Location of Primary and Secondary Osteosarcomas

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Where do primary osteosarcomas typically occur in the appendicular skeleton?

In the metadiaphysis of long bones

Which bone location is a common site for secondary osteosarcomas?

Pelvis

What is the distribution of intramedullary/central osteosarcomas?

~80%

Which of the following is a rare type of osteosarcoma according to the text?

<p>Extraskeletal osteosarcoma</p> Signup and view all the answers

What are skip metastases associated with in high-grade osteosarcomas?

<p>Non-contiguous smaller tumour foci in the same bone or adjacent bone</p> Signup and view all the answers

What is the most common subtype of primary osteosarcoma discussed in the article?

<p>Osteoblastic osteosarcoma</p> Signup and view all the answers

What is a characteristic macroscopic appearance of osteosarcomas?

<p>Areas of haemorrhage, fibrosis, and cystic degeneration</p> Signup and view all the answers

Which marker may be elevated in serum with advanced osteosarcoma?

<p>Alkaline phosphatase (ALP)</p> Signup and view all the answers

What is a common site of origin within the bone for primary osteosarcomas?

<p>Intramedullary/central location</p> Signup and view all the answers

What is a key feature of the microscopic appearance of high-grade conventional osteosarcomas?

<p>Cellular pleomorphism and mitoses</p> Signup and view all the answers

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