Long Term Potentiation and Depression (LTP & LTD) - Dr. Ali Mansour

<p>Population EPSP of the cells in the dentate gyrus</p> Signup and view all the answers

<p>Relatively permanent change due to prolonged experience</p> Signup and view all the answers

<p>Stimulation of entorhinal cortex axons</p> Signup and view all the answers

<p>To make a neuron more likely to fire</p> Signup and view all the answers

<p>It suggests that long term potentiation has occurred</p> Signup and view all the answers

<p>LTP (Long Term Potentiation)</p> Signup and view all the answers

<p>Activation of NMDA receptors and partial depolarization of post synaptic membrane</p> Signup and view all the answers

<p>Calcium (Ca2+) ion channels</p> Signup and view all the answers

<p>Glutamate</p> Signup and view all the answers

<p>Allows long term potentiation to occur</p> Signup and view all the answers

<p>Mechanism discovered in 1973 (LTP)</p> Signup and view all the answers

<p>The amplitude of the excitation potential recorded in these neurons increases for a long period</p> Signup and view all the answers

<p>Partial depolarization of post synaptic membrane</p> Signup and view all the answers

<p>Long term potentiation is a phenomenon where axons from one part of the hippocampal formation are stimulated many times in rapid succession, leading to an increase in activity in another part of the hippocampal formation, the dentate gyrus.</p> Signup and view all the answers

<p>Long term potentiation represents a relatively permanent change at the level of the neuron, which is associated with learning and memory.</p> Signup and view all the answers

<p>Glutamate activates NMDA receptors, leading to the opening of Ca2+ channels, which is necessary for long term potentiation to occur.</p> Signup and view all the answers

<p>Long term potentiation leads to an increase in activity in the dentate gyrus.</p> Signup and view all the answers

<p>Long term potentiation (LTP) is the primary manifestation of neural plasticity at the level of the neuron.</p> Signup and view all the answers

<p>The neurological basis of learning is explored through the phenomenon of long term potentiation (LTP), which demonstrates changes at the level of the neuron as a result of prolonged experience.</p> Signup and view all the answers

<p>NMDA receptors must be activated, and the membrane of the post synaptic neuron must be partially depolarized.</p> Signup and view all the answers

<p>Sustainable strengthening of synapses between neurons that are activated simultaneously.</p> Signup and view all the answers

<p>NMDA has its effects via calcium (Ca2+) ion channels.</p> Signup and view all the answers

<p>It indicates that long term potentiation has occurred.</p> Signup and view all the answers

<p>It allows for long term potentiation to occur.</p> Signup and view all the answers

<p>They make a neuron more likely to fire.</p> Signup and view all the answers

<p>It appears that the nerves in the dentate gyrus 'remember' that they have fired before, and, as a result, are more sensitive to new input.</p> Signup and view all the answers

<p>The amplitude of the excitation potential recorded in these neurons is increased for a long period (up to several weeks).</p> Signup and view all the answers

<p>Long term potentiation (LTP)</p> Signup and view all the answers

<p>It allows the sustainable strengthening of synapses between neurons that are activated simultaneously.</p> Signup and view all the answers