Lectures 5 & 6 - Intermolecular Forces I-II: Origin of Intermolecular Forces

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Questions and Answers

What are intermolecular forces also known as?

  • Ionic bonds
  • Intramolecular forces
  • Noncovalent interactions (correct)
  • Covalent interactions

Which of the following is responsible for determining the physical properties of molecules?

  • Ionic bonds
  • Covalent bonds
  • Intermolecular forces (correct)
  • Intramolecular forces

What are the functional groups that form intermolecular bonds called?

  • Covalent groups
  • Noncovalent groups
  • Ionic groups
  • Binding groups (correct)

Which of the following intermolecular forces is caused by momentary changes in electron density?

<p>Van der Waals interactions (C)</p> Signup and view all the answers

Which type of intermolecular force occurs between functional groups within the same molecule?

<p>Intramolecular interactions (B)</p> Signup and view all the answers

What is the electron cloud distribution of an alkyl group typically expected to be?

<p>Equally distributed spatially (C)</p> Signup and view all the answers

What is the purpose of the partition coefficient in drug absorption?

<p>To facilitate the distribution of the drug between immiscible phases (C)</p> Signup and view all the answers

Which type of drugs must be given parenterally?

<p>Gentamicin, Ceftriaxone (D)</p> Signup and view all the answers

What is a prodrug in pharmacology?

<p>An inactive drug linked to a carrier group (A)</p> Signup and view all the answers

Why are prodrugs generally esters or amides?

<p>To modify lipophilicity (A)</p> Signup and view all the answers

In drug solubility, what is the role of Haloperidol decanoate?

<p>It enhances lipid solubility (B)</p> Signup and view all the answers

Why must drugs exhibit some degree of aqueous solubility?

<p>To allow for distribution between immiscible phases (C)</p> Signup and view all the answers

Which of the following interactions play an important role in protein folding?

<p>Van der Waals interactions (London forces) (D)</p> Signup and view all the answers

What causes the repulsion between water molecules and non-polar molecules or groups?

<p>Hydrophobic interaction (D)</p> Signup and view all the answers

Which of the following is the strongest intermolecular bond?

<p>Ionic interactions (C)</p> Signup and view all the answers

Which of the following amino acids are positively charged at physiological pH?

<p>Arginine and Lysine (D)</p> Signup and view all the answers

What causes molecular dipoles?

<p>Unequal sharing of electrons between atoms in a molecule (D)</p> Signup and view all the answers

Which of the following amino acids are negatively charged at physiological pH?

<p>Aspartic acid and Glutamic acid (A)</p> Signup and view all the answers

What type of interactions are crucial for drug-receptor binding?

<p>van der Waals interactions (D)</p> Signup and view all the answers

If interacting functional groups are on the same molecule, what type of bonding occurs?

<p>Intramolecular bonding (C)</p> Signup and view all the answers

For intramolecular bonding to occur, what condition must be met?

<p>The functional groups must be near each other or the molecule flexible (D)</p> Signup and view all the answers

What must happen for a compound to be soluble in water?

<p>Intra- and intermolecular interactions must be broken to allow bonding with water (B)</p> Signup and view all the answers

Which type of bonding occurs when interacting functional groups are on different molecules?

<p>Intermolecular bonding (B)</p> Signup and view all the answers

Which of the following interactions are considered weak but can have a crucial overall contribution to drug-receptor binding?

<p>van der Waals interactions (A)</p> Signup and view all the answers

What does a positive π value indicate about a fragment?

<p>It is lipophilic (D)</p> Signup and view all the answers

What is the predicted solubility of a compound with a total π value of +0.7?

<p>Insoluble in water (B)</p> Signup and view all the answers

Which of the following fragments has a negative π value?

<p>Amine (C)</p> Signup and view all the answers

What is the partition coefficient used to measure?

<p>A drug's lipid solubility (C)</p> Signup and view all the answers

Based on the given π values, what is the total π value for the compound Procaine?

<p>+2.3 (D)</p> Signup and view all the answers

Which of the following is an example of partitioning?

<p>All of the above (D)</p> Signup and view all the answers

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