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Leishmania donovani and Visceral Leishmaniasis

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Leishmania donovani and Visceral Leishmaniasis

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Questions and Answers

What is the infective stage for humans in visceral leishmaniasis caused by Leishmania donovani?

The promastigote.

Where are sand flies in the genus Phlebotomus common vectors for transmitting L. donovani?

Africa, the Middle East, and Asia.

What happens to the promastigotes after being rapidly phagocytosed in the skin by macrophages?

They transform to amastigotes.

What is the vector that transmits L. donovani from person to person?

<p>The sand fly.</p> Signup and view all the answers

How does the sand fly acquire its infection?

<p>By ingesting an infected macrophage during the taking of a blood meal.</p> Signup and view all the answers

Study Notes

Visceral Leishmaniasis (L. donovani)

The infective stage for humans in visceral leishmaniasis caused by L. donovani is metacyclic promastigotes.

Vector Transmission

Sand flies in the genus Phlebotomus are common vectors for transmitting L. donovani.
The vector that transmits L. donovani from person to person is the sand fly.

Infection and Replication

After being rapidly phagocytosed in the skin by macrophages, the promastigotes transform into amastigotes and multiply within the macrophages.
The sand fly acquires its infection by feeding on an infected host, ingesting macrophages that contain amastigotes, which then transform into promastigotes in the sand fly's gut.

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Description

Test your knowledge about the transmission and infective stage of Leishmania donovani, the parasite responsible for visceral leishmaniasis. Learn about the role of sand flies in transmitting the parasite between mammalian hosts and the regions where the common vectors are found.