Podcast
Questions and Answers
What is Levodopa used as in the treatment of Parkinson's disease?
What is Levodopa used as in the treatment of Parkinson's disease?
- A dopamine precursor (correct)
- A dopamine reuptake inhibitor
- A dopamine receptor agonist
- A dopamine decarboxylase inhibitor
Where is Levodopa taken up by in the basal ganglia?
Where is Levodopa taken up by in the basal ganglia?
- GABAergic nerve endings
- Serotonergic nerve endings
- Dopaminergic nerve endings (correct)
- Noradrenergic nerve endings
What is the therapeutic value of Levodopa in Parkinson's disease?
What is the therapeutic value of Levodopa in Parkinson's disease?
- It only shows a curative activity
- It has no therapeutic value
- It has the highest therapeutic value (correct)
- It stops the natural progression of the disease
When is Levodopa not recommended to be used?
When is Levodopa not recommended to be used?
What percentage of patients respond well to Levodopa?
What percentage of patients respond well to Levodopa?
What happens to the therapeutic efficacy of Levodopa over time?
What happens to the therapeutic efficacy of Levodopa over time?
How is Levodopa administered?
How is Levodopa administered?
What happens to Levodopa when ingested with food?
What happens to Levodopa when ingested with food?
What is an indicator that the dose of a drug should not be increased further?
What is an indicator that the dose of a drug should not be increased further?
What is the primary reason levodopa is rarely used alone in treatment?
What is the primary reason levodopa is rarely used alone in treatment?
What is the purpose of carbidopa and benserazide in combined levodopa preparations?
What is the purpose of carbidopa and benserazide in combined levodopa preparations?
In which period of treatment is the efficacy of the drug typically strongest?
In which period of treatment is the efficacy of the drug typically strongest?
What occurs when the dopaminergic nerve ending is lost in the striatum?
What occurs when the dopaminergic nerve ending is lost in the striatum?
What is not used in the treatment of extrapyramidal disorders and parkinsonism caused by various drugs?
What is not used in the treatment of extrapyramidal disorders and parkinsonism caused by various drugs?
What happens to the number of D2 receptors with prolonged exposure to the agonist?
What happens to the number of D2 receptors with prolonged exposure to the agonist?
What is the purpose of using combined levodopa preparations?
What is the purpose of using combined levodopa preparations?
What can occur suddenly in the daytime due to certain medications?
What can occur suddenly in the daytime due to certain medications?
Why should Levodopa not be used with multivitamins?
Why should Levodopa not be used with multivitamins?
What can result from sudden discontinuation of Levodopa and other dopaminergic drugs?
What can result from sudden discontinuation of Levodopa and other dopaminergic drugs?
What are dopamine receptor agonists often derived from?
What are dopamine receptor agonists often derived from?
Why are anticholinergics not recommended with Levodopa?
Why are anticholinergics not recommended with Levodopa?
What can occur when Levodopa is taken concomitantly with MAO inhibitors?
What can occur when Levodopa is taken concomitantly with MAO inhibitors?
What type of effect do dopamine receptor agonists have compared to Levodopa and amantadine?
What type of effect do dopamine receptor agonists have compared to Levodopa and amantadine?
What is characterized by confusion, rigidity, and hyperthermia?
What is characterized by confusion, rigidity, and hyperthermia?
What is the primary mechanism of action of Amantadine in the treatment of Parkinson's disease?
What is the primary mechanism of action of Amantadine in the treatment of Parkinson's disease?
Why is Apomorphine used in special cases and under supervision?
Why is Apomorphine used in special cases and under supervision?
What is the primary effect of Rotigotine in the treatment of Parkinson's disease?
What is the primary effect of Rotigotine in the treatment of Parkinson's disease?
What is the common characteristic of treatment with all dopaminergic agonist drugs?
What is the common characteristic of treatment with all dopaminergic agonist drugs?
What is the effect of Selegiline on dopamine receptors?
What is the effect of Selegiline on dopamine receptors?
What is the common side effect of Amantadine?
What is the common side effect of Amantadine?
What should be done when discontinuing treatment with dopaminergic agonist drugs?
What should be done when discontinuing treatment with dopaminergic agonist drugs?
What is the therapeutic efficacy of Amantadine in the treatment of Parkinson's disease?
What is the therapeutic efficacy of Amantadine in the treatment of Parkinson's disease?
What is a potential side effect of dopamine agonists?
What is a potential side effect of dopamine agonists?
In what percentage of patients can bromocriptine produce a sufficient therapeutic effect when used alone?
In what percentage of patients can bromocriptine produce a sufficient therapeutic effect when used alone?
Why is bromocriptine preferred at the beginning of the disease?
Why is bromocriptine preferred at the beginning of the disease?
What is the elimination half-life of bromocriptine?
What is the elimination half-life of bromocriptine?
What happens to the dose of levodopa when bromocriptine is combined with it?
What happens to the dose of levodopa when bromocriptine is combined with it?
What is the systemic bioavailability of bromocriptine after oral ingestion?
What is the systemic bioavailability of bromocriptine after oral ingestion?
What is a potential long-term side effect of ergot derivatives?
What is a potential long-term side effect of ergot derivatives?
How should bromocriptine be taken?
How should bromocriptine be taken?
