Liver Functions, Assessment, and Lab Tests
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Questions and Answers

A liver transplant recipient develops hypertension in the first year post-operation. Why are ACE inhibitors and ARBs typically not the first-line treatment option?

  • Renin levels are often suppressed in the early post-transplant period. (correct)
  • They have a high risk of causing hyperkalemia in transplant patients.
  • They primarily address fluid overload, which is not the primary cause of hypertension in these patients.
  • They are contraindicated with commonly used immunosuppressants.

Which intervention is most important to include in the nursing management plan for a patient awaiting a liver transplant?

  • Coordinating interdisciplinary care and assessing financial resources and relocation needs. (correct)
  • Providing detailed instructions on surgical procedures to alleviate anxiety.
  • Limiting communication with family members to reduce stress and potential conflicts.
  • Encouraging the patient to focus solely on physical health to improve transplant outcomes.

Post-liver transplant, a patient exhibits signs of biliary obstruction. Which of the following assessment findings would be most indicative of this complication?

  • Improved coagulation studies and stable electrolyte levels.
  • Elevated liver function tests and jaundice. (correct)
  • Increased urine output and decreased creatinine.
  • Hypotension and tachycardia.

A patient who underwent a liver transplant is being discharged on a regimen of immunosuppressant medications. What is the priority nursing education point regarding these medications?

<p>They must be taken exactly as prescribed to prevent rejection, even without symptoms. (C)</p> Signup and view all the answers

Following a living donor liver transplant, both the recipient and the donor require close monitoring. For the living donor, what is a primary concern during the post-operative period?

<p>Preventing infection and monitoring for any complications related to surgery. (D)</p> Signup and view all the answers

What is the primary goal of liver transplantation before a patient's condition progresses to gastrointestinal bleeding and hepatic coma?

<p>Total removal of the diseased liver and replacement with a healthy one. (A)</p> Signup and view all the answers

Which factors are considered during pre-transplant screenings to determine a patient's suitability for liver transplantation?

<p>Physical and mental health, hepatic reserve, likelihood of survival, past medical history, and degree of need. (D)</p> Signup and view all the answers

What does the Model for End-Stage Liver Disease (MELD) classification primarily indicate?

<p>The level of illness and prediction of 3-month mortality in patients with end-stage liver disease. (B)</p> Signup and view all the answers

Why is it crucial for a patient on the transplant list to remain available and closely monitored?

<p>Because their condition may deteriorate, leading to complications or death while waiting. (D)</p> Signup and view all the answers

According to the Milan criteria, what are the size and quantity limitations for liver tumors to consider a patient for liver transplantation in cases of liver cancer?

<p>A single tumor smaller than 5 cm OR up to 3 tumors each ≤ 3 cm. (C)</p> Signup and view all the answers

What is a primary advantage of living donor liver transplantation?

<p>It allows for transplantation even when the patient is likely to die while waiting for a deceased donor liver. (D)</p> Signup and view all the answers

Which of the following is a critical role of the donor advocate team in living donor liver transplantation?

<p>To ensure the donor's needs and safety are prioritized during the intra- and post-operative periods. (A)</p> Signup and view all the answers

What surgical consideration is particularly important during liver transplantation due to the patient's condition?

<p>Managing potential extensive blood loss due to portal hypertension and collateral vessels. (B)</p> Signup and view all the answers

What is the primary purpose of administering immunosuppressive agents following a liver transplant?

<p>To prevent the rejection of the transplanted liver by the recipient's immune system. (B)</p> Signup and view all the answers

Which of the following is a common sign or symptom of acute rejection following liver transplantation?

<p>Tachycardia, right upper quadrant pain, jaundice, fever, and elevated AST/ALT. (C)</p> Signup and view all the answers

Why are liver transplant recipients at an increased risk for infections post-transplant?

<p>Due to the immunosuppressive therapy required to prevent organ rejection. (A)</p> Signup and view all the answers

What factors can increase the risk of complications after liver transplantation?

<p>Previous abdominal surgeries, presence of varices, and decreased hepatic reserve. (B)</p> Signup and view all the answers

What is a biliary anastomosis and why might a Roux-en-Y procedure be necessary during a liver transplant?

<p>Connection of the bile duct between donor and recipient livers; Roux-en-Y may be needed if there is biliary disease. (B)</p> Signup and view all the answers

A patient who underwent a liver transplant is experiencing hemodynamic instability with hypotension. What are the potential causes during the post-operative period?

<p>Blood loss, loss of vasomotor tone, and vasodilation. (A)</p> Signup and view all the answers

Why is monitoring coagulation factors and administering platelets, FFP, or blood products important during and after liver transplantation?

<p>To correct coagulopathies resulting from ischemic injury to the donor liver, portal hypertension, or fibrinolysis. (C)</p> Signup and view all the answers

A patient with cirrhosis is unable to metabolize aldosterone. Which of the following physiological changes is most likely to occur as a direct result?

<p>Increased sodium and water retention. (B)</p> Signup and view all the answers

A patient with advanced cirrhosis develops sudden, severe liver impairment. Which timeframe aligns with the definition of acute liver failure in this scenario?

<p>Over a period of weeks. (A)</p> Signup and view all the answers

A patient with cirrhosis has a decreased production of albumin. How will this impact the patient's physiological status?

<p>Decreased oncotic pressure. (A)</p> Signup and view all the answers

A patient with advanced liver disease exhibits changes in mental acuity, sleep disturbances, and a general tremor. What condition is most likely developing?

<p>Hepatic encephalopathy. (A)</p> Signup and view all the answers

A patient with known esophageal varices is prescribed propranolol. What is the primary rationale for this medication in this patient?

<p>To decrease portal pressure. (A)</p> Signup and view all the answers

A patient with a history of alcohol abuse is admitted with suspected liver dysfunction. Which laboratory marker would be most indicative of alcoholic liver disease?

<p>Elevated GGT. (D)</p> Signup and view all the answers

Which of the following factors poses the greatest risk for bleeding in a patient with esophageal varices?

<p>Straining during bowel movements. (A)</p> Signup and view all the answers

A patient with cirrhosis presents with a distended abdomen, dyspnea, and lower extremity edema. Which condition is most likely responsible for these clinical manifestations?

<p>Ascites. (C)</p> Signup and view all the answers

A patient with cirrhosis develops a life-threatening complication. What is the survival rate at 1 year for this complication?

<p>40% (C)</p> Signup and view all the answers

A patient with esophageal varices is actively bleeding. After initial stabilization, which intervention is most appropriate for preventing recurrent bleeding?

<p>Variceal banding. (C)</p> Signup and view all the answers

A nurse is caring for a patient with cirrhosis who exhibits asterixis. What assessment finding confirms the presence of asterixis?

<p>Involuntary flapping tremor of the hands. (D)</p> Signup and view all the answers

A patient with hepatic encephalopathy is prescribed lactulose. What intended therapeutic effect should the nurse monitor?

<p>Increased mental alertness. (D)</p> Signup and view all the answers

What type of jaundice is most closely associated with liver disease?

<p>Hepatocellular and obstructive (D)</p> Signup and view all the answers

A patient with liver failure has a decreased number of platelets. How will this impact the patient's physiological status?

<p>Decreased clotting ability (C)</p> Signup and view all the answers

A patient's lab results show an elevated level of ammonia. Which diet should the patient follow?

<p>Low protein (A)</p> Signup and view all the answers

Flashcards

Calcium channel blockers

Medications that induce vasodilation and lower blood pressure.

Thiazide diuretics

Medications used for hypertension, especially when multiple drugs are needed.

Interdisciplinary care

A collaborative approach involving multiple healthcare professionals for patient management.

Infection prevention post-op

Measures taken to reduce the risk of infections after surgery.

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Immunosuppressive medications

Drugs that suppress the immune response to prevent organ rejection after transplant.

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Liver Transplant Goal

To perform surgery before disease leads to complications like GI bleeding or hepatic coma.

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Total Liver Removal

Complete extraction of the diseased liver for transplant.

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Pre-Transplant Screenings

Assess physical and mental health, hepatic reserve, survival likelihood, history, and need.

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MELD Classification

Ranks severity of liver disease, predicts 3-month mortality score from 6 to 40.

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Ethical Considerations

Consideration of ethical factors in transplant decisions.

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Milan Criteria

Guidelines for transplant eligibility in liver cancer patients, focusing on tumor size.

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Living Donor Transplant

A transplant from a living adult, using the right lobe of their liver.

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Post-Transplant Survival Rate

Approximately 90% survival rate after one year post-transplant.

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Immunosuppression Post-Transplant

Meds like calcineurin inhibitors to prevent organ rejection after transplant.

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Infection Risk Post-Transplant

Infection is a significant risk due to immunosuppressive therapy, leading cause of death.

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Acute Rejection Signs

Tachycardia, pain, jaundice, fever, increased liver enzymes post-op indicate rejection.

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Bleeding Complications

Common intra-operative or post-operative bleeding problems after liver transplant.

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Technical Complications

Issues can arise from reconstructing blood vessels and biliary tracts during surgery.

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Donor Evaluation Process

Rigorous assessments for living donors ensuring health, compatibility, and consent.

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Post-Op Monitoring

Monitoring CBC, coagulation factors, and electrolytes is critical after surgery to manage bleeding.

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Liver Functions

Key roles include glucose metabolism, bile formation, and drug metabolism.

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Aspartate Aminotransferase (AST)

An enzyme measured to assess liver function, with normal levels 10-40 U/mL.

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Alanine Aminotransferase (ALT)

An enzyme critical for assessing liver disorders; normal levels are 8-40 U/mL.

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Bilirubin

A waste product from red blood cells; normal serum levels are 0.3-1 mg/dL.

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Liver Dysfunction Signs

Symptoms include jaundice, fatigue, and abdominal pain.

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Hepatic Encephalopathy

A deterioration in brain function due to liver failure, often caused by high ammonia levels.

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Ascites

Fluid accumulation in the abdomen due to liver issues or portal hypertension.

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Portal Hypertension

Increased blood pressure in the portal venous system, often due to liver damage.

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Lactulose

A medication to reduce ammonia levels in the body by promoting bowel movement.

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Transjugular Intrahepatic Portosystemic Shunt (TIPS)

A procedure to reduce portal hypertension by creating a shunt in the liver.

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Liver Biopsy

A procedure to obtain liver tissue for diagnosis.

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Hepatopulmonary Syndrome

Shortness of breath and hypoxemia secondary to liver disease.

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Jaundice

Yellowing of the skin and eyes due to high bilirubin levels.

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Liver Cancer

A rare but serious condition with risk factors including chronic liver disease.

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Study Notes

Liver Functions

  • Major role in glucose metabolism
  • Converts ammonia
  • Key role in protein metabolism
  • Involves fat metabolism
  • Stores vitamins and iron
  • Produces bile
  • Excretes bilirubin
  • Metabolizes drugs

History & Assessment

  • Assess for abnormal liver function tests (LFTs)
  • Obtain medical history including exposure to hepatotoxic substances and infectious agents
  • Evaluate occupational, recreational, and travel history
  • Note history of alcohol and drug use
  • Document medications, including Tylenol, Ketoconazole, and valproic acid
  • Assess family history of gallstones

Liver Function Tests

  • Aspartate Aminotransferase (AST): Normal 10-40 U/mL, elevated in cirrhosis, hepatitis, liver cancer
  • Alanine Aminotransferase (ALT): Normal 8-40 U/mL, elevated in liver disorders
  • Gamma-Glutamyl Transferase (GGT): Normal 0-30 U/L, elevated in cholestasis and alcoholic liver disease
  • Bilirubin: Normal direct 0.1-0.4 mg/dL, Normal total 0.3-1 mg/dL, Elevated in liver disease; jaundice occurs when bilirubin > 2.0 mg/dL
  • Protein: Normal 7-7.5 g/dL, decreased in liver disease

Signs of Liver Dysfunction

  • Pallor: Pale skin
  • Jaundice: Yellowing of skin and sclera due to high bilirubin levels
  • Muscle atrophy, weakness, fatigue
  • Edema, weight gain
  • Abdominal pain, abdominal girth (enlarged)
  • Petechiae/bruising
  • Spider angiomas
  • Palmar erythema
  • Hematochezia/hematemesis/melena
  • Cognitive changes
  • Personality changes

Acute Liver Failure

  • Severe liver impairment in ≤26 weeks
  • Phases ranging from hyperacute to subacute
  • Symptoms range from jaundice to hepatic encephalopathy to coma and death
  • Early identification is crucial for potential treatment

Cirrhosis

  • Liver scarring due to chronic inflammation or necrosis
  • Normal tissue changes become fibrotic
  • Inability to efficiently process blood or bile
  • Goal is prevention, and minimizing infection and excessive alcohol consumption

Compensated vs. Decompensated Cirrhosis

  • Compensated: Still able to perform normal functions
  • Decompensated: Inability to perform normal functions due to liver damage
  • Difficulty with protein synthesis and clotting factors leading to complications

Complications of Liver Disease

  • Jaundice: Yellowing of skin and eyes
  • Anorexia: Loss of appetite
  • Coagulation defects: Blood clotting problems
  • Kidney disease: Impaired kidney function
  • Electrolyte disturbances: Imbalances of electrolytes in the blood
  • Cardiovascular abnormalities: Issues with the heart and blood vessels
  • Infection: Increased susceptibility to infections
  • Hypoglycemia: Low blood sugar

Liver Cancer

  • Primary liver cancer is uncommon compared to metastasis
  • Risk factors include hepatitis, chronic liver disease, cirrhosis, chemical exposure
  • Early detection is uncommon

Liver Biopsy

  • Needle aspiration of small amount of tissue from the liver
  • Evaluates conditions of the liver tissues and identifies lesions
  • Bleeding is a major complication

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Description

Overview of liver functions including glucose, protein, and fat metabolism. Also covers liver function tests (LFTs) such as AST, ALT, GGT, and bilirubin levels. Assessment includes medical history, substance use, and relevant risk factors.

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