30 Questions
Which process involves the accumulation of phospholipids and cholesterol from cells lining the blood vessels?
Maturation of nascent HDL
What is the role of LCAT in HDL metabolism?
Conversion of cholesterol to cholesteryl esters
How is fatty acid transferred in the LCAT reaction?
From lecithin to cholesterol
What is the primary function of ABCA1 in HDL metabolism?
Efflux of cholesterol from cholesterol-laden cells
What is the final step in reverse cholesterol transport (HDL metabolism)?
Binding of cholesteryl ester–rich HDL to the liver and steroidogenic cells
What is the main function of CETP in HDL metabolism?
Transfer of cholesteryl esters to VLDL
What is the hydrophobic core of lipoproteins composed of?
TAGs and cholesterol esters
Which apolipoprotein activates LPL (lipoprotein lipase)?
ApoCII
What is the primary function of chylomicrons?
Transport dietary fatty acids to tissues
Which lipoprotein is the largest and least dense?
Chylomicrons (CM)
What is the major function of apolipoproteins in lipoproteins?
Activate enzymes for lipoprotein metabolism
Where is resynthesis of triglycerides in chylomicrons primarily carried out?
Intestinal epithelial cells
What is the main adverse effect of niacin (nicotinic acid) therapy?
Flushing
To prevent flushing with niacin intake, what is recommended before its administration?
Administering aspirin prior to intake
Which of the following gastrointestinal symptoms can be minimized by starting niacin therapy at lower doses?
Dyspepsia
What is a side effect of niacin (nicotinic acid) therapy that can be prevented by taking it after a meal?
Hepatotoxicity
In pregnancy, what is the FDA category for niacin (nicotinic acid)?
Category C
What condition is niacin (nicotinic acid) contraindicated in?
Chronic liver disease
What is the primary target of HMG-CoA reductase inhibitors (statins)?
HMG-CoA reductase
Which tissue is the primary site for cholesterol synthesis?
Adrenal cortex
What is the final product of the 4 stages of cholesterol synthesis?
Steroid nucleus
Which organelle plays a role in cholesterol synthesis?
Endoplasmic reticulum
What is the effect of HMG-CoA reductase inhibitors on LDL?
Increase in high-affinity LDL receptors
Which of the following is NOT a step in cholesterol synthesis?
Conversion of squalene to cholesterol
What is the role of cholesteryl esters uptake in cells via scavenger receptor (SR-B1)?
Form steroid hormones
Which lipoprotein is nearly identical in structure to LDL and is associated with an increased risk of coronary heart disease?
Lp(a)
What distinguishes Lp(a) from other lipoproteins in terms of its structure?
Additional apolipoprotein apo(a) linked to apo B-100
Which condition is characterized by high total cholesterol, low-density lipoprotein (LDL) cholesterol, or triglycerides, and low high-density lipoprotein (HDL) cholesterol?
Dyslipidemia
What are the goals of treating dyslipidemia?
Lower LDL cholesterol for heart disease prevention
What is a major cause of atherosclerotic cardiovascular diseases like CHD, ischemic cerebrovascular disease, and peripheral vascular disease?
Hyperlipidemia
Explore the world of lipid-lowering drugs and lipoprotein metabolism in this quiz. Test your knowledge on cholesterol, triglycerides, phospholipids, and the role of lipoproteins in transporting lipids. Dive into the details of hydrophobic cores, amphiphatic shells, and the essential substrates for cell membrane formation.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
