Levodopa and Carbidopa Drug Regimen for Parkinson's Disease
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Questions and Answers

What is the primary therapeutic use of the combination of levodopa and carbidopa?

  • To treat Alzheimer's disease
  • To treat multiple sclerosis
  • To treat Parkinson's disease (correct)
  • To treat amyotrophic lateral sclerosis
  • Why should levodopa be taken on an empty stomach, typically 45 minutes before a meal?

  • To avoid interactions with food
  • To decrease the drug's side effects
  • To increase the drug's absorption (correct)
  • To prolong the drug's half-life
  • What is the effect of concomitant administration of levodopa and monoamine oxidase (MAO) inhibitors?

  • It increases the effectiveness of levodopa
  • It has no significant interaction
  • It can produce a hypertensive crisis (correct)
  • It decreases the side effects of levodopa
  • What is the effect of vitamin B6 (pyridoxine) on the effectiveness of levodopa?

    <p>It decreases the effectiveness of levodopa</p> Signup and view all the answers

    What is the effect of levodopa on patients with psychosis?

    <p>It exacerbates the symptoms of psychosis</p> Signup and view all the answers

    What is the effect of levodopa on intraocular pressure in patients with glaucoma?

    <p>It increases intraocular pressure</p> Signup and view all the answers

    What is the primary mechanism of action of selegiline and rasagiline?

    <p>They irreversibly and selectively inhibit monoamine oxidase (MAO) type B.</p> Signup and view all the answers

    How does the co-administration of levodopa and carbidopa affect the metabolism of levodopa?

    <p>It inhibits the peripheral decarboxylation of levodopa.</p> Signup and view all the answers

    What is the primary therapeutic use of COMT inhibitors like entacapone and tolcapone?

    <p>They are used to treat Parkinson's disease symptoms.</p> Signup and view all the answers

    What is the main side effect associated with the use of selegiline?

    <p>Increased risk of insomnia.</p> Signup and view all the answers

    How do COMT inhibitors like entacapone and tolcapone affect the absorption and metabolism of levodopa?

    <p>They decrease the plasma concentrations of 3-O-methyldopa, leading to increased central uptake of levodopa and greater concentrations of brain dopamine.</p> Signup and view all the answers

    What is the potential interaction between levodopa/carbidopa and vitamin B6 (pyridoxine)?

    <p>Vitamin B6 increases the metabolism of levodopa, leading to decreased effectiveness.</p> Signup and view all the answers

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