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Questions and Answers
What is the infective stage for humans in visceral leishmaniasis caused by Leishmania donovani?
What is the infective stage for humans in visceral leishmaniasis caused by Leishmania donovani?
The promastigote.
Where are sand flies in the genus Phlebotomus common vectors for transmitting L. donovani?
Where are sand flies in the genus Phlebotomus common vectors for transmitting L. donovani?
Africa, the Middle East, and Asia.
What happens to the promastigotes after being rapidly phagocytosed in the skin by macrophages?
What happens to the promastigotes after being rapidly phagocytosed in the skin by macrophages?
They transform to amastigotes.
What is the vector that transmits L. donovani from person to person?
What is the vector that transmits L. donovani from person to person?
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How does the sand fly acquire its infection?
How does the sand fly acquire its infection?
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Study Notes
Visceral Leishmaniasis (L. donovani)
- The infective stage for humans in visceral leishmaniasis caused by L. donovani is metacyclic promastigotes.
Vector Transmission
- Sand flies in the genus Phlebotomus are common vectors for transmitting L. donovani.
- The vector that transmits L. donovani from person to person is the sand fly.
Infection and Replication
- After being rapidly phagocytosed in the skin by macrophages, the promastigotes transform into amastigotes and multiply within the macrophages.
- The sand fly acquires its infection by feeding on an infected host, ingesting macrophages that contain amastigotes, which then transform into promastigotes in the sand fly's gut.
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