Podcast
Questions and Answers
What is the normal concentration of ketone bodies in the circulation?
What is the normal concentration of ketone bodies in the circulation?
- 1mM (correct)
- 10mM
- 0.1mM
- 100mM
What is required for the synthesis of ketone bodies?
What is required for the synthesis of ketone bodies?
- Fatty acids available for oxidation in the liver (correct)
- Low plasma insulin only
- High plasma insulin/glucagon ratio
- Fatty acids available for oxidation in the brain
What is the role of ketone bodies in the body?
What is the role of ketone bodies in the body?
- They are used by all tissues containing mitochondria (correct)
- They are used only by the liver and kidneys
- They are not used by any tissues
- They are used only by the central nervous system
What is the primary component of cell membrane?
What is the primary component of cell membrane?
What is the consequence of a fall in plasma insulin?
What is the consequence of a fall in plasma insulin?
Where does lipolysis occur in the process of ketone body synthesis?
Where does lipolysis occur in the process of ketone body synthesis?
What is the primary function of the enzymes found in the liver and kidney?
What is the primary function of the enzymes found in the liver and kidney?
What is the usual keto-acid involved in the transamination reaction?
What is the usual keto-acid involved in the transamination reaction?
What is the product of the reaction between glutamic acid and pyruvic acid?
What is the product of the reaction between glutamic acid and pyruvic acid?
What is the product of the reaction between glutamine and glutaminase?
What is the product of the reaction between glutamine and glutaminase?
What is the purpose of detoxifying ammonia in the body?
What is the purpose of detoxifying ammonia in the body?
What is the clinical significance of transaminases in the blood?
What is the clinical significance of transaminases in the blood?
Why is early diagnosis of PKU crucial?
Why is early diagnosis of PKU crucial?
What is the composition of creatine kinase?
What is the composition of creatine kinase?
What is the byproduct of the deamination reaction?
What is the byproduct of the deamination reaction?
What is the normal blood concentration of ammonia?
What is the normal blood concentration of ammonia?
What is the consequence of a complete loss of an enzyme in the urea cycle?
What is the consequence of a complete loss of an enzyme in the urea cycle?
Which of the following is NOT a transaminase of clinical importance?
Which of the following is NOT a transaminase of clinical importance?
What is the primary purpose of a low-protein diet in the treatment of urea cycle defects?
What is the primary purpose of a low-protein diet in the treatment of urea cycle defects?
What is the source of ammonia produced during amino acid degradation?
What is the source of ammonia produced during amino acid degradation?
What is the enzyme involved in the transamination reaction?
What is the enzyme involved in the transamination reaction?
What is the molecular basis of the toxic effect of ammonia?
What is the molecular basis of the toxic effect of ammonia?
What is the purpose of replacing amino acids with keto acids in the treatment of urea cycle defects?
What is the purpose of replacing amino acids with keto acids in the treatment of urea cycle defects?
How is PKU typically diagnosed in newborns in the UK?
How is PKU typically diagnosed in newborns in the UK?
Which of the following amino acids is essential and cannot be totally removed from the diet?
Which of the following amino acids is essential and cannot be totally removed from the diet?
What is the reaction catalyzed by creatine kinase in muscle cells?
What is the reaction catalyzed by creatine kinase in muscle cells?
What is the consequence of elevated levels of homocysteine and methionine in plasma and the presence of homocystine in the urine?
What is the consequence of elevated levels of homocysteine and methionine in plasma and the presence of homocystine in the urine?
What is the significance of the amount of creatinine in blood and urine?
What is the significance of the amount of creatinine in blood and urine?
What is the toxic compound that accumulates in phenylketonuria?
What is the toxic compound that accumulates in phenylketonuria?
What is the significance of the three different enzymes of creatine kinase?
What is the significance of the three different enzymes of creatine kinase?
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