication has a reduction in hospitalizations of 31% according to the guideline?

    <p>ACEi/ARB</p> Signup and view all the answers

    Which medication is recommended for any patient with HFpEF without contraindications?

    <p>SGLT2i</p> Signup and view all the answers

    Which of the following is NOT a major contributor to anorexia in patients with advanced HF?

    <p>Hypotension</p> Signup and view all the answers

    True or False: Cardiac rehabilitation has been shown to improve clinical status and outcomes in patients with HF.

    <p>True</p> Signup and view all the answers

    Which of the following is an independent predictor of mortality in patients with HF?

    <p>Depression</p> Signup and view all the answers

    Which of the following is NOT a symptom of acute decompensated heart failure (ADHF)?

    <p>Hypertension</p> Signup and view all the answers

    Which mineralocorticoid receptor antagonist is a non-selective antagonist on mineralocorticoid and progesterone, androgen receptors?

    <p>Spironolactone</p> Signup and view all the answers

    Which mineralocorticoid receptor antagonist is a selective antagonist on mineralocorticoid receptor in the kidney, heart, and vessels?

    <p>Eplerenone</p> Signup and view all the answers

    Which class of medications is recommended for patients with chronic symptomatic HFrEF Class 2 or 3 who tolerate ACEi or ARB, to reduce mortality and morbidity?

    <p>ARNI/ACEi/ARB</p> Signup and view all the answers

    Which beta-blocker is the least lipophilic?

    <p>Bisoprolol</p> Signup and view all the answers

    Which diuretic has increased oral bioavailability, longer half-life, and beneficial effects on myocardial fibrosis, aldosterone production, sympathetic activation, ventricular remodeling, and natriuretic peptides?

    <p>Torsemide</p> Signup and view all the answers

    What is the initial goal of diuretic therapy in heart failure patients?

    <p>Net loss of 500 mL to 1 L per day</p> Signup and view all the answers

    Which combination of medications is recommended to reduce mortality in self-described African American patients with Class 3-4 heart failure receiving optimal therapy with ACEi and beta-blocker, unless contraindicated?

    <p>Vericiguat + hydralazine</p> Signup and view all the answers

    Which medication is approved to reduce hospitalizations in patients with stable heart failure and an EF < 35%, a resting HR of at least 70 BPM on maximally tolerated beta blockers?

    <p>Ivabradine</p> Signup and view all the answers

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