18 Questions
What is a basic characteristic of cancer?
Uncontrolled growth and spread of abnormal cells
What is metastasis in relation to cancer?
The spread of cancer cells to other parts of the body
What does the term 'Oncogenetics' refer to?
Field emerging from the study of genes causing neoplasia
How do genetic mutations affect cell growth in cancer?
Result in uncontrolled and aberrant cell growth
What is the fundamental belief about neoplastic cells in cancer biology?
They arise from normal progenitors due to DNA changes
Why is understanding the genetic basis of cancer crucial?
For effective prevention, early detection, and treatment
Which type of genes are mutated or inactivated in cancer, leading to uncontrolled cell division?
Tumor suppressor genes
What category of mutations is inherited from one's parents and can increase the risk of developing cancer?
Germline mutations
Which type of genetic changes can alter gene expression without changing the DNA sequence itself?
Histone modifications
What are driver mutations in a cancer genome?
Mutations directly contributing to cancer cell growth
Which genetic factors can be classified into two categories: somatic mutations and germline mutations?
Cancer genetics
In cancer, which genes directly contribute to the development of cancer by promoting cell growth and proliferation?
Oncogenes
What role do somatic mutations play in cancer development?
Lead to uncontrolled cell division
Which of the following is a characteristic of oncogenes?
Promote growth and survival of cancer cells
How do mutations in tumor suppressor genes differ from mutations in oncogenes?
Mutations in tumor suppressor genes lead to uncontrolled cell division
Which gene is implicated in the MAPK signaling pathway and is considered an oncogene?
Ras gene
How do internal factors contribute to mutations that can lead to cancer development?
Initiate somatic mutations in non-germline cells
What is the primary effect of mutations in genes controlling cell growth in cancer?
Promote uncontrolled cell division
This quiz focuses on understanding the genetic foundations of cancer, a complex and widespread disease. Explore the mechanisms behind uncontrolled cell growth, the formation of tumors, and the spread of cancerous cells through the body. This is a pivotal part of the curriculum for students looking to deepen their knowledge in human genetics and cancer biology.
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