Podcast
Questions and Answers
What is the primary reason systemic toxicity occurs with local anesthetics?
What is the primary reason systemic toxicity occurs with local anesthetics?
- High blood pressure
- Increased absorption into the systemic circulation (correct)
- Low plasma protein levels
- Inadequate dosage administration
Which organs are primarily affected by local anesthetic toxicity?
Which organs are primarily affected by local anesthetic toxicity?
- Digestive system and skin
- Lungs and kidneys
- Heart and central nervous system (correct)
- Muscles and bones
What factors influence the rate of absorption of local anesthetics into systemic circulation?
What factors influence the rate of absorption of local anesthetics into systemic circulation?
- Amount of local anesthetic administered and vascularity of the surrounding structures (correct)
- Time of day and patient age
- Type of surgical procedure and anesthesia method
- Temperature and pH of the surrounding tissue
Bupivacaine is known for which of the following characteristics?
Bupivacaine is known for which of the following characteristics?
Why can the onset of symptoms from local anesthetic toxicity happen rapidly?
Why can the onset of symptoms from local anesthetic toxicity happen rapidly?
What role do enzymes in the plasma have concerning local anesthetics?
What role do enzymes in the plasma have concerning local anesthetics?
Which statement is true regarding local anesthetic toxicity?
Which statement is true regarding local anesthetic toxicity?
How does the vascularity of surrounding structures impact local anesthetic injections?
How does the vascularity of surrounding structures impact local anesthetic injections?
What is necessary for the metabolism of local anesthetics in the body?
What is necessary for the metabolism of local anesthetics in the body?
Which of the following consequences is a significant risk of local anesthetic toxicity?
Which of the following consequences is a significant risk of local anesthetic toxicity?
Flashcards
Systemic toxicity
Systemic toxicity
The process by which a local anesthetic (LA) reaches a concentration in the bloodstream that affects vital organs like the heart and brain.
Peri-neural administration
Peri-neural administration
Local anesthetics are administered near nerves, but can be absorbed into the bloodstream.
Absorption rate
Absorption rate
The speed at which LA enters the bloodstream depends on the amount used and the blood supply to the area.
Plasma binding
Plasma binding
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Plasma protein binding
Plasma protein binding
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Plasma saturation
Plasma saturation
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Organ perfusion
Organ perfusion
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LA metabolism
LA metabolism
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Enzyme dysfunction
Enzyme dysfunction
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ATP dependence
ATP dependence
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