30 Questions
What are intermolecular forces also known as?
Noncovalent interactions
Which of the following is responsible for determining the physical properties of molecules?
Intermolecular forces
What are the functional groups that form intermolecular bonds called?
Binding groups
Which of the following intermolecular forces is caused by momentary changes in electron density?
Van der Waals interactions
Which type of intermolecular force occurs between functional groups within the same molecule?
Intramolecular interactions
What is the electron cloud distribution of an alkyl group typically expected to be?
Equally distributed spatially
What is the purpose of the partition coefficient in drug absorption?
To facilitate the distribution of the drug between immiscible phases
Which type of drugs must be given parenterally?
Gentamicin, Ceftriaxone
What is a prodrug in pharmacology?
An inactive drug linked to a carrier group
Why are prodrugs generally esters or amides?
To modify lipophilicity
In drug solubility, what is the role of Haloperidol decanoate?
It enhances lipid solubility
Why must drugs exhibit some degree of aqueous solubility?
To allow for distribution between immiscible phases
Which of the following interactions play an important role in protein folding?
Van der Waals interactions (London forces)
What causes the repulsion between water molecules and non-polar molecules or groups?
Hydrophobic interaction
Which of the following is the strongest intermolecular bond?
Ionic interactions
Which of the following amino acids are positively charged at physiological pH?
Arginine and Lysine
What causes molecular dipoles?
Unequal sharing of electrons between atoms in a molecule
Which of the following amino acids are negatively charged at physiological pH?
Aspartic acid and Glutamic acid
What type of interactions are crucial for drug-receptor binding?
van der Waals interactions
If interacting functional groups are on the same molecule, what type of bonding occurs?
Intramolecular bonding
For intramolecular bonding to occur, what condition must be met?
The functional groups must be near each other or the molecule flexible
What must happen for a compound to be soluble in water?
Intra- and intermolecular interactions must be broken to allow bonding with water
Which type of bonding occurs when interacting functional groups are on different molecules?
Intermolecular bonding
Which of the following interactions are considered weak but can have a crucial overall contribution to drug-receptor binding?
van der Waals interactions
What does a positive π value indicate about a fragment?
It is lipophilic
What is the predicted solubility of a compound with a total π value of +0.7?
Insoluble in water
Which of the following fragments has a negative π value?
Amine
What is the partition coefficient used to measure?
A drug's lipid solubility
Based on the given π values, what is the total π value for the compound Procaine?
+2.3
Which of the following is an example of partitioning?
All of the above
Explore the origin and significance of intermolecular forces, such as hydrogen bonding and van der Waals forces. Learn how these forces play a crucial role in the properties of biological macro-molecules and overall molecular behavior.
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