Podcast
Questions and Answers
A liver transplant recipient develops hypertension in the first year post-operation. Why are ACE inhibitors and ARBs typically not the first-line treatment option?
A liver transplant recipient develops hypertension in the first year post-operation. Why are ACE inhibitors and ARBs typically not the first-line treatment option?
- Renin levels are often suppressed in the early post-transplant period. (correct)
- They have a high risk of causing hyperkalemia in transplant patients.
- They primarily address fluid overload, which is not the primary cause of hypertension in these patients.
- They are contraindicated with commonly used immunosuppressants.
Which intervention is most important to include in the nursing management plan for a patient awaiting a liver transplant?
Which intervention is most important to include in the nursing management plan for a patient awaiting a liver transplant?
- Coordinating interdisciplinary care and assessing financial resources and relocation needs. (correct)
- Providing detailed instructions on surgical procedures to alleviate anxiety.
- Limiting communication with family members to reduce stress and potential conflicts.
- Encouraging the patient to focus solely on physical health to improve transplant outcomes.
Post-liver transplant, a patient exhibits signs of biliary obstruction. Which of the following assessment findings would be most indicative of this complication?
Post-liver transplant, a patient exhibits signs of biliary obstruction. Which of the following assessment findings would be most indicative of this complication?
- Improved coagulation studies and stable electrolyte levels.
- Elevated liver function tests and jaundice. (correct)
- Increased urine output and decreased creatinine.
- Hypotension and tachycardia.
A patient who underwent a liver transplant is being discharged on a regimen of immunosuppressant medications. What is the priority nursing education point regarding these medications?
A patient who underwent a liver transplant is being discharged on a regimen of immunosuppressant medications. What is the priority nursing education point regarding these medications?
Following a living donor liver transplant, both the recipient and the donor require close monitoring. For the living donor, what is a primary concern during the post-operative period?
Following a living donor liver transplant, both the recipient and the donor require close monitoring. For the living donor, what is a primary concern during the post-operative period?
What is the primary goal of liver transplantation before a patient's condition progresses to gastrointestinal bleeding and hepatic coma?
What is the primary goal of liver transplantation before a patient's condition progresses to gastrointestinal bleeding and hepatic coma?
Which factors are considered during pre-transplant screenings to determine a patient's suitability for liver transplantation?
Which factors are considered during pre-transplant screenings to determine a patient's suitability for liver transplantation?
What does the Model for End-Stage Liver Disease (MELD) classification primarily indicate?
What does the Model for End-Stage Liver Disease (MELD) classification primarily indicate?
Why is it crucial for a patient on the transplant list to remain available and closely monitored?
Why is it crucial for a patient on the transplant list to remain available and closely monitored?
According to the Milan criteria, what are the size and quantity limitations for liver tumors to consider a patient for liver transplantation in cases of liver cancer?
According to the Milan criteria, what are the size and quantity limitations for liver tumors to consider a patient for liver transplantation in cases of liver cancer?
What is a primary advantage of living donor liver transplantation?
What is a primary advantage of living donor liver transplantation?
Which of the following is a critical role of the donor advocate team in living donor liver transplantation?
Which of the following is a critical role of the donor advocate team in living donor liver transplantation?
What surgical consideration is particularly important during liver transplantation due to the patient's condition?
What surgical consideration is particularly important during liver transplantation due to the patient's condition?
What is the primary purpose of administering immunosuppressive agents following a liver transplant?
What is the primary purpose of administering immunosuppressive agents following a liver transplant?
Which of the following is a common sign or symptom of acute rejection following liver transplantation?
Which of the following is a common sign or symptom of acute rejection following liver transplantation?
Why are liver transplant recipients at an increased risk for infections post-transplant?
Why are liver transplant recipients at an increased risk for infections post-transplant?
What factors can increase the risk of complications after liver transplantation?
What factors can increase the risk of complications after liver transplantation?
What is a biliary anastomosis and why might a Roux-en-Y procedure be necessary during a liver transplant?
What is a biliary anastomosis and why might a Roux-en-Y procedure be necessary during a liver transplant?
A patient who underwent a liver transplant is experiencing hemodynamic instability with hypotension. What are the potential causes during the post-operative period?
A patient who underwent a liver transplant is experiencing hemodynamic instability with hypotension. What are the potential causes during the post-operative period?
Why is monitoring coagulation factors and administering platelets, FFP, or blood products important during and after liver transplantation?
Why is monitoring coagulation factors and administering platelets, FFP, or blood products important during and after liver transplantation?
A patient with cirrhosis is unable to metabolize aldosterone. Which of the following physiological changes is most likely to occur as a direct result?
A patient with cirrhosis is unable to metabolize aldosterone. Which of the following physiological changes is most likely to occur as a direct result?
A patient with advanced cirrhosis develops sudden, severe liver impairment. Which timeframe aligns with the definition of acute liver failure in this scenario?
A patient with advanced cirrhosis develops sudden, severe liver impairment. Which timeframe aligns with the definition of acute liver failure in this scenario?
A patient with cirrhosis has a decreased production of albumin. How will this impact the patient's physiological status?
A patient with cirrhosis has a decreased production of albumin. How will this impact the patient's physiological status?
A patient with advanced liver disease exhibits changes in mental acuity, sleep disturbances, and a general tremor. What condition is most likely developing?
A patient with advanced liver disease exhibits changes in mental acuity, sleep disturbances, and a general tremor. What condition is most likely developing?
A patient with known esophageal varices is prescribed propranolol. What is the primary rationale for this medication in this patient?
A patient with known esophageal varices is prescribed propranolol. What is the primary rationale for this medication in this patient?
A patient with a history of alcohol abuse is admitted with suspected liver dysfunction. Which laboratory marker would be most indicative of alcoholic liver disease?
A patient with a history of alcohol abuse is admitted with suspected liver dysfunction. Which laboratory marker would be most indicative of alcoholic liver disease?
Which of the following factors poses the greatest risk for bleeding in a patient with esophageal varices?
Which of the following factors poses the greatest risk for bleeding in a patient with esophageal varices?
A patient with cirrhosis presents with a distended abdomen, dyspnea, and lower extremity edema. Which condition is most likely responsible for these clinical manifestations?
A patient with cirrhosis presents with a distended abdomen, dyspnea, and lower extremity edema. Which condition is most likely responsible for these clinical manifestations?
A patient with cirrhosis develops a life-threatening complication. What is the survival rate at 1 year for this complication?
A patient with cirrhosis develops a life-threatening complication. What is the survival rate at 1 year for this complication?
A patient with esophageal varices is actively bleeding. After initial stabilization, which intervention is most appropriate for preventing recurrent bleeding?
A patient with esophageal varices is actively bleeding. After initial stabilization, which intervention is most appropriate for preventing recurrent bleeding?
A nurse is caring for a patient with cirrhosis who exhibits asterixis. What assessment finding confirms the presence of asterixis?
A nurse is caring for a patient with cirrhosis who exhibits asterixis. What assessment finding confirms the presence of asterixis?
A patient with hepatic encephalopathy is prescribed lactulose. What intended therapeutic effect should the nurse monitor?
A patient with hepatic encephalopathy is prescribed lactulose. What intended therapeutic effect should the nurse monitor?
What type of jaundice is most closely associated with liver disease?
What type of jaundice is most closely associated with liver disease?
A patient with liver failure has a decreased number of platelets. How will this impact the patient's physiological status?
A patient with liver failure has a decreased number of platelets. How will this impact the patient's physiological status?
A patient's lab results show an elevated level of ammonia. Which diet should the patient follow?
A patient's lab results show an elevated level of ammonia. Which diet should the patient follow?
Flashcards
Calcium channel blockers
Calcium channel blockers
Medications that induce vasodilation and lower blood pressure.
Thiazide diuretics
Thiazide diuretics
Medications used for hypertension, especially when multiple drugs are needed.
Interdisciplinary care
Interdisciplinary care
A collaborative approach involving multiple healthcare professionals for patient management.
Infection prevention post-op
Infection prevention post-op
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Immunosuppressive medications
Immunosuppressive medications
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Liver Transplant Goal
Liver Transplant Goal
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Total Liver Removal
Total Liver Removal
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Pre-Transplant Screenings
Pre-Transplant Screenings
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MELD Classification
MELD Classification
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Ethical Considerations
Ethical Considerations
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Milan Criteria
Milan Criteria
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Living Donor Transplant
Living Donor Transplant
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Post-Transplant Survival Rate
Post-Transplant Survival Rate
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Immunosuppression Post-Transplant
Immunosuppression Post-Transplant
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Infection Risk Post-Transplant
Infection Risk Post-Transplant
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Acute Rejection Signs
Acute Rejection Signs
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Bleeding Complications
Bleeding Complications
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Technical Complications
Technical Complications
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Donor Evaluation Process
Donor Evaluation Process
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Post-Op Monitoring
Post-Op Monitoring
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Liver Functions
Liver Functions
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Aspartate Aminotransferase (AST)
Aspartate Aminotransferase (AST)
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Alanine Aminotransferase (ALT)
Alanine Aminotransferase (ALT)
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Bilirubin
Bilirubin
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Liver Dysfunction Signs
Liver Dysfunction Signs
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Hepatic Encephalopathy
Hepatic Encephalopathy
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Ascites
Ascites
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Portal Hypertension
Portal Hypertension
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Lactulose
Lactulose
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Transjugular Intrahepatic Portosystemic Shunt (TIPS)
Transjugular Intrahepatic Portosystemic Shunt (TIPS)
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Liver Biopsy
Liver Biopsy
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Hepatopulmonary Syndrome
Hepatopulmonary Syndrome
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Jaundice
Jaundice
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Liver Cancer
Liver Cancer
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Study Notes
Liver Functions
- Major role in glucose metabolism
- Converts ammonia
- Key role in protein metabolism
- Involves fat metabolism
- Stores vitamins and iron
- Produces bile
- Excretes bilirubin
- Metabolizes drugs
History & Assessment
- Assess for abnormal liver function tests (LFTs)
- Obtain medical history including exposure to hepatotoxic substances and infectious agents
- Evaluate occupational, recreational, and travel history
- Note history of alcohol and drug use
- Document medications, including Tylenol, Ketoconazole, and valproic acid
- Assess family history of gallstones
Liver Function Tests
- Aspartate Aminotransferase (AST): Normal 10-40 U/mL, elevated in cirrhosis, hepatitis, liver cancer
- Alanine Aminotransferase (ALT): Normal 8-40 U/mL, elevated in liver disorders
- Gamma-Glutamyl Transferase (GGT): Normal 0-30 U/L, elevated in cholestasis and alcoholic liver disease
- Bilirubin: Normal direct 0.1-0.4 mg/dL, Normal total 0.3-1 mg/dL, Elevated in liver disease; jaundice occurs when bilirubin > 2.0 mg/dL
- Protein: Normal 7-7.5 g/dL, decreased in liver disease
Signs of Liver Dysfunction
- Pallor: Pale skin
- Jaundice: Yellowing of skin and sclera due to high bilirubin levels
- Muscle atrophy, weakness, fatigue
- Edema, weight gain
- Abdominal pain, abdominal girth (enlarged)
- Petechiae/bruising
- Spider angiomas
- Palmar erythema
- Hematochezia/hematemesis/melena
- Cognitive changes
- Personality changes
Acute Liver Failure
- Severe liver impairment in ≤26 weeks
- Phases ranging from hyperacute to subacute
- Symptoms range from jaundice to hepatic encephalopathy to coma and death
- Early identification is crucial for potential treatment
Cirrhosis
- Liver scarring due to chronic inflammation or necrosis
- Normal tissue changes become fibrotic
- Inability to efficiently process blood or bile
- Goal is prevention, and minimizing infection and excessive alcohol consumption
Compensated vs. Decompensated Cirrhosis
- Compensated: Still able to perform normal functions
- Decompensated: Inability to perform normal functions due to liver damage
- Difficulty with protein synthesis and clotting factors leading to complications
Complications of Liver Disease
- Jaundice: Yellowing of skin and eyes
- Anorexia: Loss of appetite
- Coagulation defects: Blood clotting problems
- Kidney disease: Impaired kidney function
- Electrolyte disturbances: Imbalances of electrolytes in the blood
- Cardiovascular abnormalities: Issues with the heart and blood vessels
- Infection: Increased susceptibility to infections
- Hypoglycemia: Low blood sugar
Liver Cancer
- Primary liver cancer is uncommon compared to metastasis
- Risk factors include hepatitis, chronic liver disease, cirrhosis, chemical exposure
- Early detection is uncommon
Liver Biopsy
- Needle aspiration of small amount of tissue from the liver
- Evaluates conditions of the liver tissues and identifies lesions
- Bleeding is a major complication
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Description
Overview of liver functions including glucose, protein, and fat metabolism. Also covers liver function tests (LFTs) such as AST, ALT, GGT, and bilirubin levels. Assessment includes medical history, substance use, and relevant risk factors.