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Levodopa and Carbidopa Drug Regimen for Parkinson's Disease

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Levodopa and Carbidopa Drug Regimen for Parkinson's Disease

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Questions and Answers

What is the primary therapeutic use of the combination of levodopa and carbidopa?

To treat Alzheimer's disease
To treat multiple sclerosis
To treat Parkinson's disease (correct)
To treat amyotrophic lateral sclerosis

Why should levodopa be taken on an empty stomach, typically 45 minutes before a meal?

To avoid interactions with food
To decrease the drug's side effects
To increase the drug's absorption (correct)
To prolong the drug's half-life

What is the effect of concomitant administration of levodopa and monoamine oxidase (MAO) inhibitors?

It increases the effectiveness of levodopa
It has no significant interaction
It can produce a hypertensive crisis (correct)
It decreases the side effects of levodopa

What is the effect of vitamin B6 (pyridoxine) on the effectiveness of levodopa?

It decreases the effectiveness of levodopa (D) Signup and view all the answers

What is the effect of levodopa on patients with psychosis?

It exacerbates the symptoms of psychosis (A) Signup and view all the answers

What is the effect of levodopa on intraocular pressure in patients with glaucoma?

It increases intraocular pressure (B) Signup and view all the answers

What is the primary mechanism of action of selegiline and rasagiline?

They irreversibly and selectively inhibit monoamine oxidase (MAO) type B. (D) Signup and view all the answers

How does the co-administration of levodopa and carbidopa affect the metabolism of levodopa?

It inhibits the peripheral decarboxylation of levodopa. (C) Signup and view all the answers

What is the primary therapeutic use of COMT inhibitors like entacapone and tolcapone?

They are used to treat Parkinson's disease symptoms. (D) Signup and view all the answers

What is the main side effect associated with the use of selegiline?

Increased risk of insomnia. (A) Signup and view all the answers

How do COMT inhibitors like entacapone and tolcapone affect the absorption and metabolism of levodopa?

They decrease the plasma concentrations of 3-O-methyldopa, leading to increased central uptake of levodopa and greater concentrations of brain dopamine. (B) Signup and view all the answers

What is the potential interaction between levodopa/carbidopa and vitamin B6 (pyridoxine)?

Vitamin B6 increases the metabolism of levodopa, leading to decreased effectiveness. (D) Signup and view all the answers