25 Questions
What was done to the precipitate after it was collected by filtration?
It was washed with chilled distilled water
What was the purpose of washing the precipitate with chilled distilled water?
To remove impurities from the precipitate
What was done to the dried precipitate?
It was recrystallized from solvents
What was the percentage of ethanol used for recrystallization?
80% ethanol
What was the purpose of recrystallization?
To purify the precipitate
What is the molecular weight of the given compound?
465.55
What is the percentage of Carbon in the given compound?
67.08
How many protons are responsible for the signal at 0.59 and 0.68 ppm in the 1H NMR?
3H
What is the structural feature of the compound responsible for the signal at 7.88 and 8.08 ppm in the 1H NMR?
N=CH
What is the molecular formula of the given compound?
C26H31N3O5
In which year was the study 'Pract Res Clin Gastroenterol' published?
2001
What is the page range of the study 'Best Biostructures'?
819-827
Who are the authors of the study 'Cikla P, Ozcavci D, Sener A and Turan S'?
Cikla P, Ozcavci D, Sener A and Turan S
In which volume of the journal is the study 'Pract Res Clin Gastroenterol' published?
15
What is the issue number of the study 'Best Biostructures'?
2
What is the purpose of using NSAIDs?
To treat various inflammatory conditions, pain, and fever
What was the purpose of using the egg white induced edema model?
To study the anti-inflammatory activity of the target compounds
What type of compounds are NSAIDs?
Heterogeneous group of compounds
How can NSAIDs be categorized by their site of action?
Into selective and nonselective inhibitors
According to the equation, what was determined for the synthesized compounds?
Their dose determination
What is presented in Table 1?
The dose determination of the synthesized compounds
What is common to both COX I and COX II inhibitors?
They are both targeted by NSAIDs
What is the main characteristic of nonselective COX inhibitors?
They target both COX I and COX II
What was studied using the egg white induced edema model?
The anti-inflammatory activity of the target compounds
What is the name of the model used to study the anti-inflammatory activity of the target compounds?
Egg white induced edema model
Study Notes
Synthesis of Compound
- The precipitate was collected by filtration, washed with chilled distilled water, and dried.
- The precipitate was then recrystallized from solvents (80% ethanol for ether).
NMR Spectroscopy
- 1H NMR spectroscopy was used to analyze the compound.
- Peaks observed at 0.59, 0.68 (3H, tt, -CH2-CH3 at C1), 1.25 (3H, t, -CH2-CH3 at C8), and others.
Molecular Structure
- The compound has a molecular formula of C26H31N3O5 and a molecular weight of 465.55.
- The compound is calculated to have 67.08% carbon.
Compound Identification
- The compound is identified as 2-(1, 8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)-N'-(pyridin-2-ylmethylene) acetohydrazide.
Research Background
- NSAIDs are a heterogeneous group of compounds used to treat various inflammatory conditions, pain, and fever.
- NSAIDs can be categorized into nonselective (COX) inhibitors and selective (COX) inhibitors.
Biological Activity
- The anti-inflammatory activity of the target compounds was studied using the egg white induced edema model.
References
- Best Pract Res Clin Gastroenterol. 2001;15(5): 801-820.
- Biostructures. 2011;6(2): 819-827.
This quiz covers the laboratory procedures for collecting and purifying a precipitate through filtration, washing, and recrystallization.
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