Podcast
Questions and Answers
Which process involves the accumulation of phospholipids and cholesterol from cells lining the blood vessels?
Which process involves the accumulation of phospholipids and cholesterol from cells lining the blood vessels?
- Esterification of cholesterol to cholesteryl esters via LCAT
- Budding of apoproteins from chylomicrons
- Maturation of nascent HDL (correct)
- Synthesis of nascent HDL
What is the role of LCAT in HDL metabolism?
What is the role of LCAT in HDL metabolism?
- Transfer of cholesteryl esters to VLDL
- Uptake of cholesterol from cholesterol-laden cells into HDL shell
- Trapping of cholesterol into HDL core
- Conversion of cholesterol to cholesteryl esters (correct)
How is fatty acid transferred in the LCAT reaction?
How is fatty acid transferred in the LCAT reaction?
- From cholesterol to VLDL
- From cholesterol to phospholipid shell
- From HDL core to HDL shell
- From lecithin to cholesterol (correct)
What is the primary function of ABCA1 in HDL metabolism?
What is the primary function of ABCA1 in HDL metabolism?
What is the final step in reverse cholesterol transport (HDL metabolism)?
What is the final step in reverse cholesterol transport (HDL metabolism)?
What is the main function of CETP in HDL metabolism?
What is the main function of CETP in HDL metabolism?
What is the hydrophobic core of lipoproteins composed of?
What is the hydrophobic core of lipoproteins composed of?
Which apolipoprotein activates LPL (lipoprotein lipase)?
Which apolipoprotein activates LPL (lipoprotein lipase)?
What is the primary function of chylomicrons?
What is the primary function of chylomicrons?
Which lipoprotein is the largest and least dense?
Which lipoprotein is the largest and least dense?
What is the major function of apolipoproteins in lipoproteins?
What is the major function of apolipoproteins in lipoproteins?
Where is resynthesis of triglycerides in chylomicrons primarily carried out?
Where is resynthesis of triglycerides in chylomicrons primarily carried out?
What is the main adverse effect of niacin (nicotinic acid) therapy?
What is the main adverse effect of niacin (nicotinic acid) therapy?
To prevent flushing with niacin intake, what is recommended before its administration?
To prevent flushing with niacin intake, what is recommended before its administration?
Which of the following gastrointestinal symptoms can be minimized by starting niacin therapy at lower doses?
Which of the following gastrointestinal symptoms can be minimized by starting niacin therapy at lower doses?
What is a side effect of niacin (nicotinic acid) therapy that can be prevented by taking it after a meal?
What is a side effect of niacin (nicotinic acid) therapy that can be prevented by taking it after a meal?
In pregnancy, what is the FDA category for niacin (nicotinic acid)?
In pregnancy, what is the FDA category for niacin (nicotinic acid)?
What condition is niacin (nicotinic acid) contraindicated in?
What condition is niacin (nicotinic acid) contraindicated in?
What is the primary target of HMG-CoA reductase inhibitors (statins)?
What is the primary target of HMG-CoA reductase inhibitors (statins)?
Which tissue is the primary site for cholesterol synthesis?
Which tissue is the primary site for cholesterol synthesis?
What is the final product of the 4 stages of cholesterol synthesis?
What is the final product of the 4 stages of cholesterol synthesis?
Which organelle plays a role in cholesterol synthesis?
Which organelle plays a role in cholesterol synthesis?
What is the effect of HMG-CoA reductase inhibitors on LDL?
What is the effect of HMG-CoA reductase inhibitors on LDL?
Which of the following is NOT a step in cholesterol synthesis?
Which of the following is NOT a step in cholesterol synthesis?
What is the role of cholesteryl esters uptake in cells via scavenger receptor (SR-B1)?
What is the role of cholesteryl esters uptake in cells via scavenger receptor (SR-B1)?
Which lipoprotein is nearly identical in structure to LDL and is associated with an increased risk of coronary heart disease?
Which lipoprotein is nearly identical in structure to LDL and is associated with an increased risk of coronary heart disease?
What distinguishes Lp(a) from other lipoproteins in terms of its structure?
What distinguishes Lp(a) from other lipoproteins in terms of its structure?
Which condition is characterized by high total cholesterol, low-density lipoprotein (LDL) cholesterol, or triglycerides, and low high-density lipoprotein (HDL) cholesterol?
Which condition is characterized by high total cholesterol, low-density lipoprotein (LDL) cholesterol, or triglycerides, and low high-density lipoprotein (HDL) cholesterol?
What are the goals of treating dyslipidemia?
What are the goals of treating dyslipidemia?
What is a major cause of atherosclerotic cardiovascular diseases like CHD, ischemic cerebrovascular disease, and peripheral vascular disease?
What is a major cause of atherosclerotic cardiovascular diseases like CHD, ischemic cerebrovascular disease, and peripheral vascular disease?
