Podcast
Questions and Answers
Which process involves the accumulation of phospholipids and cholesterol from cells lining the blood vessels?
Which process involves the accumulation of phospholipids and cholesterol from cells lining the blood vessels?
What is the role of LCAT in HDL metabolism?
What is the role of LCAT in HDL metabolism?
How is fatty acid transferred in the LCAT reaction?
How is fatty acid transferred in the LCAT reaction?
What is the primary function of ABCA1 in HDL metabolism?
What is the primary function of ABCA1 in HDL metabolism?
Signup and view all the answers
What is the final step in reverse cholesterol transport (HDL metabolism)?
What is the final step in reverse cholesterol transport (HDL metabolism)?
Signup and view all the answers
What is the main function of CETP in HDL metabolism?
What is the main function of CETP in HDL metabolism?
Signup and view all the answers
What is the hydrophobic core of lipoproteins composed of?
What is the hydrophobic core of lipoproteins composed of?
Signup and view all the answers
Which apolipoprotein activates LPL (lipoprotein lipase)?
Which apolipoprotein activates LPL (lipoprotein lipase)?
Signup and view all the answers
What is the primary function of chylomicrons?
What is the primary function of chylomicrons?
Signup and view all the answers
Which lipoprotein is the largest and least dense?
Which lipoprotein is the largest and least dense?
Signup and view all the answers
What is the major function of apolipoproteins in lipoproteins?
What is the major function of apolipoproteins in lipoproteins?
Signup and view all the answers
Where is resynthesis of triglycerides in chylomicrons primarily carried out?
Where is resynthesis of triglycerides in chylomicrons primarily carried out?
Signup and view all the answers
What is the main adverse effect of niacin (nicotinic acid) therapy?
What is the main adverse effect of niacin (nicotinic acid) therapy?
Signup and view all the answers
To prevent flushing with niacin intake, what is recommended before its administration?
To prevent flushing with niacin intake, what is recommended before its administration?
Signup and view all the answers
Which of the following gastrointestinal symptoms can be minimized by starting niacin therapy at lower doses?
Which of the following gastrointestinal symptoms can be minimized by starting niacin therapy at lower doses?
Signup and view all the answers
What is a side effect of niacin (nicotinic acid) therapy that can be prevented by taking it after a meal?
What is a side effect of niacin (nicotinic acid) therapy that can be prevented by taking it after a meal?
Signup and view all the answers
In pregnancy, what is the FDA category for niacin (nicotinic acid)?
In pregnancy, what is the FDA category for niacin (nicotinic acid)?
Signup and view all the answers
What condition is niacin (nicotinic acid) contraindicated in?
What condition is niacin (nicotinic acid) contraindicated in?
Signup and view all the answers
What is the primary target of HMG-CoA reductase inhibitors (statins)?
What is the primary target of HMG-CoA reductase inhibitors (statins)?
Signup and view all the answers
Which tissue is the primary site for cholesterol synthesis?
Which tissue is the primary site for cholesterol synthesis?
Signup and view all the answers
What is the final product of the 4 stages of cholesterol synthesis?
What is the final product of the 4 stages of cholesterol synthesis?
Signup and view all the answers
Which organelle plays a role in cholesterol synthesis?
Which organelle plays a role in cholesterol synthesis?
Signup and view all the answers
What is the effect of HMG-CoA reductase inhibitors on LDL?
What is the effect of HMG-CoA reductase inhibitors on LDL?
Signup and view all the answers
Which of the following is NOT a step in cholesterol synthesis?
Which of the following is NOT a step in cholesterol synthesis?
Signup and view all the answers
What is the role of cholesteryl esters uptake in cells via scavenger receptor (SR-B1)?
What is the role of cholesteryl esters uptake in cells via scavenger receptor (SR-B1)?
Signup and view all the answers
Which lipoprotein is nearly identical in structure to LDL and is associated with an increased risk of coronary heart disease?
Which lipoprotein is nearly identical in structure to LDL and is associated with an increased risk of coronary heart disease?
Signup and view all the answers
What distinguishes Lp(a) from other lipoproteins in terms of its structure?
What distinguishes Lp(a) from other lipoproteins in terms of its structure?
Signup and view all the answers
Which condition is characterized by high total cholesterol, low-density lipoprotein (LDL) cholesterol, or triglycerides, and low high-density lipoprotein (HDL) cholesterol?
Which condition is characterized by high total cholesterol, low-density lipoprotein (LDL) cholesterol, or triglycerides, and low high-density lipoprotein (HDL) cholesterol?
Signup and view all the answers
What are the goals of treating dyslipidemia?
What are the goals of treating dyslipidemia?
Signup and view all the answers
What is a major cause of atherosclerotic cardiovascular diseases like CHD, ischemic cerebrovascular disease, and peripheral vascular disease?
What is a major cause of atherosclerotic cardiovascular diseases like CHD, ischemic cerebrovascular disease, and peripheral vascular disease?
Signup and view all the answers
