Levothyroxine Replacement Therapy
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Questions and Answers

What is the title of the article published in the New England Journal of Medicine in 2001?

  • Global iodine status in 2011 and trends over the past decade
  • Clinical practice. Subclinical hypothyroidism (correct)
  • Iodine status in pregnant women in the National Children's Study
  • The importance of iodine in public health

    • In which year was the article 'Global iodine status in 2011 and trends over the past decade' published?

  • 2011
  • 2015
  • 2012 (correct)
  • 2018

    • Who is the author of the article 'The importance of iodine in public health'?

  • KL Caldwell
  • JH Lazarus (correct)
  • MB Zimmermann
  • PN Taylor

    • What is the title of the article published in the journal Thyroid in 2013?

    <p>Iodine status in pregnant women in the National Children's Study and in U.S. women (15-44 years)</p> Signup and view all the answers

    When was the BMJ Best Practice topic last updated?

    <p>April 13, 2021</p> Signup and view all the answers

    Who is the publisher of the BMJ Best Practice topic?

    <p>BMJ Publishing Group Ltd</p> Signup and view all the answers

    What is the title of the article published in the journal Nature Reviews Endocrinology in 2018?

    <p>Global epidemiology of hyperthyroidism and hypothyroidism</p> Signup and view all the answers

    What is the volume number of the Journal of Nutrition in which the article 'Global iodine status in 2011 and trends over the past decade' was published?

    <p>142</p> Signup and view all the answers

    What is the main complication of levothyroxine treatment?

    <p>Over-replacement of thyroid hormone</p> Signup and view all the answers

    During pregnancy, how often should thyroid-stimulating hormone (TSH) be measured in patients?

    <p>Every 4-6 weeks</p> Signup and view all the answers

    By how much might the dose of levothyroxine need to be increased during the first trimester of pregnancy?

    <p>25% to 30%</p> Signup and view all the answers

    Which condition can increase levothyroxine requirements due to malabsorption?

    <p>Coeliac disease</p> Signup and view all the answers

    What is a potential risk associated with over-replacement of thyroid hormone?

    <p>Osteoporosis</p> Signup and view all the answers

    What syndrome is mentioned as increasing levothyroxine requirements?

    <p>Nephrotic syndrome</p> Signup and view all the answers

    What is levothyroxine used for?

    <p>Replacing thyroid hormone</p> Signup and view all the answers

    Which condition necessitates measurement of TSH every 4-6 weeks in patients on levothyroxine?

    <p>Pregnancy</p> Signup and view all the answers

    What is a rare complication of untreated hypothyroidism in older patients with multiple co-morbidities?

    <p>myxedema coma</p> Signup and view all the answers

    Which complication is most likely to occur due to non-adherence to treatment?

    <p>resistant hypothyroidism</p> Signup and view all the answers

    Which of these complications is treated as a medical emergency and usually requires intensive care?

    <p>myxedema coma</p> Signup and view all the answers

    Which complication is noted to have a medium likelihood during pregnancy?

    <p>complications in pregnancy</p> Signup and view all the answers

    Which complication is associated with high initial doses of levothyroxine in patients with coronary artery disease?

    <p>angina</p> Signup and view all the answers

    What long-term complication might result from over-treatment of hypothyroidism?

    <p>osteoporosis</p> Signup and view all the answers

    Which of the following is associated with an increased risk of complications in pregnancy?

    <p>sub-clinical hypothyroidism</p> Signup and view all the answers

    Which complication is most likely to be influenced by drug interactions?

    <p>resistant hypothyroidism</p> Signup and view all the answers

    What is the format for 4-digit numbers according to BMJ Best Practice Numeral Style?

    <p>Without a comma</p> Signup and view all the answers

    How should numbers of 5 or more digits be formatted?

    <p>With a comma</p> Signup and view all the answers

    What is the correct representation for numbers less than 1?

    <p>Using decimal points</p> Signup and view all the answers

    What is the formatting style for the number 1000?

    <p>1000</p> Signup and view all the answers

    Which organization’s guidance is this numeral style aligned with?

    <p>International Bureau of Weights and Measures Service</p> Signup and view all the answers

    What is the correct phone number format for contacting BMJ support?

    <ul> <li>44 207 111 1105</li> </ul> Signup and view all the answers

    Where can the most recent version of BMJ Best Practice topics be found?

    <p>On the BMJ web version</p> Signup and view all the answers

    What is the last update date for the web version of the BMJ Best Practice topic mentioned?

    <p>April 13, 2021</p> Signup and view all the answers

    What is recommended for patients aged over 65 years with primary hypothyroidism?

    <p>A low starting dose of levothyroxine</p> Signup and view all the answers

    How often should levothyroxine be titrated in patients?

    <p>Every 4-6 weeks</p> Signup and view all the answers

    What is the goal of treatment for primary hypothyroidism?

    <p>Reduction of symptoms and prevention of long-term complications</p> Signup and view all the answers

    When should treatment for primary hypothyroidism commence?

    <p>Upon establishing the diagnosis</p> Signup and view all the answers

    Why should a lower starting dose of levothyroxine be used?

    <p>To avoid ischaemic symptoms</p> Signup and view all the answers

    Which patient population is less tolerant of full replacement initial doses?

    <p>Patients aged over 65 years</p> Signup and view all the answers

    What is necessary during the titration period of levothyroxine?

    <p>Close attention to ischaemic symptoms</p> Signup and view all the answers

    How long is the treatment for primary hypothyroidism generally administered?

    <p>Lifelong</p> Signup and view all the answers

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