Podcast
Questions and Answers
What is the primary function of statins in lipid regulation?
What is the primary function of statins in lipid regulation?
Which lipid-regulating drug should be avoided with grapefruit juice?
Which lipid-regulating drug should be avoided with grapefruit juice?
When is cholesterol synthesis in the liver typically at its peak?
When is cholesterol synthesis in the liver typically at its peak?
Which of the following is a fibrate used for lipid regulation?
Which of the following is a fibrate used for lipid regulation?
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What is the dosage form of atorvastatin marketed as Lipitor?
What is the dosage form of atorvastatin marketed as Lipitor?
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Which statin is typically taken at night to maximize its effectiveness?
Which statin is typically taken at night to maximize its effectiveness?
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Study Notes
Lipid-Regulating Drugs Overview
- Lipid-regulating drugs modify blood lipid levels to manage hyperlipidaemias and reduce cardiovascular risk.
Principal Groups of Lipid-Regulating Drugs
-
Statins: Primarily reduce cholesterol levels. Common examples include:
- Atorvastatin (Lipitor)
- Rosuvastatin (Crestor)
- Simvastatin (Zocor)
-
Fibrates: Focus on lowering triglycerides. Notable example:
- Gemfibrozil (Lopid)
Effects and Recommendations
- Statins decrease cholesterol; fibrates lower triglycerides.
- Cholesterol synthesis in the liver peaks between midnight and 3 a.m.; therefore, statins like simvastatin should be taken at night for optimal effectiveness.
- Patients on simvastatin or atorvastatin must avoid grapefruit juice to prevent increased drug concentration and heightened side effects due to grapefruit inhibiting metabolism.
Drug Details
-
Atorvastatin
- Trade Name: Lipitor (Pfizer)
- Dosage Forms: Tablets (10 mg, 20 mg, 40 mg)
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Gemfibrozil
- Trade Name: Lopid (Pfizer)
- Dosage Forms: Capsules (300 mg, 600 mg)
-
Simvastatin
- Trade Name: Zocor (MSD)
- Dosage Forms: Tablets (10 mg, 20 mg, 40 mg, 80 mg)
-
Rosuvastatin
- Trade Name: Crestor (AstraZeneca)
- Dosage Forms: Tablets (5 mg, 10 mg, 20 mg, 40 mg)
-
Omega-3 Fatty Acid
- Trade Name: Omacor (Abbott Healthcare)
- Dosage Form: Capsules (380 mg)
- May be utilized to reduce triglycerides.
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Description
This quiz covers lipid-regulating drugs used to manage hyperlipidaemias and reduce cardiovascular risk. Key classes include statins and fibrates, each with distinct effects on cholesterol and triglyceride levels. Test your knowledge on their mechanisms and important details.
