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Local Anesthetics and Systemic Toxicity

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Questions and Answers

What is the primary reason systemic toxicity occurs with local anesthetics?

High blood pressure

Increased absorption into the systemic circulation (correct)

Low plasma protein levels

Inadequate dosage administration

Which organs are primarily affected by local anesthetic toxicity?

Digestive system and skin

Lungs and kidneys

Heart and central nervous system (correct)

Muscles and bones

What factors influence the rate of absorption of local anesthetics into systemic circulation?

Amount of local anesthetic administered and vascularity of the surrounding structures (correct)

Time of day and patient age

Type of surgical procedure and anesthesia method

Temperature and pH of the surrounding tissue

Bupivacaine is known for which of the following characteristics?

High percentage of binding to plasma Signup and view all the answers

Why can the onset of symptoms from local anesthetic toxicity happen rapidly?

Plasma becomes saturated with the anesthetic very quickly Signup and view all the answers

What role do enzymes in the plasma have concerning local anesthetics?

They metabolize local anesthetics to eliminate them from the system Signup and view all the answers

Which statement is true regarding local anesthetic toxicity?

The level of free drug can rise rapidly once plasma is saturated Signup and view all the answers

How does the vascularity of surrounding structures impact local anesthetic injections?

It influences the rate of absorption into the systemic circulation Signup and view all the answers

What is necessary for the metabolism of local anesthetics in the body?

Presence of enzymes in the plasma Signup and view all the answers

Which of the following consequences is a significant risk of local anesthetic toxicity?

Life-threatening seizures and cardiac arrest Signup and view all the answers