12 Questions
What is the primary therapeutic use of the combination of levodopa and carbidopa?
To treat Parkinson's disease
Why should levodopa be taken on an empty stomach, typically 45 minutes before a meal?
To increase the drug's absorption
What is the effect of concomitant administration of levodopa and monoamine oxidase (MAO) inhibitors?
It can produce a hypertensive crisis
What is the effect of vitamin B6 (pyridoxine) on the effectiveness of levodopa?
It decreases the effectiveness of levodopa
What is the effect of levodopa on patients with psychosis?
It exacerbates the symptoms of psychosis
What is the effect of levodopa on intraocular pressure in patients with glaucoma?
It increases intraocular pressure
What is the primary mechanism of action of selegiline and rasagiline?
They irreversibly and selectively inhibit monoamine oxidase (MAO) type B.
How does the co-administration of levodopa and carbidopa affect the metabolism of levodopa?
It inhibits the peripheral decarboxylation of levodopa.
What is the primary therapeutic use of COMT inhibitors like entacapone and tolcapone?
They are used to treat Parkinson's disease symptoms.
What is the main side effect associated with the use of selegiline?
Increased risk of insomnia.
How do COMT inhibitors like entacapone and tolcapone affect the absorption and metabolism of levodopa?
They decrease the plasma concentrations of 3-O-methyldopa, leading to increased central uptake of levodopa and greater concentrations of brain dopamine.
What is the potential interaction between levodopa/carbidopa and vitamin B6 (pyridoxine)?
Vitamin B6 increases the metabolism of levodopa, leading to decreased effectiveness.
Learn about the therapeutic uses, absorption, and metabolism of levodopa in combination with carbidopa for treating Parkinson's disease. Understand the importance of taking levodopa on an empty stomach for optimal effectiveness.
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