Leptospirosis: Pathogenesis and Epidemiology

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40 Questions

What is the most accurate laboratory diagnosis for trachoma?

Nucleic acid amplification tests (NAATs)

What is the main mode of transmission for trachoma?

Contact with contaminated flies

Which serotypes of Chlamydia trachomatis are responsible for inclusion conjunctivitis?

Serotypes D-K

What is the recommended systemic treatment for neonatal conjunctivitis caused by Chlamydia trachomatis?

Erythromycin

Which Chlamydia species is a zoonotic disease transmitted by inhalation of dust contaminated with respiratory secretions or feces of infected birds?

Chlamydia psittaci

Which diagnostic test is most commonly used for Q fever?

Detection of immunoglobulins to phase II antigens

What is the treatment for chronic Q fever?

Combination of doxycycline and hydroxychloroquine

Which type of epithelial cells can Chlamydia trachomatis infect?

Nonciliated columnar, cuboidal, and transitional epithelial cells

What is the primary lesion in lymphogranuloma venereum?

Ulcerating papule at the site of inoculation

Which antibiotic is typically prescribed for C. trachomatis infections?

Azithromycin

Which phase of illness does Weil disease represent in Leptospira infection?

Second phase

What is the most common reservoir for Rickettsia rickettsii?

Ticks

Which diagnostic method is recommended for suspected Rickettsia rickettsii infection regardless of age or pregnancy?

Western blot immunoassay

What structural variant of Coxiella burnetii is resistant to environmental stress and lives in soil and milk?

Small cell variant

What is the most common presentation of chronic C. burnetii infection?

Subacute endocarditis

What is the most common cause of bacterial gastroenteritis?

Consumption of contaminated food, milk, water

At what temperature does Campylobacter jejuni grow best?

42°C

What type of cells can Chlamydia trachomatis infect?

Epithelial cells

What is the characteristic histologic damage produced by Campylobacter jejuni?

Ulcerated, edematous, and bloody mucosal surfaces

What is the primary reservoir for Campylobacter jejuni infections?

Animals

What is the most common clinical presentation of Helicobacter pylori infection?

Feeling full, nausea, vomiting, and decreased acid production in the stomach

What is the primary mode of transmission for Treponema pallidum?

Sexual contact

Which factor contributes to the difficulty in microscopy diagnosis of Campylobacter jejuni?

Highly motile corkscrew motility

What is the recommended treatment for Helicobacter pylori infection?

Combination of PPI, a macrolide, and a β-lactam

Which clinical disease is characterized by the appearance of a painless chancre at the site of infection?

Primary syphilis

Which of the following is NOT a characteristic of Leptospira?

Obligate aerobes

What is the primary mode of transmission for Rickettsia rickettsii?

Transovarian transmission in ticks

Which statement about Q fever caused by Coxiella burnetii is true?

The bacteria reach high concentrations in the placenta of infected livestock

What is the hallmark clinical manifestation of Rocky Mountain Spotted Fever (RMSF) caused by Rickettsia rickettsii?

Macular rash after approximately 3 days

Which of the following is NOT a common method for diagnosing Leptospira infection?

Microscopy

What is the primary cause of trachoma worldwide?

Serotypes A, B, Ba, and C

Which diagnostic test is most accurate for the laboratory diagnosis of trachoma?

Nucleic acid amplification tests (NAATs)

What is the recommended systemic treatment for neonatal conjunctivitis caused by Chlamydia trachomatis?

Erythromycin

Which Chlamydia serotypes can infect the urogenital tract as well as the conjunctiva?

Serotypes D-K

What is the primary mode of transmission for trachoma?

Contact transmission

Which test can be used to examine exudate from the primary chancre of syphilis patients?

Dark-field microscopy

What is the protein critical for the transmission of Borrelia burgdorferi from ticks to mammals?

Outer surface protein A (OspA)

Which test is NOT recommended for the diagnosis of B. burgdorferi infection?

Microscopy

What characteristic hook is seen at one or both ends of Leptospira spp.?

Spirochete

Which antibiotic is contraindicated for pregnant people and children in the treatment of B. recurrentis infection?

Doxycycline

Test your knowledge on the pathogenesis and epidemiology of Leptospirosis, a zoonotic infection caused by Leptospira bacteria. This quiz covers the structure of Leptospira bacteria, its transmission, hosts, and worldwide distribution.

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