LEC.2 Trypanosoma spp. and African Trypanosomiasis

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Questions and Answers

Where in the triatomine insect does the differentiation into epimastigotes occur?

  • Legs
  • Wings
  • Salivary glands
  • Midgut (correct)

What is the term for the swelling and erythema resulting from the local replication of parasites at the site of the insect bite(triatomine bug)?

  • Lymphadenopathy
  • Chagoma (correct)
  • Megacolon
  • Romana's sign

Which form of T.cruzi infects any nucleated cell in the vertebrate host but has a predilection for muscle, especially the heart and gastrointestinal tract?

  • Amastigote (correct)
  • Trypomastigote
  • Epimastigote
  • Promastigote

Which agents can suppress parasitemia and cure the acute phase of Chagas' disease in 60-80% of cases?

<p>Nifurtimox and benznidazole (D)</p> Signup and view all the answers

Which form of T.cruzi is liberated in the blood, causing lysis of infected cells and dissemination throughout the body via the bloodstream?

<p>Trypomastigote (C)</p> Signup and view all the answers

What is the term for the massive dilatation of the esophagus and/or colon due to parasympathetic denervation caused by chronic T.cruzi infection?

<p>Megacolon/megaesophagus (A)</p> Signup and view all the answers

What is the main reason why developing a protective vaccine against African trypanosomes has been unsuccessful?

<p>Antigenic variation of the most abundant surface glycoprotein VSG (B)</p> Signup and view all the answers

Which subspecies of Trypanosoma brucei is more prevalent in Eastern Africa and mostly results in acute lethal human infections?

<p>Trypanosoma brucei rhodesiense (C)</p> Signup and view all the answers

What is the characteristic symptom of the second (encephalitic) stage of human African trypanosomiasis?

<p>Disturbed circadian rhythms (A)</p> Signup and view all the answers

How is Trypanosomiasis transmitted to mammalian hosts?

<p>Through the bite of a tsetse fly (A)</p> Signup and view all the answers

What is the role of wild animals in the transmission of Trypanosomiasis?

<p>They serve as reservoirs for the live parasite (B)</p> Signup and view all the answers

What happens to the trypomastigotes that enter the midgut of the tsetse fly?

<p>They become epimastigotes (B)</p> Signup and view all the answers

How do long slender forms of trypomastigotes enter extravascular tissues in mammalian hosts?

<p>By penetrating blood vessel endothelium (A)</p> Signup and view all the answers

What is the primary method of transmission for Trypanosoma spp. in tsetse flies?

<p>During blood meals from infected hosts (A)</p> Signup and view all the answers

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