Lectures 5 & 6 - Intermolecular Forces I-II: Origin of Intermolecular Forces
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Questions and Answers

What are intermolecular forces also known as?

  • Ionic bonds
  • Intramolecular forces
  • Noncovalent interactions (correct)
  • Covalent interactions

    • Which of the following is responsible for determining the physical properties of molecules?

  • Ionic bonds
  • Covalent bonds
  • Intermolecular forces (correct)
  • Intramolecular forces

    • What are the functional groups that form intermolecular bonds called?

  • Covalent groups
  • Noncovalent groups
  • Ionic groups
  • Binding groups (correct)

    • Which of the following intermolecular forces is caused by momentary changes in electron density?

    <p>Van der Waals interactions</p> Signup and view all the answers

    Which type of intermolecular force occurs between functional groups within the same molecule?

    <p>Intramolecular interactions</p> Signup and view all the answers

    What is the electron cloud distribution of an alkyl group typically expected to be?

    <p>Equally distributed spatially</p> Signup and view all the answers

    What is the purpose of the partition coefficient in drug absorption?

    <p>To facilitate the distribution of the drug between immiscible phases</p> Signup and view all the answers

    Which type of drugs must be given parenterally?

    <p>Gentamicin, Ceftriaxone</p> Signup and view all the answers

    What is a prodrug in pharmacology?

    <p>An inactive drug linked to a carrier group</p> Signup and view all the answers

    Why are prodrugs generally esters or amides?

    <p>To modify lipophilicity</p> Signup and view all the answers

    In drug solubility, what is the role of Haloperidol decanoate?

    <p>It enhances lipid solubility</p> Signup and view all the answers

    Why must drugs exhibit some degree of aqueous solubility?

    <p>To allow for distribution between immiscible phases</p> Signup and view all the answers

    Which of the following interactions play an important role in protein folding?

    <p>Van der Waals interactions (London forces)</p> Signup and view all the answers

    What causes the repulsion between water molecules and non-polar molecules or groups?

    <p>Hydrophobic interaction</p> Signup and view all the answers

    Which of the following is the strongest intermolecular bond?

    <p>Ionic interactions</p> Signup and view all the answers

    Which of the following amino acids are positively charged at physiological pH?

    <p>Arginine and Lysine</p> Signup and view all the answers

    What causes molecular dipoles?

    <p>Unequal sharing of electrons between atoms in a molecule</p> Signup and view all the answers

    Which of the following amino acids are negatively charged at physiological pH?

    <p>Aspartic acid and Glutamic acid</p> Signup and view all the answers

    What type of interactions are crucial for drug-receptor binding?

    <p>van der Waals interactions</p> Signup and view all the answers

    If interacting functional groups are on the same molecule, what type of bonding occurs?

    <p>Intramolecular bonding</p> Signup and view all the answers

    For intramolecular bonding to occur, what condition must be met?

    <p>The functional groups must be near each other or the molecule flexible</p> Signup and view all the answers

    What must happen for a compound to be soluble in water?

    <p>Intra- and intermolecular interactions must be broken to allow bonding with water</p> Signup and view all the answers

    Which type of bonding occurs when interacting functional groups are on different molecules?

    <p>Intermolecular bonding</p> Signup and view all the answers

    Which of the following interactions are considered weak but can have a crucial overall contribution to drug-receptor binding?

    <p>van der Waals interactions</p> Signup and view all the answers

    What does a positive π value indicate about a fragment?

    <p>It is lipophilic</p> Signup and view all the answers

    What is the predicted solubility of a compound with a total π value of +0.7?

    <p>Insoluble in water</p> Signup and view all the answers

    Which of the following fragments has a negative π value?

    <p>Amine</p> Signup and view all the answers

    What is the partition coefficient used to measure?

    <p>A drug's lipid solubility</p> Signup and view all the answers

    Based on the given π values, what is the total π value for the compound Procaine?

    <p>+2.3</p> Signup and view all the answers

    Which of the following is an example of partitioning?

    <p>All of the above</p> Signup and view all the answers

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