Laboratory Techniques: Precipitation and Recrystallization
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Questions and Answers

What was done to the precipitate after it was collected by filtration?

  • It was left untouched
  • It was washed with hot water
  • It was mixed with solvents
  • It was washed with chilled distilled water (correct)

    • What was the purpose of washing the precipitate with chilled distilled water?

  • To mix the precipitate with solvents
  • To remove impurities from the precipitate (correct)
  • To recrystallize the precipitate
  • To dry the precipitate

    • What was done to the dried precipitate?

  • It was recrystallized from solvents (correct)
  • It was mixed with solvents
  • It was washed with chilled distilled water
  • It was left untouched

    • What was the percentage of ethanol used for recrystallization?

    <p>80% ethanol</p> Signup and view all the answers

    What was the purpose of recrystallization?

    <p>To purify the precipitate</p> Signup and view all the answers

    What is the molecular weight of the given compound?

    <p>465.55</p> Signup and view all the answers

    What is the percentage of Carbon in the given compound?

    <p>67.08</p> Signup and view all the answers

    How many protons are responsible for the signal at 0.59 and 0.68 ppm in the 1H NMR?

    <p>3H</p> Signup and view all the answers

    What is the structural feature of the compound responsible for the signal at 7.88 and 8.08 ppm in the 1H NMR?

    <p>N=CH</p> Signup and view all the answers

    What is the molecular formula of the given compound?

    <p>C26H31N3O5</p> Signup and view all the answers

    In which year was the study 'Pract Res Clin Gastroenterol' published?

    <p>2001</p> Signup and view all the answers

    What is the page range of the study 'Best Biostructures'?

    <p>819-827</p> Signup and view all the answers

    Who are the authors of the study 'Cikla P, Ozcavci D, Sener A and Turan S'?

    <p>Cikla P, Ozcavci D, Sener A and Turan S</p> Signup and view all the answers

    In which volume of the journal is the study 'Pract Res Clin Gastroenterol' published?

    <p>15</p> Signup and view all the answers

    What is the issue number of the study 'Best Biostructures'?

    <p>2</p> Signup and view all the answers

    What is the purpose of using NSAIDs?

    <p>To treat various inflammatory conditions, pain, and fever</p> Signup and view all the answers

    What was the purpose of using the egg white induced edema model?

    <p>To study the anti-inflammatory activity of the target compounds</p> Signup and view all the answers

    What type of compounds are NSAIDs?

    <p>Heterogeneous group of compounds</p> Signup and view all the answers

    How can NSAIDs be categorized by their site of action?

    <p>Into selective and nonselective inhibitors</p> Signup and view all the answers

    According to the equation, what was determined for the synthesized compounds?

    <p>Their dose determination</p> Signup and view all the answers

    What is presented in Table 1?

    <p>The dose determination of the synthesized compounds</p> Signup and view all the answers

    What is common to both COX I and COX II inhibitors?

    <p>They are both targeted by NSAIDs</p> Signup and view all the answers

    What is the main characteristic of nonselective COX inhibitors?

    <p>They target both COX I and COX II</p> Signup and view all the answers

    What was studied using the egg white induced edema model?

    <p>The anti-inflammatory activity of the target compounds</p> Signup and view all the answers

    What is the name of the model used to study the anti-inflammatory activity of the target compounds?

    <p>Egg white induced edema model</p> Signup and view all the answers

    Study Notes

    Synthesis of Compound

    • The precipitate was collected by filtration, washed with chilled distilled water, and dried.
    • The precipitate was then recrystallized from solvents (80% ethanol for ether).

    NMR Spectroscopy

    • 1H NMR spectroscopy was used to analyze the compound.
    • Peaks observed at 0.59, 0.68 (3H, tt, -CH2-CH3 at C1), 1.25 (3H, t, -CH2-CH3 at C8), and others.

    Molecular Structure

    • The compound has a molecular formula of C26H31N3O5 and a molecular weight of 465.55.
    • The compound is calculated to have 67.08% carbon.

    Compound Identification

    • The compound is identified as 2-(1, 8-diethyl-1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)-N'-(pyridin-2-ylmethylene) acetohydrazide.

    Research Background

    • NSAIDs are a heterogeneous group of compounds used to treat various inflammatory conditions, pain, and fever.
    • NSAIDs can be categorized into nonselective (COX) inhibitors and selective (COX) inhibitors.

    Biological Activity

    • The anti-inflammatory activity of the target compounds was studied using the egg white induced edema model.

    References

    • Best Pract Res Clin Gastroenterol. 2001;15(5): 801-820.
    • Biostructures. 2011;6(2): 819-827.

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    Description

    This quiz covers the laboratory procedures for collecting and purifying a precipitate through filtration, washing, and recrystallization.

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