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Questions and Answers
What is the main product of lipolysis?
What is the main product of lipolysis?
- Free fatty acids (correct)
- Adipose tissue
- Glycerol
- Triacylglycerols
Where does the fate of glycerol and free fatty acids lie after being released from adipocytes?
Where does the fate of glycerol and free fatty acids lie after being released from adipocytes?
- Stored as triglycerides in the liver
- Converted to glucose in muscle cells
- Used for energy production in adipose tissue cells
- Converted to dihydroxyacetone phosphate (DHAP) in the liver (correct)
What is the rate-limiting step of lipolysis in adipocytes?
What is the rate-limiting step of lipolysis in adipocytes?
- Activation of hormone-sensitive lipase by cAMP-dependent protein kinase (correct)
- Release of free fatty acids from adipose tissue
- Hydrolysis of triacylglycerols to glycerol and free fatty acids
- Transport of free fatty acids through the blood
Which hormones act to increase cAMP synthesis by adenylate cyclase and stimulate lipolysis?
Which hormones act to increase cAMP synthesis by adenylate cyclase and stimulate lipolysis?
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Which substance acts as a fat mobilizing substance from the pituitary and stimulates lipolysis?
Which substance acts as a fat mobilizing substance from the pituitary and stimulates lipolysis?
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Study Notes
Lipolysis
- The main product of lipolysis is glycerol and free fatty acids.
- After being released from adipocytes, glycerol is transported to the liver and converted to glucose or oxidized to produce energy, whereas free fatty acids are transported to the liver and other tissues, where they can be oxidized to produce energy or re-esterified to form triglycerides.
- The rate-limiting step of lipolysis in adipocytes is the phosphorylation of hormone-sensitive lipase (HSL) by protein kinase A.
- Hormones that act to increase cAMP synthesis by adenylate cyclase and stimulate lipolysis are epinephrine, norepinephrine, and glucagon.
- The substance that acts as a fat mobilizing substance from the pituitary and stimulates lipolysis is adrenocorticotropic hormone (ACTH).
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