Questions and Answers
What is Linezolid approved to treat? (Select all that apply)
What are the available formulations of Linezolid?
Oral and parenteral formulations
Food decreases peak plasma concentrations of oral Linezolid.
False
How does Linezolid work against bacteria?
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The only contraindication for Linezolid is hypersensitivity.
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What are some common adverse effects of Linezolid? (Select all that apply)
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What should be avoided while taking Linezolid due to interactions?
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Study Notes
Linezolid Pharmacotherapeutics
- Approved for treating bacteremia associated with Vancomycin-resistant Enterococcus (VRE).
- Indicated for complicated skin infections and pneumonia, both nosocomial and community-acquired.
- Used in the management of infective endocarditis and peritonitis in patients on peritoneal dialysis.
Linezolid Pharmacokinetics
- Available in oral and parenteral formulations, interchangeable with no dosage adjustments needed.
- Oral linezolid is 100% bioavailable and rapidly absorbed from the gastrointestinal tract.
- Food can delay absorption but doesn't reduce peak plasma concentrations.
- Partially metabolized in the liver and primarily excreted in urine.
Linezolid Pharmacodynamics
- Functions by blocking early stages of bacterial protein synthesis.
- Unique mechanism reduces the likelihood of rapid resistance development and cross-resistance with other antibiotics.
Linezolid Contraindications and Precautions
- Only contraindicated in cases of hypersensitivity.
- Caution required for patients with phenylketonuria due to aspartame in the oral suspension.
- Use cautiously in individuals with blood dyscrasias, hypertension, severe cardiac disease, or untreated hyperthyroid disease.
- Classified as a pregnancy category C drug, indicating potential risks.
Linezolid Adverse Effects
- Generally well tolerated with common adverse effects including rash, fever, diarrhea, headache, nausea, and vomiting.
- Serious adverse effects may include seizures, blood dyscrasias, myelosuppression, lactic acidosis, serotonin syndrome, elevated hepatic enzymes, pseudomembranous colitis, and hypertension.
- Risk of super infections similar to other antibiotics.
Linezolid Drug Interactions
- A reversible, nonselective monoamine oxidase (MAO) inhibitor; primarily interacts with adrenergic and serotonergic agents.
- Advised to avoid foods containing tyramine to prevent adverse interactions.
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Description
Test your knowledge on the pharmacotherapeutics of Linezolid. This quiz covers its approved uses, including treatments for infections like VRE, pneumonia, and infective endocarditis. Challenge yourself to remember key information about this important antibiotic.
